| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Orit Bar-Am, Orly Weinreb, Tamar Amit, Moussa B H Youdi. The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats. Journal of molecular neuroscience : MN. vol 37. issue 2. 2009-03-05. PMID:18751929. |
in addition to its unique combination of che and mao enzyme inhibition, these results indicate that ladostigil displays neuroprotective activity against oxidative stress-induced cell apoptosis, which might be valuable for aging and age-associated neurodegenerative diseases. |
2009-03-05 |
2023-08-12 |
human |
| Erin Carlton, Qingshan Teng, Thais Federici, Jun Yang, Jonathan Riley, Nicholas M Bouli. Fusion of the tetanus toxin C fragment binding domain and Bcl-xL for protection of peripheral nerve neurons. Neurosurgery. vol 63. issue 6. 2009-02-19. PMID:19057331. |
apoptosis has been shown to play an important role in motor neuron (mn) degeneration in both neurodegenerative disease and peripheral neuropathy. |
2009-02-19 |
2023-08-12 |
Not clear |
| Agnieszka Dejda, Valérie Jolivel, Steve Bourgault, Tommy Seaborn, Alain Fournier, Hubert Vaudry, David Vaudr. Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases. Journal of molecular neuroscience : MN. vol 36. issue 1-3. 2009-02-17. PMID:18506634. |
inhibitory effect of pacap on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases. |
2009-02-17 |
2023-08-12 |
Not clear |
| Pin-Chao Liao, Hung-Yu Lin, Chiou-Hwa Yuh, Lin-Kwei Yu, Horng-Dar Wan. The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila. Biochemical and biophysical research communications. vol 376. issue 4. 2008-11-13. PMID:18796296. |
heat shock proteins (hsps) are chaperones thought to increase lifespan, enhance stress resistance, and prevent apoptosis and neurodegenerative diseases. |
2008-11-13 |
2023-08-12 |
drosophila_melanogaster |
| Jae Keun Lee, Jin Hee Shin, JaeHong Suh, In Sun Choi, Keun Sil Ryu, Byoung Joo Gwa. Tissue inhibitor of metalloproteinases-3 (TIMP-3) expression is increased during serum deprivation-induced neuronal apoptosis in vitro and in the G93A mouse model of amyotrophic lateral sclerosis: a potential modulator of Fas-mediated apoptosis. Neurobiology of disease. vol 30. issue 2. 2008-10-13. PMID:18316197. |
these findings provide evidence that timp-3 is an upstream mediator of neuronal apoptosis and likely contributes to neuronal loss in neurodegenerative diseases such as amyotrophic lateral sclerosis. |
2008-10-13 |
2023-08-12 |
mouse |
| Joel A Dietz, Yan Li, Lisa M Chung, Brian S Yandell, Cassandra L Schlamp, Robert W Nickell. Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice. BMC neuroscience. vol 9. 2008-09-10. PMID:18671875. |
intrinsic apoptosis of neuronal somas is one aspect of neurodegenerative diseases that can be influenced by genetic background. |
2008-09-10 |
2023-08-12 |
mouse |
| Seong Soo Joo, Yeong Min Yoo, Byung Woo Ahn, Sang Yun Nam, Yun-Bae Kim, Kwang Woo Hwang, Do Ik Le. Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biological & pharmaceutical bulletin. vol 31. issue 7. 2008-09-02. PMID:18591781. |
considering the importance of inflammation and apoptosis in neurodegenerative conditions, the potential suppressive effects of the rg3, a by-product obtained during the steaming of red ginseng, may indicate that rg3 could provide a beneficial therapeutic approach to treating or preventing neurodegenerative disease. |
2008-09-02 |
2023-08-12 |
Not clear |
| b' Nazmi G\\xc3\\xbcltekin, Kamil Karao\\xc4\\x9flu, Emine K\\xc3\\xbc\\xc3\\xa7\\xc3\\xbckate\\xc5\\x9. [New discoveries in the mechanisms of apoptosis and cell survival and novel potential therapeutic strategies]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir. vol 36. issue 2. 2008-08-14. PMID:18497559.' |
the discovery of mechanisms of apoptosis and cell survival has enabled the development of new therapeutic strategies in heart diseases, cancers, neurodegenerative diseases, aids, and many disorders. |
2008-08-14 |
2023-08-12 |
Not clear |
| Francis G Blankenber. In vivo detection of apoptosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49 Suppl 2. 2008-08-06. PMID:18523067. |
the dysregulation of apoptosis can lead to the destruction of normal tissues in a variety of disorders, including autoimmune and neurodegenerative diseases (too much apoptosis) or the growth of tumors (too little apoptosis). |
2008-08-06 |
2023-08-12 |
Not clear |
| LingLing Hou, Tao Hon. Stem cells and neurodegenerative diseases. Science in China. Series C, Life sciences. vol 51. issue 4. 2008-07-29. PMID:18368305. |
neurodegenerative diseases are characterized by the neurodegenerative changes or apoptosis of neurons involved in networks, which are important to specific physiological functions. |
2008-07-29 |
2023-08-12 |
Not clear |
| S G Kalinichenko, N Yu Matveev. Morphological characteristics of apoptosis and its significance in neurogenesis. Neuroscience and behavioral physiology. vol 38. issue 4. 2008-07-24. PMID:18401722. |
apoptosis affects the ordering of connections in neural networks and is involved in the pathogenesis of neurodegenerative diseases--epilepsy, schizophrenia, and alzheimer's disease. |
2008-07-24 |
2023-08-12 |
Not clear |
| James W Simpkins, James A Dyken. Mitochondrial mechanisms of estrogen neuroprotection. Brain research reviews. vol 57. issue 2. 2008-07-01. PMID:17512984. |
the mitochondrial involvement in neurodegenerative diseases reflects the regulatory role mitochondrial failure plays in both necrotic cell death and apoptosis. |
2008-07-01 |
2023-08-12 |
Not clear |
| Zelda H Cheung, Ke Gong, Nancy Y I. Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 19. 2008-06-13. PMID:18463240. |
accumulating evidence indicates that deregulation of cyclin-dependent kinase 5 (cdk5) activity is associated with apoptosis in various neurodegenerative disease models. |
2008-06-13 |
2023-08-12 |
Not clear |
| Hongjun Fu, Juan Dou, Wenming Li, Jialie Luo, Kenny C Li, Colin S C Lam, Nelson T K Lee, Mingtao Li, Yifan Ha. Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms. Neuropharmacology. vol 54. issue 4. 2008-06-12. PMID:18222492. |
neuronal loss via apoptosis caused by various stimuli may be the fundamental mechanism underlying chronic and acute neurodegenerative diseases. |
2008-06-12 |
2023-08-12 |
Not clear |
| Yun Feng, Yingwei Lu, Xin Lin, Yanfeng Gao, Qianyu Zhao, Wei Li, Rui Wan. Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse. Life sciences. vol 82. issue 13-14. 2008-06-09. PMID:18272183. |
furthermore, these drugs blocked the enhanced release of cytochrome c (cyt c), and consequently inhibited the cell apoptosis induced by the release of cyt c. our results suggest that em1/2 and mor effectively protect brain mitochondria against oxidative stresses induced by in vitro anoxia-reoxygenation and may play an important role in the prevention of deleterious effects during brain ischemia-reperfusion and neurodegenerative diseases. |
2008-06-09 |
2023-08-12 |
mouse |
| Isabelle Lang-Rollin, Georgia Dermentzaki, Kostas Vekrellis, Maria Xilouri, Hardy J Rideout, Leonidas Stefani. A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18194212. |
the type of death described herein may be relevant to neurodegenerative diseases, where morphological evidence for apoptosis has been scant. |
2008-05-22 |
2023-08-12 |
mouse |
| Sonja Dittmer, Mert Sahin, Anna Pantlen, Ambrish Saxena, Diamandis Toutzaris, Ana-Luisa Pina, Andreas Geerts, Stefan Golz, Axel Methne. The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18180304. |
we conclude that gpr39 is a novel inhibitor of cell death, which might represent a therapeutic target with implications for processes involving apoptosis and endoplasmic reticulum stress like cancer, ischemia/reperfusion injury, and neurodegenerative disease. |
2008-05-20 |
2023-08-12 |
Not clear |
| M Miloso, A Scuteri, D Foudah, G Tredic. MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases. Current medicinal chemistry. vol 15. issue 6. 2008-05-19. PMID:18336268. |
although they are characterized by different features and a different onset, all the neurodegenerative diseases share the final steps that lead to cell death by apoptosis. |
2008-05-19 |
2023-08-12 |
Not clear |
| Monica Bari, Sergio Oddi, Chiara De Simone, Paola Spagnolo, Valeria Gasperi, Natalia Battista, Diego Centonze, Mauro Maccarron. Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells. Neuropharmacology. vol 54. issue 1. 2008-04-18. PMID:17714745. |
these findings may be relevant for the manifold cb1r-dependent activities of endocannabinoids, like the regulation of apoptosis and of neurodegenerative diseases. |
2008-04-18 |
2023-08-12 |
Not clear |
| Domagoj Vuci. Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors. Current cancer drug targets. vol 8. issue 2. 2008-04-17. PMID:18336193. |
dysregulation of apoptosis leading to early cell death or the absence of normal cell death contributes to a number of disease conditions including neurodegenerative diseases and cancer. |
2008-04-17 |
2023-08-12 |
human |