| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E M Sloand, P N Kumar, S Kim, A Chaudhuri, F F Weichold, N S Youn. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood. vol 94. issue 3. 1999-08-17. PMID:10419894. |
in this study, we examined the effect of protease inhibitors on fas-r (cd95), ice (caspase 1) expression, apoptosis, and cell death in cd4(+) t cells of (1) hiv-infected patients who were receiving protease inhibitors, and (2) normal and patient cd4(+) t cells cultured with a protease inhibitor in vitro. |
1999-08-17 |
2023-08-12 |
human |
| E M Sloand, P N Kumar, S Kim, A Chaudhuri, F F Weichold, N S Youn. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood. vol 94. issue 3. 1999-08-17. PMID:10419894. |
fifteen patients with advanced hiv disease on treatment showed dramatically decreased cd4(+) t-cell ice expression, diminished apoptosis, and increased numbers of cd4(+) cells within 6 weeks of institution of protease inhibitor therapy, and before down-modulation of fas-r (cd95) expression was evident. |
1999-08-17 |
2023-08-12 |
human |
| E M Sloand, P N Kumar, S Kim, A Chaudhuri, F F Weichold, N S Youn. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood. vol 94. issue 3. 1999-08-17. PMID:10419894. |
stimulated and unstimulated normal cd4(+) t cells, cultured with protease inhibitor, demonstrated markedly decreased apoptosis and ice expression (p =. |
1999-08-17 |
2023-08-12 |
human |
| E M Sloand, P N Kumar, S Kim, A Chaudhuri, F F Weichold, N S Youn. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood. vol 94. issue 3. 1999-08-17. PMID:10419894. |
in conclusion, protease inhibitors appear to decrease cd4(+) t-cell ice expression and apoptosis before they affect fas-r expression in hiv-infected patients. |
1999-08-17 |
2023-08-12 |
human |
| M Scudeletti, L Lanza, E Monaco, M Monetti, F Puppo, G Filaci, F Indiver. Immune regulatory properties of corticosteroids: prednisone induces apoptosis of human T lymphocytes following the CD3 down-regulation. Annals of the New York Academy of Sciences. vol 876. 1999-08-09. PMID:10415607. |
we have analyzed whether gch are able to affect the expression of the tcr-associated molecules cd3, cd4, and cd8 on pbl-pha, and whether the modulation of those receptors is related to the gch-driven apoptosis of the pbl-pha. |
1999-08-09 |
2023-08-12 |
human |
| L Di Marzio, S Moretti, S D'Alò, F Zazzeroni, S Marcellini, C Smacchia, E Alesse, M G Cifone, C De Simon. Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation. Clinical immunology (Orlando, Fla.). vol 92. issue 1. 1999-07-30. PMID:10413658. |
the aim of this study was to investigate the impact of long-term acetyl-l-carnitine administration on cd4 and cd8 absolute counts, apoptosis, and insulin-like growth factor-1 (igf-1) serum levels in hiv-1-infected subjects. |
1999-07-30 |
2023-08-12 |
human |
| R K Singh, M L Varney, S Buyukberber, K Ino, A G Ageitos, E Reed, S Tarantolo, J E Talmadg. Fas-FasL-mediated CD4+ T-cell apoptosis following stem cell transplantation. Cancer research. vol 59. issue 13. 1999-07-28. PMID:10397252. |
these data suggest that "primed" fas+ cd4+ lymphocytes interact with activated monocytes that express fasl, resulting in apoptosis, leading to deletion of cd4+ t cells, an inversion in the cd4:cd8 t-cell ratio, and immune dysfunction. |
1999-07-28 |
2023-08-12 |
Not clear |
| J A Esté, C Cabrera, J Blanco, A Gutierrez, G Bridger, G Henson, B Clotet, D Schols, E De Clerc. Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4. Journal of virology. vol 73. issue 7. 1999-07-23. PMID:10364306. |
the emergence of x4 human immunodeficiency virus type 1 (hiv-1) strains in hiv-1-infected individuals has been associated with cd4(+) t-cell depletion, hiv-mediated cd8(+) cell apoptosis, and an impaired humoral response. |
1999-07-23 |
2023-08-12 |
human |
| C Coito, M Bomse. B7 cosignal potentiates apoptosis of uninfected CD4+ T lymphocytic cell lines primed by HIV envelope proteins. AIDS research and human retroviruses. vol 15. issue 6. 1999-06-29. PMID:10221528. |
finally, we characterized two enzymes, pi3kinase and pi-plc, which are both downstream effectors of the cd4 (hiv envelope protein receptor) and cd28 (b7 receptor) activation pathways, and that participated in the early steps of priming for apoptosis. |
1999-06-29 |
2023-08-12 |
Not clear |
| F P Siegal, N Kadowaki, M Shodell, P A Fitzgerald-Bocarsly, K Shah, S Ho, S Antonenko, Y J Li. The nature of the principal type 1 interferon-producing cells in human blood. Science (New York, N.Y.). vol 284. issue 5421. 1999-06-25. PMID:10364556. |
"natural ifn-producing cells" (ipcs) in human blood express cd4 and major histocompatibility complex class ii proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, and lack of lineage markers. |
1999-06-25 |
2023-08-12 |
human |
| C Gidon-Jeangirard, B Hugel, V Holl, F Toti, J L Laplanche, D Meyer, J M Freyssine. Annexin V delays apoptosis while exerting an external constraint preventing the release of CD4+ and PrPc+ membrane particles in a human T lymphocyte model. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 10. 1999-06-14. PMID:10229803. |
in this study, we report the delaying action of annexin v on apoptosis in the cem human t cell line expressing cd4 and the normal cellular prion protein (prpc), two ags of particular relevance to cell degeneration and with different attachments to the membrane. |
1999-06-14 |
2023-08-12 |
mouse |
| A Potter, C Kim, K A Gollahon, P S Rabinovitc. Apoptotic human lymphocytes have diminished CD4 and CD8 receptor expression. Cellular immunology. vol 193. issue 1. 1999-05-07. PMID:10202111. |
we found that cd4(+) and cd8(+) cells were significantly underrepresented in the apoptotic pbmc and that the percentage of cd4(+) and cd8(+) pbmc each markedly decreased as apoptosis increased. |
1999-05-07 |
2023-08-12 |
human |
| A Potter, C Kim, K A Gollahon, P S Rabinovitc. Apoptotic human lymphocytes have diminished CD4 and CD8 receptor expression. Cellular immunology. vol 193. issue 1. 1999-05-07. PMID:10202111. |
this analysis of a wide variety of apoptotic stimuli demonstrates that diminished cd4 and cd8 surface receptor expression is a common feature of human t lymphocyte apoptosis. |
1999-05-07 |
2023-08-12 |
human |
| G Cutrona, N Leanza, M Ulivi, M B Majolini, G Taborelli, S Zupo, C T Baldari, S Roncella, M Ferrarin. Apoptosis induced by crosslinking of CD4 on activated human B cells. Cellular immunology. vol 193. issue 1. 1999-05-07. PMID:10202115. |
apoptosis induced by crosslinking of cd4 on activated human b cells. |
1999-05-07 |
2023-08-12 |
human |
| G Cutrona, N Leanza, M Ulivi, M B Majolini, G Taborelli, S Zupo, C T Baldari, S Roncella, M Ferrarin. Apoptosis induced by crosslinking of CD4 on activated human B cells. Cellular immunology. vol 193. issue 1. 1999-05-07. PMID:10202115. |
crosslinking of cd4 on lcl or on tonsillar activated b cells resulted in apoptosis in vitro, a finding that indicates the capacity of cd4 to deliver functional signals to b cells and to play a regulatory function in their physiology. |
1999-05-07 |
2023-08-12 |
human |
| G Cutrona, N Leanza, M Ulivi, M B Majolini, G Taborelli, S Zupo, C T Baldari, S Roncella, M Ferrarin. Apoptosis induced by crosslinking of CD4 on activated human B cells. Cellular immunology. vol 193. issue 1. 1999-05-07. PMID:10202115. |
exposure of cd4 expressing b cells to gp120 under conditions that resulted in cd4 crosslinking also caused apoptosis suggesting some implications for the pathophysiology of aids. |
1999-05-07 |
2023-08-12 |
human |
| C S Hirsch, Z Toossi, G Vanham, J L Johnson, P Peters, A Okwera, R Mugerwa, P Mugyenyi, J J Ellne. Apoptosis and T cell hyporesponsiveness in pulmonary tuberculosis. The Journal of infectious diseases. vol 179. issue 4. 1999-04-21. PMID:10068591. |
both spontaneous and mtb-induced apoptosis (in cd4 and non-cd4 t cells) from tb patients was increased when compared with healthy control subjects, whereas coculture with control antigen (candida) had no effect on t cell apoptosis in either group of study subjects. |
1999-04-21 |
2023-08-12 |
human |
| M Gaubin, M Autiero, S Basmaciogullari, D Métivier, Z Mis hal, R Culerrier, A Oudin, J Guardiola, D Piatier-Tonnea. Potent inhibition of CD4/TCR-mediated T cell apoptosis by a CD4-binding glycoprotein secreted from breast tumor and seminal vesicle cells. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 5. 1999-04-14. PMID:10072505. |
as a follow up to our previous findings that gp17 binds to cd4 with high affinity and interferes with both hiv-1 gp120 binding to cd4 and syncytium formation, we investigated whether gp17 could affect the t lymphocyte apoptosis induced by a separate ligation of cd4 and tcr. |
1999-04-14 |
2023-08-12 |
human |
| M A McGargill, K A Hogquis. Antigen-induced coreceptor down-regulation on thymocytes is not a result of apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973375. |
furthermore, when thymocyte apoptosis was blocked, cd4 and cd8 were down-regulated in response to tcr stimulation. |
1999-04-13 |
2023-08-12 |
Not clear |
| D E Lewis, D S Ng Tang, X Wang, C Kozinet. Costimulatory pathways mediate monocyte-dependent lymphocyte apoptosis in HIV. Clinical immunology (Orlando, Fla.). vol 90. issue 3. 1999-04-13. PMID:10075859. |
examination of annexin v binding, an indicator of early apoptosis, on lymphocytes from hiv+ people immediately after isolation showed that both cd4(+) and cd8(+) t cells were apoptotic, whereas b cell apoptosis was induced mainly after incubation. |
1999-04-13 |
2023-08-12 |
Not clear |