| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Caputo, V Carratore, M Ciullo, C Tiberio, J C Mani, D Piatier-Tonneau, J Guardiol. Biosynthesis and immunobiochemical characterization of gp17/GCDFP-15. A glycoprotein from seminal vesicles and from breast tumors, in HeLa cells and in Pichia pastoris yeast. European journal of biochemistry. vol 265. issue 2. 1999-11-22. PMID:10504398. |
the gp17 factor is a secretory product of human seminal vesicle cells which binds to cd4 and acts as a potent inhibitor of t lymphocyte apoptosis induced by cd4 crosslinking and subsequent t-cell receptor (tcr) activation. |
1999-11-22 |
2023-08-12 |
human |
| J J Chen, M W Cloy. The potential importance of HIV-induction of lymphocyte homing to lymph nodes. International immunology. vol 11. issue 10. 1999-11-19. PMID:10508176. |
recent studies have demonstrated that hiv binding to resting cd4 lymphocytes causes them to home from the blood into lymph node, and during the homing process, they are induced into apoptosis only to secondary signals through the homing receptors. |
1999-11-19 |
2023-08-12 |
Not clear |
| J K Howard, G M Lord, G Matarese, S Vendetti, M A Ghatei, M A Ritter, R I Lechler, S R Bloo. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. The Journal of clinical investigation. vol 104. issue 8. 1999-11-16. PMID:10525043. |
we found that ob/ob mice had a high level of thymocyte apoptosis resulting in a ratio of cd4(+)cd8(+) (cortical) to cd4(-)cd8(-) (precursor) thymocytes that was 4-fold lower than that observed in wild-type mice. |
1999-11-16 |
2023-08-12 |
mouse |
| J K Howard, G M Lord, G Matarese, S Vendetti, M A Ghatei, M A Ritter, R I Lechler, S R Bloo. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. The Journal of clinical investigation. vol 104. issue 8. 1999-11-16. PMID:10525043. |
peripheral administration of recombinant leptin to ob/ob mice reduced thymocyte apoptosis and substantially increased both thymic cellularity and the cd4(+)cd8(+)/cd4(-)cd8(-) ratio. |
1999-11-16 |
2023-08-12 |
mouse |
| S J Chavan, S L Tamma, M Kaplan, M Gersten, S G Pahw. Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy. Clinical immunology (Orlando, Fla.). vol 93. issue 1. 1999-11-05. PMID:10497008. |
the absolute decrease and slope of t cell apoptosis correlated with plasma virus load and with activated cd8 t cells and was inversely correlated with cd4 t cells. |
1999-11-05 |
2023-08-12 |
Not clear |
| Y Choi, V R Ramnath, A S Eaton, A Chen, K L Simon-Stoos, D E Kleiner, J Erikson, J M Puc. Expression in transgenic mice of dominant interfering Fas mutations: a model for human autoimmune lymphoproliferative syndrome. Clinical immunology (Orlando, Fla.). vol 93. issue 1. 1999-11-05. PMID:10497009. |
alps patients, like fas-deficient mrl lpr/lpr mice, have lymphoproliferation, autoimmunity, increased cd4(-)/cd8(-) t lymphocytes, and apoptosis defects. |
1999-11-05 |
2023-08-12 |
mouse |
| B Goldberg, R B Stricke. Apoptosis and HIV infection: T-cells fiddle while the immune system burns. Immunology letters. vol 70. issue 1. 1999-11-05. PMID:10541045. |
enhancement of programmed cell death (apoptosis) of cd4 t-cells by human immunodeficiency virus (hiv) is thought to be an important factor in the pathogenesis of hiv disease. |
1999-11-05 |
2023-08-12 |
human |
| Y Zhang, D Schols, E De Clerc. Selective activity of various antiviral compounds against HHV-7 infection. Antiviral research. vol 43. issue 1. 1999-11-01. PMID:10480261. |
antiviral activity was monitored by inhibition of: (i) cd4 expression down-regulation; (ii) giant cell formation and (iii) apoptosis induction. |
1999-11-01 |
2023-08-12 |
human |
| N E Crompton, R Miralbell, H P Rutz, F Ersoy, O Sanal, D Wellmann, S Bieri, P A Coucke, G C Emery, Y Q Shi, H Blattmann, M Ozsahi. Altered apoptotic profiles in irradiated patients with increased toxicity. International journal of radiation oncology, biology, physics. vol 45. issue 3. 1999-10-27. PMID:10524426. |
a retrospective study of radiation-induced apoptosis in cd4 and cd8 t-lymphocytes, from 12 cancer patients who displayed enhanced toxicity to radiation therapy and 9 ataxia telangiectasia patients, was performed to test for altered response compared to healthy blood-donors and normal cancer patients. |
1999-10-27 |
2023-08-12 |
Not clear |
| D L Wiest, M A Berger, M Carleto. Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand? Seminars in immunology. vol 11. issue 4. 1999-10-12. PMID:10441211. |
immature thymocytes that productively rear-range the gene segments of the tcrbeta locus undergo proliferative expansion and mature to the cd4(+)cd8(+)stage; those failing to do so die by apoptosis. |
1999-10-12 |
2023-08-12 |
Not clear |
| M T Winkler, A Doster, C Jone. Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle. Journal of virology. vol 73. issue 10. 1999-10-12. PMID:10482619. |
the decrease in cd4(+) t cells correlated with an increase in apoptosis. |
1999-10-12 |
2023-08-12 |
cattle |
| M T Winkler, A Doster, C Jone. Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle. Journal of virology. vol 73. issue 10. 1999-10-12. PMID:10482619. |
taken together, these results indicate that bhv-1 can infect cd4(+) t cells in cattle, leading to apoptosis and suppression of cell-mediated immunity. |
1999-10-12 |
2023-08-12 |
cattle |
| L B King, E Tolosa, J M Lenczowski, F Lu, E F Lind, R Hunziker, H T Petrie, J D Ashwel. A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes. International immunology. vol 11. issue 8. 1999-09-24. PMID:10421778. |
the decrease in the number of cd4(+)cd8(+) thymocytes did not appear to be due to an enhanced rate of apoptosis but rather to a decrease in the number of cd4(-)cd8(-)cd25(-) cells in the s + g(2)/m stages of the cell cycle. |
1999-09-24 |
2023-08-12 |
mouse |
| P Yotnda, P Mintz, K Grigoriadou, F Lemonnier, E Vilmer, P Langlade-Demoye. Analysis of T-cell defects in the specific immune response against acute lymphoblastic leukemia cells. Experimental hematology. vol 27. issue 9. 1999-09-22. PMID:10480428. |
in bone marrow of all patients, t cells do not express cd40l and cd25 markers, their apoptosis rate is increased, and a predominance of a cd4 cell subset expressing a th2 phenotype is detected. |
1999-09-22 |
2023-08-12 |
Not clear |
| A D Badley, K Parato, D W Cameron, S Kravcik, B N Phenix, D Ashby, A Kumar, D H Lynch, J Tschopp, J B Ange. Dynamic correlation of apoptosis and immune activation during treatment of HIV infection. Cell death and differentiation. vol 6. issue 5. 1999-09-09. PMID:10381636. |
these observations have led to the hypothesis cd4 t cell apoptosis may be a mechanism of cd4 t cell depletion and the pathogenesis of aids. |
1999-09-09 |
2023-08-12 |
Not clear |
| A D Badley, K Parato, D W Cameron, S Kravcik, B N Phenix, D Ashby, A Kumar, D H Lynch, J Tschopp, J B Ange. Dynamic correlation of apoptosis and immune activation during treatment of HIV infection. Cell death and differentiation. vol 6. issue 5. 1999-09-09. PMID:10381636. |
furthermore, spontaneous apoptosis decreases in both cd4 and cd8 t cells (cd4 apoptosis 17.4 vs 2.6%, p=0.005; cd8 apoptosis 15.0 vs 1.0%, p<0.001), as does both fas mediated apoptosis (cd4 apoptosis 19.0 vs 3.5%, p=0.03; cd8 apoptosis 13.7 vs 1.5%, p=0.002) and cd3 induced aicd (cd4 apoptosis 13.7 vs 3.2%, p=0.001; cd8 apoptosis 29 vs 2.2%, p=0.08). |
1999-09-09 |
2023-08-12 |
Not clear |
| A D Badley, K Parato, D W Cameron, S Kravcik, B N Phenix, D Ashby, A Kumar, D H Lynch, J Tschopp, J B Ange. Dynamic correlation of apoptosis and immune activation during treatment of HIV infection. Cell death and differentiation. vol 6. issue 5. 1999-09-09. PMID:10381636. |
these findings support the hypothesis that apoptosis mediates hiv induced cd4 t cell depletion, but indicate the need for further studies into the molecular regulation of hiv induced apoptosis. |
1999-09-09 |
2023-08-12 |
Not clear |
| E M Sloand, P N Kumar, S Kim, A Chaudhuri, F F Weichold, N S Youn. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood. vol 94. issue 3. 1999-08-17. PMID:10419894. |
human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood cd4(+) t cells and decreases their susceptibility to apoptosis in vitro and in vivo. |
1999-08-17 |
2023-08-12 |
human |
| E M Sloand, P N Kumar, S Kim, A Chaudhuri, F F Weichold, N S Youn. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood. vol 94. issue 3. 1999-08-17. PMID:10419894. |
cd4(+) t cells from patients with human immunodeficiency virus (hiv) infection undergo apoptosis at an increased rate, which leads to their depletion during disease progression. |
1999-08-17 |
2023-08-12 |
human |
| E M Sloand, P N Kumar, S Kim, A Chaudhuri, F F Weichold, N S Youn. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood. vol 94. issue 3. 1999-08-17. PMID:10419894. |
both the fas-receptor (fas-r) and interleukin-1beta (il-1beta)-converting enzyme (ice; caspase 1) appear to play a role in the mechanism of apoptosis of cd4(+) lymphocytes. |
1999-08-17 |
2023-08-12 |
human |