| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Gemmell, S Prajaneh, D A Grieco, J J Taylor, G J Seymou. Apoptosis in Porphyromonas gingivalis-specific T-cell lines. Oral microbiology and immunology. vol 14. issue 6. 2000-07-20. PMID:10895687. |
while this study has shown apoptosis occurring in the t-cell lines, it has not shown definitively that the reversion in the cd4:cd8 ratio in the p. gingivalis-specific t cells following antigen presentation by autologous epstein-barr virus-transformed b cells is due to apoptosis of a cd4 population. |
2000-07-20 |
2023-08-12 |
Not clear |
| J D Ashwell, F W Lu, M S Vacchi. Glucocorticoids in T cell development and function*. Annual review of immunology. vol 18. 2000-07-12. PMID:10837061. |
glucocorticoids are also potent inducers of apoptosis, and even glucocorticoid concentrations achieved during a stress response can cause the death of cd4(+)cd8(+ )thymocytes. |
2000-07-12 |
2023-08-12 |
Not clear |
| S Basmaciogullari, M Autiero, R Culerrier, J C Mani, M Gaubin, Z Mishal, J Guardiola, C Granier, D Piatier-Tonnea. Mapping the CD4 binding domain of gp17, a glycoprotein secreted from seminal vesicles and breast carcinomas. Biochemistry. vol 39. issue 18. 2000-07-06. PMID:10820003. |
we previously demonstrated that gp17 binds to cd4 with high affinity and strongly inhibits t lymphocyte apoptosis induced by sequential cross-linking of cd4 and t cell receptor (tcr). |
2000-07-06 |
2023-08-12 |
human |
| M T Winkler, A Doster, C Jone. Persistence and reactivation of bovine herpesvirus 1 in the tonsils of latently infected calves. Journal of virology. vol 74. issue 11. 2000-06-27. PMID:10799611. |
our previous results concluded that cd4(+) t cells in the tonsil and other adjacent lymph nodes are infected and undergo apoptosis during acute infection (m. t. winkler, a. doster, and c. jones, j. virol. |
2000-06-27 |
2023-08-12 |
cattle |
| Y X Jin, L Y Xu, H Guo, M Ishikawa, H Link, B G Xia. TGF-beta1 inhibits protracted-relapsing experimental autoimmune encephalomyelitis by activating dendritic cells. Journal of autoimmunity. vol 14. issue 3. 2000-06-26. PMID:10756083. |
in studying mechanisms of apoptosis in tgf-beta1-treated rats, in vitro experiments demonstrated that tgf-beta1-treated dc induced apoptosis of cd4(+)t cells by a no pathway after co-culture with t cells. |
2000-06-26 |
2023-08-12 |
rat |
| Y X Jin, L Y Xu, H Guo, M Ishikawa, H Link, B G Xia. TGF-beta1 inhibits protracted-relapsing experimental autoimmune encephalomyelitis by activating dendritic cells. Journal of autoimmunity. vol 14. issue 3. 2000-06-26. PMID:10756083. |
these results support the hypothesis that tgf-beta1-induced suppression of pr-eae is associated with apoptosis of cd4(+)t cells induced by dc-derived no. |
2000-06-26 |
2023-08-12 |
rat |
| W Krenger, S Rossi, G A Hollände. Apoptosis of thymocytes during acute graft-versus-host disease is independent of glucocorticoids. Transplantation. vol 69. issue 10. 2000-06-23. PMID:10852622. |
because agvhd has been associated with elevated glucocorticoid (gc) production, and cd4,cd8 double-positive thymocytes undergo rapid apoptosis in response to gcs, we hypothesized that administration of the gc receptor antagonist ru486 (mifepristone) should alter agvhd-mediated thymocyte apoptosis. |
2000-06-23 |
2023-08-12 |
Not clear |
| F Somma, L Tuosto, M S Gilardini Montani, M M Di Somma, E Cundari, E Piccolell. Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 10. 2000-06-07. PMID:10799864. |
engagement of cd4 before tcr triggering regulates both bax- and fas (cd95)-mediated apoptosis. |
2000-06-07 |
2023-08-12 |
Not clear |
| N Ishimaru, T Yoneda, K Saegusa, K Yanagi, N Haneji, K Moriyama, I Saito, Y Hayash. Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis. The American journal of pathology. vol 156. issue 5. 2000-06-02. PMID:10793067. |
in addition, a decrease in fas expression was found on splenic cd4(+) t cells in the aged mice, and anti-fas mab-stimulated apoptosis was down-regulated on cd4(+) t cells. |
2000-06-02 |
2023-08-12 |
mouse |
| N Ishimaru, T Yoneda, K Saegusa, K Yanagi, N Haneji, K Moriyama, I Saito, Y Hayash. Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis. The American journal of pathology. vol 156. issue 5. 2000-06-02. PMID:10793067. |
these results indicate that age-associated dysregulation of cd4(+) t cells may play a crucial role on acceleration of organ-specific autoimmune lesions in a murine model for primary ss through fas-mediated apoptosis. |
2000-06-02 |
2023-08-12 |
mouse |
| L Caggiari, S Zanussi, M T Bortolin, M D'andrea, G Nasti, C Simonelli, U Tirelli, P De Paol. Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients. Clinical and experimental immunology. vol 120. issue 1. 2000-05-08. PMID:10759770. |
the kinetics and effects of in vivo spontaneous apoptosis and activation-induced cell death (aicd) upon cd4+ and cd8+ lymphocyte subsets and cd4 naive cell numbers were studied in hiv+ subjects with cd4 pretreatment values > 200/mm3, who were subsequently treated for 48 weeks with haart alone or in combination with six cycles of subcutaneous il-2. |
2000-05-08 |
2023-08-12 |
human |
| L Caggiari, S Zanussi, M T Bortolin, M D'andrea, G Nasti, C Simonelli, U Tirelli, P De Paol. Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients. Clinical and experimental immunology. vol 120. issue 1. 2000-05-08. PMID:10759770. |
the percentage of cd4 cells undergoing spontaneous apoptosis and aicd was significantly reduced in all patients after 4 weeks and this reduction was maintained until the end of therapy; however, the level always remained significantly higher in comparison with healthy subjects. |
2000-05-08 |
2023-08-12 |
human |
| L Caggiari, S Zanussi, M T Bortolin, M D'andrea, G Nasti, C Simonelli, U Tirelli, P De Paol. Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients. Clinical and experimental immunology. vol 120. issue 1. 2000-05-08. PMID:10759770. |
together these data suggest that a reduction in the level of apoptosis may contribute to the early rise in cd4 numbers measured after haart, but that later on haart is unable to improve further this biological parameter. |
2000-05-08 |
2023-08-12 |
human |
| L Caggiari, S Zanussi, M T Bortolin, M D'andrea, G Nasti, C Simonelli, U Tirelli, P De Paol. Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients. Clinical and experimental immunology. vol 120. issue 1. 2000-05-08. PMID:10759770. |
although the use of il-2 had no additional effects on spontaneous apoptosis and aicd, it may be beneficial by stimulating a late increase in the numbers of cd4 naive cells in hiv-treated subjects. |
2000-05-08 |
2023-08-12 |
human |
| E M Sloand, S Kim, J P Maciejewski, F Van Rhee, A Chaudhuri, J Barrett, N S Youn. Pharmacologic doses of granulocyte colony-stimulating factor affect cytokine production by lymphocytes in vitro and in vivo. Blood. vol 95. issue 7. 2000-04-27. PMID:10733495. |
increased apoptosis of ifn-gamma-producing cd4(+) cells was not responsible for the shift in th1/th2 subsets. |
2000-04-27 |
2023-08-12 |
mouse |
| J D Alvarez, D H Yasui, H Niida, T Joh, D Y Loh, T Kohwi-Shigemats. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes & development. vol 14. issue 5. 2000-04-24. PMID:10716941. |
the few peripheral cd4(+) single positive (sp) cells underwent apoptosis and failed to proliferate in response to activating stimuli. |
2000-04-24 |
2023-08-12 |
mouse |
| P J Blair, J L Riley, D M Harlan, R Abe, D K Tadaki, S C Hoffmann, L White, T Francomano, S J Perfetto, A D Kirk, C H Jun. CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. The Journal of experimental medicine. vol 191. issue 4. 2000-04-19. PMID:10684857. |
cd40 ligand (cd154) triggers a short-term cd4(+) t cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. |
2000-04-19 |
2023-08-12 |
Not clear |
| P J Blair, J L Riley, D M Harlan, R Abe, D K Tadaki, S C Hoffmann, L White, T Francomano, S J Perfetto, A D Kirk, C H Jun. CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. The Journal of experimental medicine. vol 191. issue 4. 2000-04-19. PMID:10684857. |
together, these data suggest that the graft-sparing effect of hu5c8 in vivo may result in part from early and direct effects on cd4(+) t cells, including a vigorous induction of immunomodulatory cytokines and/or apoptosis of allograft-specific t cells. |
2000-04-19 |
2023-08-12 |
Not clear |
| M Biard-Piechaczyk, V Robert-Hebmann, V Richard, J Roland, R A Hipskind, C Devau. Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120). Virology. vol 268. issue 2. 2000-04-18. PMID:10704341. |
human immunodeficiency virus type 1 (hiv-1) envelope glycoproteins interact with cd4 and chemokine receptors on t cells to deliver signals that trigger either activation, anergy, or apoptosis. |
2000-04-18 |
2023-08-12 |
human |
| A Shanker, S M Singh, A Sodh. Impairment of T-cell functions with the progressive ascitic growth of a transplantable T-cell lymphoma of spontaneous origin. FEMS immunology and medical microbiology. vol 27. issue 3. 2000-04-14. PMID:10683470. |
it has been observed that the progressive ascitic growth of a transplantable t-cell lymphoma of spontaneous origin, designated dalton's lymphoma (dl), in a murine host induces inhibition of various immune responses and is associated with an involution of thymus accompanied by a massive depletion of the cortical region and alteration in the distribution of thymocytes caused by tumour serum-dependent induction of apoptosis with a decrease of cd4(+)cd8(+), cd4(+)cd8(-) and cd4(-)cd8(+) thymocytes. |
2000-04-14 |
2023-08-12 |
mouse |