| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M T Viscomi, S Oddi, L Latini, E Bisicchia, M Maccarrone, M Molinar. The endocannabinoid system: a new entry in remote cell death mechanisms. Experimental neurology. vol 224. issue 1. 2010-06-28. PMID:20353775. |
endocannabinoids constitute a novel class of lipids that regulate mammalian cell apoptosis and the pathogenesis of neuroinflammatory and neurodegenerative diseases. |
2010-06-28 |
2023-08-12 |
human |
| Eun-Mee Kim, Eun-Jung Shin, Ji Hyun Choi, Hyo Jin Son, Il-Seon Park, Tong H Joh, Onyou Hwan. Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress. The Journal of biological chemistry. vol 285. issue 22. 2010-06-17. PMID:20368330. |
although endoplasmic reticulum (er) stress-induced apoptosis has been associated with pathogenesis of neurodegenerative diseases, the cellular components involved have not been well delineated. |
2010-06-17 |
2023-08-12 |
Not clear |
| M Laburthe, T Voisin, A El Fira. Orexins/hypocretins and orexin receptors in apoptosis: a mini-review. Acta physiologica (Oxford, England). vol 198. issue 3. 2010-06-14. PMID:19719798. |
finally, this mini-review will also speculate on: (1) the potential importance of tyrosine-based motifs in the large family of gpcrs; (2) the interest of orexin receptors as therapeutic targets in cancer therapy; (3) the possible role of orexin receptor-mediated apoptosis in physiology and pathophysiology in the brain (neurodevelopment, neurodegenerative diseases) and in the periphery. |
2010-06-14 |
2023-08-12 |
Not clear |
| Gustav J Strijkers, Geralda A F van Tilborg, Tessa Geelen, Chris P M Reutelingsperger, Klaas Nicola. Current applications of nanotechnology for magnetic resonance imaging of apoptosis. Methods in molecular biology (Clifton, N.J.). vol 624. 2010-06-14. PMID:20217606. |
insufficient apoptosis is important in the pathology of various disorders such as cancer and autoimmune diseases, whereas a high apoptotic activity is associated with myocardial infarction, neurodegenerative diseases, and advanced atherosclerotic lesions. |
2010-06-14 |
2023-08-12 |
Not clear |
| Heng Du, Shirley ShiDu Ya. Mitochondrial medicine for neurodegenerative diseases. The international journal of biochemistry & cell biology. vol 42. issue 5. 2010-06-11. PMID:20067840. |
commonly seen types of mitochondrial dysfunction in neurodegenerative diseases include excessive free radical generation, lowered atp production, mitochondrial permeability transition, mitochondrial dna lesions, perturbed mitochondrial dynamics and apoptosis. |
2010-06-11 |
2023-08-12 |
Not clear |
| Tingting Yan, Yan Feng, Qiwei Zha. Axon degeneration: Mechanisms and implications of a distinct program from cell death. Neurochemistry international. vol 56. issue 4. 2010-05-25. PMID:20117162. |
axon degeneration has been proposed to be a new therapeutic target for neurodegenerative diseases, because it usually occurs earlier than neuronal cell body death with a distinct active program from apoptosis and necrosis. |
2010-05-25 |
2023-08-12 |
mouse |
| Yan-Ping Zou, Yan-Hua Lu, Dong-Zhi We. Protective effects of a flavonoid-rich extract of Hypericum perforatum L. against hydrogen peroxide-induced apoptosis in PC12 cells. Phytotherapy research : PTR. vol 24 Suppl 1. 2010-05-10. PMID:19548287. |
these results suggested that fehp possessed protective effects against h2o2-induced apoptosis in pc12 cells and fehp might be useful in the treatment of oxidative stress-related neurodegenerative diseases such as parkinson's disease and alzheimer's disease. |
2010-05-10 |
2023-08-12 |
rat |
| Shehua Zhang, Junli Ye, Guoxiong Don. Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. Journal of molecular neuroscience : MN. vol 40. issue 3. 2010-05-07. PMID:19731100. |
taken together, these results suggest that baicalein can block h2o2-induced apoptosis by prevention of oxidative stress as well as regulation of bcl-2 family members and suppression of mitochondria dysfunction, which might be beneficial for the treatment of oxidative stress in aging and age-associated neurodegenerative diseases. |
2010-05-07 |
2023-08-12 |
Not clear |
| Johanna Vrielink, Mariette S Heins, Rita Setroikromo, Eva Szegezdi, Margaret M Mullally, Afshin Samali, Wim J Qua. Synthetic constrained peptide selectively binds and antagonizes death receptor 5. The FEBS journal. vol 277. issue 7. 2010-05-04. PMID:20156289. |
dysregulation of apoptosis is implicated in the pathogenesis of diseases such as cancer, neurodegenerative diseases and autoimmune disorders. |
2010-05-04 |
2023-08-12 |
Not clear |
| Maria-Mihaela Bădulescu, Andreea-Roxana Lupu, Lidia Cremer, Ana Călugăru, Natalia Simona Apetrei, M Moscovici, Georgeta Mocanu, G Szegl. The modulation of reactive oxygen species production from human polymorphonuclear cells by curdlan derivatives as dectin-1 agonists/antagonists. Roumanian archives of microbiology and immunology. vol 68. issue 2. 2010-05-04. PMID:20361523. |
reactive oxygen species (ros) are well known to be cytotoxic and have been implicated in the etiology of a wide array of human diseases including diabetes, neurodegenerative diseases, cancer and also influence central cellular processes such as proliferation, apoptosis, senescence etc. |
2010-05-04 |
2023-08-12 |
human |
| Robert B Campeno. NGF uptake and retrograde signaling mechanisms in sympathetic neurons in compartmented cultures. Results and problems in cell differentiation. vol 48. 2010-04-22. PMID:19343309. |
apoptosis resulting from the loss of retrograde ngf signaling contributes to the elimination of excess and misconnected neurons during development and to the death of neurons during the course of neurodegenerative diseases. |
2010-04-22 |
2023-08-12 |
Not clear |
| Knut H Lauritzen, Olve Moldestad, Lars Eide, Harald Carlsen, Gaute Nesse, Johan F Storm, Isabelle M Mansuy, Linda H Bergersen, Arne Klunglan. Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Molecular and cellular biology. vol 30. issue 6. 2010-04-09. PMID:20065039. |
mitochondrial dysfunction underlying changes in neurodegenerative diseases is often associated with apoptosis and a progressive loss of neurons, and damage to the mitochondrial genome is proposed to be involved in such pathologies. |
2010-04-09 |
2023-08-12 |
mouse |
| Julia C Knight, Eugene L Scharf, Yang Mao-Draaye. Fas activation increases neural progenitor cell survival. Journal of neuroscience research. vol 88. issue 4. 2010-03-25. PMID:19830835. |
although there is a sizable amount of research focusing on adult neural progenitor cells (npcs) as a therapeutic approach for many neurodegenerative diseases, including multiple sclerosis, little is known about the pathways that govern npc survival and apoptosis. |
2010-03-25 |
2023-08-12 |
Not clear |
| Xuri Li, Chunsik Lee, Zhongshu Tang, Fan Zhang, Pachiappan Arjunan, Yang Li, Xu Hou, Anil Kumar, Lijin Don. VEGF-B: a survival, or an angiogenic factor? Cell adhesion & migration. vol 3. issue 4. 2010-03-05. PMID:19684473. |
(3) using different types of neuro-injury and neurodegenerative disease models, vegf-b treatment protected endangered neurons from apoptosis without inducing undesired blood vessel growth or permeability. |
2010-03-05 |
2023-08-12 |
Not clear |
| Mei-Jie Jou, Tsung-I Peng, Lee-Fen Hsu, Shuo-Bin Jou, Russel J Reiter, Chuen-Mao Yang, Chuan-Chin Chiao, Yi-Fan Lin, Chun-Chia Che. Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes. Journal of pineal research. vol 48. issue 1. 2010-03-04. PMID:19925580. |
as astrocytes are actively involve in regulating synaptic transmission and neurovascular coupling in the cns, these multiple mitochondrial layers of protection provided by melatonin against mca(2+)-and/or mros-mediated apoptosis in astrocytes may be crucial for future therapeutic prevention and treatment of astrocyte-mediated neurodegenerative diseases in the cns. |
2010-03-04 |
2023-08-12 |
rat |
| Emily K Schroeder, Natalie A Kelsey, Jeanne Doyle, Elise Breed, Ron J Bouchard, F Alexandra Loucks, R Alex Harbison, Daniel A Linsema. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxidants & redox signaling. vol 11. issue 3. 2010-03-01. PMID:18754708. |
these properties of egcg make it an interesting therapeutic candidate for neurodegenerative diseases involving neuronal apoptosis triggered by mitochondrial oxidative stress. |
2010-03-01 |
2023-08-12 |
rat |
| Lilia Alberghina, Anna Maria Colangel. The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration. BMC neuroscience. vol 7 Suppl 1. 2010-02-25. PMID:17118156. |
apoptosis is a programmed cell death that plays a critical role during the development of the nervous system and in many chronic neurodegenerative diseases, including alzheimer's disease (ad). |
2010-02-25 |
2023-08-12 |
Not clear |
| Jon Zárate, Encarnación Goicoechea, Jesús Pascual, Enrique Echevarría, Mariá D Guillé. A study of the toxic effect of oxidized sunflower oil containing 4-hydroperoxy-2-nonenal and 4-hydroxy-2-nonenal on cortical TrkA receptor expression in rats. Nutritional neuroscience. vol 12. issue 6. 2010-02-24. PMID:19925718. |
these results indicate that toxic substances present in the oxidized sunflower oil, among them 4-hydroxy-trans-2-nonenal (hne) and 4-hydroperoxy-trans-2-nonenal (hpne), could disrupt survival signalling of frontal cortex cholinergic neurons, which could lead to apoptosis and neurodegenerative diseases. |
2010-02-24 |
2023-08-12 |
rat |
| Julie Bournival, Patrik Quessy, Maria-Grazia Martinol. Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cellular and molecular neurobiology. vol 29. issue 8. 2010-02-17. PMID:19466539. |
these findings support the role of these natural polyphenols in preventive and/or complementary therapies for several human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2010-02-17 |
2023-08-12 |
human |
| Carolina E Abrahan, Gisela E Miranda, Daniela L Agnolazza, Luis E Politi, Nora P Rotstei. Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. Investigative ophthalmology & visual science. vol 51. issue 2. 2010-02-17. PMID:19797232. |
oxidative stress is involved in inducing apoptosis of photoreceptors in many retinal neurodegenerative diseases. |
2010-02-17 |
2023-08-12 |
Not clear |