| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen A Varvel, Benjamin F Cravatt, April E Engram, Aron H Lichtma. Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16352706. |
more generally, faah may represent a novel therapeutic target that circumvents the undesirable cognitive side effects commonly associated with direct-acting cannabinoid agonists. |
2006-05-25 |
2023-08-12 |
mouse |
| Mauro Maccarrone, Anna Fiori, Monica Bari, Filippo Granata, Valeria Gasperi, M Egle De Stefano, Alessandro Finazzi-Agrò, Roberto Stro. Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells. Thrombosis and haemostasis. vol 95. issue 1. 2006-04-27. PMID:16543970. |
type-1 and type-2 cannabinoid receptors (cb1r and cb2r), a selective aea membrane transporter (amt), an aea-degrading fatty acid amide hydrolase, and the aea-synthesizing enzymes n-acyltransferase and n-acyl-phosphatidylethanolamines-specific phospholipase d. we also show that activation of cb1r enhances amt activity through increased nitric oxide synthase (nos) activity and subsequent increase of no production. |
2006-04-27 |
2023-08-12 |
cattle |
| Sandra Holt, Francesca Comelli, Barbara Costa, Christopher J Fowle. Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors. British journal of pharmacology. vol 146. issue 3. 2006-04-25. PMID:16100529. |
inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors. |
2006-04-25 |
2023-08-12 |
mouse |
| J Fernández-Ruiz, S Gonzále. Cannabinoid control of motor function at the basal ganglia. Handbook of experimental pharmacology. issue 168. 2006-04-19. PMID:16596785. |
this three-fold evidence has provided support to the idea that cannabinoid-based compounds, which act at key steps of the endocannabinoid transmission [receptors, transporter, fatty acid amide hydrolase (faah)], might be of interest because of their potential ability to alleviate motor symptoms and/or provide neuroprotection in a variety of neurological pathologies directly affecting basal ganglia structures, such as parkinson's disease and huntington's chorea, or indirectly, such as multiple sclerosis and alzheimer's disease. |
2006-04-19 |
2023-08-12 |
Not clear |
| Sherrye T Glaser, S John Gatley, Andrew N Giffor. Ex vivo imaging of fatty acid amide hydrolase activity and its inhibition in the mouse brain. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16278311. |
these data indicate faah activity generates heterogeneous regional accumulation of [3h]anandamide and metabolites, and they suggest the modulation of endocannabinoid tone by faah inhibitors depends upon not only the dose and compound used but also on the degree of faah expression in the brain regions examined. |
2006-04-13 |
2023-08-12 |
mouse |
| Sabatino Maione, Tiziana Bisogno, Vito de Novellis, Enza Palazzo, Luigia Cristino, Marta Valenti, Stefania Petrosino, Vittorio Guglielmotti, Francesco Rossi, Vincenzo Di Marz. Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16284279. |
elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. |
2006-04-13 |
2023-08-12 |
rat |
| Sabatino Maione, Tiziana Bisogno, Vito de Novellis, Enza Palazzo, Luigia Cristino, Marta Valenti, Stefania Petrosino, Vittorio Guglielmotti, Francesco Rossi, Vincenzo Di Marz. Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. The Journal of pharmacology and experimental therapeutics. vol 316. issue 3. 2006-04-13. PMID:16284279. |
we studied in healthy rats the effect of elevation of pag endocannabinoid [anandamide and 2-arachidonoylglycerol (2-ag)] levels produced by intra-pag injections of the inhibitor of fatty acid amide hydrolase urb597 [cyclohexylcarbamic acid-3'-carbamoyl-biphenyl-3-yl ester] on 1) nociception in the "plantar test" and 2) spontaneous and tail-flick-related activities of rvm neurons. |
2006-04-13 |
2023-08-12 |
rat |
| Sherrye T Glaser, Dale G Deutsch, Keith M Studholme, Sarah Zimov, Stephen Yazull. Endocannabinoids in the intact retina: 3 H-anandamide uptake, fatty acid amide hydrolase immunoreactivity and hydrolysis of anandamide. Visual neuroscience. vol 22. issue 6. 2006-04-04. PMID:16469181. |
here we focused on one endocannabinoid, anandamide (aea), and its major hydrolyzing enzyme, fatty acid amide hydrolase (faah), in the goldfish retina. |
2006-04-04 |
2023-08-12 |
rat |
| Gustav Schelling, Daniela Hauer, Shahnaz Christina Azad, Martin Schmoelz, Alexander Chouker, Michael Schmidt, Cyrill Hornuss, Markus Rippberger, Josef Briegel, Manfred Thiel, Michael Vogese. Effects of general anesthesia on anandamide blood levels in humans. Anesthesiology. vol 104. issue 2. 2006-03-21. PMID:16436846. |
the endocannabinoid system includes g-protein-coupled cannabinoid receptors, the endocannabinoids n-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol, and multiple enzymes involved in the biosynthesis and degradation of endocannabinoids, including the anandamide metabolizing enzyme fatty acid amide hydrolase. |
2006-03-21 |
2023-08-12 |
Not clear |
| David A Karanian, Queenie B Brown, Alexandros Makriyannis, Therese A Kosten, Ben A Bah. Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 34. 2006-03-03. PMID:16120783. |
dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. |
2006-03-03 |
2023-08-12 |
Not clear |
| David A Karanian, Queenie B Brown, Alexandros Makriyannis, Therese A Kosten, Ben A Bah. Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 34. 2006-03-03. PMID:16120783. |
besides direct activation with cb1 receptor agonists, cannabinergic signaling can be modulated through inhibition of endocannabinoid transport and fatty acid amide hydrolase (faah), two mechanisms of endocannabinoid inactivation. |
2006-03-03 |
2023-08-12 |
Not clear |
| Jessica P Alexander, Benjamin F Cravat. Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chemistry & biology. vol 12. issue 11. 2006-03-02. PMID:16298297. |
fatty acid amide hydrolase (faah) regulates a large class of signaling lipids, including the endocannabinoid anandamide. |
2006-03-02 |
2023-08-12 |
Not clear |
| Cristiano Ruch Werneck Guimarães, Dale L Boger, William L Jorgense. Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations. Journal of the American Chemical Society. vol 127. issue 49. 2006-02-22. PMID:16332087. |
fatty acid amide hydrolase (faah) is a serine hydrolase responsible for the degradation of anandamide, an endogenous cannabinoid agonist, and oleamide, a sleep-inducing lipid. |
2006-02-22 |
2023-08-12 |
Not clear |
| Giulio G Muccioli, Nicola Fazio, Gerhard K E Scriba, Wolfgang Poppitz, Fabio Cannata, Jacques H Poupaert, Johan Wouters, Didier M Lamber. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates. Journal of medicinal chemistry. vol 49. issue 1. 2006-02-16. PMID:16392827. |
in the present study, we synthesized several derivatives exhibiting interesting faah inhibitory activity and devoid of affinity for the cb(1) and cb(2) cannabinoid receptors. |
2006-02-16 |
2023-08-12 |
Not clear |
| Giulio G Muccioli, Nicola Fazio, Gerhard K E Scriba, Wolfgang Poppitz, Fabio Cannata, Jacques H Poupaert, Johan Wouters, Didier M Lamber. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates. Journal of medicinal chemistry. vol 49. issue 1. 2006-02-16. PMID:16392827. |
in conclusion, it appears that even though several 3-substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one and 3-substituted 5,5'-diphenylimidazolidine-2,4-dione derivatives have been previously shown to behave as cb(1) cannabinoid receptor ligands, appropriate substitutions of these templates can result in faah inhibitors devoid of affinity for the cannabinoid receptors. |
2006-02-16 |
2023-08-12 |
Not clear |
| Alessia Ligresti, Maria Grazia Cascio, Vincenzo Di Marz. Endocannabinoid metabolic pathways and enzymes. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375679. |
five endocannabinoid enzymes have been cloned to date: two are responsible for the biosynthesis and degradation of anandamide, the nape-selective phospholipase d and the fatty acid amide hydrolase, respectively; the other three catalyse the biosynthesis and degradation of 2-ag, the sn-1-selective diacylglycerol lipases alpha and beta and the monoacylglycerol lipase, respectively. |
2006-02-07 |
2023-08-12 |
human |
| Enrico Dainese, Valeria Gasperi, Mauro Maccarron. Partial QSAR analysis of some selected natural inhibitors of FAAH suggests a working hypothesis for the development of endocannabinoid-based drugs. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375688. |
the discovery of n-arachidonoylethanolamine (anandamide, aea) and of the enzyme that terminates its signaling, i. e. fatty acid amide hydrolase (faah), has inspired pharmacological strategies to augment endocannabinoid tone and biological activity through inhibition of faah. |
2006-02-07 |
2023-08-12 |
Not clear |
| Enrico Dainese, Valeria Gasperi, Mauro Maccarron. Partial QSAR analysis of some selected natural inhibitors of FAAH suggests a working hypothesis for the development of endocannabinoid-based drugs. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375688. |
here we discuss the role of natural endocannabinoid derivatives, like the hydroxy-anandamides (oh-aeas) generated from aea via lipoxygenase activity, as powerful inhibitors of faah. |
2006-02-07 |
2023-08-12 |
Not clear |
| Enrico Dainese, Valeria Gasperi, Mauro Maccarron. Partial QSAR analysis of some selected natural inhibitors of FAAH suggests a working hypothesis for the development of endocannabinoid-based drugs. Current drug targets. CNS and neurological disorders. vol 4. issue 6. 2006-02-07. PMID:16375688. |
we propose that these compounds, by reversibly inhibiting faah, may control in vivo the endocannabinoid tone. |
2006-02-07 |
2023-08-12 |
Not clear |
| Mauro Maccarrone, Barbara Barboni, Andrea Paradisi, Nicola Bernabò, Valeria Gasperi, Maria Gabriella Pistilli, Filomena Fezza, Pia Lucidi, Mauro Mattiol. Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction. Journal of cell science. vol 118. issue Pt 19. 2006-01-27. PMID:16144868. |
type-1 cannabinoid receptors (cb1r), vanilloid receptors (trpv1), aea-synthesizing phospholipase d (nape-pld), aea transporter (amt) and aea hydrolase (faah). |
2006-01-27 |
2023-08-12 |
Not clear |