| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U Mahlknecht, C Deng, M C Lu, T C Greenough, J L Sullivan, W A O'Brien, G Herbei. Resistance to apoptosis in HIV-infected CD4+ T lymphocytes is mediated by macrophages: role for Nef and immune activation in viral persistence. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 11. 2001-01-11. PMID:11086083. |
tnf-alpha (tnf) expressed on the surface of macrophages prevented apoptosis in nef-expressing, productively infected cd4(+) t lymphocytes. |
2001-01-11 |
2023-08-12 |
Not clear |
| A H Patki, S P Zielske, S F Sieg, M M Lederma. Preferential S phase entry and apoptosis of CD4(+) T lymphocytes of HIV-1-infected patients after in vitro cultivation. Clinical immunology (Orlando, Fla.). vol 97. issue 3. 2001-01-11. PMID:11112363. |
preferential s phase entry and apoptosis of cd4(+) t lymphocytes of hiv-1-infected patients after in vitro cultivation. |
2001-01-11 |
2023-08-12 |
Not clear |
| A H Patki, S P Zielske, S F Sieg, M M Lederma. Preferential S phase entry and apoptosis of CD4(+) T lymphocytes of HIV-1-infected patients after in vitro cultivation. Clinical immunology (Orlando, Fla.). vol 97. issue 3. 2001-01-11. PMID:11112363. |
in experiments using cells obtained from hiv-1-infected patients, spontaneous apoptosis was more frequent in cd4(+) t lymphocytes than in cd8(+) t lymphocytes (17.6% vs 9.5%, p < 0.005). |
2001-01-11 |
2023-08-12 |
Not clear |
| A H Patki, S P Zielske, S F Sieg, M M Lederma. Preferential S phase entry and apoptosis of CD4(+) T lymphocytes of HIV-1-infected patients after in vitro cultivation. Clinical immunology (Orlando, Fla.). vol 97. issue 3. 2001-01-11. PMID:11112363. |
among healthy controls, spontaneous apoptosis in cd4(+) and cd8(+) t lymphocytes was comparable (4.5% vs 5.1%). |
2001-01-11 |
2023-08-12 |
Not clear |
| A H Patki, S P Zielske, S F Sieg, M M Lederma. Preferential S phase entry and apoptosis of CD4(+) T lymphocytes of HIV-1-infected patients after in vitro cultivation. Clinical immunology (Orlando, Fla.). vol 97. issue 3. 2001-01-11. PMID:11112363. |
the present studies indicate that most apoptotic cells in this system are cd4(+) and kinetic analyses reveal that s phase cells are more likely to undergo spontaneous apoptosis than g(0)-g(1) cells. |
2001-01-11 |
2023-08-12 |
Not clear |
| T Hertoghe, A Wajja, L Ntambi, A Okwera, M A Aziz, C Hirsch, J Johnson, Z Toossi, R Mugerwa, P Mugyenyi, R Colebunders, J Ellner, G Vanha. T cell activation, apoptosis and cytokine dysregulation in the (co)pathogenesis of HIV and pulmonary tuberculosis (TB). Clinical and experimental immunology. vol 122. issue 3. 2001-01-11. PMID:11122240. |
in vivo cd4 t cell depletion, in vitro increased spontaneous cd4 t cell apoptosis and defects in ifn-gamma responses upon mitogenic stimulation were restricted to hiv+ subjects (with or without ptb). |
2001-01-11 |
2023-08-12 |
human |
| J G Baseta, O Stutma. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 10. 2000-12-22. PMID:11067918. |
our studies showed that tnf regulates mouse thymocyte production, inducing both apoptosis and proliferation of the most immature cd3(-)cd4(-)cd8(-) triple negative (tn) subset within a broad range of dosages (10(1)-10(5) pg/ml) in the presence of il-7. |
2000-12-22 |
2023-08-12 |
mouse |
| I V Lyadova, E B Eruslanov, S V Khaidukov, V V Yeremeev, K B Majorov, A V Pichugin, B V Nikonenko, T K Kondratieva, A S Ap. Comparative analysis of T lymphocytes recovered from the lungs of mice genetically susceptible, resistant, and hyperresistant to Mycobacterium tuberculosis-triggered disease. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 10. 2000-12-22. PMID:11067954. |
in contrast, in susceptible i/st mice lung cd4(+) cells proliferated much more strongly in response to mycobacterial sonicate, and a higher proportion of these cells expressed cd95 and underwent apoptosis compared with a/sn cells. |
2000-12-22 |
2023-08-12 |
mouse |
| A D Badley, A A Pilon, A Landay, D H Lync. Mechanisms of HIV-associated lymphocyte apoptosis. Blood. vol 96. issue 9. 2000-12-11. PMID:11049971. |
the many mechanisms that contribute to hiv-associated lymphocyte apoptosis include chronic immunologic activation; gp120/160 ligation of the cd4 receptor; enhanced production of cytotoxic ligands or viral proteins by monocytes, macrophages, b cells, and cd8 t cells from hiv-infected patients that kill uninfected cd4 t cells; and direct infection of target cells by hiv, resulting in apoptosis. |
2000-12-11 |
2023-08-12 |
human |
| S Parlato, A M Giammarioli, M Logozzi, F Lozupone, P Matarrese, F Luciani, M Falchi, W Malorni, S Fai. CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway. The EMBO journal. vol 19. issue 19. 2000-12-08. PMID:11013215. |
in fact, cd95 co-immunoprecipitates with ezrin exclusively in lymphoblastoid cd4(+) t cells and primary long-term activated t lymphocytes, which are prone to cd95-mediated apoptosis, but not in short-term activated t lymphocytes, which are refractory to the same stimuli, even expressing equal levels of cd95 on the cell membrane. |
2000-12-08 |
2023-08-12 |
human |
| C Ferreira, T Barthlott, S Garcia, R Zamoyska, B Stockinge. Differential survival of naive CD4 and CD8 T cells. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 7. 2000-11-03. PMID:11034373. |
transgenic cd4 t cells have an intrinsically lower capacity for survival, reflected in their gradual disappearance in thymectomized hosts, their increased sensitivity to apoptosis in vitro, and fewer divisions during homeostatic proliferation upon transfer into syngeneic lymphopenic hosts compared with cd8 t cells. |
2000-11-03 |
2023-08-12 |
Not clear |
| A Pazirandeh, Y Xue, S Okret, M Jonda. Glucocorticoid resistance in thymocytes from mice expressing a T cell receptor transgene. Biochemical and biophysical research communications. vol 276. issue 1. 2000-10-26. PMID:11006105. |
we now report that immature cd4(+)cd8(+) double-positive thymocytes from these mice are comparatively more resistant to corticosterone-induced apoptosis. |
2000-10-26 |
2023-08-12 |
mouse |
| X Li, M C Multon, Y Henin, F Schweighoffer, C Venot, J LaVecchio, J Josef, P Stuckert, A Mhashilkar, B Tocqué, W A Marasc. Upregulation of the apoptosis-associated protein Grb3-3 in HIV-1-infected human CD4(+) lymphocytes. Biochemical and biophysical research communications. vol 276. issue 1. 2000-10-26. PMID:11006130. |
we find that grb3-3 is markedly up-regulated following hiv-1 infection of cd4(+) peripheral blood mononuclear cells undergoing apoptosis. |
2000-10-26 |
2023-08-12 |
human |
| X Li, M C Multon, Y Henin, F Schweighoffer, C Venot, J LaVecchio, J Josef, P Stuckert, A Mhashilkar, B Tocqué, W A Marasc. Upregulation of the apoptosis-associated protein Grb3-3 in HIV-1-infected human CD4(+) lymphocytes. Biochemical and biophysical research communications. vol 276. issue 1. 2000-10-26. PMID:11006130. |
although il-2 deprived cd4(+) cells also undergo apoptosis to a similar extent, grb3-3 upregulation is not detected under these experimental conditions. |
2000-10-26 |
2023-08-12 |
human |
| F Ensoli, V Fiorelli, C Alario, M De Cristofaro, D Santini Muratori, A Novi, M G Cunsolo, F Mazzetta, A Giovannetti, B Mollicone, E Pinter, F Aiut. Decreased T cell apoptosis and T cell recovery during highly active antiretroviral therapy (HAART). Clinical immunology (Orlando, Fla.). vol 97. issue 1. 2000-10-25. PMID:10998313. |
in the present study, the effects of highly active antiretroviral therapy (haart) on the spontaneous apoptosis of distinct t cell subsets were investigated during a 6-month follow-up in a cohort of hiv-1-infected individuals with cd4(+) cell counts between 100 and 500 cells/microliter and plasma hiv-1 rna levels >/=10, 000 copies/ml. |
2000-10-25 |
2023-08-12 |
Not clear |
| Z Huan. Structural chemistry and therapeutic intervention of protein-protein interactions in immune response, human immunodeficiency virus entry, and apoptosis. Pharmacology & therapeutics. vol 86. issue 3. 2000-09-18. PMID:10882809. |
this review outlines the basic concepts for two of these approaches, based on structural and chemical strategies, by illustrating their application in the design of small molecule inhibitors for three biological systems: (1) cell surface molecules cd4 and cd8 involved in immune response, (2) chemokine receptor-ligand interactions implicated in human immunodeficiency virus entry, and (3) b-cell leukemia/lymphoma-2 family proteins essential for regulation of programmed cell death or apoptosis. |
2000-09-18 |
2023-08-12 |
human |
| J C Grivel, N Malkevitch, L Margoli. Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue. Journal of virology. vol 74. issue 17. 2000-09-14. PMID:10933717. |
human immunodeficiency virus type 1 induces apoptosis in cd4(+) but not in cd8(+) t cells in ex vivo-infected human lymphoid tissue. |
2000-09-14 |
2023-08-12 |
human |
| J C Grivel, N Malkevitch, L Margoli. Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue. Journal of virology. vol 74. issue 17. 2000-09-14. PMID:10933717. |
we report that whereas productive infection of lymphoid tissue ex vivo with r5 and x4 hiv-1 isolates induced apoptosis in cd4(+) t cells, neither viral isolate induced apoptosis in cd8(+) t cells. |
2000-09-14 |
2023-08-12 |
human |
| J C Grivel, N Malkevitch, L Margoli. Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue. Journal of virology. vol 74. issue 17. 2000-09-14. PMID:10933717. |
thus, whereas hiv-1 infection per se in human lymphoid tissue is sufficient to trigger apoptosis in cd4(+) t cells, the death of cd8(+) t cells apparently requires additional factors. |
2000-09-14 |
2023-08-12 |
human |
| K Nam, H Akari, K Terao, H Shibata, S Kawamura, Y Yoshikaw. Peripheral blood extrathymic CD4(+)CD8(+) T cells with high cytotoxic activity are from the same lineage as CD4(+)CD8(-) T cells in cynomolgus monkeys. International immunology. vol 12. issue 7. 2000-09-07. PMID:10882421. |
in spite of lacking cd28 expression, dp t cells showed similar proliferative ability and apoptosis sensitivity to cd4 sp and cd8 sp t cells. |
2000-09-07 |
2023-08-12 |
monkey |