| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Zhu, P Hoell, B Ahlemeyer, J Krieglstei. PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis : an international journal on programmed cell death. vol 11. issue 2. 2006-06-15. PMID:16502258. |
these findings demonstrated that pten is a crucial mediator of mitochondria-dependent apoptosis, and thus could become a molecular target for interfering with neurodegenerative diseases. |
2006-06-15 |
2023-08-12 |
rat |
| R N Saha, K Paha. HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell death and differentiation. vol 13. issue 4. 2006-06-05. PMID:16167067. |
gradual disclosure of the molecular basis of selective neuronal apoptosis during neurodegenerative diseases reveals active participation of acetylating and deacetylating agents during the process. |
2006-06-05 |
2023-08-12 |
Not clear |
| Claudio A Hetz, Claudio Sot. Stressing out the ER: a role of the unfolded protein response in prion-related disorders. Current molecular medicine. vol 6. issue 1. 2006-05-25. PMID:16472111. |
transmissible spongiform encephalopathies are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and the accumulation of an abnormally folded form of the cellular prion protein (prp), denoted prp(sc). |
2006-05-25 |
2023-08-12 |
Not clear |
| Yusuke Sekine, Kohsuke Takeda, Hidenori Ichij. The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. Current molecular medicine. vol 6. issue 1. 2006-05-25. PMID:16472116. |
several lines of evidence suggest that er stress-induced apoptosis plays critical roles in the pathogenesis of neurodegenerative diseases such as alzheimer's disease, parkinson's disease, polyglutamine (polyq) diseases and amyotrophic lateral sclerosis (als). |
2006-05-25 |
2023-08-12 |
Not clear |
| Yusuke Sekine, Kohsuke Takeda, Hidenori Ichij. The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. Current molecular medicine. vol 6. issue 1. 2006-05-25. PMID:16472116. |
recent studies have shown that the ask1-mapk cascades are involved in er stress-induced apoptosis and in the neuronal cell death in some model systems of neurodegenerative diseases. |
2006-05-25 |
2023-08-12 |
Not clear |
| YueMei Zhang, Bhagu R Bhavnan. Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release. BMC neuroscience. vol 6. 2006-04-06. PMID:15730564. |
apoptosis plays a key role in cell death observed in neurodegenerative diseases marked by a progressive loss of neurons as seen in alzheimer's disease. |
2006-04-06 |
2023-08-12 |
Not clear |
| Yi Wen, Shaohua Yang, Ran Liu, James W Simpkin. Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353210. |
finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases. |
2006-03-23 |
2023-08-12 |
human |
| Nathalie Thiriet, Xiaolin Deng, Marcello Solinas, Bruce Ladenheim, Wendy Curtis, Steven R Goldberg, Richard D Palmiter, Jean Lud Cade. Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 22. 2006-03-02. PMID:15930374. |
methamphetamine (meth) is an illicit drug that causes neuronal apoptosis in the mouse striatum, in a manner similar to the neuronal loss observed in neurodegenerative diseases. |
2006-03-02 |
2023-08-12 |
mouse |
| Cathy W Levenso. Trace metal regulation of neuronal apoptosis: from genes to behavior. Physiology & behavior. vol 86. issue 3. 2006-02-21. PMID:16125208. |
the genetically programmed form of neuronal death known as apoptosis plays a role in many neurodegenerative diseases including alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis (als) and huntington's disease. |
2006-02-21 |
2023-08-12 |
Not clear |
| Laurent M Dejean, Sonia Martinez-Caballero, Stephen Manon, Kathleen W Kinnall. Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins. Biochimica et biophysica acta. vol 1762. issue 2. 2006-02-16. PMID:16055309. |
programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. |
2006-02-16 |
2023-08-12 |
Not clear |
| Guo-Hua Fan, Chen Qi, Sheng-Di Che. Heat shock proteins reduce toxicity of 1-methyl-4-phenylpyridinium ion in SK-N-SH cells. Journal of neuroscience research. vol 82. issue 4. 2006-02-16. PMID:16235253. |
heat shock proteins (hsps) have many functions, including inhibition of apoptosis and necrosis, protection from oxidative stress, and maintenance of the mitochondrial membrane potential, that are related to neurodegenerative diseases. |
2006-02-16 |
2023-08-12 |
human |
| Xie Minjie, Wang Wei, Zhu Zhou, Yu Yongfe. Capillary electrophoresis analysis of hydrogen peroxide induced apoptosis in PC12 cells. Journal of pharmaceutical and biomedical analysis. vol 39. issue 5. 2006-02-08. PMID:16039084. |
results show that ce can distinguish cell apoptosis and necrosis, quantify the degree of apoptosis in cells and have advantages of high efficiency, fast sample analysis speed, minute sample consumption and reliable results, which provides an accessorial method in the research of multiple diseases with abnormal apoptosis such as cancer and neurodegenerative diseases. |
2006-02-08 |
2023-08-12 |
rat |
| Baolu Zha. Natural antioxidants for neurodegenerative diseases. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953828. |
the author reviews the studies on the preventing effects of natural antioxidants, such as vitamins e and c, flavonoids, and polyphenols on neurodegenerative diseases, especially summarizing the results on the protective effect of ginkgo biloba extract on neuron cells, preventing effects of green tea polyphenols on apoptosis of pc12 cells (parkison's disease model), preventing effects of genestien on amyloid-beta-induced apoptosis of hippocampal neuronal cells (alzhemer's disease model), and preventing effect of crataegus flavonoids on ischemic-reperfusion damage to the brain of the mongolian gerbil (stroke model) in the laboratory. |
2006-01-24 |
2023-08-12 |
Not clear |
| b' Sonsoles Hortelano, Miriam Zeini, Paqui G Trav\\xc3\\xa9s, Lisardo Bosc\\xc3\\xa. Nitric oxide and cell signaling: in vivo evaluation of NO-dependent apoptosis by MRI and not NMR techniques. Methods in enzymology. vol 396. 2006-01-24. PMID:16291264.' |
apoptosis plays a key role in many pathological circumstances, such as neurodegenerative diseases. |
2006-01-24 |
2023-08-12 |
Not clear |
| Faris Q Alenz. Apoptosis and diseases: regulation and clinical relevance. Saudi medical journal. vol 26. issue 11. 2006-01-23. PMID:16311648. |
for instance, an increase in apoptosis leads to cell loss accompanied by neurodegenerative diseases, whereas we know that genetically determined defects of apoptosis result in deregulated cell proliferation, typical of cancer. |
2006-01-23 |
2023-08-12 |
human |
| Hwa Sun Kim, Chan Kee Par. Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program. Brain research. vol 1057. issue 1-2. 2006-01-04. PMID:16139821. |
neuronal cells undergo apoptosis when deprived of neurotrophic factors due to injury, trauma, or neurodegenerative disease. |
2006-01-04 |
2023-08-12 |
human |
| Y Huang, N Erdmann, H Peng, Y Zhao, Jialin Zhen. The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases. Cellular & molecular immunology. vol 2. issue 2. 2005-12-12. PMID:16191417. |
in this review, we summarize the possible common aspects that trail involved those neurodegenerative diseases, trail induced apoptosis signaling in the cns cells, and specific role of trail in individual diseases. |
2005-12-12 |
2023-08-12 |
Not clear |
| Marc Adrian Williams, Jadwiga Turchan, Yang Lu, Avindra Nath, Daniel B Drachma. Protection of human cerebral neurons from neurodegenerative insults by gene delivery of soluble tumor necrosis factor p75 receptor. Experimental brain research. vol 165. issue 3. 2005-12-01. PMID:15827736. |
apoptosis plays an important role in neuronal cell death in both chronic and acute human neurodegenerative diseases, including amyotrophic lateral sclerosis, huntington's disease, cerebral ischemia, and human immunodeficiency virus (hiv) encephalopathy. |
2005-12-01 |
2023-08-12 |
human |
| Stéphane Bach, Marie Knockaert, Jens Reinhardt, Olivier Lozach, Sophie Schmitt, Blandine Baratte, Marcel Koken, Stephen P Coburn, Lin Tang, Tao Jiang, Dong-Cai Liang, Hervé Galons, Jean-Francois Dierick, Lorenzo A Pinna, Flavio Meggio, Frank Totzke, Christoph Schächtele, Andrea S Lerman, Amancio Carnero, Yongqin Wan, Nathanael Gray, Laurent Meije. Roscovitine targets, protein kinases and pyridoxal kinase. The Journal of biological chemistry. vol 280. issue 35. 2005-10-25. PMID:15975926. |
besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infections, and glomerulonephritis. |
2005-10-25 |
2023-08-12 |
Not clear |
| Gonzalo Arboleda, Catherine Waters, Rosemary M Gibso. Metabolic activity: a novel indicator of neuronal survival in the murine dopaminergic cell line CAD. Journal of molecular neuroscience : MN. vol 27. issue 1. 2005-10-13. PMID:16055947. |
apoptosis is implicated in many neurodegenerative diseases, including parkinson's disease (pd). |
2005-10-13 |
2023-08-12 |
Not clear |