| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16956707. |
several studies suggest that some organophosphorus toxicants can potentially modify cannabinergic signaling by direct binding to cannabinoid receptors and inhibition of enzymes responsible for cannabinoid degradation (i.e., fatty acid amide hydrolase and monoacylglycerol lipase). |
2006-11-29 |
2023-08-12 |
rat |
| Anke M Mulder, Benjamin F Cravat. Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. Biochemistry. vol 45. issue 38. 2006-11-08. PMID:16981687. |
endocannabinoid metabolism in the absence of fatty acid amide hydrolase (faah): discovery of phosphorylcholine derivatives of n-acyl ethanolamines. |
2006-11-08 |
2023-08-12 |
mouse |
| Anke M Mulder, Benjamin F Cravat. Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines. Biochemistry. vol 45. issue 38. 2006-11-08. PMID:16981687. |
termination of the activity of the n-acyl ethanolamine (nae) class of lipid-signaling molecules, including the endocannabinoid anandamide (aea), is principally mediated by the integral membrane enzyme fatty acid amide hydrolase (faah) in vivo. |
2006-11-08 |
2023-08-12 |
mouse |
| Josée Guindon, Pierre Beaulie. Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. Neuropharmacology. vol 50. issue 7. 2006-10-06. PMID:16442133. |
nonsteroidal anti-inflammatory drugs (nsaids) inhibit fatty acid amidohydrolase (faah), the enzyme responsible for the metabolism of anandamide, an endocannabinoid. |
2006-10-06 |
2023-08-12 |
rat |
| Haibin Wang, Huirong Xie, Yong Guo, Hao Zhang, Toshifumi Takahashi, Philip J Kingsley, Lawrence J Marnett, Sanjoy K Das, Benjamin F Cravatt, Sudhansu K De. Fatty acid amide hydrolase deficiency limits early pregnancy events. The Journal of clinical investigation. vol 116. issue 8. 2006-09-14. PMID:16886060. |
faah inactivation yielding higher anandamide or experimentally induced higher cannabinoid [(-)-delta9-tetrahydrocannabinol] levels constrain preimplantation embryo development with aberrant expression of cdx2, nanog, and oct3/4, genes known to direct lineage specification. |
2006-09-14 |
2023-08-12 |
mouse |
| Daniele Piomelli, Giorgio Tarzia, Andrea Duranti, Andrea Tontini, Marco Mor, Timothy R Compton, Olivier Dasse, Edward P Monaghan, Jeff A Parrott, David Putma. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS drug reviews. vol 12. issue 1. 2006-09-08. PMID:16834756. |
in the present article, we review the pharmacological properties of kds-4103 (urb597), a highly potent and selective inhibitor of the enzyme fatty-acid amide hydrolase (faah), which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide. |
2006-09-08 |
2023-08-12 |
mouse |
| Alan Saghatelian, Michele K McKinney, Michael Bandell, Ardem Patapoutian, Benjamin F Cravat. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. vol 45. issue 30. 2006-09-05. PMID:16866345. |
most of the physiological substrates of faah characterized to date belong to the n-acyl ethanolamine (nae) class of fatty acid amides, including the endocannabinoid anandamide, the anti-inflammatory lipid n-palmitoyl ethanolamine, and the satiating factor n-oleoyl ethanolamine. |
2006-09-05 |
2023-08-12 |
mouse |
| Susanna M Saario, Antti Poso, Risto O Juvonen, Tomi Järvinen, Outi M H Salo-Ahe. Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. Journal of medicinal chemistry. vol 49. issue 15. 2006-08-31. PMID:16854070. |
fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. |
2006-08-31 |
2023-08-12 |
human |
| Susanna M Saario, Antti Poso, Risto O Juvonen, Tomi Järvinen, Outi M H Salo-Ahe. Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. Journal of medicinal chemistry. vol 49. issue 15. 2006-08-31. PMID:16854070. |
the endocannabinoid system consists of two cannabinoid receptors (cb1 and cb2), endogenous ligands (endocannabinoids), and the enzymes involved in the metabolism of the endocannabinoids, including fatty acid amide hydrolase (faah) and monoglyceride lipase (mgl). |
2006-08-31 |
2023-08-12 |
human |
| Marcello Solinas, Zuzana Justinova, Steven R Goldberg, Gianluigi Tand. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. Journal of neurochemistry. vol 98. issue 2. 2006-08-18. PMID:16805835. |
anandamide produced two distinctly different effects on dopamine levels: (1) a rapid, transient increase that was blocked by the cannabinoid cb1 receptor antagonist rimonabant, but not by the vanilloid vr1 receptor antagonist capsazepine, and was magnified and prolonged by the fatty acid amide hydrolase (faah) enzyme inhibitor, urb597; (2) a smaller delayed and long-lasting increase, not sensitive to cb1, vr1 or faah blockade. |
2006-08-18 |
2023-08-12 |
rat |
| Gilda Cobellis, Giovanna Cacciola, Donatella Scarpa, Rosaria Meccariello, Rosanna Chianese, Maria Fosca Franzoni, Ken Mackie, Riccardo Pierantoni, Silvia Fasan. Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. Biology of reproduction. vol 75. issue 1. 2006-08-10. PMID:16611862. |
endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. |
2006-08-10 |
2023-08-12 |
mouse |
| Gilda Cobellis, Giovanna Cacciola, Donatella Scarpa, Rosaria Meccariello, Rosanna Chianese, Maria Fosca Franzoni, Ken Mackie, Riccardo Pierantoni, Silvia Fasan. Endocannabinoid system in frog and rodent testis: type-1 cannabinoid receptor and fatty acid amide hydrolase activity in male germ cells. Biology of reproduction. vol 75. issue 1. 2006-08-10. PMID:16611862. |
here we provide direct evidence on the presence of the "endocannabinoid system," constituted by type-1 cannabinoid receptor (cnr1) and fatty acid amide hydrolase (faah), in the frog rana esculenta testis demonstrating its expression in tubular compartment. |
2006-08-10 |
2023-08-12 |
mouse |
| Rhidaya Shrestha, Sang-chul Kim, John M Dyer, Richard A Dixon, Kent D Chapma. Plant fatty acid (ethanol) amide hydrolases. Biochimica et biophysica acta. vol 1761. issue 3. 2006-07-17. PMID:16624618. |
fatty acid amide hydrolase (faah) plays a central role in modulating endogenous n-acylethanolamine (nae) levels in vertebrates, and, in part, constitutes an "endocannabinoid" signaling pathway that regulates diverse physiological and behavioral processes in animals. |
2006-07-17 |
2023-08-12 |
rat |
| Kent-Olov Jonsson, Sandra Holt, Christopher J Fowle. The endocannabinoid system: current pharmacological research and therapeutic possibilities. Basic & clinical pharmacology & toxicology. vol 98. issue 2. 2006-07-07. PMID:16445584. |
the main topics covered are: the mechanism of action of cannabinoid(2) receptor agonists; identification of the endocannabinoid(s) involved in retrograde signalling; the elusive mechanism(s) of endocannabinoid uptake; therapeutic possibilities for fatty acid amide hydrolase inhibitors; and the cyclooxygenase-2 and lipoxygenase-derived biologically active metabolites of the endocannabinoids. |
2006-07-07 |
2023-08-12 |
Not clear |
| Josée Guindon, André De Léan, Pierre Beaulie. Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. Pain. vol 121. issue 1-2. 2006-06-02. PMID:16480822. |
anandamide, an endocannabinoid, is degraded by the enzyme fatty acid amide hydrolase which can be inhibited by nonsteroidal anti-inflammatory drugs (nsaids). |
2006-06-02 |
2023-08-12 |
rat |
| Lynsey G Bilsland, James R T Dick, Gareth Pryce, Stefania Petrosino, Vincenzo Di Marzo, David Baker, Linda Greensmit. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16571781. |
furthermore, genetic ablation of the faah enzyme, which results in raised levels of the endocannabinoid anandamide, prevented the appearance of disease signs in 90-day-old sod1g93a mice. |
2006-06-01 |
2023-08-12 |
mouse |
| Lynsey G Bilsland, James R T Dick, Gareth Pryce, Stefania Petrosino, Vincenzo Di Marzo, David Baker, Linda Greensmit. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16571781. |
surprisingly, elevation of cannabinoid levels with either win55,212-2 or faah ablation had no effect on life span. |
2006-06-01 |
2023-08-12 |
mouse |
| Tiziana Bisogno, Maria Grazia Cascio, Bijali Saha, Anu Mahadevan, Paolo Urbani, Alberto Minassi, Giovanni Appendino, Carmela Saturnino, Billy Martin, Raj Razdan, Vincenzo Di Marz. Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochimica et biophysica acta. vol 1761. issue 2. 2006-05-31. PMID:16466961. |
apart from being almost inactive on magl, these two compounds showed high selectivity over rat liver triacylglycerol lipase, rat n-acylphosphatidyl-ethanolamine-selective phospholipase d (involved in anandamide biosynthesis), rat fatty acid amide hydrolase and human recombinant cannabinoid cb1 and cb2 receptors. |
2006-05-31 |
2023-08-12 |
human |
| John M McPartland, Isabel Matias, Vincenzo Di Marzo, Michelle Glas. Evolutionary origins of the endocannabinoid system. Gene. vol 370. 2006-05-26. PMID:16434153. |
within this limited number of twelve organisms, the endocannabinoid genes exhibited heterogeneous evolutionary trajectories, with functional orthologs limited to mammals (trpv1 and gpr55), or vertebrates (cb2 and daglbeta), or chordates (magl and cox2), or animals (daglalpha and cb1-like receptors), or opisthokonta (animals and fungi, nape-pld), or eukaryotes (faah). |
2006-05-26 |
2023-08-12 |
mouse |
| Filomena Fezza, Natalia Battista, Monica Bari, Mauro Maccarron. Methods to assay anandamide hydrolysis and transport in synaptosomes. Methods in molecular medicine. vol 123. 2006-05-26. PMID:16506407. |
the biological activity of aea at cannabinoid and noncannabinoid receptors depends on its life span in the extracellular space, which is regulated by a rapid cellular uptake, followed by intracellular degradation by the enzyme aea hydrolase (fatty acid amide hydrolase). |
2006-05-26 |
2023-08-12 |
Not clear |