| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Ling Cheng, Stoytcho Stoev, Maurice Manning, Sylvain Derick, Ana Pena, Mohamed Ben Mimoun, Gilles Guillo. Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. Journal of medicinal chemistry. vol 47. issue 9. 2004-05-20. PMID:15084136. |
the glutamine(4) residue in [deamino-cys(1)]arginine vasopressin (davp) was replaced by a broad series of aliphatic, aromatic, polar, and charged amino acids to give the following peptides: d[gly(4)]avp (1), d[ala(4)]avp (2), d[abu(4)]avp (3), d[nva(4)]avp (4), d[nle(4)]avp (5), d[leu(4)]avp (6), d[ile(4)]avp (7), d[thi(4)]avp (8), d[phe(4)]avp (9), d[tyr(4)]avp (10), d[trp(4)]avp (11), d[asn(4)]avp (12), d[ser(4)]avp (13), d[thr(4)]avp (14), d[dap(4)]avp (15), d[dab(4)]avp (16), d[orn(4)]avp (17), d[lys(4)]avp (18), d[arg(4)]avp (19), d[har(4)]avp (20), and d[glu(4)]avp (21). |
2004-05-20 |
2023-08-12 |
human |
| Hirokazu Nakayama, Natsuko Wada, Mitsutomo Tsuhak. Intercalation of amino acids and peptides into Mg-Al layered double hydroxide by reconstruction method. International journal of pharmaceutics. vol 269. issue 2. 2004-05-11. PMID:14706258. |
for gly, ala, ser, thr, pro, asn, gln, asp, glu, and aspartame the intercalation accompanied the expansion of interlayer distance of the solid products, whereas the other amino acids and oligoglycine showed no expansion. |
2004-05-11 |
2023-08-12 |
Not clear |
| Dorit Avrahami, Yechiel Sha. A new group of antifungal and antibacterial lipopeptides derived from non-membrane active peptides conjugated to palmitic acid. The Journal of biological chemistry. vol 279. issue 13. 2004-05-07. PMID:14709550. |
the peptides investigated have the sequence k(4)x(7)w, where x designates gly, ala, val, or leu (designated d-x peptides). |
2004-05-07 |
2023-08-12 |
Not clear |
| Wei Liu, Markus Eilers, Ashish B Patel, Steven O Smit. Helix packing moments reveal diversity and conservation in membrane protein structure. Journal of molecular biology. vol 337. issue 3. 2004-04-27. PMID:15019789. |
in gpcrs, as well as membrane channels and transporters, amino acid residues with small side-chains (gly, ala, ser, cys) allow tight helix packing by mediating strong van der waals interactions between helices. |
2004-04-27 |
2023-08-12 |
Not clear |
| Takehiro Chiba, Yao-Hua Li, Takuya Yamane, Osamu Ogikubo, Muneyoshi Fukuoka, Ryohachi Arai, Sho Takahashi, Takanobu Ohtsuka, Iwao Ohkubo, Nobuo Matsu. Inhibition of recombinant dipeptidyl peptidase III by synthetic hemorphin-like peptides. Peptides. vol 24. issue 5. 2004-04-20. PMID:12895665. |
the order of k(i) values was ile> or =trp>phe> or =tyr>leu>ala>val>ser>gly. |
2004-04-20 |
2023-08-12 |
Not clear |
| Jhimli Dasgupta, Udayaditya Sen, J K Dattagupt. In silico mutations and molecular dynamics studies on a winged bean chymotrypsin inhibitor protein. Protein engineering. vol 16. issue 7. 2004-04-07. PMID:12915726. |
to understand the contribution of this scaffolding residue on the stability of the reactive site loop, it was mutated in silico to gly, ala, ser, thr, leu and val and molecular dynamics (md) simulations were carried out on the mutants. |
2004-04-07 |
2023-08-12 |
Not clear |
| Toshihiko Utsumi, Kengo Nakano, Takeshi Funakoshi, Yoshiyuki Kayano, Sayaka Nakao, Nagisa Sakurai, Hiroyuki Iwata, Rumi Ishisak. Vertical-scanning mutagenesis of amino acids in a model N-myristoylation motif reveals the major amino-terminal sequence requirements for protein N-myristoylation. European journal of biochemistry. vol 271. issue 4. 2004-03-30. PMID:14764103. |
when ser was located at position 6, 11 amino acids (gly, ala, ser, cys, thr, val, asn, leu, ile, gln, his) were permitted at position 3 to direct efficient protein n-myristoylation. |
2004-03-30 |
2023-08-12 |
rabbit |
| Arunendu Mondal, Eric L Klein, Masood A Khan, Robert P House. TACN-amino acid conjugates and their copperII complexes. Inorganic chemistry. vol 42. issue 18. 2004-03-23. PMID:12950186. |
triazacyclononane (tacn) was coupled to glycine (l(gly)), alanine (l(ala)), and phenylalanine (l(phe)) via standard solution phase peptide coupling techniques. |
2004-03-23 |
2023-08-12 |
Not clear |
| Arunendu Mondal, Eric L Klein, Masood A Khan, Robert P House. TACN-amino acid conjugates and their copperII complexes. Inorganic chemistry. vol 42. issue 18. 2004-03-23. PMID:12950186. |
copper(ii) complexes of these new ligand-amino acid conjugates, [(cul(gly))(2)](clo(4))(4) (1), [(cul(ala))(2)cl](clo(4))(3) (2), and [cu(2)l(phe)cl(4)] (3), were synthesized and characterized. |
2004-03-23 |
2023-08-12 |
Not clear |
| Masakazu Kikuchi, Mizuho Kataoka, Takehiro Kojima, Tomohisa Horibe, Kanae Fujieda, Taiji Kimura, Toshiki Tanak. Single chain antibodies that recognize the N-glycosylation site. Archives of biochemistry and biophysics. vol 422. issue 2. 2004-03-17. PMID:14759610. |
although ser and thr have different side chains, the scfv proteins thus isolated bound to both ncs and nct with kd values of the order of 10(-6) m and accepted the substitution of the cys residue with various amino acids, including ala, gly, and val. |
2004-03-17 |
2023-08-12 |
cattle |
| Hua Wang, Winston Chu, Swapan K Das, Zhengxian Zheng, Sandra J Hasstedt, Steven C Elbei. Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. Molecular genetics and metabolism. vol 79. issue 3. 2004-03-09. PMID:12855222. |
only 1 snp was nonsynonymous, resulting in ala to gly at residue 464 (exon 10). |
2004-03-09 |
2023-08-12 |
human |
| Balvinder S Vig, Thomas F Murray, Jane V Aldric. Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3. Journal of medicinal chemistry. vol 47. issue 2. 2004-03-05. PMID:14711314. |
substitutions of gly(3) by ala, d-ala, trp, and d-trp in cyclo[d-asp(2),dap(5)]dyn a-(1-11)nh(2) and its linear counterpart [d-asp(2),dap(5)]dyn a-(1-11)nh(2) were generally well tolerated by both kappa and micro opioid receptors. |
2004-03-05 |
2023-08-12 |
Not clear |
| Jorge A Vila, Héctor A Baldoni, Daniel R Ripoll, Harold A Scherag. Unblocked statistical-coil tetrapeptides in aqueous solution: quantum-chemical computation of the carbon-13 NMR chemical shifts. Journal of biomolecular NMR. vol 26. issue 2. 2004-03-04. PMID:12766407. |
here, we carry out a cluster analysis of the ensembles of conformations generated in that study, and use them to compute the boltzmann-averaged values of the quantum-chemical (13)c chemical shifts for different amino acids in the unblocked tetrapeptides ggxa (where x stands for phe, arg, his, glu, ile, lys, gln, tyr, leu, thr, ala, gly and val). |
2004-03-04 |
2023-08-12 |
Not clear |
| Subrayashastry Aravinda, Narayanaswamy Shamala, Abhishek Bandyopadhyay, Padmanabhan Balara. Probing the role of the C-H...O hydrogen bond stabilized polypeptide chain reversal at the C-terminus of designed peptide helices. Structural characterization of three decapeptides. Journal of the American Chemical Society. vol 125. issue 49. 2004-02-26. PMID:14653741. |
the crystal structures of the peptides boc-leu-aib-val-xxx-leu-aib-val-(d)ala-(d)leu-aib-ome, (xxx = gly 2, (d)ala 3, aib 4) have been determined and compared with those reported earlier for peptide 1 (xxx = ala) and the all l analogue boc-leu-aib-val-ala-leu-aib-val-ala-leu-aib-ome, which yielded a perfect right-handed alpha-helical structure. |
2004-02-26 |
2023-08-12 |
Not clear |
| Dilip Chandu, Dipankar Nand. PepN is the major aminopeptidase in Escherichia coli: insights on substrate specificity and role during sodium-salicylate-induced stress. Microbiology (Reading, England). vol 149. issue Pt 12. 2004-02-23. PMID:14663077. |
kinetic characterization revealed the aminopeptidase cleavage preference of e. coli pepn to be arg>ala>lys>gly. |
2004-02-23 |
2023-08-12 |
Not clear |
| Masayuki Oda, Atsuo Tamura, Kenji Kanaori, Shuichi Kojima, Kin-Ichiro Miura, Keiko Momma, Ben'ichiro Tonomura, Kazuyuki Akasak. Functional tolerance of Streptomyces subtilisin inhibitor toward conformational and stability changes caused by single-point mutations in the hydrophobic core. Journal of biochemistry. vol 132. issue 6. 2004-02-19. PMID:12473203. |
(1)h nmr investigations showed that the conformational stress caused by the replacement of met103 with gly, ala, val, and ile, namely, the effects of the cavities generated by replacements with smaller side-chains and of the steric distortions generated by beta-branched side-chains, caused considerable changes in the structural arrangement of the side-chains within the core. |
2004-02-19 |
2023-08-12 |
Not clear |
| Bang Liu, Zheng-Mao Zhu, Mei Yu, Jian-Hua Cao, Li Lin, Tong-An Xiong, Meng-Jin Zhu, Zhong-Zhen Peng, Kui L. [Characterization of novel alleles and new mutation sites of porcine MHC class II DQA]. Yi chuan xue bao = Acta genetica Sinica. vol 30. issue 10. 2004-02-11. PMID:14669513. |
they were val-->ala(60), lys-->glu(65), asp-->gly(81) and lys-->ile(93). |
2004-02-11 |
2023-08-12 |
Not clear |
| Zhenglan Chen, Glenn H Dillon, Renqi Huan. Molecular determinants of proton modulation of glycine receptors. The Journal of biological chemistry. vol 279. issue 2. 2004-02-10. PMID:14563849. |
in alpha1 homomers, removal of the hydroxyl group by mutation of residue thr-112 to ala or phe abolished inhibition of glycine currents by acidification. |
2004-02-10 |
2023-08-12 |
human |
| N P Brenwald, A P Frais. Triclosan resistance in methicillin-resistant Staphylococcus aureus (MRSA). The Journal of hospital infection. vol 55. issue 2. 2004-02-02. PMID:14529640. |
one mutant had a predicted change in the gene product on fabi (thr 147-->his), whilst only one clinical isolate had predicted fabi amino-acid changes (ala 198-->gly, and leu 208-->phe). |
2004-02-02 |
2023-08-12 |
Not clear |
| Toratane Munegumi, Akira Shimoyam. Development of homochiral peptides in the chemical evolutionary process: Separation of homochiral and heterochiral oligopeptides. Chirality. vol 15 Suppl. 2004-01-30. PMID:12884382. |
similar results were given from the calculation of most linear dipeptides and all cyclic ones composed of gly, ala, val, or asp. |
2004-01-30 |
2023-08-12 |
Not clear |