| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ravi Shankar Akundi, Eduardo Candelario-Jalil, Sandra Hess, Michael Hüll, Klaus Lieb, Peter J Gebicke-Haerter, Bernd L Fiebic. Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia. vol 51. issue 3. 2005-09-08. PMID:15800925. |
this potential nature of ceramides in activating microglia suggests that endogenously produced ceramides during neuronal apoptosis in ischemia or neurodegenerative diseases could also contribute to the amplification of neuroinflammatory events. |
2005-09-08 |
2023-08-12 |
rat |
| Pascale Gaillard, Isabelle Jeanclaude-Etter, Vittoria Ardissone, Steve Arkinstall, Yves Cambet, Montserrat Camps, Christian Chabert, Dennis Church, Rocco Cirillo, Denise Gretener, Serge Halazy, Anthony Nichols, Cedric Szyndralewiez, Pierre-Alain Vitte, Jean-Pierre Gottelan. Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. Journal of medicinal chemistry. vol 48. issue 14. 2005-08-16. PMID:15999997. |
several lines of evidence support the hypothesis that c-jun n-terminal kinase (jnks) plays a critical role in a wide range of diseases including cell death (apoptosis)-related disorders (neurodegenerative diseases, brain, heart, and renal ischemia, epilepsy) and inflammatory disorders (multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases). |
2005-08-16 |
2023-08-12 |
rat |
| Jin Zhong, Jixian Deng, Jennifer Phan, Stephen Dlouhy, Huangbing Wu, Weiguo Yao, Ping Ye, A Joseph D'Ercole, Wei-Hua Le. Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice. Journal of neuroscience research. vol 80. issue 4. 2005-07-25. PMID:15846777. |
these results confirm our previous suggestion that a lack of igf-i activity contributes to apoptosis of weaver granule neurons in vivo and supports igf-i's potential therapeutic use in neurodegenerative disease. |
2005-07-25 |
2023-08-12 |
mouse |
| Min Deng, Jin Yuan Zhao, Peng Fei Tu, Yong Jiang, Zheng Bin Li, Yao Hong Wan. Echinacoside rescues the SHSY5Y neuronal cells from TNFalpha-induced apoptosis. European journal of pharmacology. vol 505. issue 1-3. 2005-05-16. PMID:15556132. |
thus, echinacoside has the neuroprotective capacity to antagonize tnfalpha-induced apoptosis in shsy5y cells and may be useful in treating some neurodegenerative diseases. |
2005-05-16 |
2023-08-12 |
human |
| De-Maw Chuang, Christopher Hough, Vladimir V Senatoro. Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. Annual review of pharmacology and toxicology. vol 45. 2005-05-12. PMID:15822178. |
glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. |
2005-05-12 |
2023-08-12 |
Not clear |
| Manus W Ward, Donat Kögel, Jochen H M Preh. Neuronal apoptosis: BH3-only proteins the real killers? Journal of bioenergetics and biomembranes. vol 36. issue 4. 2005-04-20. PMID:15377860. |
at present there is a poor understanding of the events that lead up to neuronal apoptosis that occurs in neurodegenerative diseases and following acute ischemic episodes. |
2005-04-20 |
2023-08-12 |
Not clear |
| Alfons Lawen, Jennifer D Ly, Darius J R Lane, Kristof Zarschler, Angela Messina, Vito De Pint. Voltage-dependent anion-selective channel 1 (VDAC1)--a mitochondrial protein, rediscovered as a novel enzyme in the plasma membrane. The international journal of biochemistry & cell biology. vol 37. issue 2. 2005-03-29. PMID:15474974. |
regulation of the enzyme will have impacts on cancer and autoimmune diseases (insufficient apoptosis) as well as neurodegenerative diseases (excessive apoptosis). |
2005-03-29 |
2023-08-12 |
Not clear |
| Rebecca Clayton, John B Clark, Martyn Sharp. Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease. Journal of neurochemistry. vol 92. issue 4. 2005-03-21. PMID:15686486. |
cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease. |
2005-03-21 |
2023-08-12 |
rat |
| Anne Marcilha. [Intracellular signaling pathways, apoptosis and neurodegenerative diseases]. Psychologie & neuropsychiatrie du vieillissement. vol 2. issue 3. 2005-03-01. PMID:15689335. |
[intracellular signaling pathways, apoptosis and neurodegenerative diseases]. |
2005-03-01 |
2023-08-12 |
Not clear |
| Thomas Rückle, Marco Biamonte, Tania Grippi-Vallotton, Steve Arkinstall, Yves Cambet, Montserrat Camps, Christian Chabert, Dennis J Church, Serge Halazy, Xuliang Jiang, Isabelle Martinou, Anthony Nichols, Wolfgang Sauer, Jean-Pierre Gottelan. Design, synthesis, and biological activity of novel, potent, and selective (benzoylaminomethyl)thiophene sulfonamide inhibitors of c-Jun-N-terminal kinase. Journal of medicinal chemistry. vol 47. issue 27. 2005-02-14. PMID:15615541. |
several lines of evidence support the hypothesis that c-jun n-terminal kinases (jnks) play a critical role in a wide range of disease states including cell death (apoptosis)-related and inflammatory disorders (epilepsy, brain, heart and renal ischemia, neurodegenerative diseases, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel syndrome). |
2005-02-14 |
2023-08-12 |
Not clear |
| Tetsumori Yamashim. Ca2+-dependent proteases in ischemic neuronal death: a conserved 'calpain-cathepsin cascade' from nematodes to primates. Cell calcium. vol 36. issue 3-4. 2005-01-27. PMID:15261484. |
recent data suggest that necrosis rather than apoptosis appear to be the crucial component of the damage to the nervous system during human ischemic injuries and neurodegenerative diseases. |
2005-01-27 |
2023-08-12 |
human |
| Fumitaka Osakada, Asami Hashino, Toshiaki Kume, Hiroshi Katsuki, Shuji Kaneko, Akinori Akaik. Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology. vol 47. issue 6. 2005-01-13. PMID:15527824. |
oxidative stress and apoptosis play pivotal roles in the pathogenesis of neurodegenerative diseases. |
2005-01-13 |
2023-08-12 |
rat |
| Serge Przedborsk. Molecular targets for neuroprotection. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases. vol 5 Suppl 1. 2005-01-11. PMID:15512862. |
apoptosis has emerged as a significant pathogenic factor in several neurodegenerative diseases, including als. |
2005-01-11 |
2023-08-12 |
Not clear |
| Donald R Johns, Kathryn A Colb. Treatment of Leber's hereditary optic neuropathy: theory to practice. Seminars in ophthalmology. vol 17. issue 1. 2004-12-14. PMID:15513454. |
advances in neuroprotection, apoptosis, and neurodegenerative diseases may provide important clues for potential therapeutic agents for lhon. |
2004-12-14 |
2023-08-12 |
Not clear |
| Ying Wang, Xianting Li, Lu Wang, Peiguo Ding, Yingmei Zhang, Wenling Han, Dalong M. An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression. Journal of cell science. vol 117. issue Pt 8. 2004-12-10. PMID:15020679. |
accumulating reports demonstrate that apoptosis does not explain all the forms of programmed cell death (pcd), particularly in individual development and neurodegenerative disease. |
2004-12-10 |
2023-08-12 |
Not clear |
| Joaquin Castilla, Claudio Hetz, Claudio Sot. Molecular mechanisms of neurotoxicity of pathological prion protein. Current molecular medicine. vol 4. issue 4. 2004-11-24. PMID:15354870. |
transmissible spongiform encephalopathies or prion related disorders are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and accumulation of a misfolded form of the cellular prion protein (prp), denoted prp(sc). |
2004-11-24 |
2023-08-12 |
Not clear |
| Brigitte Onténient. Natural and synthetic inhibitors of caspases: targets for novel drugs. Current drug targets. CNS and neurological disorders. vol 3. issue 4. 2004-11-23. PMID:15379609. |
along with inflammation, apoptosis appears a common feature of cell death in non-infectious neurodegenerative diseases. |
2004-11-23 |
2023-08-12 |
Not clear |
| Christiane Charriaut-Marlangu. Apoptosis: a target for neuroprotection. Therapie. vol 59. issue 2. 2004-10-18. PMID:15359610. |
consistent with the proposal that apoptosis plays a central role in human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and alzheimer's disease. |
2004-10-18 |
2023-08-12 |
mouse |
| S Oyadomari, M Mor. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell death and differentiation. vol 11. issue 4. 2004-10-14. PMID:14685163. |
here, we summarize the current understanding of the roles of chop/gadd153 in er stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease. |
2004-10-14 |
2023-08-12 |
Not clear |
| M Francesca Cordeiro, Li Guo, Vy Luong, Glen Harding, Wei Wang, Helen E Jones, Stephen E Moss, Adam M Sillito, Frederick W Fitzk. Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 36. 2004-09-30. PMID:15340151. |
we have been able to image changes occurring in nerve cell apoptosis over hours, days, and months and show that effects depend on the magnitude of the initial apoptotic inducer in several models of neurodegenerative disease in rat and primate. |
2004-09-30 |
2023-08-12 |
rat |