| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C K Ullrich, J E Groopman, R K Ganj. HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases. Blood. vol 96. issue 4. 2000-09-07. PMID:10942389. |
recently, the alpha-chemokine receptor cxcr4 has been reported to mediate apoptosis in neuronal cells and in cd4(+) and cd8(+) t cells after its binding to hiv-1 envelope proteins. |
2000-09-07 |
2023-08-12 |
human |
| b' P Popovi\\xc4\\x87, M Coli\\xc4\\x87, D Vucevi\\xc4\\x87, S Gasi\\xc4\\x87, L Pavici\\xc4\\x8. Comparison of signaling pathways involved in apoptosis of a thymocyte hybridoma triggered by a rat thymic medullary epithelial cell line, dexamethasone or T-cell receptor cross-linking. Immunology letters. vol 72. issue 2. 2000-08-25. PMID:10841942.' |
using an in vitro co-culture assay we found that a rat medullary thymic epithelial cell (tec) line (te-r2.5) induces apoptosis of the bwrt8 thymocyte hybridoma (th) (cd4(hi)cd8(low) alphabetatcr(hi)). |
2000-08-25 |
2023-08-12 |
rat |
| S Piconi, D Trabattoni, M L Fusi, F Milazzo, L P Dix, G Rizzardini, F Colombo, D Bray, M Cleric. Effect of two different combinations of antiretrovirals (AZT+ddI and AZT+3TC) on cytokine production and apoptosis in asymptomatic HIV infection. Antiviral research. vol 46. issue 3. 2000-08-22. PMID:10867155. |
immunologic (cd4 and cd8 counts, mitogen-stimulated cytokine production, unstimulated and mitogen-stimulated apoptosis) and virologic (hiv viral load) determinations were performed pre-therapy and 15, 30, 90, 200 and 360 days after initiation of therapy. |
2000-08-22 |
2023-08-12 |
Not clear |
| D K Dalton, L Haynes, C Q Chu, S L Swain, S Wittme. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880532. |
interferon gamma eliminates responding cd4 t cells during mycobacterial infection by inducing apoptosis of activated cd4 t cells. |
2000-08-15 |
2023-08-12 |
mouse |
| D K Dalton, L Haynes, C Q Chu, S L Swain, S Wittme. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880532. |
contraction of the activated cd4 t cell population in wild-type mice was associated with increased apoptosis of activated cd4 t cells. |
2000-08-15 |
2023-08-12 |
mouse |
| D K Dalton, L Haynes, C Q Chu, S L Swain, S Wittme. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880532. |
in bcg-infected interferon (ifn)-gamma knockout (ko) mice, the activated cd4 t cell population did not undergo apoptosis. |
2000-08-15 |
2023-08-12 |
mouse |
| D K Dalton, L Haynes, C Q Chu, S L Swain, S Wittme. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880532. |
addition of ifn-gamma to cultured splenocytes from bcg-infected ifn-gamma ko mice induced apoptosis of activated cd4 t cells. |
2000-08-15 |
2023-08-12 |
mouse |
| C Q Chu, S Wittmer, D K Dalto. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880533. |
cd4(+)cd44(hi) t cells in the spleen and central nervous system of ifn-gamma ko mice during eae showed markedly increased in vivo proliferation and significantly decreased ex vivo apoptosis compared with those of wild-type mice. |
2000-08-15 |
2023-08-12 |
mouse |
| C Q Chu, S Wittmer, D K Dalto. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880533. |
ifn-gamma completely suppressed proliferation and significantly induced apoptosis of cd4(+)cd44(hi) t cells responding to antigen and hence inhibited accumulation of live, activated cd4 t cells. |
2000-08-15 |
2023-08-12 |
mouse |
| M T Lin, L H Tseng, H Frangoul, T Gooley, J Pei, A Barsoukov, Y Akatsuka, J A Hanse. Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation. Blood. vol 95. issue 12. 2000-08-10. PMID:10845917. |
the extent of cd4(+) t-cell apoptosis was greater in patients with grade ii-iv acute graft-versus-host disease (gvhd) (33. |
2000-08-10 |
2023-08-12 |
human |
| M T Lin, L H Tseng, H Frangoul, T Gooley, J Pei, A Barsoukov, Y Akatsuka, J A Hanse. Increased apoptosis of peripheral blood T cells following allogeneic hematopoietic cell transplantation. Blood. vol 95. issue 12. 2000-08-10. PMID:10845917. |
the intensity of apoptosis among cd4(+) t cells was significantly correlated with a lower cd4(+) t-cell count. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
cd4 t lymphocytes are primed to express fas ligand by cd4 cross-linking and to contribute to cd8 t-cell apoptosis via fas/fasl death signaling pathway. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
however, cross-ligation of cd4 molecules prior to tcr stimulation has been shown to prime cd4 t cells to undergo apoptosis. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
although in vivo and in vitro experiments have implicated the involvement of fas/fasl interaction in this cd4 cross-linking (cd4xl)-induced apoptosis, detailed mechanisms to account for cell death induction have not been elucidated. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
in the present study, we demonstrate that cd4xl in purified t cells not only led to fas up-regulation but also primed cd4 t cells to express fasl upon cd3 stimulation and rendered the t cells susceptible to fas-mediated apoptosis. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
notably, in addition to cd4(+) t cells, cd4xl-induced sensitization for apoptosis was observed in cd8(+) t cells as well and was associated with bcl-x down-modulation. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
both cd4 and cd8 t-cell subsets underwent apoptosis following cell-cell contact with fasl(+) cd4 t cells. |
2000-08-10 |
2023-08-12 |
human |
| M Tateyama, N Oyaizu, T W McCloskey, S Than, S Pahw. CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood. vol 96. issue 1. 2000-08-10. PMID:10891451. |
as cd4 molecules are the primary receptors for human immunodeficiency virus 1 (hiv-1), we conclude that hiv-1 envelope mediated cd4xl can lead to the generation of fasl-expressing cd4(+) t cells that can lead to apoptosis of cd4 as well as cd8 t cells. |
2000-08-10 |
2023-08-12 |
human |
| L Kremer, J Estaquier, I Wolowczuk, F Biet, J C Ameisen, C Loch. Ineffective cellular immune response associated with T-cell apoptosis in susceptible Mycobacterium bovis BCG-infected mice. Infection and immunity. vol 68. issue 7. 2000-07-20. PMID:10858244. |
an in vitro defect in t-cell proliferation in response to t-cell receptor (tcr) stimulation with mitogens or anti-cd3 antibodies was associated with enhanced levels of cd4(+) and cd8(+) t-cell apoptosis in susceptible but not in resistant mice 2 weeks after infection. |
2000-07-20 |
2023-08-12 |
mouse |
| L Kremer, J Estaquier, I Wolowczuk, F Biet, J C Ameisen, C Loch. Ineffective cellular immune response associated with T-cell apoptosis in susceptible Mycobacterium bovis BCG-infected mice. Infection and immunity. vol 68. issue 7. 2000-07-20. PMID:10858244. |
in vitro addition of neutralizing anti-tnf-alpha antibodies led to a significant reduction in cd3-induced t-cell apoptosis of both cd4(+) and cd8(+) t cells of c57bl/6 mice, while the blockade of fas-fasl interactions reduced apoptosis only in cd4(+) but not in cd8(+) t cells. |
2000-07-20 |
2023-08-12 |
mouse |