| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanna Calandra-Buonaura, Pietro Guaraldi, Luisa Sambati, Giovanna Lopane, Annagrazia Cecere, Giorgio Barletta, Federica Provini, Manuela Contin, Paolo Martinelli, Pietro Cortell. Multiple system atrophy with prolonged survival: is late onset of dysautonomia the clue? Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 10. 2014-06-02. PMID:23728718. |
multiple system atrophy (msa) is a neurodegenerative disease characterised by cardiovascular autonomic failure and/or urinary dysfunctions, associated with parkinsonism, cerebellar and/or corticospinal signs, usually leading to death after an average of 7 years. |
2014-06-02 |
2023-08-12 |
Not clear |
| Matthis Synofzik, Michael A Gonzalez, Charles Marques Lourenco, Marie Coutelier, Tobias B Haack, Adriana Rebelo, Didier Hannequin, Tim M Strom, Holger Prokisch, Christoph Kernstock, Alexandra Durr, Ludger Schöls, Marcos M Lima-Martínez, Amjad Farooq, Rebecca Schüle, Giovanni Stevanin, Wilson Marques, Stephan Züchne. PNPLA6 mutations cause Boucher-Neuhauser and Gordon Holmes syndromes as part of a broad neurodegenerative spectrum. Brain : a journal of neurology. vol 137. issue Pt 1. 2014-03-11. PMID:24355708. |
our findings show that pnpla6 influences a manifold of neuronal systems, from the retina to the cerebellum, upper and lower motor neurons and the neuroendocrine system, with damage of this protein causing an extraordinarily broad continuous spectrum of associated neurodegenerative disease. |
2014-03-11 |
2023-08-12 |
Not clear |
| Giuseppe Di Fede, Giorgio Giaccone, Fabrizio Tagliavin. Hereditary and sporadic beta-amyloidoses. Frontiers in bioscience (Landmark edition). vol 18. 2014-01-24. PMID:23747877. |
cerebral amyloidoses are chronic, progressive neurodegenerative diseases that are caused by the aggregation and deposition of misfolded proteins in the central nervous system, and lead to cognitive deficits, stroke, and focal neurological dysfunction including cerebellar and extrapyramidal signs. |
2014-01-24 |
2023-08-12 |
Not clear |
| Laura Segabinazzi Pacheco, Aron Ferreira da Silveira, Alexis Trott, Lucien J Houenou, Thaís Doeler Algarve, Caroline Belló, Adriano Flesch Lenz, Maria Fernanda Mânica-Cattani, Ivana Beatrice Mânica da Cru. Association between Machado-Joseph disease and oxidative stress biomarkers. Mutation research. Genetic toxicology and environmental mutagenesis. vol 757. issue 2. 2014-01-17. PMID:23994570. |
spinocerebellar ataxia type 3, also called machado-joseph disease (mjd), is an hereditary autosomal dominant neurodegenerative disease that affects the cerebellum and its afferent and efferent connections. |
2014-01-17 |
2023-08-12 |
human |
| S Bavithra, K Selvakumar, G Krishnamoorthy, P Venkataraman, J Arunakara. Melatonin attenuates polychlorinated biphenyls induced apoptosis in the neuronal cells of cerebral cortex and cerebellum of adult male rats--in vivo. Environmental toxicology and pharmacology. vol 36. issue 1. 2013-12-12. PMID:23619521. |
the progressive loss of neurons in cerebral cortex and cerebellum, leads to various neurodegenerative diseases. |
2013-12-12 |
2023-08-12 |
rat |
| Elisa J Cops, Maithili Sashindranath, Maria Daglas, Kieran M Short, Candida da Fonseca Pereira, Terence Y Pang, Roger H Lijnen, Ian M Smyth, Anthony J Hannan, Andre L Samson, Robert L Medcal. Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait. Experimental neurology. vol 249. 2013-12-09. PMID:23939410. |
therapeutically lowering cerebellar tpa levels may represent a novel means of preserving purkinje cell integrity and motor coordination across a wide range of neurodegenerative diseases. |
2013-12-09 |
2023-08-12 |
mouse |
| Sarah C Janicki, Stephanie Cosentino, Elan D Loui. The cognitive side of essential tremor: what are the therapeutic implications? Therapeutic advances in neurological disorders. vol 6. issue 6. 2013-11-14. PMID:24228071. |
cognitive changes could be a byproduct of the cerebellar dysfunction of et itself; alternately, they may be a feature of concomitant neurodegenerative diseases that have been associated in several studies with et, including alzheimer's disease, parkinson's disease or progressive supranuclear palsy. |
2013-11-14 |
2023-08-12 |
Not clear |
| Wim Robberecht, Thomas Philip. The changing scene of amyotrophic lateral sclerosis. Nature reviews. Neuroscience. vol 14. issue 4. 2013-05-06. PMID:23463272. |
in addition, these breakthroughs have revealed mechanistic links between als and frontotemporal dementia, as well as between als and other neurodegenerative diseases, such as the cerebellar atrophies, myotonic dystrophy and inclusion body myositis. |
2013-05-06 |
2023-08-12 |
Not clear |
| Domenico Ciavardelli, Ada Consalvo, Valentina Caldaralo, Maria Laura Di Vacri, Stefano Nisi, Carlo Corona, Valerio Frazzini, Paolo Sacchetta, Andrea Urbani, Carmine Di Ilio, Stefano L Sens. Characterisation of element profile changes induced by long-term dietary supplementation of zinc in the brain and cerebellum of 3xTg-AD mice by alternated cool and normal plasma ICP-MS. Metallomics : integrated biometal science. vol 4. issue 12. 2013-05-02. PMID:23151739. |
characterisation of element profile changes induced by long-term dietary supplementation of zinc in the brain and cerebellum of 3xtg-ad mice by alternated cool and normal plasma icp-ms. metal dyshomeostasis plays a crucial role in promoting several neurodegenerative diseases including alzheimer's disease (ad), a condition that has been linked to deregulation of brain levels of al, fe, mn, cu, and zn. |
2013-05-02 |
2023-08-12 |
mouse |
| Wen-juan Guan, Jun-ling Wang, Bei-sha Tan. [Recent advance in genetic study of hereditary autosomal recessive cerebellar ataxia]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 29. issue 6. 2013-04-03. PMID:23225047. |
autosomal recessive cerebellar ataxias (arca) are a highly heterogeneous group of rare neurodegenerative diseases affecting both central and peripheral nervous systems. |
2013-04-03 |
2023-08-12 |
Not clear |
| Alexis Trott, Lucien J Houeno. Mini-review: spinocerebellar ataxias: an update of SCA genes. Recent patents on DNA & gene sequences. vol 6. issue 2. 2013-01-09. PMID:22670601. |
autosomal dominant spinocerebellar ataxias (scas) are a complex group of debilitating and neurodegenerative diseases that affect the cerebellum and its main connections and characterized by a generalized incoordination of gait, speech, and limb movements. |
2013-01-09 |
2023-08-12 |
Not clear |
| Kay Seidel, Sonny Siswanto, Ewout R P Brunt, Wilfred den Dunnen, Horst-Werner Korf, Udo Rü. Brain pathology of spinocerebellar ataxias. Acta neuropathologica. vol 124. issue 1. 2012-10-30. PMID:22684686. |
the autosomal dominant cerebellar ataxias (adcas) represent a heterogeneous group of neurodegenerative diseases with progressive ataxia and cerebellar degeneration. |
2012-10-30 |
2023-08-12 |
Not clear |
| Oliver P Forman, Luisa De Risio, Jennifer Stewart, Cathryn S Mellersh, Elsa Beltra. Genome-wide mRNA sequencing of a single canine cerebellar cortical degeneration case leads to the identification of a disease associated SPTBN2 mutation. BMC genetics. vol 13. 2012-10-12. PMID:22781464. |
neonatal cerebellar cortical degeneration is a neurodegenerative disease described in several canine breeds including the beagle. |
2012-10-12 |
2023-08-12 |
Not clear |
| Mariela Guevara-García, Lizette Gil-del Valle, Luis Velásquez-Pérez, Julio César García-Rodrígue. Oxidative stress as a cofactor in spinocerebellar ataxia type 2. Redox report : communications in free radical research. vol 17. issue 2. 2012-09-06. PMID:22564351. |
spinocerebellar ataxia type 2 (sca2) is a redox-sensitive neurodegenerative disease affecting the cerebellum, fibre connections in the cerebellum, the peripheral nervous system, and extracerebellar central pathways. |
2012-09-06 |
2023-08-12 |
Not clear |
| Sébastien Blaise, Marie Kneib, Adrien Rousseau, Frederic Gambino, Marie-Pierre Chenard, Nadia Messadeq, Martine Muckenstrum, Fabien Alpy, Catherine Tomasetto, Yann Humeau, Marie-Christine Ri. In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis. PloS one. vol 7. issue 2. 2012-06-29. PMID:22363515. |
altogether, these results provide conclusive evidence for the pivotal contribution of traf4 to myelination and to cerebellar homeostasis, and link the loss of traf4 function to demyelinating or neurodegenerative diseases. |
2012-06-29 |
2023-08-12 |
mouse |
| Xianghong Kuang, Mingshan Yan, Joanne M Ajmo, Virginia L Scofield, George Stoica, Paul K Y Won. Activation of AMP-activated protein kinase in cerebella of Atm-/- mice is attributable to accumulation of reactive oxygen species. Biochemical and biophysical research communications. vol 418. issue 2. 2012-04-09. PMID:22260947. |
together, our results suggest that oxidative activation of ampk in the cerebellum may contribute to the neurodegeneration in atm-/- mice, and that ros and ampk signaling pathways are promising therapeutic targets for treatment of a-t and other neurodegenerative diseases. |
2012-04-09 |
2023-08-12 |
mouse |
| Zhengshan Zhao, Jing Wang, Chunying Zhao, Weina Bi, Zhenyu Yue, Zhongmin Alex M. Genetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activation. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046428. |
infantile neuroaxonal dystrophy (inad) is a progressive, autosomal recessive neurodegenerative disease characterized by axonal dystrophy, abnormal iron deposition and cerebellar atrophy. |
2012-03-26 |
2023-08-12 |
mouse |
| Zhengshan Zhao, Jing Wang, Chunying Zhao, Weina Bi, Zhenyu Yue, Zhongmin Alex M. Genetic ablation of PLA2G6 in mice leads to cerebellar atrophy characterized by Purkinje cell loss and glial cell activation. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046428. |
our study suggests that ipla(2)β(-/-) mice are a valuable model for cerebellar atrophy in inad and that early anti-inflammatory therapy may help slow the progression of cerebellar atrophy in this deadly neurodegenerative disease. |
2012-03-26 |
2023-08-12 |
mouse |
| Caroline Kizilyaprak, Danièle Spehner, Didier Devys, Patrick Schult. The linker histone H1C contributes to the SCA7 nuclear phenotype. Nucleus (Austin, Tex.). vol 2. issue 5. 2012-03-06. PMID:21970987. |
spinocerebellar ataxia type 7 (sca7) is a neurodegenerative disease caused by a polyglutamine expansion in ataxin-7, a subunit of the saga coactivator, which leads to progressive neuronal dysfunction and cell death in cerebellum, brainstem and retina. |
2012-03-06 |
2023-08-12 |
mouse |
| Kerri M Carlson, Laura Melcher, Shaojuan Lai, Huda Y Zoghbi, H Brent Clark, Harry T Or. Characterization of the zebrafish atxn1/axh gene family. Journal of neurogenetics. vol 23. issue 3. 2011-12-27. PMID:19085187. |
expansion of the polyglutamine tract in atxn1 causes the neurodegenerative disease, spinocerebellar ataxia type 1 (sca1) with prominent cerebellar pathology. |
2011-12-27 |
2023-08-12 |
human |