| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Bliziotes, A Eshleman, B Burt-Pichat, X-W Zhang, J Hashimoto, K Wiren, C Chen. Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells. Bone. vol 39. issue 6. 2007-02-20. PMID:16884969. |
the clonal murine osteocytic cell line, mlo-y4, demonstrates expression of the serotonin transporter (5-htt), and the 5-ht1a, and 5-ht2a receptors by real-time rt-pcr and immunoblot analysis. |
2007-02-20 |
2023-08-12 |
human |
| Wiesław Jerzy Cubała, Jerzy Landowsk. [Serotoninergic system and limbic-hypothalamic-pituitary-adrenal axis (LHPA axis) in depression]. Psychiatria polska. vol 40. issue 3. 2007-02-08. PMID:17037809. |
in depression, the 5-ht system exhibits impaired presynaptic activity of 5-ht neurones, an increased activity of central postsynaptic 5-ht2a receptors, decreased activity of postsynaptic 5-ht1a receptors and altered synaptic 5-ht uptake. |
2007-02-08 |
2023-08-12 |
Not clear |
| Ju Shi, Bozena Zemaitaitis, Nancy A Mum. Phosphorylation of Galpha11 protein contributes to agonist-induced desensitization of 5-HT2A receptor signaling. Molecular pharmacology. vol 71. issue 1. 2007-02-01. PMID:17056873. |
we investigated the role of phosphorylation of galpha q/11 proteins in agonist-induced desensitization of serotonin 2a (5-ht2a) receptors. |
2007-02-01 |
2023-08-12 |
rat |
| Michael R Braden, Jason C Parrish, John C Naylor, David E Nichol. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular pharmacology. vol 70. issue 6. 2007-01-30. PMID:17000863. |
molecular interaction of serotonin 5-ht2a receptor residues phe339(6.51) and phe340(6.52) with superpotent n-benzyl phenethylamine agonists. |
2007-01-30 |
2023-08-12 |
human |
| Jaime M Monti, Héctor Janto. Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. European journal of pharmacology. vol 553. issue 1-3. 2007-01-24. PMID:17059817. |
effects of the serotonin 5-ht2a/2c receptor agonist doi and of the selective 5-ht2a or 5-ht2c receptor antagonists emd 281014 and sb-243213, respectively, on sleep and waking in the rat. |
2007-01-24 |
2023-08-12 |
rat |
| Tatsuru Tsurumaki, Shingo Nagai, Xu Bo, Akira Toyosato, Hiroshi Higuch. Potentiation by neuropeptide Y of 5HT2A receptor-mediated contraction in porcine coronary artery. European journal of pharmacology. vol 544. issue 1-3. 2007-01-12. PMID:16844110. |
5-ht caused concentration-dependent contraction through 5-ht2a receptors. |
2007-01-12 |
2023-08-12 |
Not clear |
| Peter Flagstad, Jørn Arnt, Christina K Olse. Classical as well as novel antipsychotic drugs increase self-stimulation threshold in the rat--similar mechanism of action? European journal of pharmacology. vol 544. issue 1-3. 2007-01-12. PMID:16860313. |
the results obtained with the receptor specific antagonists showed that dopamine d2, alpha1-adrenoceptor and serotonin 5-ht2a receptor antagonisms inhibit intracranial self-stimulation behaviour and that muscarinic receptor antagonism is without effect. |
2007-01-12 |
2023-08-12 |
rat |
| Kathleen Van Craenenbroeck, Evelien Gellynck, Béatrice Lintermans, Josée E Leysen, Hubert H M Van Tol, Guy Haegeman, Peter Vanhoenacke. Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor. Life sciences. vol 80. issue 1. 2007-01-04. PMID:16978659. |
addition of the dopamine d4 receptor and serotonin 5-ht2a receptor antagonist pipamperone to these cells further increased the expression of the dopamine receptor, reaching 3800 +/- 60 fmol/mg membrane protein. |
2007-01-04 |
2023-08-12 |
Not clear |
| Kathleen Van Craenenbroeck, Evelien Gellynck, Béatrice Lintermans, Josée E Leysen, Hubert H M Van Tol, Guy Haegeman, Peter Vanhoenacke. Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor. Life sciences. vol 80. issue 1. 2007-01-04. PMID:16978659. |
this up-regulation was not restricted to the dopamine d4 receptor but was also found for the serotonin 5-ht2a receptor. |
2007-01-04 |
2023-08-12 |
Not clear |
| Yuan-Sheng Liu, Mo Yan. The effect of 5-hydroxtryptamine on the regulation of megakaryocytopoiesis. Hematology (Amsterdam, Netherlands). vol 11. issue 1. 2006-12-27. PMID:16522551. |
in the late stages, 5-ht may be involved in platelet release by inducing nitric oxide (no) synthesis via 5-ht2a receptors. |
2006-12-27 |
2023-08-12 |
Not clear |
| Klas Nordlind, Kristoffer Thorslund, Solbritt Lonne-Rahm, Sheila Mohabbati, Timea Berki, Marisela Morales, Efrain C Azmiti. Expression of serotonergic receptors in psoriatic skin. Archives of dermatological research. vol 298. issue 3. 2006-12-22. PMID:16794822. |
distribution of serotonin receptors was studied in involved and noninvolved skin in patients with psoriasis and compared to normal skin, by using immunohistochemistry and antibodies to 5-ht1a, 5-ht2a and 5-ht3 receptors (r). |
2006-12-22 |
2023-08-12 |
Not clear |
| Jerzy Kossakowski, Aldona Raszkiewicz, Ryszard Bugno, Andrzej J Bojarsk. Introduction of a new complex imide system into the structure of LCAPs. The synthesis and a 5-HT1A, 5-HT2A and D2 receptor binding study. Polish journal of pharmacology. vol 56. issue 6. 2006-12-21. PMID:15662099. |
a series of 17 long-chain arylpiperazines containing bulky, complex imide systems (5,8-dimethyl-3b,9-epoxy-(3a,4,5,6,7,8,9,9a)-octahydro-1h-benzo[e]isoindole-1,3(2h)-dione or 4,9-diphenyl-4,9-epoxy-3a,4,9,9a-tetra-hydro-1h-benzo[f]isoindole-1,3(2h)-dione) was synthesized and evaluated for their affinity for serotonin 5-ht1a, 5-ht2a and dopamine d2 receptors. |
2006-12-21 |
2023-08-12 |
Not clear |
| J Song, D Hanniford, C Doucette, E Graham, M F Poole, A Ting, B Sherf, J Harrington, K Brunden, A Stricker-Krongra. Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes. Assay and drug development technologies. vol 3. issue 6. 2006-12-20. PMID:16438660. |
the serotonin (5-hydroxytryptamine) 5-ht2 receptor subfamily consists of three members, 5-ht2a, 5-ht2b, and 5-ht2c. |
2006-12-20 |
2023-08-12 |
human |
| J Song, D Hanniford, C Doucette, E Graham, M F Poole, A Ting, B Sherf, J Harrington, K Brunden, A Stricker-Krongra. Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes. Assay and drug development technologies. vol 3. issue 6. 2006-12-20. PMID:16438660. |
the agonist high-affinity binding sites accounted for 2.3% (5-ht(2c) receptor), 4.0% (5-ht2a receptor), and 22% (5-ht2b receptor) of the total receptor population. |
2006-12-20 |
2023-08-12 |
human |
| J Song, D Hanniford, C Doucette, E Graham, M F Poole, A Ting, B Sherf, J Harrington, K Brunden, A Stricker-Krongra. Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes. Assay and drug development technologies. vol 3. issue 6. 2006-12-20. PMID:16438660. |
the ki values of 5-ht, (r)(-)doi, and ver-3323 for the 5-ht2a, 5-ht2b, and 5-ht2c receptors by spa format were equivalent to published data determined by filtration binding assays. |
2006-12-20 |
2023-08-12 |
human |
| Ju Shi, Katerina J Damjanoska, Bozena Zemaitaitis, Francisca Garcia, Gonzalo Carrasco, Nicole R Sullivan, Yijin She, Kathleen H Young, George Battaglia, Louis D Van De kar, David S Howland, Nancy A Mum. Alterations in 5-HT2A receptor signaling in male and female transgenic rats over-expressing either Gq or RGS-insensitive Gq protein. Neuropharmacology. vol 51. issue 3. 2006-12-14. PMID:16769091. |
serotonin 2a (5-ht2a) receptors are coupled to galphaq and galpha11 proteins to activate phospholipase c (plc). |
2006-12-14 |
2023-08-12 |
rat |
| Erik Hedner, Martin Sjögren, Per-Anders Frändberg, Tobias Johansson, Ulf Göransson, Mia Dahlström, Per Jonsson, Fred Nyberg, Lars Bohli. Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. Journal of natural products. vol 69. issue 10. 2006-12-14. PMID:17067154. |
barettin selectively interacted with the serotonin receptors 5-ht2a, 5-ht2c, and 5-ht4 at concentrations close to that of endogenous serotonin, with the corresponding ki values being 1.93, 0.34, and 1.91 microm, respectively. |
2006-12-14 |
2023-08-12 |
human |
| José Brea, Marián Castro, M Isabel Loza, Christian F Masaguer, Enrique Raviña, Cristina Dezi, Manuel Pastor, Ferran Sanz, Araceli Cabrero-Castel, Beatriz Galán-Rodríguez, Emilio Fernández-Espejo, Rafael Maldonado, Patricia Robled. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine. Neuropharmacology. vol 51. issue 2. 2006-12-04. PMID:16697427. |
this compound showed a multi-receptor profile with affinities similar to those of clozapine for serotonin (5-ht2a, 5-ht1a, and 5-ht2c), dopamine (d1, d2, d3 and d4), alpha-adrenergic (alpha1, alpha2), muscarinic (m1, m2) and histamine h1 receptors. |
2006-12-04 |
2023-08-12 |
Not clear |
| Alberto J Kaumann, Finn Olav Lev. 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacology & therapeutics. vol 111. issue 3. 2006-12-04. PMID:16960982. |
acute vascular constriction by 5-ht is usually shared by 5-ht1b and 5-ht2a receptors, except in intracranial arteries which constrict only through 5-ht1b receptors. |
2006-12-04 |
2023-08-12 |
human |
| Marcy J Bubar, Kathryn A Cunningha. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Current topics in medicinal chemistry. vol 6. issue 18. 2006-11-30. PMID:17017968. |
serotonin 5-ht2a and 5-ht2c receptors as potential targets for modulation of psychostimulant use and dependence. |
2006-11-30 |
2023-08-12 |
human |