| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Caputo, G Manco, L Mandrich, J Guardiol. A novel aspartyl proteinase from apocrine epithelia and breast tumors. The Journal of biological chemistry. vol 275. issue 11. 2000-04-12. PMID:10713110. |
gcdfp-15/gp17 is a ligand of cd4 and is a potent inhibitor of t-cell apoptosis induced by sequential cd4/t-cell receptor triggering. |
2000-04-12 |
2023-08-12 |
human |
| F Pandolfi, M Pierdominici, M Marziali, M Livia Bernardi, G Antonelli, V Galati, G D'Offizi, F Aiut. Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART. Clinical immunology (Orlando, Fla.). vol 94. issue 3. 2000-04-07. PMID:10692234. |
low-dose il-2 reduces lymphocyte apoptosis and increases naive cd4 cells in hiv-1 patients treated with haart. |
2000-04-07 |
2023-08-12 |
Not clear |
| F Pandolfi, M Pierdominici, M Marziali, M Livia Bernardi, G Antonelli, V Galati, G D'Offizi, F Aiut. Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART. Clinical immunology (Orlando, Fla.). vol 94. issue 3. 2000-04-07. PMID:10692234. |
here we investigated the effects of subcutaneous low-dose il-2 administration in combination with haart on in vitro apoptosis and the relationship between apoptosis, cd4(+) counts, and hiv replication. |
2000-04-07 |
2023-08-12 |
Not clear |
| F Pandolfi, M Pierdominici, M Marziali, M Livia Bernardi, G Antonelli, V Galati, G D'Offizi, F Aiut. Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART. Clinical immunology (Orlando, Fla.). vol 94. issue 3. 2000-04-07. PMID:10692234. |
as the percentage of apoptosis decreased, there was a significantly higher increase of both cd4(+) and cd4(+) naive t cells in arm ii vs arm i. hiv plasma viremia was reduced in all patients after therapy. |
2000-04-07 |
2023-08-12 |
Not clear |
| K Sato, H Nagayama, M Enomoto, K Tadokoro, T Juji, T A Takahash. Autocrine activation-induced cell death of T cells by human peripheral blood monocyte-derived CD4+ dendritic cells. Cellular immunology. vol 199. issue 2. 2000-04-07. PMID:10698621. |
here we describe experiments in which mature t cells were subjected to apoptosis following stimulation with cd4(+) dendritic cells (dcs) during ag presentation. |
2000-04-07 |
2023-08-12 |
human |
| U Bommhardt, Y Scheuring, C Bickel, R Zamoyska, T Hüni. MEK activity regulates negative selection of immature CD4+CD8+ thymocytes. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 5. 2000-03-23. PMID:10679067. |
cd4+cd8+ thymocytes are either positively selected and subsequently mature to cd4 single positive (sp) or cd8 sp t cells, or they die by apoptosis due to neglect or negative selection. |
2000-03-23 |
2023-08-12 |
mouse |
| Y X Zhao, G Lajoie, H Zhang, B Chiu, U Payne, R D Inma. Tumor necrosis factor receptor p55-deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance. Infection and immunity. vol 68. issue 3. 2000-03-16. PMID:10678933. |
c57bl/6 mice showed evidence of extensive apoptosis in the spleen accompanied by a selective decrease in the cd4(+)-t-cell population of splenocytes, whereas tnfrp55(-/-) mice were spared these changes. |
2000-03-16 |
2023-08-12 |
mouse |
| A A Aza. Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells? Biochemical and biophysical research communications. vol 267. issue 3. 2000-03-09. PMID:10673351. |
extracellular vpr and c-terminal fragments of vpr cause membrane permeabilization and apoptosis of a wide range of cd4(+) and non-cd4(+) cells, and could also contribute to depletion of bystander cells. |
2000-03-09 |
2023-08-12 |
mouse |
| P Michel, A T Balde, C Roussilhon, G Aribot, J L Sarthou, M L Gougeo. Reduced immune activation and T cell apoptosis in human immunodeficiency virus type 2 compared with type 1: correlation of T cell apoptosis with beta2 microglobulin concentration and disease evolution. The Journal of infectious diseases. vol 181. issue 1. 2000-03-03. PMID:10608752. |
ex vivo apoptosis was found in both infections in all lymphocyte subsets, including cd4 and cd8 t cells, as well as b cells, but was lower in hiv-2 than in hiv-1 infection. |
2000-03-03 |
2023-08-12 |
human |
| P Michel, A T Balde, C Roussilhon, G Aribot, J L Sarthou, M L Gougeo. Reduced immune activation and T cell apoptosis in human immunodeficiency virus type 2 compared with type 1: correlation of T cell apoptosis with beta2 microglobulin concentration and disease evolution. The Journal of infectious diseases. vol 181. issue 1. 2000-03-03. PMID:10608752. |
interestingly, high correlations were found in hiv-2- and hiv-1-infected donors between the level of cd4 t cell apoptosis and beta2m concentration and progression of the disease. |
2000-03-03 |
2023-08-12 |
human |
| b' M D Mossalayi, P A Becherel, P Debr\\xc3\\xa. Critical role of nitric oxide during the apoptosis of peripheral blood leukocytes from patients with AIDS. Molecular medicine (Cambridge, Mass.). vol 5. issue 12. 2000-03-01. PMID:10666481.' |
as oxidative stress plays an important role during human immunodeficiency virus type 1 (hiv-1)-associated dementia and lymphocyte apoptosis, we asked whether the nitric oxide (no) pathway plays a role in the in vitro survival of peripheral blood mononuclear cells (pbmc) from hiv-1(+) patients and how it correlates with peripheral cd4(+) cell levels. |
2000-03-01 |
2023-08-12 |
human |
| M L Gougeon, L Montagnie. Programmed cell death as a mechanism of CD4 and CD8 T cell deletion in AIDS. Molecular control and effect of highly active anti-retroviral therapy. Annals of the New York Academy of Sciences. vol 887. 2000-02-25. PMID:10668476. |
the chronic immune activation induces the continuous expression of death factors which could turn lymphocytes, including cd4 t cells, cd8 ctl or apc, into effectors of apoptosis, leading to the destruction of healthy activated non-infected cells. |
2000-02-25 |
2023-08-12 |
human |
| M Hagihara, J Chargui, B Gansuvd, F Tsuchida, T Sato, T Hotta, S Kat. Umbilical cord blood T lymphocytes are induced to apoptosis after being allo-primed in vitro. Bone marrow transplantation. vol 24. issue 11. 2000-02-18. PMID:10642813. |
ucb (cd4 and cd8) t cells separately showed much higher frequencies of apoptosis after a primary allo-priming, compared with pb cd4 and cd8 t cells (cd4, ucb 30.5% vs pb 0.8%; cd8, ucb 32% vs pb 1.3%). |
2000-02-18 |
2023-08-12 |
Not clear |
| C Merritt, H Enslen, N Diehl, D Conze, R J Davis, M Rincó. Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells. Molecular and cellular biology. vol 20. issue 3. 2000-02-14. PMID:10629051. |
activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of cd8(+) but not cd4(+) t cells. |
2000-02-14 |
2023-08-12 |
Not clear |
| Y W He, M J Beva. High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. The Journal of experimental medicine. vol 190. issue 12. 2000-01-28. PMID:10601365. |
recent studies have demonstrated that engagement of tcr and fas induces naive cd4(+) t cells to undergo apoptosis, and the same treatment enhances the proliferation of memory cd4(+) t cells. |
2000-01-28 |
2023-08-12 |
Not clear |
| S Moretti, E Alesse, S Marcellini, L Di Marzio, F Zazzeroni, R Parroni, G Famularo, A Boschini, M G Cifone, C De Simon. Combined antiviral therapy reduces HIV-1 plasma load and improves CD4 counts but does not interfere with ongoing lymphocyte apoptosis. Immunopharmacology and immunotoxicology. vol 21. issue 4. 2000-01-07. PMID:10584202. |
combined antiviral therapy reduces hiv-1 plasma load and improves cd4 counts but does not interfere with ongoing lymphocyte apoptosis. |
2000-01-07 |
2023-08-12 |
Not clear |
| S Moretti, E Alesse, S Marcellini, L Di Marzio, F Zazzeroni, R Parroni, G Famularo, A Boschini, M G Cifone, C De Simon. Combined antiviral therapy reduces HIV-1 plasma load and improves CD4 counts but does not interfere with ongoing lymphocyte apoptosis. Immunopharmacology and immunotoxicology. vol 21. issue 4. 2000-01-07. PMID:10584202. |
a discrepancy exists between the positive impact of combined azt and ddl treatment on plasma viral load and cd4 counts and the lack of any effect on the process of lymphocyte apoptosis. |
2000-01-07 |
2023-08-12 |
Not clear |
| H Naora, M L Gougeo. Interleukin-15 is a potent survival factor in the prevention of spontaneous but not CD95-induced apoptosis in CD4 and CD8 T lymphocytes of HIV-infected individuals. Correlation with its ability to increase BCL-2 expression. Cell death and differentiation. vol 6. issue 10. 1999-12-23. PMID:10556978. |
interleukin-15 is a potent survival factor in the prevention of spontaneous but not cd95-induced apoptosis in cd4 and cd8 t lymphocytes of hiv-infected individuals. |
1999-12-23 |
2023-08-12 |
Not clear |
| D R Plymale, D S Tang, A M Comardelle, C D Fermin, D E Lewis, R F Garr. Both necrosis and apoptosis contribute to HIV-1-induced killing of CD4 cells. AIDS (London, England). vol 13. issue 14. 1999-12-02. PMID:10513640. |
both necrosis and apoptosis contribute to hiv-1-induced killing of cd4 cells. |
1999-12-02 |
2023-08-12 |
Not clear |
| C A Devau. [Molecular dialogue between human retroviruses and host cells]. Journal de la Societe de biologie. vol 193. issue 3. 1999-11-23. PMID:10542964. |
viral envelope glycoproteins interaction with cd4 controls cell activation and proliferation required for virus production whereas interaction with cxcr4 favors apoptosis thereby decreasing the host immune response. |
1999-11-23 |
2023-08-12 |
human |