| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Snow, M W Douglas, C M Parson. Phytase effects on amino acid digestibility in molted laying hens. Poultry science. vol 82. issue 3. 2003-07-02. PMID:12705409. |
a significant interaction between diet type and phytase level for ala, gly, leu, and met was observed. |
2003-07-02 |
2023-08-12 |
Not clear |
| Aie Kawajiri, Yoshihiro Yasui, Hidemasa Goto, Masaaki Tatsuka, Masahide Takahashi, Koh-Ichi Nagata, Masaki Inagak. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phosphorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Molecular biology of the cell. vol 14. issue 4. 2003-06-24. PMID:12686604. |
desmin mutants, in which in vitro phosphorylation sites by aurora-b and/or rho-kinase are changed to ala or gly, cause dramatic defects in filament separation between daughter cells in cytokinesis. |
2003-06-24 |
2023-08-12 |
Not clear |
| Yusuke Jin, Kenji Tonan, Shun-ichi Ikaw. Competitive formation of 10- and 7-membered hydrogen-bonded rings of proline-containing model peptides. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 58. issue 12. 2003-06-23. PMID:12396062. |
intramolecularly hydrogen-bonded structures of proline-containing model peptides with a sequence of n-tert-butoxycarbonyl-prolyl-xaa-nhch3 [xaa = gly (glycyl), ala (alanyl), phe (phenylalanyl), leu (leucyl), ile (isoleucyl), and val (valyl)] were studied by proton nuclear magnetic resonance and infrared spectroscopy. |
2003-06-23 |
2023-08-12 |
Not clear |
| Miriam Krugliak, Jianmin Zhang, Edna Nissani, Sonia Steiner-Mordoch, Hagai Ginsbur. Killing of intraerythrocytic Plasmodium falciparum by lysosomotropic amino acid esters. Parasitology research. vol 89. issue 6. 2003-06-23. PMID:12658456. |
similar to the findings with leishmania, alcohol esters of glu, leu, met, phe and trp are more toxic to plasmodium whereas ala, gly, his and ile are much less noxious. |
2003-06-23 |
2023-08-12 |
Not clear |
| R Geracitano, E Paolucci, S Prisco, E Guatteo, C Zona, P Longone, M Ammassari-Teule, G Bernardi, N Berretta, N B Mercur. Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699776. |
altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human cu/zn superoxide dismutase (gly(93)-->ala) mutation. |
2003-06-16 |
2023-08-12 |
mouse |
| R Geracitano, E Paolucci, S Prisco, E Guatteo, C Zona, P Longone, M Ammassari-Teule, G Bernardi, N Berretta, N B Mercur. Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699776. |
to describe the functional alterations specifically associated with this dopaminergic dysfunction, we have investigated the corticostriatal synaptic plasticity in mice overexpressing the human sod1 (sod1+) and the mutated (gly(93)-->ala) form (g93a+) of the same enzyme. |
2003-06-16 |
2023-08-12 |
mouse |
| Jaewon Kim, Stephen R Brych, Jihun Lee, Timothy M Logan, Michael Blabe. Identification of a key structural element for protein folding within beta-hairpin turns. Journal of molecular biology. vol 328. issue 4. 2003-06-12. PMID:12729767. |
here we report a study of the effects of gly, ala and asn substitutions found within the l-alpha region at a characteristic position in defined beta-hairpin turns within human acidic fibroblast growth factor, and demonstrate consistent effects upon stability and folding kinetics. |
2003-06-12 |
2023-08-12 |
human |
| J Fujita, K Dohmoto, S Hojo, Y Ueda, S Bandoh, Y Yang, Y Yamaji, Y Ohtsuki, T Ishid. The point mutation in the promoter region and the single nucleotide polymorphism in exon 1 of the cytokeratin 19 gene in human lung cancer cell lines. Lung cancer (Amsterdam, Netherlands). vol 34. issue 3. 2003-06-10. PMID:11714536. |
in addition, point mutations within exon 1 (at 90, t-->c, ala-->ala and at 179, g-->c, gly-->ala) were also demonstrated in three cell lines (lu135, hi1017, and lc2/ad). |
2003-06-10 |
2023-08-12 |
human |
| Sonja Hess, Jacco van Beek, Lewis K Pannel. Acid hydrolysis of silk fibroins and determination of the enrichment of isotopically labeled amino acids using precolumn derivatization and high-performance liquid chromatography-electrospray ionization-mass spectrometry. Analytical biochemistry. vol 311. issue 1. 2003-06-10. PMID:12441148. |
thus, spiders and moth larvae were fed with stable isotope tracers such as [1-13c]ala or [1-13c]gly and silked. |
2003-06-10 |
2023-08-12 |
Not clear |
| Sonja Hess, Jacco van Beek, Lewis K Pannel. Acid hydrolysis of silk fibroins and determination of the enrichment of isotopically labeled amino acids using precolumn derivatization and high-performance liquid chromatography-electrospray ionization-mass spectrometry. Analytical biochemistry. vol 311. issue 1. 2003-06-10. PMID:12441148. |
depending on the feeding protocol, enrichments of up to 58% in gly and 31% in ala were found in the investigated silks. |
2003-06-10 |
2023-08-12 |
Not clear |
| Shereen A Ghali, Bruce Gottlieb, Rose Lumbroso, Lenore K Beitel, Youssef Elhaji, Jian Wu, Leonard Pinsky, Mark A Trifir. The use of androgen receptor amino/carboxyl-terminal interaction assays to investigate androgen receptor gene mutations in subjects with varying degrees of androgen insensitivity. The Journal of clinical endocrinology and metabolism. vol 88. issue 5. 2003-05-28. PMID:12727974. |
these were arg(871)gly (mild), ser(814)asn (partial), glu(772)ala (partial), val(866)met (complete), and arg(774)cys (complete). |
2003-05-28 |
2023-08-12 |
human |
| Lan Guan, Miklós Sahin-Tóth, Tamás Kálai, Kálmán Hideg, H Ronald Kabac. Probing the mechanism of a membrane transport protein with affinity inactivators. The Journal of biological chemistry. vol 278. issue 12. 2003-05-05. PMID:12471022. |
when the ala(122)-->cys mutation is combined with a mutation (cys(154)-->gly) that blocks transport but increases binding affinity, discrimination between the mts-galactose and -glucose derivatives is abolished, and deltamu(h(+)) has no effect. |
2003-05-05 |
2023-08-12 |
Not clear |
| Mads Toustrup-Jensen, Bente Vilse. Importance of conserved Thr214 in domain A of the Na+,K+ -ATPase for stabilization of the phosphoryl transition state complex in E2P dephosphorylation. The Journal of biological chemistry. vol 278. issue 13. 2003-05-02. PMID:12531906. |
thr(214) of the highly conserved (214)tges sequence in domain a of the na(+),k(+)-atpase was replaced with alanine, and the mutant was compared functionally with the previously characterized domain a mutant gly(263) --> ala. thr(214) --> ala displayed a conspicuous 150-fold reduction of the apparent vanadate affinity for inhibition of atpase activity, which could not simply be explained by the observed shifts of the conformational equilibria in favor of e(1) and e(1)p. the intrinsic vanadate affinity of the e(2) form and the effect on the apparent vanadate affinity of displacement of the e(1)-e(2) equilibrium were determined in a phosphorylation assay that allows the enzyme-vanadate complex to be formed under equilibrium conditions. |
2003-05-02 |
2023-08-12 |
Not clear |
| Mads Toustrup-Jensen, Bente Vilse. Importance of conserved Thr214 in domain A of the Na+,K+ -ATPase for stabilization of the phosphoryl transition state complex in E2P dephosphorylation. The Journal of biological chemistry. vol 278. issue 13. 2003-05-02. PMID:12531906. |
when the e(2) form prevailed, thr(214) --> ala retained a reduced vanadate affinity relative to wild type, whereas the affinity of gly(263) --> ala became wild type-like. |
2003-05-02 |
2023-08-12 |
Not clear |
| Peter Terry Mayer, Tian-Xiang Xiang, Riku Niemi, Bradley D Anderso. A hydrophobicity scale for the lipid bilayer barrier domain from peptide permeabilities: nonadditivities in residue contributions. Biochemistry. vol 42. issue 6. 2003-05-02. PMID:12578376. |
under closer scrutiny, delta(delta g degrees )(x) for the ala and gly residues decrease with increasing peptide length. |
2003-05-02 |
2023-08-12 |
Not clear |
| Xiaohong Zhao, Barry J Lamphear, Dingding Xiong, Kirk Knowlton, Robert E Rhoad. Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease. The Journal of biological chemistry. vol 278. issue 7. 2003-04-30. PMID:12475969. |
we changed gly at the p1'-position of the secondary site to ala to produce eif4g-1(dm). |
2003-04-30 |
2023-08-12 |
rabbit |
| D K Ball, E E-D A Moussad, M A E Rageh, S A Kemper, D R Brigstoc. Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction (Cambridge, England). vol 125. issue 2. 2003-04-29. PMID:12578541. |
db1 cells produced 38 kda ctgf and low molecular mass ctgfs that had n-termini between modules 2 and 3 at ala(181) (20 kda), leu(184) (18 kda) or ala(197) (16 kda) or between modules 3 and 4 at gly(253) (10 kda). |
2003-04-29 |
2023-08-12 |
human |
| S Casares, M Sadqi, O López-Mayorga, J C Martínez, F Conejero-Lar. Structural cooperativity in the SH3 domain studied by site-directed mutagenesis and amide hydrogen exchange. FEBS letters. vol 539. issue 1-3. 2003-04-24. PMID:12650939. |
the mutation of asn47 to gly or ala in the distal loop brings about significant changes to the global stability of the domain in spite of not affecting its structure to any great extent. |
2003-04-24 |
2023-08-12 |
Not clear |
| Michael Teufel, Vladimir Saudek, Jean-Pierre Ledig, Annie Bernhardt, Sylviane Boularand, Alexandra Carreau, Nigel J Cairns, Christopher Carter, David J Cowley, Danielle Duverger, Axel J Ganzhorn, Chantal Guenet, Blanche Heintzelmann, Veronique Laucher, Claude Sauvage, Tatiana Smirnov. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. The Journal of biological chemistry. vol 278. issue 8. 2003-04-22. PMID:12473676. |
cn1 was identified as a homodimeric dipeptidase with a narrow substrate specificity for xaa-his dipeptides including those with xaa = beta ala (carnosine, k(m) 1.2 mm), n-methyl beta ala, ala, gly, and gamma-aminobutyric acid (homocarnosine, k(m) 200 microm), an isoelectric point of ph 4.5, and maximal activity at ph 8.5. |
2003-04-22 |
2023-08-12 |
mouse |
| Tsutomu Sato, Shigehiro Sasahara, Toshiyuki Yamakami, Tsutomu Hoshin. Functional analyses of Tyr420 and Leu607 of Alicyclobacillus acidocaldarius squalene-hopene cyclase. Neoachillapentaene, a novel triterpene with the 1,5,6-trimethylcyclohexene moiety produced through folding of the constrained boat structure. Bioscience, biotechnology, and biochemistry. vol 66. issue 8. 2003-04-14. PMID:12353625. |
the mutation at position 420 into ala and gly gave bicyclic alpha-and gamma-polypodatetraene in significant amounts, but with a trace amount of tricyclic malabaricatriene. |
2003-04-14 |
2023-08-12 |
Not clear |