| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Shilpa, T R Anju, M S Ajayan, C S Paulos. Increased cortical neuronal survival during liver injury: effect of gamma aminobutyric acid and 5-HT chitosan nanoparticles. Journal of biomedical nanotechnology. vol 10. issue 4. 2014-05-01. PMID:24734514. |
in the present study, partially hepatectomised rats treated with gamma aminobutyric acid (gaba) and serotonin (5-ht) chitosan nanoparticles, individually and in combination, were evaluated to analyse their role in gabab, and 5-ht2a receptors functional regulation, interrelated neuronal survival mechanisms by nuclear factor kappa b (nf-kappab), tumour necrosis factor-a (tnf-alpha), akt-1 and the antioxidant enzyme superoxide dismutase (sod) in the cerebral cortex. |
2014-05-01 |
2023-08-13 |
rat |
| Susan H Fo. Non-dopaminergic treatments for motor control in Parkinson's disease. Drugs. vol 73. issue 13. 2014-04-10. PMID:23917951. |
other options include 5-ht2a antagonists, and drugs that have mixed binding properties involving serotonin and acetylcholine, such as clozapine and the antidepressant mirtazapine, can be effective in reducing pd tremor. |
2014-04-10 |
2023-08-12 |
human |
| Jian Cao, Xiangtao Liu, Shizhong Han, Clarence K Zhang, Zongzhi Liu, Dawei L. Association of the HTR2A gene with alcohol and heroin abuse. Human genetics. vol 133. issue 3. 2014-04-07. PMID:24178752. |
positive genetic associations of rs6313 (102t/c at exon 1) and rs6311 (-1438a/g) on the 5-hydroxytryptamine (serotonin) 2a receptor gene (htr2a or 5-ht2a) were reported for alcohol and drug abuse; however, other association studies failed to produce consistent results supporting the susceptibility of the two single nucleotide polymorphisms (snps). |
2014-04-07 |
2023-08-12 |
Not clear |
| Shuji Gamoh, Hiroaki Hisa, Ryuichi Yamamot. 5-hydroxytryptamine receptors as targets for drug therapies of vascular-related diseases. Biological & pharmaceutical bulletin. vol 36. issue 9. 2014-04-01. PMID:23995651. |
the vasoconstrictive effects of 5-ht are mediated by 5-ht1b and 5-ht2a receptors located on the membrane of smooth muscle cells, except in the intracranial arteries which constrict only through 5-ht1b receptors. |
2014-04-01 |
2023-08-12 |
Not clear |
| Takuji Machida, Kenji Iizuka, Masahiko Hirafuj. 5-hydroxytryptamine and its receptors in systemic vascular walls. Biological & pharmaceutical bulletin. vol 36. issue 9. 2014-04-01. PMID:23995652. |
in vsmcs, 5-ht induces proliferation and migration via 5-ht2a receptors. |
2014-04-01 |
2023-08-12 |
Not clear |
| J L Klotz, G E Aiken, J M Johnson, K R Brown, L P Bush, J R Stricklan. Antagonism of lateral saphenous vein serotonin receptors from steers grazing endophyte-free, wild-type, or novel endophyte-infected tall fescue. Journal of animal science. vol 91. issue 9. 2014-03-31. PMID:23825335. |
pharmacologic profiling of serotonin (5ht) receptors of bovine lateral saphenous vein has shown that cattle grazing endophyte-infected (neotyphodium coenophialum) tall fescue (lolium arundinaceum) have altered responses to ergovaline, 5ht, 5ht2a, and 5ht7 agonists. |
2014-03-31 |
2023-08-12 |
cattle |
| J L Klotz, G E Aiken, J M Johnson, K R Brown, L P Bush, J R Stricklan. Antagonism of lateral saphenous vein serotonin receptors from steers grazing endophyte-free, wild-type, or novel endophyte-infected tall fescue. Journal of animal science. vol 91. issue 9. 2014-03-31. PMID:23825335. |
to determine if 5ht receptor activity of tall fescue alkaloids is affected by grazing endophyte-free (ef), wild-type [kentucky-31 (ky31)], novel endophyte ar542-infected (maxq), or novel endophyte ar584-infected (ar584) tall fescue, contractile responses of lateral saphenous veins biopsied from cattle grazing these different fescue-endophyte combinations were evaluated in presence or absence of antagonists for 5ht2a (ketanserin) or 5ht7 (sb-269970) receptors. |
2014-03-31 |
2023-08-12 |
cattle |
| Maiko Kawamura, Masanori Ishiguro, Takashi Nagamine, Kiyohiro Houki. Sarpogrelate dilates cerebral arteries in the absence of exogenous serotonin. Neurologia medico-chirurgica. vol 53. issue 5. 2014-03-28. PMID:23708219. |
vasoconstriction of arteries induced by serotonin (5-hydroxytryptamine: 5-ht) is mediated by 5-ht2a and 5-ht1b receptors localized on smooth muscle. |
2014-03-28 |
2023-08-12 |
rabbit |
| Maiko Kawamura, Masanori Ishiguro, Takashi Nagamine, Kiyohiro Houki. Sarpogrelate dilates cerebral arteries in the absence of exogenous serotonin. Neurologia medico-chirurgica. vol 53. issue 5. 2014-03-28. PMID:23708219. |
the present study investigated the impact of sarpogrelate, a 5-ht2a receptor antagonist, on cerebral artery diameter in the presence and absence of exogenous 5-ht. |
2014-03-28 |
2023-08-12 |
rabbit |
| Dong Jun Sung, Hyun Ju Noh, Jae Gon Kim, Sang Woong Park, Bokyung Kim, Hana Cho, Young Min Ba. Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase. Experimental & molecular medicine. vol 45. 2014-03-20. PMID:24336234. |
serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive kv channels via the 5-ht2a receptor and src tyrosine kinase. |
2014-03-20 |
2023-08-12 |
rat |
| Dong Jun Sung, Hyun Ju Noh, Jae Gon Kim, Sang Woong Park, Bokyung Kim, Hana Cho, Young Min Ba. Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase. Experimental & molecular medicine. vol 45. 2014-03-20. PMID:24336234. |
the effects of 5-ht on kv currents and arterial contraction were markedly prevented by the 5-ht2a receptor antagonists ketanserin and spiperone. |
2014-03-20 |
2023-08-12 |
rat |
| Dong Jun Sung, Hyun Ju Noh, Jae Gon Kim, Sang Woong Park, Bokyung Kim, Hana Cho, Young Min Ba. Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase. Experimental & molecular medicine. vol 45. 2014-03-20. PMID:24336234. |
5-ht constricts the arteries by inhibiting kv channels via the 5-ht2a receptor and src tyrosine kinase pathway. |
2014-03-20 |
2023-08-12 |
rat |
| Taro Kishi, Nakao Iwat. Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials. CNS drugs. vol 27. issue 9. 2014-03-19. PMID:23812802. |
perospirone is a second-generation antipsychotic (sga) used only in japan, and acts as a serotonin (5-ht)1a receptor partial agonist, 5-ht2a receptor inverse agonist, and dopamine (d)₂, d₄, and α₁-adrenergic receptor antagonist. |
2014-03-19 |
2023-08-12 |
Not clear |
| Hiroto Nakayama, Sumiyo Umeda, Masashi Nibuya, Takeshi Terao, Koichi Nisijima, Soichiro Nomur. Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation. Neuropsychiatric disease and treatment. vol 10. 2014-03-14. PMID:24627634. |
animal studies have indicated that mild serotonin excess induces low body temperature through 5-ht1a, whereas severe serotonin excess induces high body temperature through 5-ht2a activation. |
2014-03-14 |
2023-08-12 |
Not clear |
| Hiroto Nakayama, Sumiyo Umeda, Masashi Nibuya, Takeshi Terao, Koichi Nisijima, Soichiro Nomur. Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation. Neuropsychiatric disease and treatment. vol 10. 2014-03-14. PMID:24627634. |
therefore, it could be hypothesized that mild serotonin excess induces side effects through 5-ht1a, and severe serotonin excess induces lethal side effects with hyperthermia through 5-ht2a. |
2014-03-14 |
2023-08-12 |
Not clear |
| Hiroto Nakayama, Sumiyo Umeda, Masashi Nibuya, Takeshi Terao, Koichi Nisijima, Soichiro Nomur. Two cases of mild serotonin toxicity via 5-hydroxytryptamine 1A receptor stimulation. Neuropsychiatric disease and treatment. vol 10. 2014-03-14. PMID:24627634. |
serotonin toxicity via a low dose of paroxetine that is coadministered with perospirone, which acts agonistically on the 5-ht1a receptor and antagonistically on the 5-ht2a receptor, clearly indicated 5-ht1a receptor involvement in mild serotonin toxicity. |
2014-03-14 |
2023-08-12 |
Not clear |
| Michel Hamon, Pierre Blie. Monoamine neurocircuitry in depression and strategies for new treatments. Progress in neuro-psychopharmacology & biological psychiatry. vol 45. 2014-02-26. PMID:23602950. |
in particular, 5-ht systems were shown to exert negative influence on ne and da systems through 5-ht2a and 5-ht2c receptor- mediated mechanisms, respectively. |
2014-02-26 |
2023-08-12 |
Not clear |
| Jeffrey Cummings, Stuart Isaacson, Roger Mills, Hilde Williams, Kathy Chi-Burris, Anne Corbett, Rohit Dhall, Clive Ballar. Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet (London, England). vol 383. issue 9916. 2014-02-25. PMID:24183563. |
we aimed to assess safety and efficacy of pimavanserin, a selective serotonin 5-ht2a inverse agonist, in this population. |
2014-02-25 |
2023-08-12 |
Not clear |
| J Shilpa, M Anitha, C S Paulos. Increased neuronal survival in the brainstem during liver injury: role of γ-aminobutyric acid and serotonin chitosan nanoparticles. Journal of neuroscience research. vol 91. issue 9. 2014-02-24. PMID:23861071. |
in the present study, gabab and 5-ht2a receptor functional regulation, interrelated actions of neuronal survival factors, and expression of apoptotic factors in the brainstem during gaba and 5-ht chitosan nanoparticles-induced active liver regeneration in partially hepatectomized rats were evaluated. |
2014-02-24 |
2023-08-12 |
rat |
| Anders Ettrup, Søren Holm, Martin Hansen, Muhammad Wasim, Martin Andreas Santini, Mikael Palner, Jacob Madsen, Claus Svarer, Jesper Langgaard Kristensen, Gitte Moos Knudse. Preclinical safety assessment of the 5-HT2A receptor agonist PET radioligand [ 11C]Cimbi-36. Molecular imaging and biology. vol 15. issue 4. 2014-02-11. PMID:23306971. |
[11c]cimbi-36 was recently developed as an agonist radioligand for brain imaging of serotonin 2a receptors (5-ht2a) with positron emission tomography (pet). |
2014-02-11 |
2023-08-12 |
Not clear |