| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Den. Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D₂ but not 5-HT2A/2C bindings in rat brains. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25149912. |
this study investigated the effects of chronic treatment of olanzapine and/or betahistine on the binding density of the serotonergic 5-ht2a (5-ht2ar) and 5-ht2c (5-ht2cr) receptors, 5-ht transporter (5-htt), and dopaminergic d₂ receptors (d₂r) in the brain regions involved in antipsychotic efficacy, including the prefrontal cortex (pfc), cingulate cortex (cg), nucleus accumbens (nac), and caudate putamen (cpu). |
2015-07-31 |
2023-08-13 |
rat |
| Elizabeth Glenn Guy, Paul J Fletche. Responding for a conditioned reinforcer, and its enhancement by nicotine, is blocked by dopamine receptor antagonists and a 5-HT(2C) receptor agonist but not by a 5-HT(2A) receptor antagonist. Pharmacology, biochemistry, and behavior. vol 125. 2015-07-28. PMID:25158104. |
in this study, we assessed roles for dopamine (da) d1 or d2 receptors, and two serotonin (5-ht) receptor subtypes known to modulate da activity, the 5-ht2c or 5-ht2a subtypes, on nicotine-enhanced responding for a conditioned reinforcer. |
2015-07-28 |
2023-08-13 |
rat |
| Elizabeth Glenn Guy, Paul J Fletche. Responding for a conditioned reinforcer, and its enhancement by nicotine, is blocked by dopamine receptor antagonists and a 5-HT(2C) receptor agonist but not by a 5-HT(2A) receptor antagonist. Pharmacology, biochemistry, and behavior. vol 125. 2015-07-28. PMID:25158104. |
to examine potential roles for dopamine (da) and serotonin (5-ht) receptors in this effect, separate groups of animals were used to assess the impact of administering the d1 receptor antagonist sch 23390, d2 receptor antagonist eticlopride, 5-ht2c receptor agonist ro 60-0175, or 5-ht2a receptor antagonist m100907 on nicotine-enhanced responding for conditioned reinforcement. |
2015-07-28 |
2023-08-13 |
rat |
| Zeng Li, Jiye Huang, Haifeng Sun, Shengbin Zhou, Lin Guo, Yu Zhou, Xuechu Zhen, Hong Li. Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles. Bioorganic & medicinal chemistry. vol 22. issue 21. 2015-07-22. PMID:25308766. |
a novel scaffold derived from l-spd with a substituted thiophene group in the d ring were designed, synthesized, and evaluated for their binding affinities at dopamine (d1, d2 and d3) and serotonin (5-ht1a and 5-ht2a) receptors. |
2015-07-22 |
2023-08-13 |
Not clear |
| Ambalika Sarkar, Parul Chachra, Vidita A Vaidy. Postnatal fluoxetine-evoked anxiety is prevented by concomitant 5-HT2A/C receptor blockade and mimicked by postnatal 5-HT2A/C receptor stimulation. Biological psychiatry. vol 76. issue 11. 2015-07-20. PMID:24315410. |
we examined the role of serotonin 2a (5-ht2a), serotonin 2c (5-ht2c) and serotonin 1a (5-ht1a) receptors, implicated in the development of anxiety, in the behavioral consequences of postnatal fluoxetine (pnflx). |
2015-07-20 |
2023-08-12 |
Not clear |
| Jian-Ming Peng, You-Jiang Yu, Lan-Di Su, Xue Lu. Meta-analysis of 5-hydroxytryptamine type 2A receptor polymorphisms and migraine susceptibility. The International journal of neuroscience. vol 124. issue 12. 2015-07-20. PMID:25019276. |
epidemiologic studies have investigated the association of polymorphisms in 5-hydroxytryptamine type 2a receptor (5ht2a) gene and migraine susceptibility, but the results of those studies are inconclusive. |
2015-07-20 |
2023-08-13 |
Not clear |
| Carolina Muguruza, Patricia Miranda-Azpiazu, Rebeca Díez-Alarcia, Benito Morentin, Javier González-Maeso, Luis F Callado, J Javier Mean. Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment. Neuropharmacology. vol 86. 2015-07-14. PMID:25150943. |
several studies have demonstrated alterations in serotonin 5-ht2a (5-ht2ar) and glutamate metabotropic mglu2 (mglu2r) receptors in depression, but never in the same sample population. |
2015-07-14 |
2023-08-13 |
human |
| Chunyan Chen, Xinyuan Han, Fenling Fan, Ya Liu, Tingzhong Wang, Juanjuan Wang, Peijing Hu, Aiqun Ma, Hongyan Tia. Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-β1/Smad3-mediated fibrotic responses through 5-HT(2A) receptors. Molecular and cellular biochemistry. vol 397. issue 1-2. 2015-06-29. PMID:25185755. |
these results demonstrated that 5-ht can directly activate pafs through 5-ht2a receptor and promote fibroblasts phenotypic alterations and adventitia fibrosis depending on the signaling of the tgf-β1/smad3 pathway. |
2015-06-29 |
2023-08-13 |
rat |
| Karunakaran Vijayakaran, Manickam Kesavan, Kandasamy Kannan, Palanisamy Sankar, Surendra Kumar Tandan, Souvendra Nath Sarka. Arsenic decreases antinociceptive activity of paracetamol: possible involvement of serotonergic and endocannabinoid receptors. Environmental toxicology and pharmacology. vol 38. issue 2. 2015-06-23. PMID:25128769. |
serotonin content and gene expression of 5-ht1a, 5-ht2a and cb1 receptors were evaluated in brainstem and frontal cortex. |
2015-06-23 |
2023-08-13 |
rat |
| E S Ramos Neto, J O Mágulas, J J S Sousa, A C M Moura, G R Pinto, F K N Yoshioka, R Canalle, F J N Mott. Study of polymorphic variants of the serotonin 2A receptor gene (5-HT2A) and its possible effects on smoking habits of a population from northeastern Brazil. Genetics and molecular research : GMR. vol 13. issue 4. 2015-06-22. PMID:25366721. |
study of polymorphic variants of the serotonin 2a receptor gene (5-ht2a) and its possible effects on smoking habits of a population from northeastern brazil. |
2015-06-22 |
2023-08-13 |
Not clear |
| Leonard L Howell, Kathryn A Cunningha. Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder. Pharmacological reviews. vol 67. issue 1. 2015-06-15. PMID:25505168. |
however, the 5-ht2a and 5-ht2c receptors in particular have been implicated as likely candidates for mediating the influence of 5-ht in cocaine abuse as well as to traits (e.g., impulsivity) that contribute to the development of cocaine use disorder and relapse in humans. |
2015-06-15 |
2023-08-13 |
Not clear |
| Silvia Victoria Navarro, Valeria Gutiérrez-Ferre, Pilar Flores, Margarita Moren. Activation of serotonin 5-HT2A receptors inhibits high compulsive drinking on schedule-induced polydipsia. Psychopharmacology. vol 232. issue 4. 2015-06-12. PMID:25155310. |
activation of serotonin 5-ht2a receptors inhibits high compulsive drinking on schedule-induced polydipsia. |
2015-06-12 |
2023-08-13 |
rat |
| M E Haahr, D L Hansen, P M Fisher, C Svarer, D S Stenbæk, K Madsen, J Madsen, J J Holst, W F C Baaré, L Hojgaard, T Almdal, G M Knudse. Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 14. 2015-06-11. PMID:25855196. |
in vivo cerebral 5-ht2a receptor and 5-ht transporter binding was determined by positron emission tomography in 21 obese [four men; body mass index (bmi), 40.1 ± 4.1 kg/m(2)] and 10 lean (three men; bmi, 24.6 ± 1.5 kg/m(2)) individuals. |
2015-06-11 |
2023-08-13 |
Not clear |
| M E Haahr, D L Hansen, P M Fisher, C Svarer, D S Stenbæk, K Madsen, J Madsen, J J Holst, W F C Baaré, L Hojgaard, T Almdal, G M Knudse. Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 14. 2015-06-11. PMID:25855196. |
importantly, we found that higher presurgical 5-ht2a receptor binding predicted greater weight loss after rygb and that the change in 5-ht2a receptor and 5-ht transporter binding correlated with weight loss after rygb. |
2015-06-11 |
2023-08-13 |
Not clear |
| Uli Hacksell, Ethan S Burstein, Krista McFarland, Roger G Mills, Hilde William. On the discovery and development of pimavanserin: a novel drug candidate for Parkinson's psychosis. Neurochemical research. vol 39. issue 10. 2015-06-08. PMID:24682754. |
using molecular pharmacological profiling of a large collection of marketed drugs, we discovered that potent inverse agonist activity against 5-ht2a serotonin receptors was a common feature of atypical apds, especially the atypical apds used to treat pdp. |
2015-06-08 |
2023-08-12 |
Not clear |
| Robert D Johnson, Sabra R Botch-Jones, Tiffany Flowers, Connie A Lewi. An evaluation of 25B-, 25C-, 25D-, 25H-, 25I- and 25T2-NBOMe via LC-MS-MS: method validation and analyte stability. Journal of analytical toxicology. vol 38. issue 8. 2015-06-05. PMID:25217535. |
as potent serotonin (5-ht2a) receptor agonists, the nbome class of drugs including 25b-, 25c-, 25d-, 25h-, 25i- and 25t2-nbome is frequently abused due to the intense hallucinations that they induce. |
2015-06-05 |
2023-08-13 |
Not clear |
| Hong-Yi Chiu, Ming-Huan Chan, Mei-Yi Lee, Shao-Tsu Chen, Zih-Yi Zhan, Hwei-Hsien Che. Long-lasting alterations in 5-HT2A receptor after a binge regimen of methamphetamine in mice. The international journal of neuropsychopharmacology. vol 17. issue 10. 2015-06-02. PMID:24763081. |
the present study aimed to examine the effects of ma binge exposure on 5-ht2a receptors, the subtype of serotonin receptors putatively involved in psychosis. |
2015-06-02 |
2023-08-13 |
mouse |
| Ferdinando Fiorino, Elisa Magli, Beatrice Severino, Angela Corvino, Antonio Ciano, Elisa Perissutti, Francesco Frecentese, Paola Massarelli, Cristina Nencini, Vincenzo Santagada, Giuseppe Caliend. Synthesis and in vitro pharmacological evaluation of novel 2-hydroxypropyl-4-arylpiperazine derivatives as serotoninergic ligands. Archiv der Pharmazie. vol 347. issue 10. 2015-06-01. PMID:25113046. |
this paper reports the synthesis of new norbornene and exo-n-hydroxy-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide derivatives and their binding to the 5-ht1a , 5-ht2a , and 5-ht2c receptors, in order to identify selective ligands for these 5-hydroxytryptamine (5-ht, serotonine) receptor subtypes. |
2015-06-01 |
2023-08-13 |
Not clear |
| Brendon P Boo. Comprehensive treatment of dementia with Lewy bodies. Alzheimer's research & therapy. vol 7. issue 1. 2015-06-01. PMID:26029267. |
pimavanserin, a selective serotonin 5-ht2a inverse agonist, holds promise as an alternative therapy for synuclein-associated psychosis. |
2015-06-01 |
2023-08-13 |
Not clear |
| Giuliana Cerulo, Simona Tafuri, Valeria De Pasquale, Silviana Rea, Simona Romano, Anna Costagliola, Rossella Della Morte, Luigi Avallone, Luigi Michele Pavon. Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells. Biochimie. vol 105. 2015-05-29. PMID:24997405. |
here, we first demonstrate the expression of serotonin transporter sert and 5-ht2a receptor subtype in rat thyroid epithelial cell line frt both at mrna and protein levels. |
2015-05-29 |
2023-08-13 |
rat |