| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Béatrice Terouanne, Philippe Nirdé, Fanja Rabenoelina, William Bourguet, Charles Sultan, Gilles Auzo. Mutation of the androgen receptor at amino acid 708 (Gly-->Ala) abolishes partial agonist activity of steroidal antiandrogens. Molecular pharmacology. vol 63. issue 4. 2003-04-09. PMID:12644579. |
mutation of the androgen receptor at amino acid 708 (gly-->ala) abolishes partial agonist activity of steroidal antiandrogens. |
2003-04-09 |
2023-08-12 |
human |
| Ana P Silva, Arsélio P Carvalho, Caetana M Carvalho, João O Malv. Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus. Neuropharmacology. vol 44. issue 2. 2003-04-02. PMID:12623227. |
we could also pharmacologically dissect the npy receptors activity by using y1, y2 and y5 receptor agonists ([leu(31),pro(34)]npy, npy13-36, npy (19-23)-(gly(1),ser(3),gln(4),thr(6),ala(31),aib(32),gln(34))-pancreatic polypeptide (pp), respectively), and in all the cases we observed that these agonists could inhibited the kcl-induced release of glutamate. |
2003-04-02 |
2023-08-12 |
rat |
| Toshiharu Suzuki, Masako Yasugi, Fumio Arisaka, Tairo Oshima, Akihiko Yamagish. Cold-adaptation mechanism of mutant enzymes of 3-isopropylmalate dehydrogenase from Thermus thermophilus. Protein engineering. vol 15. issue 6. 2003-03-25. PMID:12082165. |
to understand the molecular mechanism, residue 126 was substituted with one of eight other residues, gly, ala, ser, thr, glu, leu, ile or phe. |
2003-03-25 |
2023-08-12 |
cat |
| Maddalena Cross, Zhiguang Xiao, Estelle M Maes, Roman S Czernuszewicz, Simon C Drew, John R Pilbrow, Graham N George, Anthony G Wed. Removal of a cysteine ligand from rubredoxin: assembly of Fe(2)S(2) and Fe(S-Cys)(3)(OH) centres. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 7. issue 7-8. 2003-03-24. PMID:12203014. |
mutant proteins c9g, c9a, c42g and c42a, in which cysteine ligands are replaced by non-ligating gly or ala residues, have been expressed in escherichia coli. |
2003-03-24 |
2023-08-12 |
Not clear |
| Noboru Sueok. Wide intra-genomic G+C heterogeneity in human and chicken is mainly due to strand-symmetric directional mutation pressures: dGTP-oxidation and symmetric cytosine-deamination hypotheses. Gene. vol 300. issue 1-2. 2003-03-14. PMID:12468095. |
(3) patterns of amino acid-specific pr2-biases detected by plotting pr2 corollaries against the g+c content of third codon position revealed that eight four-codon amino acids can be divided into three types by the second codon letter: (a) c(2)-type (ala, pro, ser4, and thr), (b) g(2)-type (arg4 and gly), and (c) t(2)-type (leu4 and val). |
2003-03-14 |
2023-08-12 |
human |
| Stéphanie Madec, Claudine Blin, Rajagopal Krishnamoorthy, Bertrand Picard, El Bachir Chaibi, Martine Fouchereau-Péron, Roger Labi. Substitution of Met-69 by Ala or Gly in TEM-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors. FEMS microbiology letters. vol 211. issue 1. 2003-03-13. PMID:12052544. |
substitution of met-69 by ala or gly in tem-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors. |
2003-03-13 |
2023-08-12 |
Not clear |
| Geoffrey K-W Kong, Galina Polekhina, William J McKinstry, Michael W Parker, Beatrice Dragani, Antonio Aceto, Domenico Paludi, Daniela Rossi Principe, Bengt Mannervik, Gun Stenber. Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1. The Journal of biological chemistry. vol 278. issue 2. 2003-03-07. PMID:12414796. |
however even this gly --> ala substitution inactivates the enzyme at 37 degrees c. thermodynamic analysis of all variants confirms, together with previous findings, the critical role played by gst motif ii for overall protein stability. |
2003-03-07 |
2023-08-12 |
human |
| Hanne Duve, Anders H Johnsen, Alan G Scott, Alan Thorp. Allatostatins of the tiger prawn, Penaeus monodon (Crustacea: Penaeidea). Peptides. vol 23. issue 6. 2003-03-04. PMID:12126730. |
the peptides can be arranged in seven sub-groups according to the variable post-tyrosyl residue represented by ala, gly, ser, thr, asn, asp, and glu. |
2003-03-04 |
2023-08-12 |
Not clear |
| Ki-Hyuk Shin, Jin-Man Kim, Kyong Su Rho, Kyung-Hee Park, Ju-Eun Oh, Byung-Moo Mi. Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas. International journal of oncology. vol 21. issue 5. 2003-03-04. PMID:12370746. |
of the msi cancers containing the pten mutation, case 36 had a missense mutation from lys (aaa) to glu (gaa) at codon 254, case 43 contained a frameshift mutation (one a deletion) in a 6 bp poly(a) tract affecting codon 265-267, and case 64 harbored two missense mutations from val (gtg) to ala (gcg) at codon 222, and from gly (gga) to arg (aga) at codon 230 indicating biallelic mutation of pten. |
2003-03-04 |
2023-08-12 |
human |
| Simon C Lovell, Ian W Davis, W Bryan Arendall, Paul I W de Bakker, J Michael Word, Michael G Prisant, Jane S Richardson, David C Richardso. Structure validation by Calpha geometry: phi,psi and Cbeta deviation. Proteins. vol 50. issue 3. 2003-02-21. PMID:12557186. |
[proteins 2002 (this issue)] for ala and gly dipeptides, using mixed quantum mechanics and molecular mechanics, fit our nonrepetitive data in excellent detail. |
2003-02-21 |
2023-08-12 |
Not clear |
| Ken Nakazawa, Hideaki Sawa, Hiloe Ojima, Reiko Ishii-Nozawa, Koichi Takeuchi, Yasuo Ohn. Size of side-chain at channel pore mouth affects Ca(2+) block of P2X(2) receptor. European journal of pharmacology. vol 449. issue 3. 2003-02-13. PMID:12167461. |
when asn(333) was replaced with various amino acid residues with neutral side chains (gly, ala, val, leu and ile), the block by ca(2+) was attenuated according to the sizes of the side chains. |
2003-02-13 |
2023-08-12 |
Not clear |
| J M Izco, M Tormo, R Jiménez-Flore. Rapid simultaneous determination of organic acids, free amino acids, and lactose in cheese by capillary electrophoresis. Journal of dairy science. vol 85. issue 9. 2003-02-10. PMID:12362443. |
a capillary electrophoresis (ce) method for the simultaneous separation of 11 metabolically important organic acids (oxalic, formic, citric, succinic, orotic, uric, acetic, pyruvic, propionic, lactic, and butyric), 10 amino acids (asp, glu, tyr, gly, ala, ser, leu, phe, lys, and trp), and lactose has been optimized, validated, and tested in dairy products. |
2003-02-10 |
2023-08-12 |
Not clear |
| V Radha, Ch Sudhakar, P Ray, G Swaru. Induction of cytochrome c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3. Apoptosis : an international journal on programmed cell death. vol 7. issue 3. 2003-02-07. PMID:11997663. |
overexpression of a mutant ush3 domain (gly --> ala), that disrupts membrane localization, did not induce high level of apoptosis. |
2003-02-07 |
2023-08-12 |
Not clear |
| Luke A Miles, Catherine Y Dy, Jake Nielsen, Kevin J Barnham, Mark G Hinds, Baldomero M Olivera, Grzegorz Bulaj, Raymond S Norto. Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif. The Journal of biological chemistry. vol 277. issue 45. 2003-02-06. PMID:12193600. |
the chemically synthesized gm9a elicited the same symptomatology described previously for natively folded tx9a, and gm9a and tx9a were of similar potency, implying that neither the two gamma-carboxyglutamate (gla) residues found in tx9a (ser(8) and ala(13) in gm9a) nor gly(1) (ser(1) in gm9a) are crucial for biological activity. |
2003-02-06 |
2023-08-12 |
mouse |
| S Moses Dennison, Norma Greenfield, John Lenard, Barry R Lent. VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion. Biochemistry. vol 41. issue 50. 2003-01-30. PMID:12475241. |
helical instability induced by gly residues in the transmembrane domain (tmd) of g protein, the fusion protein of vesicular stomatitis virus (vsv), was speculated to aid in the later steps of the fusion process, because g protein with ala's substituted for the two tmd gly's was inactive (cleverley, d. z., and lenard, j. |
2003-01-30 |
2023-08-12 |
Not clear |
| Takashi Hibino, Rungaroon Waditee, Etsuko Araki, Hiroshi Ishikawa, Kenji Aoki, Yoshito Tanaka, Teruhiro Takab. Functional characterization of choline monooxygenase, an enzyme for betaine synthesis in plants. The Journal of biological chemistry. vol 277. issue 44. 2003-01-17. PMID:12192001. |
changes of cys-181 in spinach cmo to ser, thr, and ala and his-287 to gly, val, and ala abolished the accumulation of betaine. |
2003-01-17 |
2023-08-12 |
Not clear |
| K Y Zhu, Y Huang, L M Ta. [Changes of amino acids in cerebrospinal fluid of patients with cerebral infarction]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 25. issue 3. 2003-01-13. PMID:12212163. |
using high performance liquid chromatography, we measured the asp, glu, ser, gly, thr, arg, ala, tyr, met, val, phe, ile, ley, lys, gaba concentrations in cerebrospinal fluid(csf) of 15 patients with ischemic cerebral infarction and 10 control subjects. |
2003-01-13 |
2023-08-12 |
human |
| Y Sato, K Ohe, M Murakami, M Fukuyama, K Furuhata, S Kishikawa, Y Suzuki, A Kiuchi, M Hara, Y Ishikawa, A Tanen. Phylogenetic analysis of field isolates of feline calcivirus (FCV) in Japan by sequencing part of its capsid gene. Veterinary research communications. vol 26. issue 3. 2002-12-31. PMID:12090292. |
similarly, the amino acid at position 539 in the f region was alanine (ala) or proline (pro) in group i, while it was valine (val) in group ii; glycine (gly) at position 557 in group i was serine (ser) in group ii; and phenylalanine (phe) or leucine (leu) at position 566 in genogroup i was tyrosine (tyr) in group ii. |
2002-12-31 |
2023-08-12 |
Not clear |
| Richard D Bagshaw, Sunqu Zhang, Alina Hinek, Marie Anne Skomorowski, Donald Whelan, Joe T R Clarke, John W Callaha. Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease. Biochimica et biophysica acta. vol 1588. issue 3. 2002-12-31. PMID:12393180. |
novel mutations (asn 484 lys, thr 500 ala, gly 438 glu) in morquio b disease. |
2002-12-31 |
2023-08-12 |
Not clear |
| Hirokazu Satoh, Yoshimi Nakano, Hideki Shibata, Masatoshi Mak. The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner. Biochimica et biophysica acta. vol 1600. issue 1-2. 2002-12-31. PMID:12445460. |
both the n-terminal regulatory domain of annexin xi (anx11n) and the alg-2-binding domain of alix/aip1 are rich in pro, gly, ala, tyr and gln. |
2002-12-31 |
2023-08-12 |
Not clear |