| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cesar V Borlonga. Recent preclinical evidence advancing cell therapy for Alzheimer's disease. Experimental neurology. vol 237. issue 1. 2012-11-05. PMID:22766481. |
to this end, nerve growth factor (ngf) has been examined as a possible preventative treatment against cholinergic neuronal death while enhancing memory capabilities; however, ngf brain bioavailability is challenging as it does not cross the blood-brain barrier. |
2012-11-05 |
2023-08-12 |
Not clear |
| Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andrés Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo, Francisca C Bronfma. Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease. Molecular neurodegeneration. vol 7. 2012-10-26. PMID:22458984. |
as models, we used i) npc1-deficient mice to evaluate the central cholinergic septo-hippocampal pathway and its response to nerve growth factor (ngf) after axotomy and ii) pc12 cells treated with u18666a, a pharmacological cellular model of npc, stimulated with ngf. |
2012-10-26 |
2023-08-12 |
mouse |
| Lars U Wahlberg, Göran Lind, Per M Almqvist, Philip Kusk, Jens Tornøe, Bengt Juliusson, Michael Söderman, Eva Selldén, Åke Seiger, Maria Eriksdotter-Jönhagen, Bengt Linderot. Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgery. Journal of neurosurgery. vol 117. issue 2. 2012-10-11. PMID:22655593. |
the authors describe the first clinical trial with encapsulated cell biodelivery (ecb) implants that deliver nerve growth factor (ngf) to the cholinergic basal forebrain with the intention of halting the degeneration of cholinergic neurons and the associated cognitive decline in patients with alzheimer disease (ad). |
2012-10-11 |
2023-08-12 |
human |
| A Claudio Cuello, E P Pioro, A Ribeiro-da-Silv. Cellular and subcellular localization of nerve growth factor receptor-like immunoreactivity in the rat CNS. Neurochemistry international. vol 17. issue 2. 2012-10-02. PMID:20504621. |
since the relatively recent discovery that ngf exerts neurotrophic effects on cholinergic neurons of the rat basal forebrain, in addition to its previously known actions on sympathetic and sensory neurons of the peripheral nervous system, numerous morphological studies have localized the ngfr to such neurons in the forebrain. |
2012-10-02 |
2023-08-12 |
rat |
| A Claudio Cuello, E P Pioro, A Ribeiro-da-Silv. Cellular and subcellular localization of nerve growth factor receptor-like immunoreactivity in the rat CNS. Neurochemistry international. vol 17. issue 2. 2012-10-02. PMID:20504621. |
these findings expand on the notion that ngf effects are not restricted to cholinergic neurons. |
2012-10-02 |
2023-08-12 |
rat |
| G Miller Jonakait, Lorelei Pratt, Giselles Acevedo, Li N. Microglial regulation of cholinergic differentiation in the basal forebrain. Developmental neurobiology. vol 72. issue 6. 2012-09-28. PMID:21898853. |
however, a microglial cell line produced high-molecular weight forms of ngf (pro-ngf) that were lethal to mature cholinergic neurons. |
2012-09-28 |
2023-08-12 |
rat |
| Daniela Ehrlich, Michael Pirchl, Christian Humpe. Ethanol transiently suppresses choline-acetyltransferase in basal nucleus of Meynert slices. Brain research. vol 1459. 2012-09-18. PMID:22560095. |
thus, the aims of the present study were (1) to investigate the effect of different etoh concentrations on cholinergic neurons in organotypic brain slices of the nucleus basalis of meynert (nbm) and (2) to study if the most potent cholinotrophic substance nerve growth factor (ngf) or inhibitors of mitogen activated kinase (mapk) p38- and nitric-oxide synthase (nos)-pathways may counteract any etoh effect. |
2012-09-18 |
2023-08-12 |
rat |
| Daniela Ehrlich, Michael Pirchl, Christian Humpe. Ethanol transiently suppresses choline-acetyltransferase in basal nucleus of Meynert slices. Brain research. vol 1459. 2012-09-18. PMID:22560095. |
inhibition of mapk p38 (sb 203580, 10 μm) and nos (l-thiocitrulline, 10 μm) counteracted the etoh-induced decline of cholinergic neurons and ngf protected cholinergic neurons against the etoh-induced effect. |
2012-09-18 |
2023-08-12 |
rat |
| A Claudio Cuell. Gangliosides, NGF, brain aging and disease: a mini-review with personal reflections. Neurochemical research. vol 37. issue 6. 2012-08-31. PMID:22484968. |
we have also validated this pathway in vivo demonstrating that the pharmacological inhibition of the pro-to mature ngf conversion results in the brain accumulation of prongf and loss and atrophy of cortical cholinergic synapses. |
2012-08-31 |
2023-08-12 |
Not clear |
| A Claudio Cuell. Gangliosides, NGF, brain aging and disease: a mini-review with personal reflections. Neurochemical research. vol 37. issue 6. 2012-08-31. PMID:22484968. |
furthermore, we have gathered neurochemical evidence for a compromise of this newly discovered ngf metabolic pathway in alzheimer's disease, explaining the vulnerability of ngf-dependent forebrain cholinergic neurons in this disease despite normal ngf synthesis and abundance of ngf precursor. |
2012-08-31 |
2023-08-12 |
Not clear |
| Chris Carte. Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System. International journal of Alzheimer's disease. vol 2011. 2012-08-23. PMID:22254144. |
ngf or tau antibodies promote beta-amyloid deposition, neurofibrillary tangles, or cholinergic neuronal loss, and, with other autoantibodies, such as anti-atpase, are potential agents of destruction, whose formation is dictated by sequence homology between pathogen and human proteins, and thus by pathogen strain and human genes. |
2012-08-23 |
2023-08-12 |
human |
| Lan Guo, Mason L Yeh, Verginia C Cuzon Carlson, Erin M Johnson-Venkatesh, Hermes H Ye. Nerve growth factor in the hippocamposeptal system: evidence for activity-dependent anterograde delivery and modulation of synaptic activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 22. 2012-08-06. PMID:22649248. |
these acute actions of ngf display cell type and functional selectivity insofar as (1) they were found in cholinergic, but not gabaergic, ms/db neurons, and (2) glutamate-mediated excitatory synaptic activity as well as ampa-activated current responses were unaffected. |
2012-08-06 |
2023-08-12 |
mouse |
| Henri Autio, Kert Mätlik, Tomi Rantamäki, Lothar Lindemann, Marius C Hoener, Moses Chao, Urmas Arumäe, Eero Castré. Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21820453. |
basal forebrain cholinergic neurons are dependent upon trophic support by nerve growth factor (ngf) through its neurotrophin receptor, trka. |
2012-08-01 |
2023-08-12 |
mouse |
| K Belarbi, S Burnouf, F-J Fernandez-Gomez, J Desmercières, L Troquier, J Brouillette, L Tsambou, M-E Grosjean, R Caillierez, D Demeyer, M Hamdane, K Schindowski, D Blum, L Bué. Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology? Current Alzheimer research. vol 8. issue 6. 2012-07-19. PMID:21605043. |
analysis of nerve growth factor (ngf) levels supports an accumulation of the mature neurotrophin in the hippocampus of thy-tau22 mice, consistent with a decrease of its uptake or retrograde transport by cholinergic terminals. |
2012-07-19 |
2023-08-12 |
mouse |
| Maria Eriksdotter-Jönhagen, Bengt Linderoth, Göran Lind, Layth Aladellie, Ove Almkvist, Niels Andreasen, Kaj Blennow, Nenad Bogdanovic, Vesna Jelic, Ahmadul Kadir, Agneta Nordberg, Erik Sundström, Lars-Olof Wahlund, Anders Wall, Maria Wiberg, Bengt Winblad, Ake Seiger, Per Almqvist, Lars Wahlber. Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 33. issue 1. 2012-07-18. PMID:22377499. |
targeted delivery of exogenous nerve growth factor (ngf) has emerged as a potential ad therapy due to its regenerative effects on the basal forebrain cholinergic neurons in ad animal models. |
2012-07-18 |
2023-08-12 |
Not clear |
| Luigi Manni, M L Rocco, Samuele Barbaro Paparo, Morena Guaragn. Electroacupucture and nerve growth factor: potential clinical applications. Archives italiennes de biologie. vol 149. issue 2. 2012-06-21. PMID:21701996. |
the nerve growth factor (ngf) is a neurotrophin regulating the survival and function peripheral sensory and sympathetic neurons and of forebrain cholinergic neurons. |
2012-06-21 |
2023-08-12 |
Not clear |
| Luigi Manni, M L Rocco, Samuele Barbaro Paparo, Morena Guaragn. Electroacupucture and nerve growth factor: potential clinical applications. Archives italiennes de biologie. vol 149. issue 2. 2012-06-21. PMID:21701996. |
both peripheral neuropathies and brain cholinergic dysfunctions could benefit from ngfbased therapies, but the clinical use of ngf has been so far hampered by the development of important side effects, like hyperalgesia and autonomic dysfunctions. |
2012-06-21 |
2023-08-12 |
Not clear |
| Oscar V Ramos, Pablo Torterolo, Vincent Lim, Michael H Chase, Sharon Sampogna, Jack Yamu. The role of mesopontine NGF in sleep and wakefulness. Brain research. vol 1413. 2012-06-12. PMID:21840513. |
to determine if ngf is involved in naturally-occurring rem sleep, we examined whether it is present in mesopontine cholinergic structures that promote the initiation of rem sleep, and whether the blockade of ngf production in these structures suppresses rem sleep. |
2012-06-12 |
2023-08-12 |
cat |
| Scott E Counts, Shaoli Che, Stephen D Ginsberg, Elliott J Mufso. Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease. Journal of chemical neuroanatomy. vol 42. issue 2. 2012-06-01. PMID:21397006. |
to address whether gender affects ngf signaling system expression within the cbf, we used single cell rna amplification and custom microarray technologies to compare gene expression profiles of single cholinergic nb neurons in tissue specimens from male and female members of the religious orders study who died with a clinical diagnosis of no cognitive impairment (nci), mild cognitive impairment (mci), or mild/moderate ad. |
2012-06-01 |
2023-08-12 |
human |
| Efrain Sanchez-Ortiz, Daishi Yui, Dongli Song, Yun Li, John L Rubenstein, Louis F Reichardt, Luis F Parad. TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 12. 2012-05-18. PMID:22442072. |
consistent with a potential link to ad pathogenesis, trka, a ngf receptor, is expressed in cholinergic forebrain neuronal populations including those in bf and striatum, and is markedly reduced in individuals with mild cognitive impairment (mci) without dementia and early-stage ad. |
2012-05-18 |
2023-08-12 |
mouse |