| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miranda Mladinic, Christophe Lefèvre, Elaine Del Bel, John Nicholls, Matthew Digb. Developmental changes of gene expression after spinal cord injury in neonatal opossums. Brain research. vol 1363. 2011-02-24. PMID:20849836. |
by contrast, at 13 days, up-regulation occurred of inhibitory molecules, including annexins, ephrins, and genes related to apoptosis and neurodegenerative diseases. |
2011-02-24 |
2023-08-12 |
Not clear |
| Sara Baratchi, Rupinder K Kanwar, Jagat R Kanwa. Survivin: a target from brain cancer to neurodegenerative disease. Critical reviews in biochemistry and molecular biology. vol 45. issue 6. 2011-02-24. PMID:20925597. |
due to the various roles of survivin during cell division and apoptosis, targeting this protein illustrates a new therapeutic window for the treatment of neurodegenerative diseases. |
2011-02-24 |
2023-08-12 |
Not clear |
| E A Tendi, R Cunsolo, D Bellia, R L Messina, S Paratore, P Calissano, S Cavallar. Drug target identification for neuronal apoptosis through a genome scale screening. Current medicinal chemistry. vol 17. issue 26. 2011-01-28. PMID:20858172. |
however, neuronal apoptosis subsequent to this developmental window is physiologically inappropriate for most systems and can contribute to neurodegenerative diseases. |
2011-01-28 |
2023-08-12 |
Not clear |
| Daniela Schifilliti, Giovanni Grasso, Alfredo Conti, Vincenzo Fodal. Anaesthetic-related neuroprotection: intravenous or inhalational agents? CNS drugs. vol 24. issue 11. 2011-01-26. PMID:20932063. |
taken as a whole, the available data appear to indicate that anaesthetic drugs such as barbiturates, propofol, xenon and most volatile anaesthetics (halothane, isoflurane, desflurane, sevoflurane) show neuroprotective effects that protect cerebral tissue from adverse events--such as apoptosis, degeneration, inflammation and energy failure--caused by chronic neurodegenerative diseases, ischaemia, stroke or nervous system trauma. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mikhail A Kutuzov, Nelly Bennett, Alexandra V Andreev. Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1). The international journal of biochemistry & cell biology. vol 42. issue 11. 2011-01-18. PMID:20674765. |
apoptosis signal regulating kinase-1 (ask1) is a map kinase kinase kinase implicated in cancer, cardiovascular and neurodegenerative diseases. |
2011-01-18 |
2023-08-12 |
human |
| Shan Lu, Chunhua Lu, Qin Han, Jing Li, Zhijian Du, Lianming Liao, Robert Chunhua Zha. Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation. Toxicology. vol 279. issue 1-3. 2011-01-14. PMID:21040751. |
glutamate excitotoxicity has been implicated as one of the factors contributing to neuronal apoptosis and is involved in many neurodegenerative diseases. |
2011-01-14 |
2023-08-12 |
Not clear |
| Shan Lu, Chunhua Lu, Qin Han, Jing Li, Zhijian Du, Lianming Liao, Robert Chunhua Zha. Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation. Toxicology. vol 279. issue 1-3. 2011-01-14. PMID:21040751. |
these results suggest that amscs can effectively protect pc12 cells from glutamate excitotoxicity-induced apoptosis and support the hypothesis that amscs may be a useful treatment for stroke or neurodegenerative diseases which often involve excitotoxicity. |
2011-01-14 |
2023-08-12 |
Not clear |
| Nurit Keinan, Dalia Tyomkin, Varda Shoshan-Barmat. Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis. Molecular and cellular biology. vol 30. issue 24. 2011-01-13. PMID:20937774. |
thus, targeting the oligomeric status of vdac, and hence apoptosis, offers a therapeutic strategy for combating cancers and neurodegenerative diseases. |
2011-01-13 |
2023-08-12 |
Not clear |
| Takahiro Yaguchi, Tetsu Nagata, Tomoyuki Nishizak. 1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death. Behavioral and brain functions : BBF. vol 6. 2011-01-11. PMID:20831835. |
endoplasmic reticulum (er) stress-induced neuronal apoptosis, on the other hand, is a critical factor for pathogenesis of neurodegenerative diseases such as alzheimer disease and parkinson disease, senile dementia, and ischemic neuronal damage. |
2011-01-11 |
2023-08-12 |
Not clear |
| Laurent M Dejean, Shin-Young Ryu, Sonia Martinez-Caballero, Oscar Teijido, Pablo M Peixoto, Kathleen W Kinnall. MAC and Bcl-2 family proteins conspire in a deadly plot. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20083086. |
apoptosis is also involved in many pathologies including cancer, neurodegenerative diseases, aging, and infarcts. |
2011-01-10 |
2023-08-12 |
Not clear |
| Marie-Pierre Hinault, America Farina Henriquez Cuendet, Rayees U H Mattoo, Mounir Mensi, Giovanni Dietler, Hilal A Lashuel, Pierre Goloubinof. Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. The Journal of biological chemistry. vol 285. issue 49. 2010-12-30. PMID:20847048. |
together, our findings suggest that inhibition of the hsp70/hsp40 chaperone system by α-syn oligomers may contribute to the disruption of protein homeostasis in dopaminergic neurons, leading to apoptosis and tissue loss in parkinson disease and related neurodegenerative diseases. |
2010-12-30 |
2023-08-12 |
human |
| Tjakko J van Ham, James Mapes, David Kokel, Randall T Peterso. Live imaging of apoptotic cells in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 11. 2010-12-21. PMID:20601526. |
many debilitating diseases, including neurodegenerative diseases, involve apoptosis. |
2010-12-21 |
2023-08-12 |
zebrafish |
| Bettina Wagner, Maria Sibili. Methods to study MAP kinase signalling in the central nervous system. Methods in molecular biology (Clifton, N.J.). vol 661. 2010-12-14. PMID:20812003. |
mapks and their upstream signalling receptors play also an important role in the development of neurodegenerative diseases due to their capacity to control neural cell apoptosis. |
2010-12-14 |
2023-08-12 |
Not clear |
| Hui-Juan Zhang, Michelle Kwan-Yee Siu, Li-Li Jiang, Victor Chun-Yin Mak, Hextan Yuen-Sheung Ngan, Annie Nga-Yin Cheun. Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 29. issue 5. 2010-12-10. PMID:20736773. |
dj-1 is found to be important in human neurodegenerative diseases and cancers by regulating oxidative damage and apoptosis. |
2010-12-10 |
2023-08-12 |
human |
| Lilian Kisiswa, Julie Albon, James E Morgan, Michael A Wrid. Cellular inhibitor of apoptosis (cIAP1) is down-regulated during retinal ganglion cell (RGC) maturation. Experimental eye research. vol 91. issue 5. 2010-11-05. PMID:20831867. |
apoptosis, is the main type of cell death that occurs in ageing and neurodegenerative disease, such as glaucoma. |
2010-11-05 |
2023-08-12 |
rat |
| Se-Eun Park, Seung Kim, Kumar Sapkota, Sung-Jun Ki. Neuroprotective effect of Rosmarinus officinalis extract on human dopaminergic cell line, SH-SY5Y. Cellular and molecular neurobiology. vol 30. issue 5. 2010-09-16. PMID:20563702. |
these findings indicate that r. officinalis is able to protect the neuronal cells against h2o2-induced injury and suggest that r. officinalis might potentially serve as an agent for prevention of several human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2010-09-16 |
2023-08-12 |
human |
| Sayaka Suzuki, Utako Yokoyama, Takaya Abe, Hiroshi Kiyonari, Naoya Yamashita, Yuko Kato, Reiko Kurotani, Motohiko Sato, Satoshi Okumura, Yoshihiro Ishikaw. Differential roles of Epac in regulating cell death in neuronal and myocardial cells. The Journal of biological chemistry. vol 285. issue 31. 2010-09-14. PMID:20516079. |
because the disruption of epac exerted a protective effect on neuronal apoptosis in vivo, the inhibition of epac may be a consideration in designing a therapeutic strategy for the treatment of neurodegenerative diseases. |
2010-09-14 |
2023-08-12 |
mouse |
| Gunnar P H Diet. Cell-penetrating peptide technology to deliver chaperones and associated factors in diseases and basic research. Current pharmaceutical biotechnology. vol 11. issue 2. 2010-08-05. PMID:20166965. |
the delivery of heat shock proteins (hsp) using cpp has been applied in models for apoptosis, necrosis, oxidative stress, neurodegenerative diseases, stroke, cystic fibrosis, smooth muscle relaxation, myocardial injury, scar formation, and others. |
2010-08-05 |
2023-08-12 |
Not clear |
| Rawan Tarawneh, James E Galvi. Potential future neuroprotective therapies for neurodegenerative disorders and stroke. Clinics in geriatric medicine. vol 26. issue 1. 2010-07-15. PMID:20176298. |
although neurodegenerative diseases such as alzheimer disease, parkinson disease, and huntington disease each have distinct clinical symptoms and pathologies, they all share common mechanisms such as protein aggregation, oxidative injury, inflammation, apoptosis, and mitochondrial injury that contribute to neuronal loss. |
2010-07-15 |
2023-08-12 |
Not clear |
| Michal Levy, Anthony H Futerma. Mammalian ceramide synthases. IUBMB life. vol 62. issue 5. 2010-07-13. PMID:20222015. |
different cers also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases. |
2010-07-13 |
2023-08-12 |
Not clear |