| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Scheipers, H Reise. Fas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 17. 1998-09-17. PMID:9707604. |
here we provide evidence that ctla-4 crosslinking on the surface of activated murine cd4(+) t lymphocytes leads to death of a substantial fraction of the cells whereas in resting cd4(+) t cells the same stimulation conditions induce cell cycle arrest without apoptosis. |
1998-09-17 |
2023-08-12 |
human |
| C Wang, G A Splitte. CD4(+) cytotoxic T-lymphocyte activity against macrophages pulsed with bovine herpesvirus 1 polypeptides. Journal of virology. vol 72. issue 9. 1998-09-16. PMID:9696796. |
apoptosis of bhv-1-expressing target cells was observed in cd4(+) ctl assays by terminal deoxynucleotidyltransferase-mediated dutp nick end labeling (tunel) analysis. |
1998-09-16 |
2023-08-12 |
cattle |
| C Wang, G A Splitte. CD4(+) cytotoxic T-lymphocyte activity against macrophages pulsed with bovine herpesvirus 1 polypeptides. Journal of virology. vol 72. issue 9. 1998-09-16. PMID:9696796. |
these findings support the concept that cd4(+) ctl lyse macrophages pulsed with bhv-1 polypeptides through a fas-mediated lytic pathway by inducing apoptosis in the target cells. |
1998-09-16 |
2023-08-12 |
cattle |
| N Moulian, J Bidault, C Planché, S Berrih-Akni. Two signaling pathways can increase fas expression in human thymocytes. Blood. vol 92. issue 4. 1998-09-10. PMID:9694718. |
(4) cytokine-activated thymocytes were more susceptible than anti-cd3-activated thymocytes to fas-induced apoptosis, a difference mainly accounted for by cd4(+) cells. |
1998-09-10 |
2023-08-12 |
human |
| W D Thomas, P Herse. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 5. 1998-09-10. PMID:9725211. |
tnf-related apoptosis-inducing ligand (trail) induces apoptosis in fas ligand-resistant melanoma cells and mediates cd4 t cell killing of target cells. |
1998-09-10 |
2023-08-12 |
human |
| W D Thomas, P Herse. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 5. 1998-09-10. PMID:9725211. |
in the present study, we have tested melanoma cells for their susceptibility to apoptosis induced by human tnf-related apoptosis-inducing ligand (trail) and the ability of a mab against trail to inhibit apoptosis and cd4 ctl-mediated killing of melanoma and jurkat target cells. |
1998-09-10 |
2023-08-12 |
human |
| N Johnson, J M Parki. Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis. Clinical and experimental immunology. vol 113. issue 2. 1998-09-09. PMID:9717972. |
the objective of this study was to assess the role of anti-retroviral therapy (art) on the susceptibility of peripheral blood lymphocytes (pbl) from hiv-1-infected individuals to activation-induced apoptosis and in comparison with changes in cd4 lymphocyte counts. |
1998-09-09 |
2023-08-12 |
Not clear |
| N Johnson, J M Parki. Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis. Clinical and experimental immunology. vol 113. issue 2. 1998-09-09. PMID:9717972. |
ex vivo apoptosis was measured in phytohaemagglutinin (pha)-stimulated pbl and cd4 subsets by flow cytometry, at baseline and after 1 month (4-6 weeks) and 2/3 months of art. |
1998-09-09 |
2023-08-12 |
Not clear |
| N Johnson, J M Parki. Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis. Clinical and experimental immunology. vol 113. issue 2. 1998-09-09. PMID:9717972. |
cd4 counts showed a reciprocal relationship to changes in apoptosis. |
1998-09-09 |
2023-08-12 |
Not clear |
| N Johnson, J M Parki. Anti-retroviral therapy reverses HIV-associated abnormalities in lymphocyte apoptosis. Clinical and experimental immunology. vol 113. issue 2. 1998-09-09. PMID:9717972. |
the association of changes in apoptosis with those in cd4 counts suggests a link between programmed cell death and lymphocyte depletion. |
1998-09-09 |
2023-08-12 |
Not clear |
| Y Kang, E F Melo, D W Scot. An ongoing immune response to HIV envelope gp120 in human CD4-transgenic mice contributes to T cell decline upon intravenous administration of gp120. European journal of immunology. vol 28. issue 8. 1998-09-03. PMID:9710203. |
these in vivo results are consistent with in vitro data demonstrating that cross-linking cd4 on splenocytes of hucd4 tg by rgp120sf2 and anti-gp120 not only sensitizes t cells for apoptosis, but also induces apoptosis per se, and suggest that anti-gp120 responsiveness can contribute to t cell depletion in aids. |
1998-09-03 |
2023-08-12 |
mouse |
| S E Howie, G J Cotton, I Heslop, N J Martin, D J Harrison, R Ramag. Synthetic peptides representing discontinuous CD4 binding epitopes of HIV-1 gp120 that induce T cell apoptosis and block cell death induced by gp120. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 11. 1998-09-02. PMID:9707171. |
synthetic peptides representing discontinuous cd4 binding epitopes of hiv-1 gp120 that induce t cell apoptosis and block cell death induced by gp120. |
1998-09-02 |
2023-08-12 |
human |
| S E Howie, G J Cotton, I Heslop, N J Martin, D J Harrison, R Ramag. Synthetic peptides representing discontinuous CD4 binding epitopes of HIV-1 gp120 that induce T cell apoptosis and block cell death induced by gp120. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 11. 1998-09-02. PMID:9707171. |
the peptide incorporating three cd4 binding residues competitively inhibited gp 120-induced t lymphocyte apoptosis. |
1998-09-02 |
2023-08-12 |
human |
| R D Huby, R Hicks, L K Gof. Kinetics of thymocyte subset development and selection revealed by cyclosporin A treatment. Developmental immunology. vol 4. issue 2. 1998-08-18. PMID:9700361. |
apoptosis of tcr-v beta 3 + thymocytes caused by mtv-6, quantified according to the down-regulation of cd4 and cd8 on immature thymocytes, was partially inhibited by csa, to maximal effect within 24 hours. |
1998-08-18 |
2023-08-12 |
Not clear |
| J Hesselgesser, D Taub, P Baskar, M Greenberg, J Hoxie, D L Kolson, R Horu. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Current biology : CB. vol 8. issue 10. 1998-08-12. PMID:9601645. |
we now find that both iiib gp120 and the cys-x-cys chemokine sdf-1 alpha can directly induce apoptosis in hnt neurons in the absence of cd4 and in a dose-dependent manner. |
1998-08-12 |
2023-08-12 |
human |
| L Evrard, S Louryan, N Vanmuylder, R Glineur, M Rooze, N Douro. [The role of apoptosis during craniofacial development: concepts and importance in pathology]. Revue medicale de Bruxelles. vol 19. issue 1. 1998-08-06. PMID:9553451. |
apoptosis is an essential common final pathway in numerous pathological conditions such as malignant tumors, hiv-related cd4 lymphocytes degeneration, neurodegenerative disorders, and in programmed cell death events during normal embryogenesis. |
1998-08-06 |
2023-08-12 |
Not clear |
| L L Carter, X Zhang, C Dubey, P Rogers, L Tsui, S L Swai. Regulation of T cell subsets from naive to memory. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 21. issue 3. 1998-07-17. PMID:9610909. |
to gain insights into the development and regulation of immune responses, we have studied the phenotype, cytokine profiles, activation requirements, and susceptibility to apoptosis of naive cd4, th1, th2 polarized effectors, resting memory, and memory effector cells. |
1998-07-17 |
2023-08-12 |
mouse |
| L L Carter, X Zhang, C Dubey, P Rogers, L Tsui, S L Swai. Regulation of T cell subsets from naive to memory. Journal of immunotherapy (Hagerstown, Md. : 1997). vol 21. issue 3. 1998-07-17. PMID:9610909. |
cd4 subsets also differ dramatically in their susceptibility to apoptosis. |
1998-07-17 |
2023-08-12 |
mouse |
| C Callebaut, E Jacotot, J Blanco, B Krust, A G Hovanessia. Increased rate of HIV-1 entry and its cytopathic effect in CD4+/CXCR4+ T cells expressing relatively high levels of CD26. Experimental cell research. vol 241. issue 2. 1998-07-14. PMID:9637777. |
our results demonstrate that with equivalently expressed levels of cd4 and cxcr4 in cell lines established from cem cells, relatively high levels of cd26 contribute to an increased rate of hiv entry, infection, and apoptosis. |
1998-07-14 |
2023-08-12 |
Not clear |
| S Moretti, E Alesse, L Di Marzio, F Zazzeroni, B Ruggeri, S Marcellini, G Famularo, S M Steinberg, A Boschini, M G Cifone, C De Simon. Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study. Blood. vol 91. issue 10. 1998-06-12. PMID:9573019. |
the aim of this study was to study, in a preliminary fashion, the impact of long-term l-carnitine administration on cd4 and cd8 absolute counts, rate, and apoptosis in hiv-1-infected subjects. |
1998-06-12 |
2023-08-12 |
human |