| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsumori Yamashima, Shinji Oikaw. The role of lysosomal rupture in neuronal death. Progress in neurobiology. vol 89. issue 4. 2010-02-12. PMID:19772886. |
however, apoptosis is only part of the story, and inhibition of neuronal necrosis may have greater impact than apoptosis, on the treatment of stroke, traumatic brain injury, and neurodegenerative diseases. |
2010-02-12 |
2023-08-12 |
human |
| Chang-jiang Huang, Tatyana Gurlo, Leena Haataja, Safia Costes, Marie Daval, Sergey Ryazantsev, Xiuji Wu, Alexandra E Butler, Peter C Butle. Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. The Journal of biological chemistry. vol 285. issue 1. 2010-01-26. PMID:19861418. |
the islet in type 2 diabetes (t2dm) and the brain in neurodegenerative diseases share progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed amyloidogenic proteins (islet amyloid polypeptide (iapp) in t2dm). |
2010-01-26 |
2023-08-12 |
human |
| b' Zeljko Ferenci\\xc4\\x8. [Apoptosis in toxicologic pathology]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 63 Suppl 2. 2010-01-26. PMID:19999544.' |
also, the disbalance in apoptosis processes is documented in viral, autoimmune and neurodegenerative diseases, as well as in tumors. |
2010-01-26 |
2023-08-12 |
human |
| Johnson Agniswamy, Bin Fang, Irene T Webe. Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7. Apoptosis : an international journal on programmed cell death. vol 14. issue 10. 2010-01-19. PMID:19655253. |
caspase-mediated apoptosis has important roles in normal cell differentiation and aging and in many diseases including cancer, neuromuscular disorders and neurodegenerative diseases. |
2010-01-19 |
2023-08-12 |
Not clear |
| Chun-Yi Liu, Cheng-Feng Lee, Yau-Huei We. Role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases associated with mitochondrial DNA mutations. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 108. issue 8. 2009-12-09. PMID:19666347. |
role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases associated with mitochondrial dna mutations. |
2009-12-09 |
2023-08-12 |
human |
| Chun-Yi Liu, Cheng-Feng Lee, Yau-Huei We. Role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases associated with mitochondrial DNA mutations. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 108. issue 8. 2009-12-09. PMID:19666347. |
in this review, we focus on the involvement of mtdna-mutation-associated oxidative stress and susceptibility to apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases. |
2009-12-09 |
2023-08-12 |
human |
| Juliette Gafni, Xin Cong, Sylvia F Chen, Bradford W Gibson, Lisa M Ellerb. Calpain-1 cleaves and activates caspase-7. The Journal of biological chemistry. vol 284. issue 37. 2009-11-02. PMID:19617626. |
caspase-7 is an executioner caspase that plays a key role in apoptosis, cancer, and a number of neurodegenerative diseases. |
2009-11-02 |
2023-08-12 |
Not clear |
| Christopher L Daugherty, Hilda Curtis, Tony Realini, Judie F Charlton, Sepideh Zarepars. Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism. Molecular vision. vol 15. 2009-10-28. PMID:19784392. |
apoptosis has been implicated as the mechanism for retinal ganglion cell death in primary open-angle glaucoma (poag), a complex neurodegenerative disease. |
2009-10-28 |
2023-08-12 |
Not clear |
| Wei Liu, Xing-Wang Zhou, Shaojun Liu, Kunhua Hu, Chong Wang, Qingyu He, Mingtao L. Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons. Proteomics. vol 9. issue 14. 2009-10-07. PMID:19639589. |
study of calpain-mediated cleavage events and related functions may contribute to a better understanding of neuronal apoptosis and neurodegenerative diseases. |
2009-10-07 |
2023-08-12 |
Not clear |
| M Yeste-Velasco, J Folch, G Casadesús, M A Smith, M Pallàs, A Camin. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience. vol 159. issue 3. 2009-09-21. PMID:19356694. |
increasing evidence implicates the c-jun nh(2)-terminal kinase (jnk) pathway in the regulation of apoptosis in neurodegenerative diseases. |
2009-09-21 |
2023-08-12 |
rat |
| Ivana Sirangelo, Clara Iannuzzi, Silvia Vilasi, Gaetano Irace, Gaia Giuberti, Gabriella Misso, Annamaria D'Alessandro, Alberto Abbruzzese, Michele Caragli. W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac. Journal of cellular physiology. vol 221. issue 2. 2009-09-09. PMID:19585524. |
our results indicate a role for ras and rac in the induction of both intracellular ros increased levels and apoptosis mediated by pfas and disclose a new scenario of intervention in neurodegenerative diseases. |
2009-09-09 |
2023-08-12 |
human |
| Kengo Homma, Kazumi Katagiri, Hideki Nishitoh, Hidenori Ichij. Targeting ASK1 in ER stress-related neurodegenerative diseases. Expert opinion on therapeutic targets. vol 13. issue 6. 2009-08-05. PMID:19456270. |
in this review, we summarize the molecular mechanisms of the upr and er stress-induced apoptosis and the possible roles of ask1 activation in neurodegenerative diseases. |
2009-08-05 |
2023-08-12 |
Not clear |
| Katrina McGonigal, Jamshid Tanha, Elitza Palazov, Shenghua Li, Deyzi Gueorguieva-Owens, Siyaram Pande. Isolation and functional characterization of single domain antibody modulators of Caspase-3 and apoptosis. Applied biochemistry and biotechnology. vol 157. issue 2. 2009-07-08. PMID:18553063. |
these v(h)h antagonist and agonist of apoptosis could have potential for the development of therapeutics for neurodegenerative diseases and cancer, respectively. |
2009-07-08 |
2023-08-12 |
human |
| K Yamagata, S Ichinose, A Miyashita, M Tagam. Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Neuroscience. vol 153. issue 2. 2009-06-29. PMID:18384965. |
ebselen may be effective in the prevention and/or treatment of neurodegenerative diseases associated with excessive apoptosis in patients with stroke. |
2009-06-29 |
2023-08-12 |
rat |
| Nazzareno Ballatori, Suzanne M Krance, Sylvia Notenboom, Shujie Shi, Kim Tieu, Christine L Hammon. Glutathione dysregulation and the etiology and progression of human diseases. Biological chemistry. vol 390. issue 3. 2009-06-12. PMID:19166318. |
glutathione (gsh) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and as a result, disturbances in gsh homeostasis are implicated in the etiology and/or progression of a number of human diseases, including cancer, diseases of aging, cystic fibrosis, and cardiovascular, inflammatory, immune, metabolic, and neurodegenerative diseases. |
2009-06-12 |
2023-08-12 |
human |
| Baolu Zha. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochemical research. vol 34. issue 4. 2009-06-03. PMID:19125328. |
the author reviews the studies on the protecting effects of natural antioxidants on neurons in neurodegenerative diseases, especially summarized the results about protective effect of green tea polyphenols on neurons against apoptosis of cellular and animal pd models, and of genestine and nicotine on neurons against a beta-induced apoptosis of hippocampal neuronal and transgenic mouse ad models. |
2009-06-03 |
2023-08-12 |
mouse |
| Volodymyr Rybalchenko, Sung-Yong Hwang, Nataliya Rybalchenko, Peter Koule. The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity. The international journal of biochemistry & cell biology. vol 40. issue 1. 2009-05-01. PMID:17709274. |
exaggerated chronic ca(2+) release can trigger cellular apoptosis underlying a variety of neurodegenerative diseases. |
2009-05-01 |
2023-08-12 |
mouse |
| Parco M Siu, Stephen E Alwa. Response and adaptation of skeletal muscle to denervation stress: the role of apoptosis in muscle loss. Frontiers in bioscience (Landmark edition). vol 14. 2009-04-07. PMID:19273076. |
apoptosis is a well-conserved cellular destructive event which has been implicated in a variety of diseases such as cancers and neurodegenerative diseases. |
2009-04-07 |
2023-08-12 |
Not clear |
| Adrienne M Gorma. Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. Journal of cellular and molecular medicine. vol 12. issue 6A. 2009-04-02. PMID:18624755. |
this review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, alzheimer's, parkinson's and huntington's diseases. |
2009-04-02 |
2023-08-12 |
Not clear |
| Cheng-Gang Zou, Xiu-Zhen Cao, Yue-Shui Zhao, Shun-Yu Gao, Shu-De Li, Xian-Yong Liu, Yan Zhang, Ke-Qin Zhan. The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I. Endocrinology. vol 150. issue 1. 2009-03-12. PMID:18801901. |
the molecular mechanism of endoplasmic reticulum stress-induced apoptosis in pc-12 neuronal cells: the protective effect of insulin-like growth factor i. endoplasmic reticulum (er) stress has been implicated in several neurodegenerative diseases. |
2009-03-12 |
2023-08-12 |
Not clear |