| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David D Hackney, Maryanne F Stock, Jodi Moore, Reid A Patterso. Modulation of kinesin half-site ADP release and kinetic processivity by a spacer between the head groups. Biochemistry. vol 42. issue 41. 2004-01-13. PMID:14556632. |
ala(345) is the first residue in the coiled-coil of the neck, and its replacement with glycine or proline produces no significant change in the k(cat) or k(0.5(mt)) values for activation of their atpase by microtubules (mts) or in their k(bi(ratio)) value for the average number of atp molecules hydrolyzed during a processive encounter with a mt. |
2004-01-13 |
2023-08-12 |
cat |
| Massimo Pieri, Federica Albo, Chiara Gaetti, Alida Spalloni, C Peter Bengtson, Patrizia Longone, Silvio Cavalcanti, Cristina Zon. Altered excitability of motor neurons in a transgenic mouse model of familial amyotrophic lateral sclerosis. Neuroscience letters. vol 351. issue 3. 2004-01-12. PMID:14623129. |
in the present work, the excitability of motor neurons has been tested in a transgenic mouse model of a familial form of als, associated with a mutation in cu,zn superoxide dismutase (gly(93)-->ala). |
2004-01-12 |
2023-08-12 |
mouse |
| Mannix Auger-Messier, Martin Clement, Pascal M Lanctot, Patrice C Leclerc, Richard Leduc, Emanuel Escher, Gaetan Guillemett. The constitutively active N111G-AT1 receptor for angiotensin II maintains a high affinity conformation despite being uncoupled from its cognate G protein Gq/11alpha. Endocrinology. vol 144. issue 12. 2004-01-05. PMID:12960024. |
we evaluated the functional and g protein-coupling properties of mutant at1 receptors in which asn111 was substituted with smaller (ala or gly) or larger residues (gln or trp). |
2004-01-05 |
2023-08-12 |
Not clear |
| Siiri E Iismaa, Sara Holman, Merridee A Wouters, Laszlo Lorand, Robert M Graham, Ahsan Husai. Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 22. 2004-01-05. PMID:14566064. |
although substitution of the trp-241 side chain with ala or gly had only a small effect on the michaelis constant km (1.5-fold increase), it caused a >300-fold lowering of the catalytic rate constant kcat. |
2004-01-05 |
2023-08-12 |
Not clear |
| Hiroshi Sawada, Hiroshi Nakato, Toru Togawa, Motoko Nakagoshi, Shin-Ichiro Takikawa, Kenjiro Dohke, Teruhiko Iino, Keisuke Mase, Toshio Yamamoto, Susumu Izum. Molecular cloning and characterization of a cDNA encoding a novel cuticle protein in the silkworm, Bombyx mori. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 134. issue 3. 2003-12-23. PMID:12628383. |
both a typical tandem repeat (a-a-p-a/v) for cuticle protein and a unique tandem repeat with ser, ala, gly, pro, val, tyr and thr were observed in the predicted amino acid sequence of the cdna encoding bmcpa. |
2003-12-23 |
2023-08-12 |
Not clear |
| Hiroshi Sawada, Hiroshi Nakato, Toru Togawa, Motoko Nakagoshi, Shin-Ichiro Takikawa, Kenjiro Dohke, Teruhiko Iino, Keisuke Mase, Toshio Yamamoto, Susumu Izum. Molecular cloning and characterization of a cDNA encoding a novel cuticle protein in the silkworm, Bombyx mori. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 134. issue 3. 2003-12-23. PMID:12628383. |
approximately 80% of the amino acids in bmcpa were composed of ser, ala, gly, pro, val and tyr. |
2003-12-23 |
2023-08-12 |
Not clear |
| Insa Barelmann, Diana Uría Fernández, Herbert Budzikiewicz, Jean-Marie Meye. The pyoverdine from Pseudomonas chlororaphis D-TR133 showing mutual acceptance with the pyoverdine of Pseudomonas fluorescens CHAO. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 16. issue 2. 2003-12-15. PMID:12572684. |
an unexpected feature is that the main pyoverdine of p. chlororaphis d-tr133 is accompanied by a minor one where specifically one ala is replaced by gly. |
2003-12-15 |
2023-08-12 |
Not clear |
| U Kosior-Korzecka, R Bobowie. Changes in the level of endogenous leptin, FSH, 17beta-oestradiol and metabolites during lupin-induced increase in ovulation rate in ewes. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. vol 50. issue 7. 2003-12-12. PMID:14633226. |
moreover, in the ewes fed lupin the plasma concentrations of glucose and nine glycogenic amino acids (gly, ala, val, met, leu, ile, tyr, phe and arg) were increased. |
2003-12-12 |
2023-08-12 |
human |
| Michele Arienzo, Antonio De Martino, Renato Capasso, Antimo Di Maro, Augusto Parent. Analysis of carbohydrates and amino acids in vegetable waste waters by ion chromatography. Phytochemical analysis : PCA. vol 14. issue 2. 2003-12-08. PMID:12693630. |
the sugars determined were arabinose, fructose, galactose, glucose, rhamnose, xylose, galacturonic and glucuronic acids, and the amino acids were asp, glu, thr, ser, pro, gly, ala, val, met, ile, leu, tyr, phe, lys, his, arg and cys. |
2003-12-08 |
2023-08-12 |
Not clear |
| Yolanda Sáenz, Myriam Zarazaga, Laura Briñas, Fernanda Ruiz-Larrea, Carmen Torre. Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals. The Journal of antimicrobial chemotherapy. vol 51. issue 4. 2003-12-05. PMID:12654733. |
a single change in the gyra protein was detected in all 61 nalr strains with ciprofloxacin mics leu (54), ser-83-->ala (one), ser-83-->val (one), asp-87-->asn (two), asp-87-->tyr (two) and asp-87-->gly (one). |
2003-12-05 |
2023-08-12 |
Not clear |
| Ling Han, Sven-Olof Enfors, Lena Häggströ. Escherichia coli high-cell-density culture: carbon mass balances and release of outer membrane components. Bioprocess and biosystems engineering. vol 25. issue 4. 2003-12-02. PMID:14504997. |
acetate, lactate, ethanol, formate, succinate and amino acids (glu, gln, asp, asn, ala, gly, ser) were detected in the culture medium, but made up only a few percent of the extracellular carbon mass. |
2003-12-02 |
2023-08-12 |
Not clear |
| Luca Raiteri, Egle Paolucci, Simona Prisco, Maurizio Raiteri, Giambattista Bonann. Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis. British journal of pharmacology. vol 138. issue 6. 2003-11-24. PMID:12684256. |
the release of [(3)h]d-aspartate ([(3)h]d-asp) or [(3)h]gaba evoked by glycine from spinal cord synaptosomes was compared in mice expressing mutant human sod1 with a gly(93) ala substitution ([sod1-g93a(+)]), a transgenic model of amyotrophic lateral sclerosis, and in control mice. |
2003-11-24 |
2023-08-12 |
mouse |
| Adam Sokolowski, Maciej Wolowicz, Herman Humme. Free amino acids in the clam Macoma balthica L. (Bivalvia, Mollusca) from brackish waters of the southern Baltic Sea. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 134. issue 3. 2003-11-21. PMID:12600667. |
in the brackish waters of the baltic, the main pool of faa is composed of ala, gln, arg, gly and orn which represent approximately 80% of the total. |
2003-11-21 |
2023-08-12 |
Not clear |
| Tzu-Fun Fu, Emily S Boja, Martin K Safo, Verne Schirc. Role of proline residues in the folding of serine hydroxymethyltransferase. The Journal of biological chemistry. vol 278. issue 33. 2003-11-10. PMID:12773539. |
the 5 pro residues were each mutated to both a gly and ala residue, and each mutant shmt was purified and characterized with respect to kinetic properties, stability, secondary structure, and folding mechanism. |
2003-11-10 |
2023-08-12 |
human |
| Paul M C Benton, Mikhail Laryukhin, Suzanne M Mayer, Brian M Hoffman, Dennis R Dean, Lance C Seefeld. Localization of a substrate binding site on the FeMo-cofactor in nitrogenase: trapping propargyl alcohol with an alpha-70-substituted MoFe protein. Biochemistry. vol 42. issue 30. 2003-11-06. PMID:12885243. |
substitution of the mofe protein alpha-70(val) residue with ala or gly expands the substrate range of nitrogenase, allowing the reduction of larger alkynes, including propargyl alcohol (hc[triple bond]cch(2)oh). |
2003-11-06 |
2023-08-12 |
Not clear |
| Taro Q P Uyeda, Bruce Patterson, Leonardo Mendoza, Yuichi Hiratsuk. Amino acids 519-524 of Dictyostelium myosin II form a surface loop that aids actin binding by facilitating a conformational change. Journal of muscle research and cell motility. vol 23. issue 7-8. 2003-10-30. PMID:12952067. |
replacement with a single gly residue instead of ala yielded partial function, suggesting that structural flexibility, rather than hydrophobicity, is the key feature of the loop. |
2003-10-30 |
2023-08-12 |
Not clear |
| Yasumoto Nakazawa, Mie Bamba, Satoko Nishio, Tetsuo Asakur. Tightly winding structure of sequential model peptide for repeated helical region in Samia cynthia ricini silk fibroin studied with solid-state NMR. Protein science : a publication of the Protein Society. vol 12. issue 4. 2003-10-23. PMID:12649423. |
in this paper, a sequential model peptide, ggagggyggdgg(a)(12)ggagdgygag, which is a typical sequence of the silk fibroin, was synthesized, and the atomic-level conformations of gly residues at the n- and c-terminal ends of the polyalanine region were determined as well as that of the central ala residue using (13)c 2d spin diffusion solid-state nuclear magnetic resonance (nmr) under off-magic angle spinning. |
2003-10-23 |
2023-08-12 |
Not clear |
| Yasumoto Nakazawa, Mie Bamba, Satoko Nishio, Tetsuo Asakur. Tightly winding structure of sequential model peptide for repeated helical region in Samia cynthia ricini silk fibroin studied with solid-state NMR. Protein science : a publication of the Protein Society. vol 12. issue 4. 2003-10-23. PMID:12649423. |
in the model peptide with alpha-helical conformation, the torsion angle of the central ala residue, the 19th ala, was determined to be (phi, psi) = (-60 degrees, -50 degrees ), which was a typical alpha-helical structure, but the torsion angles of two gly residues, the 12th and 25th gly residues, which are located at the n- and c-terminal ends of the polyalanine region, were determined to be (phi, psi) = (-70 degrees, -30 degrees ) and (phi, psi) = (-70 degrees, -20 degrees ), respectively. |
2003-10-23 |
2023-08-12 |
Not clear |
| Oxana V Galzitskaya, Bogdan S Melni. Prediction of protein domain boundaries from sequence alone. Protein science : a publication of the Protein Society. vol 12. issue 4. 2003-10-23. PMID:12649427. |
on the one hand, relatively high ala and gly content on the domain boundary results in high conformational entropy of the backbone chain between the domains. |
2003-10-23 |
2023-08-12 |
Not clear |
| Qian Yi, Ponni Rajagopal, Rachel E Klevit, David Bake. Structural and kinetic characterization of the simplified SH3 domain FP1. Protein science : a publication of the Protein Society. vol 12. issue 4. 2003-10-23. PMID:12649436. |
the simplified sh3 domain sequence, fp1, obtained in phage display selection experiments has an amino acid composition that is 95% ile, lys, glu, ala, gly. |
2003-10-23 |
2023-08-12 |
Not clear |