| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuliana Cerulo, Simona Tafuri, Valeria De Pasquale, Silviana Rea, Simona Romano, Anna Costagliola, Rossella Della Morte, Luigi Avallone, Luigi Michele Pavon. Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells. Biochimie. vol 105. 2015-05-29. PMID:24997405. |
here, we first demonstrate the expression of serotonin transporter sert and 5-ht2a receptor subtype in rat thyroid epithelial cell line frt both at mrna and protein levels. |
2015-05-29 |
2023-08-13 |
rat |
| Giuliana Cerulo, Simona Tafuri, Valeria De Pasquale, Silviana Rea, Simona Romano, Anna Costagliola, Rossella Della Morte, Luigi Avallone, Luigi Michele Pavon. Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells. Biochimie. vol 105. 2015-05-29. PMID:24997405. |
cell exposure to the selective 5-ht2a receptor agonist doi recapitulated the effects of 5-ht on erk1/2 phosphorylation. |
2015-05-29 |
2023-08-13 |
rat |
| Giuliana Cerulo, Simona Tafuri, Valeria De Pasquale, Silviana Rea, Simona Romano, Anna Costagliola, Rossella Della Morte, Luigi Avallone, Luigi Michele Pavon. Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells. Biochimie. vol 105. 2015-05-29. PMID:24997405. |
by contrast, administration of m100907, a specific 5-ht2a receptor inhibitor, prevented 5-ht induced erk1/2 activation. |
2015-05-29 |
2023-08-13 |
rat |
| Giuliana Cerulo, Simona Tafuri, Valeria De Pasquale, Silviana Rea, Simona Romano, Anna Costagliola, Rossella Della Morte, Luigi Avallone, Luigi Michele Pavon. Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells. Biochimie. vol 105. 2015-05-29. PMID:24997405. |
overall, our findings demonstrate that low levels of serotonin, interacting with 5-ht2a receptor, are able to activate proliferative signals in the thyroid epithelial cells, while high levels of serotonin cause pro-apoptotic responses, thus suggesting an active role of the amine in the thyroid functions and disorders. |
2015-05-29 |
2023-08-13 |
rat |
| Maria Martí-Solano, Alba Iglesias, Gianni de Fabritiis, Ferran Sanz, José Brea, M Isabel Loza, Manuel Pastor, Jana Selen. Detection of new biased agonists for the serotonin 5-HT2A receptor: modeling and experimental validation. Molecular pharmacology. vol 87. issue 4. 2015-05-26. PMID:25661038. |
detection of new biased agonists for the serotonin 5-ht2a receptor: modeling and experimental validation. |
2015-05-26 |
2023-08-13 |
Not clear |
| Maria Martí-Solano, Alba Iglesias, Gianni de Fabritiis, Ferran Sanz, José Brea, M Isabel Loza, Manuel Pastor, Jana Selen. Detection of new biased agonists for the serotonin 5-HT2A receptor: modeling and experimental validation. Molecular pharmacology. vol 87. issue 4. 2015-05-26. PMID:25661038. |
detection of biased agonists for the serotonin 5-ht2a receptor can guide the discovery of safer and more efficient antipsychotic drugs. |
2015-05-26 |
2023-08-13 |
Not clear |
| Philip D Harve. The clinical utility of lurasidone in schizophrenia: patient considerations. Neuropsychiatric disease and treatment. vol 11. 2015-05-21. PMID:25995636. |
in addition to full antagonist activity at the dopamine d2 (ki, 1 nm) and serotonin 5-ht2a (ki, 0.5 nm) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-ht7 receptors (0.5 nm) and its partial agonist activity at 5-ht1a receptors (ki, 6.4 nm). |
2015-05-21 |
2023-08-13 |
Not clear |
| Emily K Stephens, Daniel Avesar, Allan T Gulledg. Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex. Frontiers in neural circuits. vol 8. 2015-05-15. PMID:25206322. |
layer 5 pyramidal neurons (l5pns) in the mouse prefrontal cortex respond to serotonin (5-ht) according to their long-distance axonal projections; 5-ht1a (1a) receptors mediate inhibitory responses in corticopontine (cpn) l5pns, while 5-ht2a (2a) receptors can enhance action potential (ap) output in callosal/commissural (com) l5pns, either directly (in "com-excited" neurons), or following brief 1a-mediated inhibition (in "com-biphasic" neurons). |
2015-05-15 |
2023-08-13 |
mouse |
| Maciej Bieliński, Marta Tomaszewska, Marcin Jaracz, Joanna Pulkowska-Ulfig, Dominika Długosz, Marcin Sikora, Andrzej Tretyn, Anna Kamińska, Roman Junik, Alina Borkowsk. The polymorphisms in serotonin-related genes (5-HT₂A and SERT) and the prevalence of depressive symptoms in obese patients. Neuroscience letters. vol 586. 2015-05-14. PMID:25486590. |
two polymorphisms were tested: a 44-bp insertion/deletion in the serotonin transporter (sert) gene and a single-nucleotide variation (1438g/a) in the serotonin 2a receptor (5-ht2a) gene. |
2015-05-14 |
2023-08-13 |
human |
| David O'Sullivan, Laura Green, Sarrabeth Stone, Pirooz Zareie, Marie Kharkrang, Dahna Fong, Bronwen Connor, Anne Camille La Flamm. Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis. PloS one. vol 9. issue 8. 2015-04-23. PMID:25116424. |
recent studies have demonstrated that atypical antipsychotic agents, which are known to antagonize dopamine d2 and serotonin 5-ht2a receptors, have immunomodulatory properties. |
2015-04-23 |
2023-08-13 |
Not clear |
| A S Tsybko, T V Il'chibaeva, E M Kondaurova, D V Bazovkina, V S Naumenk. [The effect of central administration of the neurotrophic factors BDNF and GDNF on the functional activity and expression of the serotonin 5-HT2A receptors in mice genetically predisposed to depressive-like behavior]. Molekuliarnaia biologiia. vol 48. issue 6. 2015-04-17. PMID:25845239. |
[the effect of central administration of the neurotrophic factors bdnf and gdnf on the functional activity and expression of the serotonin 5-ht2a receptors in mice genetically predisposed to depressive-like behavior]. |
2015-04-17 |
2023-08-13 |
mouse |
| Monika Szabo, Herman D Lim, Carmen Klein Herenbrink, Arthur Christopoulos, J Robert Lane, Ben Capuan. Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors. Journal of medicinal chemistry. vol 58. issue 3. 2015-04-14. PMID:25590655. |
proof of concept study for designed multiple ligands targeting the dopamine d2, serotonin 5-ht2a, and muscarinic m1 acetylcholine receptors. |
2015-04-14 |
2023-08-13 |
Not clear |
| Maria Cano-Colino, Rita Almeida, David Gomez-Cabrero, Francesc Artigas, Albert Compt. Serotonin regulates performance nonmonotonically in a spatial working memory network. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 9. 2015-04-13. PMID:23629582. |
we found that 5-ht modulates network's swm performance nonmonotonically via 5-ht1a and 5-ht2a receptors, following an inverted u-shape. |
2015-04-13 |
2023-08-12 |
Not clear |
| Takayuki Matsumoto, Shun Watanabe, Kumiko Taguchi, Tsuneo Kobayash. Mechanisms underlying increased serotonin-induced contraction in carotid arteries from chronic type 2 diabetic Goto-Kakizaki rats. Pharmacological research. vol 87. 2015-04-13. PMID:25034165. |
carotid arterial expressions of monoamine oxidase-a (mao-a), serotonin transporter (sert), and 5-ht2a were detected by immunoblotting. |
2015-04-13 |
2023-08-13 |
rat |
| Ke-Zhu Wu, Yun-Gen Jiang, Ying Zuo, Ai-Xiu L. Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill. Interdisciplinary sciences, computational life sciences. vol 6. issue 2. 2015-04-10. PMID:25172450. |
the potential targets of this compound pharmaceutics were searched through relevant pharmacological studies and three pharmacophore models which involved the platelet activating factor (paf) receptor, the angiotensin converting enzyme (ace) and the 5-hydroxytryptamine receptor (5-ht2a) were constructed by discotech method of sybyl. |
2015-04-10 |
2023-08-13 |
Not clear |
| Nur Iwani A Rozak, Imran Ahmad, Siew Hua Gan, Ruzilawati Abu Baka. Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays. Scientia pharmaceutica. vol 82. issue 3. 2015-04-08. PMID:25853073. |
lack of association between the serotonin transporter (5-htt) and serotonin receptor (5-ht2a) gene polymorphisms with smoking behavior among malaysian malays. |
2015-04-08 |
2023-08-13 |
Not clear |
| Nur Iwani A Rozak, Imran Ahmad, Siew Hua Gan, Ruzilawati Abu Baka. Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays. Scientia pharmaceutica. vol 82. issue 3. 2015-04-08. PMID:25853073. |
an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-httlpr) and a polymorphism (rs6313) in the serotonin 2a receptor gene (5-ht2a) have previously been linked to smoking behavior. |
2015-04-08 |
2023-08-13 |
Not clear |
| D S Yakovlev, A A Spasov, D V Mal'tsev, V A Anisimov. Effect of 5-HT(2A) receptor antagonists on blood flow in the carotid vessels upon elevation of serotonin level. Bulletin of experimental biology and medicine. vol 157. issue 3. 2015-03-31. PMID:25070162. |
ritanserin, ketanserin, and 5-ht2a receptor antagonist ru-476 reduced the effect of serotonin on the blood fl ow velocity in the internal carotid artery by 2.3, 1.7, and 2.6 times, respectively. |
2015-03-31 |
2023-08-13 |
rat |
| Bruce E Blough, Antonio Landavazo, John S Partilla, Ann M Decker, Kevin M Page, Michael H Baumann, Richard B Rothma. Alpha-ethyltryptamines as dual dopamine-serotonin releasers. Bioorganic & medicinal chemistry letters. vol 24. issue 19. 2015-03-30. PMID:25193229. |
the dopamine (da), serotonin (5-ht), and norepinephrine (ne) transporter releasing activity and serotonin-2a (5-ht2a) receptor agonist activity of a series of substituted tryptamines are reported. |
2015-03-30 |
2023-08-13 |
Not clear |
| Monika Kloza, Marta Baranowska-Kuczko, Anna Pędzińska-Betiuk, Konrad Jackowski, Hanna Kozłowsk. [Serotonin hypothesis and pulmonary artery hypertension]. Postepy higieny i medycyny doswiadczalnej (Online). vol 68. 2015-03-25. PMID:24934532. |
5-ht mediates contraction of pulmonary vessels via 5-ht1b and 5-ht2a receptors. |
2015-03-25 |
2023-08-13 |
Not clear |