| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johann Schoenberger, Johann Bauer, Jutta Moosbauer, Christoph Eilles, Daniela Grim. Innovative strategies in in vivo apoptosis imaging. Current medicinal chemistry. vol 15. issue 2. 2008-04-03. PMID:18220774. |
apoptosis (programmed cell death) plays a key role in the pathogenesis of many disorders including cerebral and myocardial ischemia, autoimmune and neurodegenerative diseases, infections, organ and bone marrow transplant rejection, and tumor response to chemotherapy and/or radiotherapy. |
2008-04-03 |
2023-08-12 |
Not clear |
| Daniel Zemke, Seema Azhar, Arshad Maji. The mTOR pathway as a potential target for the development of therapies against neurological disease. Drug news & perspectives. vol 20. issue 8. 2008-03-27. PMID:18080036. |
many neurodegenerative diseases are characterized by neuronal death via apoptosis, and it is possible that modulation of mtor activity may offer some protection against their effects. |
2008-03-27 |
2023-08-12 |
Not clear |
| Maik Hüttemann, Icksoo Lee, Lobelia Samavati, Hong Yu, Jeffrey W Doa. Regulation of mitochondrial oxidative phosphorylation through cell signaling. Biochimica et biophysica acta. vol 1773. issue 12. 2008-02-15. PMID:18240421. |
a lack of cellular energy, excessive radical production, and dysregulated apoptosis are found alone or in combination in most human diseases, including neurodegenerative diseases, stroke, cardiovascular disorders, ischemia/reperfusion, and cancer. |
2008-02-15 |
2023-08-12 |
human |
| Xiao-Tian Zhang, Tian-Bao Song, Bao-Ling Du, Dong-Min Li, Xiao-Ming L. Caspase-3 antisense oligodeoxynucleotides inhibit apoptosis in gamma-irradiated human leukemia HL-60 cells. Apoptosis : an international journal on programmed cell death. vol 12. issue 4. 2008-01-14. PMID:17219053. |
the results suggest that antisense approach may be useful for therapeutic treatment of certain neurodegenerative diseases in which apoptosis is involved. |
2008-01-14 |
2023-08-12 |
human |
| B E Morrison, N Majdzadeh, S R D'Mell. Histone deacetylases: focus on the nervous system. Cellular and molecular life sciences : CMLS. vol 64. issue 17. 2007-11-09. PMID:17530170. |
neurodegenerative disease strikes millions worldwide and there is mounting evidence suggesting that underlying the onset and progression of these debilitating diseases is inappropriate neuronal apoptosis. |
2007-11-09 |
2023-08-12 |
Not clear |
| Zhenquan Jia, Hara P Misr. Exposure to mixtures of endosulfan and zineb induces apoptotic and necrotic cell death in SH-SY5Y neuroblastoma cells, in vitro. Journal of applied toxicology : JAT. vol 27. issue 5. 2007-10-25. PMID:17309119. |
these findings suggest that the cytotoxicity of endosulfan and zineb, both individually and in mixtures, is associated with the occurrence of early and late apoptotic/necrotic processes in sh-sy5y human neuroblastoma cells and support the contention that pesticide-induced neuronal cell death leading to neurodegenerative disease may, at least in part, be associated with early and late apoptosis of dopaminergic neurons. |
2007-10-25 |
2023-08-12 |
human |
| Wenya Wang, Yi Yang, Chunyi Ying, Wenming Li, Haolan Ruan, Xiaonan Zhu, Yan You, Yifan Han, Ruzhu Chen, Yizheng Wang, Mingtao L. Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology. vol 52. issue 8. 2007-10-25. PMID:17517424. |
glycogen synthase kinase-3beta (gsk-3beta) is closely involved in neuronal apoptosis and pathogenesis of many neurodegenerative diseases, such as alzheimer's disease. |
2007-10-25 |
2023-08-12 |
Not clear |
| Gonzalo Arboleda, Catherine Waters, Rosemary Gibso. Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells. Neuroscience letters. vol 421. issue 3. 2007-10-12. PMID:17573191. |
evidence has implicated apoptosis as a mechanism underlying cell death in diverse neurodegenerative diseases including parkinson's disease (pd). |
2007-10-12 |
2023-08-12 |
Not clear |
| Hiroshi Nishida, Megumi Kushida, Yuki Nakajima, Yoshihiro Ogawa, Naoto Tatewaki, Shinji Sato, Tetsuya Konish. Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction. Journal of pharmacological sciences. vol 104. issue 1. 2007-10-09. PMID:17485916. |
sms prevents the apoptosis through the enhancement of anti-oxidant enzymes and inhibition of the jnk signaling pathway with the promotion of nerve cell maturation, thus suggesting benefits of sms for the treating of neurodegenerative diseases. |
2007-10-09 |
2023-08-12 |
Not clear |
| Masahiro Okouchi, Oleksandr Ekshyyan, Magdalena Maracine, Tak Yee A. Neuronal apoptosis in neurodegeneration. Antioxidants & redox signaling. vol 9. issue 8. 2007-09-14. PMID:17571960. |
current and new experimental models for apoptosis research in neurodegenerative diseases are also discussed. |
2007-09-14 |
2023-08-12 |
Not clear |
| R Miller, W Bradley, M Cudkowicz, J Hubble, V Meininger, H Mitsumoto, D Moore, H Pohlmann, D Sauer, V Silani, M Strong, M Swash, E Vernotic. Phase II/III randomized trial of TCH346 in patients with ALS. Neurology. vol 69. issue 8. 2007-09-14. PMID:17709710. |
apoptosis is considered to be a key pathogenic mechanism in neurodegenerative diseases including als. |
2007-09-14 |
2023-08-12 |
Not clear |
| Susan Elmor. Apoptosis: a review of programmed cell death. Toxicologic pathology. vol 35. issue 4. 2007-09-05. PMID:17562483. |
inappropriate apoptosis (either too little or too much) is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. |
2007-09-05 |
2023-08-12 |
human |
| Li Zhang, Huixin Yu, Yang Sun, Xiufeng Lin, Bo Chen, Chen Tan, Guoxian Cao, Zhengwu Wan. Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. European journal of pharmacology. vol 564. issue 1-3. 2007-08-17. PMID:17349619. |
these results suggest that salidroside has protective effects against oxidative stress-induced cell apoptosis, which might be a potential therapeutic agent for treating or preventing neurodegenerative diseases implicated with oxidative stress. |
2007-08-17 |
2023-08-12 |
human |
| Yumei Wu, Mikiro Tada, Kyota Takahata, Kazuhito Tomizawa, Hideki Matsu. Inhibitory effect of polyunsaturated fatty acids on apoptosis induced by etoposide, okadaic acid and AraC in Neuro2a cells. Acta medica Okayama. vol 61. issue 3. 2007-07-25. PMID:17593950. |
neuronal apoptosis is involved in neurodegenerative diseases such as alzheimer's disease and parkinson.s disease. |
2007-07-25 |
2023-08-12 |
mouse |
| Ramon Roset, Laura Ortet, Gabriel Gil-Gome. Role of Bcl-2 family members on apoptosis: what we have learned from knock-out mice. Frontiers in bioscience : a journal and virtual library. vol 12. 2007-06-29. PMID:17485408. |
deregulation of their role may subvert the homeostasis of a given tissue and collaborate in the genesis of a myriad of diseases characterised by exacerbated or insufficient apoptosis, including diseases such as neurodegenerative diseases or cancer. |
2007-06-29 |
2023-08-12 |
mouse |
| Zoltán Urbányi, Miklós Sass, Judit Laszy, Viktor Takács, István Gyertyán, Tamás Pázmán. Serum amyloid P component induces TUNEL-positive nuclei in rat brain after intrahippocampal administration. Brain research. vol 1145. 2007-06-26. PMID:17337265. |
apoptosis is an important form of cell death in different neurodegenerative diseases including alzheimer's disease. |
2007-06-26 |
2023-08-12 |
rat |
| David A Elliott, Woojin S Kim, David A Jans, Brett Garne. Apoptosis induces neuronal apolipoprotein-E synthesis and localization in apoptotic bodies. Neuroscience letters. vol 416. issue 2. 2007-06-22. PMID:17320289. |
neuronal apoptosis is crucial for central nervous system development and also contributes to neurodegenerative disease. |
2007-06-22 |
2023-08-12 |
human |
| Sodhi K Rupinder, Aulakh K Gurpreet, Singh Manjee. Cell suicide and caspases. Vascular pharmacology. vol 46. issue 6. 2007-06-14. PMID:17382599. |
conversely dysregulation of apoptosis, resulting in either too less or excessive cell death is implicated in pathogenesis of stroke, myocardial infarction, neurodegenerative diseases, cancer and autoimmmune disorders. |
2007-06-14 |
2023-08-12 |
Not clear |
| M I Smith, M Deshmuk. Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell death and differentiation. vol 14. issue 5. 2007-05-23. PMID:17218955. |
apoptosis triggered by endoplasmic reticulum (er) stress is associated with various pathophysiological conditions including neurodegenerative diseases and ischemia. |
2007-05-23 |
2023-08-12 |
Not clear |
| M Naoi, W Maruyama, Y Akao, H Yi, Y Yamaok. Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection. Journal of neural transmission. Supplementum. issue 71. 2007-05-17. PMID:17447417. |
in neurodegenerative diseases, including parkinson's and alzheimer's diseases, apoptosis is a common type of cell death, and mitochondria emerge as the major organelle to initiate death cascade. |
2007-05-17 |
2023-08-12 |
human |