| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I King Jordan, Fyodor A Kondrashov, Ivan A Adzhubei, Yuri I Wolf, Eugene V Koonin, Alexey S Kondrashov, Shamil Sunyae. A universal trend of amino acid gain and loss in protein evolution. Nature. vol 433. issue 7026. 2005-03-03. PMID:15660107. |
cys, met, his, ser and phe accrue in at least 14 taxa, whereas pro, ala, glu and gly are consistently lost. |
2005-03-03 |
2023-08-12 |
human |
| Denis B Tikhonov, Boris S Zhoro. In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices. Biophysical journal. vol 87. issue 3. 2005-03-02. PMID:15345533. |
the simulated activation of the gly(99)ala mutant yielded essentially similar results. |
2005-03-02 |
2023-08-12 |
Not clear |
| Manal A Swairjo, Paul R Schimme. Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 4. 2005-03-01. PMID:15657145. |
ala and gly are bound in similar orientations in a side-chain-accommodating pocket, where alpha-amino and carboxyl groups are stabilized by salt bridges, and the carboxyl by an h-bond from the side chain nh2 of asn-194. |
2005-03-01 |
2023-08-12 |
Not clear |
| Philippe Lacan, Michel Becchi, Isabelle Zanella-Cleon, Martine Aubry, Martine Ffrench, Nicole Couprie, Alain Francin. Two new beta-chain variants: Hb Tripoli [beta26(B8)Glu-->Ala] and Hb Tizi-Ouzou [beta29(B11)Gly-->Ser]. Hemoglobin. vol 28. issue 3. 2005-02-16. PMID:15481887. |
two new beta-chain variants: hb tripoli [beta26(b8)glu-->ala] and hb tizi-ouzou [beta29(b11)gly-->ser]. |
2005-02-16 |
2023-08-12 |
Not clear |
| Philippe Lacan, Michel Becchi, Isabelle Zanella-Cleon, Martine Aubry, Martine Ffrench, Nicole Couprie, Alain Francin. Two new beta-chain variants: Hb Tripoli [beta26(B8)Glu-->Ala] and Hb Tizi-Ouzou [beta29(B11)Gly-->Ser]. Hemoglobin. vol 28. issue 3. 2005-02-16. PMID:15481887. |
two new beta-globin chain variants: hb tripoli: codon 26, gag-->gcg [beta26(b8)glu-->ala] and hb tizi-ouzou: codon 29, ggc-->agc [beta29(b11)gly-->ser] are described on the first exon of the beta-globin gene. |
2005-02-16 |
2023-08-12 |
Not clear |
| Kirstine L Andersen, Søren M Echwald, Lesli H Larsen, Yasmin H Hamid, Charlotte Glümer, Torben Jørgensen, Knut Borch-Johnsen, Teis Andersen, Thorkild I A Sørensen, Torben Hansen, Oluf Pederse. Variation of the McKusick-Kaufman gene and studies of relationships with common forms of obesity. The Journal of clinical endocrinology and metabolism. vol 90. issue 1. 2005-02-10. PMID:15483080. |
five variants were identified, including two synonymous mutations (pro(39)pro and ile(178)ile) and three nonsynonymous variants (ala(242)ser, arg(517)cys, and gly(532)val). |
2005-02-10 |
2023-08-12 |
human |
| David B Zax, Daniel E Armanios, Sally Horak, Chris Brodowski, Chris Malowniak, Zhitong Yan. Variation of mechanical properties with amino acid content in the silk of Nephila clavipes. Biomacromolecules. vol 5. issue 3. 2005-02-08. PMID:15132654. |
cohorts of female n. clavipes spiders were selected for diets deprived of alanine (ala) and glycine (gly), arginine (arg), leucine (leu), or tyrosine (tyr), and their silk was harvested twice weekly during the one-month course of the diet. |
2005-02-08 |
2023-08-12 |
spider |
| David B Zax, Daniel E Armanios, Sally Horak, Chris Brodowski, Chris Malowniak, Zhitong Yan. Variation of mechanical properties with amino acid content in the silk of Nephila clavipes. Biomacromolecules. vol 5. issue 3. 2005-02-08. PMID:15132654. |
diets deprived of ala and gly appear to most directly impact the load-bearing foundation of dragline silk. |
2005-02-08 |
2023-08-12 |
spider |
| Gregory M K Poon, Rashid M Abu-Ghazalah, Robert B Macgrego. Ionic mobilities of duplex and frayed wire DNA in discontinuous buffer electrophoresis: evidence of interactions with amino acids. Biochemistry. vol 43. issue 51. 2005-02-03. PMID:15610028. |
here we employ electrophoresis to investigate dna-amino acid interactions by using a set of amino acids (ala, gln, gly, met, phe, val, bicine and tricine) as trailing ions in a discontinuous buffer, and monitoring their interactions with duplex (from 12 to 3000 bp) and frayed wire [a set of self-assembled superstructures arising from d(a(15)g(15)) oligodeoxyribonucleotides] dna by the change in their ionic mobility (in terms of %r(f)) as a function of amino acid concentration in a polyacrylamide matrix. |
2005-02-03 |
2023-08-12 |
Not clear |
| Isei Tanida, Takashi Ueno, Eiki Kominam. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. The Journal of biological chemistry. vol 279. issue 46. 2005-01-21. PMID:15355958. |
when map1lc3b-3xflag and myc-map1lc3b-his were expressed in hek293 cells, their carboxyl termini were cleaved, whereas there was little cleavage of mutant proteins map1lc3b(g120a)-3xflag and myc-map1lc3b(g120a)-his, containing ala in place of gly(120). |
2005-01-21 |
2023-08-12 |
human |
| Makoto T Fujiwara, Ayako Nakamura, Ryuuichi Itoh, Yukihisa Shimada, Shigeo Yoshida, Simon Geir Mølle. Chloroplast division site placement requires dimerization of the ARC11/AtMinD1 protein in Arabidopsis. Journal of cell science. vol 117. issue Pt 11. 2005-01-14. PMID:15126639. |
genomic sequence analysis revealed that arc11 contains a missense mutation in alpha-helix 11 of the chloroplast-targeted atmind1 changing an ala at position 296 to gly (a296g). |
2005-01-14 |
2023-08-12 |
Not clear |
| Paola Picotti, Anna Marabotti, Alessandro Negro, Valeria Musi, Barbara Spolaore, Marcello Zambonin, Angelo Fontan. Modulation of the structural integrity of helix F in apomyoglobin by single amino acid replacements. Protein science : a publication of the Protein Society. vol 13. issue 6. 2005-01-11. PMID:15152090. |
the rate of limited proteolysis of the three apomb variants by thermolysin and proteinase k was in the order native > pro88gly >> pro88ala, in agreement with the scale of helix propensity of ala, gly, and pro. |
2005-01-11 |
2023-08-12 |
Not clear |
| Dirk Schneider, Donald M Engelma. Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. Journal of molecular biology. vol 343. issue 4. 2004-12-28. PMID:15476801. |
to test whether gxxxg is equivalent to (small)xxx(small), we investigated the effect of a substitution of either of the two gly residues in the glycophorin a gxxxg-motif by ala or ser using the recently developed gallex system. |
2004-12-28 |
2023-08-12 |
Not clear |
| Dirk Schneider, Donald M Engelma. Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions. Journal of molecular biology. vol 343. issue 4. 2004-12-28. PMID:15476801. |
the results of this mutational study demonstrate that, while a replacement of either of the two gly by ala strongly disrupts gpa homo-dimerization, the mutation to ser partly stabilizes a dimeric structure. |
2004-12-28 |
2023-08-12 |
Not clear |
| Christian Tessier, Fernande D Rochon, André L Beaucham. Binding of the oxo-rhenium(V) core to methionine and to N-terminal histidine dipeptides. Inorganic chemistry. vol 43. issue 23. 2004-12-23. PMID:15530097. |
complexes of the type [reox(2)(his-aa)]x (x = cl, br) are isolated with the dipeptides his-aa (aa = gly, ala, leu, and phe). |
2004-12-23 |
2023-08-12 |
Not clear |
| James J Campanella, Adebanke F Olajide, Volker Magnus, Jutta Ludwig-Mülle. A novel auxin conjugate hydrolase from wheat with substrate specificity for longer side-chain auxin amide conjugates. Plant physiology. vol 135. issue 4. 2004-12-16. PMID:15299127. |
taiar3 did not convert the methyl esters of the iba conjugates with ala and gly. |
2004-12-16 |
2023-08-12 |
Not clear |
| Gianguido Coffa, Alan R Bras. A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 44. 2004-12-06. PMID:15496467. |
we have now identified a single residue in the lipoxygenase catalytic domain that is important for stereocontrol; it is conserved as an ala in s lipoxygenases and a gly in r lipoxygenases. |
2004-12-06 |
2023-08-12 |
mouse |
| Gianguido Coffa, Alan R Bras. A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 44. 2004-12-06. PMID:15496467. |
our results with mutation of the conserved ala to gly in two s lipoxygenases (mouse 8s-lox and human 15-lox-2) and the corresponding gly-ala substitution in two r lipoxygenases (human 12r-lox and coral 8r-lox) reveal that the basis for r or s stereo-control also involves a switch in the position of oxygenation on the substrate. |
2004-12-06 |
2023-08-12 |
mouse |
| Gianguido Coffa, Alan R Bras. A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 44. 2004-12-06. PMID:15496467. |
the ala residue promotes oxygenation on the reactive pentadiene at the end deep in the substrate binding pocket and s stereochemistry of the product hydroperoxide, and a gly residue promotes oxygenation at the proximal end of the reactive pentadiene resulting in r stereochemistry. |
2004-12-06 |
2023-08-12 |
mouse |
| Gianguido Coffa, Alan R Bras. A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 44. 2004-12-06. PMID:15496467. |
a model of lipoxygenase reaction specificity is proposed in which product regiochemistry and stereochemistry are determined by fixed relationships between substrate orientation, hydrogen abstraction, and the gly or ala residue we have identified. |
2004-12-06 |
2023-08-12 |
mouse |