| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrizia Fattoretti, Carlo Bertoni-Freddari, Rina Recchioni, Belinda Giorgetti, Marta Balietti, Yessica Grossi, Moreno Solazzi, Tiziana Casoli, Giuseppina Di Stefano, Fiorella Marchesell. Experimental apoptosis provides clues about the role of mitochondrial changes in neuronal death. Annals of the New York Academy of Sciences. vol 1090. 2007-04-26. PMID:17384249. |
a better understanding of the mitochondrial role in neuronal apoptosis may suggest potential interventions to prevent the extensive nerve cell death typical of neurodegenerative diseases. |
2007-04-26 |
2023-08-12 |
human |
| Chor Hui Vivien Koh, Nam Sang Cheun. Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease. Cellular signalling. vol 18. issue 11. 2007-04-10. PMID:16797161. |
this review provides a consolidation of work done using u18666a in the past half century and focuses on the implications of our research findings on the mechanism of u18666a-mediated neuronal apoptosis in primary cortical neurons, which may provide an insight to elucidate the mechanisms of neurodegenerative diseases, particularly npc and ad, where apoptosis might occur through a similar mechanism. |
2007-04-10 |
2023-08-12 |
Not clear |
| Salvador Harguindey, Stephan J Reshkin, Gorka Orive, Jose Luis Arranz, Eduardo Anitu. Growth and trophic factors, pH and the Na+/H+ exchanger in Alzheimer's disease, other neurodegenerative diseases and cancer: new therapeutic possibilities and potential dangers. Current Alzheimer research. vol 4. issue 1. 2007-03-27. PMID:17316166. |
recent discoveries in research and treatment have shown that failure to induce selective cell apoptosis in hyperproliferative processes, like neoplastic diseases, and the failure to prevent spontaneous cell death in neurodegenerative diseases (hndds) such as alzheimer's disease (ad), multiple sclerosis (ms), amyothrophic lateral sclerosis (als), huntington's disease (hd), and retinitis pigmentosa (rp), can be interpreted as problems stemming from the same basic mechanisms but moving in diametrically opposed directions. |
2007-03-27 |
2023-08-12 |
human |
| Kyu-Yong Lee, Seong-Ho Koh, Min Young Noh, Kun-Woo Park, Young Joo Lee, Seung Hyun Ki. Glycogen synthase kinase-3beta activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells. Brain research. vol 1129. issue 1. 2007-03-22. PMID:17157278. |
these results suggest that optimized inhibitor levels for modulating gsk-3beta activity may prevent apoptosis induced by oxidative stress associated with neurodegenerative diseases. |
2007-03-22 |
2023-08-12 |
Not clear |
| Gülgün Tezel, Martin B Wa. Glaucoma. Chemical immunology and allergy. vol 92. 2007-03-21. PMID:17264498. |
glaucoma is a chronic neurodegenerative disease of the optic nerve, in which apoptosis of retinal ganglion cells (rgcs) and progressive loss of optic nerve axons result in structural and functional deficits in glaucoma patients. |
2007-03-21 |
2023-08-12 |
Not clear |
| Daniela Sanges, Antonella Comitato, Roberta Tammaro, Valeria Marig. Apoptosis in retinal degeneration involves cross-talk between apoptosis-inducing factor (AIF) and caspase-12 and is blocked by calpain inhibitors. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 46. 2007-01-05. PMID:17088543. |
molecular mechanisms underlying apoptosis in retinitis pigmentosa, as in other neurodegenerative diseases, are still elusive, and this fact hampers the development of a cure for this blinding disease. |
2007-01-05 |
2023-08-12 |
mouse |
| Peter Waldmeier, Donna Bozyczko-Coyne, Michael Williams, Jeffry L Vaugh. Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. Biochemical pharmacology. vol 72. issue 10. 2006-12-15. PMID:16901468. |
recent clinical failures in parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. |
2006-12-15 |
2023-08-12 |
Not clear |
| Peter Waldmeier, Donna Bozyczko-Coyne, Michael Williams, Jeffry L Vaugh. Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. Biochemical pharmacology. vol 72. issue 10. 2006-12-15. PMID:16901468. |
these recent clinical failures require a reassessment of both the relevance of apoptosis to neurodegenerative disease etiology and the available animal models used to prioritize nces for advancement to the clinic in this area. |
2006-12-15 |
2023-08-12 |
Not clear |
| Cassandra L Schlamp, Yan Li, Joel A Dietz, Katherine T Janssen, Robert W Nickell. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC neuroscience. vol 7. 2006-11-14. PMID:17018142. |
glaucoma is a chronic neurodegenerative disease of the retina, characterized by the degeneration of axons in the optic nerve and retinal ganglion cell apoptosis. |
2006-11-14 |
2023-08-12 |
mouse |
| Pawel Kermer, Jan Liman, Jochen H Weishaupt, Mathias Bäh. Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application. Neuro-degenerative diseases. vol 1. issue 1. 2006-09-26. PMID:16908969. |
neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application. |
2006-09-26 |
2023-08-12 |
Not clear |
| Pawel Kermer, Jan Liman, Jochen H Weishaupt, Mathias Bäh. Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application. Neuro-degenerative diseases. vol 1. issue 1. 2006-09-26. PMID:16908969. |
the present article will provide an overview of basic apoptotic mechanisms, the contribution of neuronal apoptosis to the above-mentioned disorders, potential clinical applications and their limitations and the possible implications for future studies regarding these neurodegenerative diseases. |
2006-09-26 |
2023-08-12 |
Not clear |
| Chor Hui Vivien Koh, Matthew Whiteman, Qiao-Xin Li, Barry Halliwell, Andrew M Jenner, Boon Seng Wong, Katrina M Laughton, Markus Wenk, Colin L Masters, Philip M Beart, Ora Bernard, Nam Sang Cheun. Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons. Journal of neurochemistry. vol 98. issue 4. 2006-09-21. PMID:16771828. |
the association of neuronal apoptosis with oxidative stress and abeta accumulation may provide clues to the pathogenesis of alzheimer's disease, as well as the role oxidative stress plays in other neurodegenerative diseases. |
2006-09-21 |
2023-08-12 |
Not clear |
| Brinda Ravikumar, Zdenek Berger, Coralie Vacher, Cahir J O'Kane, David C Rubinsztei. Rapamycin pre-treatment protects against apoptosis. Human molecular genetics. vol 15. issue 7. 2006-09-19. PMID:16497721. |
thus, rapamycin (pro-autophagic) treatment may be useful in certain disease conditions (including various neurodegenerative diseases) where a slow but increased rate of apoptosis is evident, even if they are not associated with overt aggregate formation. |
2006-09-19 |
2023-08-12 |
mouse |
| Beata Sikorsk. Mechanisms of neuronal death in transmissible spongiform encephalopathies. Folia neuropathologica. vol 42 Suppl B. 2006-09-19. PMID:16903144. |
however, there is no direct and convincing evidence of apoptosis of nerve cells in most neurodegenerative diseases. |
2006-09-19 |
2023-08-12 |
Not clear |
| Kazuhiro Takum. [Mitochondrial dysfunction and apoptosis in neurodegenerative diseases]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 127. issue 5. 2006-08-18. PMID:16819239. |
[mitochondrial dysfunction and apoptosis in neurodegenerative diseases]. |
2006-08-18 |
2023-08-12 |
Not clear |
| Karin Thevissen, Isabelle E J A François, Joris Winderickx, Christophe Pannecouque, Bruno P A Cammu. Ceramide involvement in apoptosis and apoptotic diseases. Mini reviews in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16787381. |
apoptosis is implicated in a number of diseases, including neurodegenerative diseases and aids. |
2006-08-11 |
2023-08-12 |
Not clear |
| Paul C Chin, Santosh R D'Mell. Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-07-07. PMID:15574392. |
increasing evidence implicates aberrant apoptosis as a fundamental cause of neurodegenerative diseases. |
2006-07-07 |
2023-08-12 |
Not clear |
| Paul C Chin, Santosh R D'Mell. Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-07-07. PMID:15574392. |
this review discusses the major molecules and signaling pathways leading to neuronal survival or apoptosis with emphasis on several small molecule inhibitors that target neuronal survival with the hope of impeding the detrimental effects of neurodegenerative diseases. |
2006-07-07 |
2023-08-12 |
Not clear |
| E D Burg, C V Remillard, J X-J Yua. K+ channels in apoptosis. The Journal of membrane biology. vol 209. issue 1. 2006-07-06. PMID:16685597. |
in neurodegenerative diseases, uncontrolled apoptosis leads to loss of brain tissue. |
2006-07-06 |
2023-08-12 |
Not clear |
| Jue Judy Liu, Wenge Wang, David T Dicker, Wafik S El-Deir. Bioluminescent imaging of TRAIL-induced apoptosis through detection of caspase activation following cleavage of DEVD-aminoluciferin. Cancer biology & therapy. vol 4. issue 8. 2006-07-05. PMID:16177559. |
apoptosis, the most common and well-defined form of programmed cell death (pcd), is often impaired in cancer and neurodegenerative diseases and can limit conventional therapy. |
2006-07-05 |
2023-08-12 |
human |