| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon Allard, Wanda C Leon, Prateep Pakavathkumar, Martin A Bruno, Alfredo Ribeiro-da-Silva, A Claudio Cuell. Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323714. |
impact of the ngf maturation and degradation pathway on the cortical cholinergic system phenotype. |
2012-03-27 |
2023-08-12 |
rat |
| Simon Allard, Wanda C Leon, Prateep Pakavathkumar, Martin A Bruno, Alfredo Ribeiro-da-Silva, A Claudio Cuell. Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323714. |
nerve growth factor (ngf) is the neurotrophin responsible for the phenotypic maintenance of basal forebrain cholinergic neurons in the mature and fully differentiated cns. |
2012-03-27 |
2023-08-12 |
rat |
| Simon Allard, Wanda C Leon, Prateep Pakavathkumar, Martin A Bruno, Alfredo Ribeiro-da-Silva, A Claudio Cuell. Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323714. |
using cognitive-behavioral tests, western blotting, and confocal and electron microscopy, this study demonstrates that a pharmacologically induced chronic failure in extracellular ngf maturation leads to a reduction in mngf levels, prongf accumulation, cholinergic degeneration, and cognitive impairment in rats. |
2012-03-27 |
2023-08-12 |
rat |
| Simon Allard, Wanda C Leon, Prateep Pakavathkumar, Martin A Bruno, Alfredo Ribeiro-da-Silva, A Claudio Cuell. Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323714. |
it also shows that inhibiting ngf degradation increases endogenous levels of the mature neurotrophin and increases the density of cortical cholinergic boutons. |
2012-03-27 |
2023-08-12 |
rat |
| S Capsoni, R Brandi, I Arisi, M D'Onofrio, A Cattane. A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model. CNS & neurological disorders drug targets. vol 10. issue 5. 2012-02-03. PMID:21631402. |
the neurotrophin nerve growth factor (ngf) is essential for the maintenance and differentiation of basal forebrain cholinergic neurons. |
2012-02-03 |
2023-08-12 |
mouse |
| S Capsoni, R Brandi, I Arisi, M D'Onofrio, A Cattane. A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model. CNS & neurological disorders drug targets. vol 10. issue 5. 2012-02-03. PMID:21631402. |
since basal forebrain cholinergic neurons represent one major neuronal population affected and progressively degenerating in alzheimer's disease (ad), interest has grown for ngf as a potential therapeutic agent in neurodegenerative disorders linked to aging, particularly for ad. |
2012-02-03 |
2023-08-12 |
mouse |
| S Capsoni, R Brandi, I Arisi, M D'Onofrio, A Cattane. A dual mechanism linking NGF/proNGF imbalance and early inflammation to Alzheimer's disease neurodegeneration in the AD11 anti-NGF mouse model. CNS & neurological disorders drug targets. vol 10. issue 5. 2012-02-03. PMID:21631402. |
however, no evidence was available, to link, in a cause-effect manner, deficits in ngf signalling to the broader activation in the alzheimer's cascade, besides cholinergic deficits. |
2012-02-03 |
2023-08-12 |
mouse |
| John E McGeary, Volkan Gurel, Valerie S Knopik, James Spaulding, John McMichae. Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain. Neuropeptides. vol 45. issue 5. 2012-02-03. PMID:21820738. |
overlap was found between the mrna levels of genes altered by ngf and the two antidepressant medications including genes related to the cholinergic and dopaminergic systems. |
2012-02-03 |
2023-08-12 |
rat |
| Francesca Gelfo, Paola Tirassa, Paola De Bartolo, Carlo Caltagirone, Laura Petrosini, Francesco Angelucc. Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 25. issue 2. 2011-11-04. PMID:21368378. |
to characterize the time course of ngf changes in an ad animal model, we measured ngf brain and serum levels at 3, 7, and 15 days from cholinergic depletion. |
2011-11-04 |
2023-08-12 |
human |
| Francesca Gelfo, Paola Tirassa, Paola De Bartolo, Carlo Caltagirone, Laura Petrosini, Francesco Angelucc. Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 25. issue 2. 2011-11-04. PMID:21368378. |
ngf levels increased in the frontal cortex and hippocampus at 3 and 7 days and decreased in the serum at 7 days from lesion, suggesting that opposite changes in brain and serum occur at early stages of cholinergic depletion. |
2011-11-04 |
2023-08-12 |
human |
| Tahar Aboulkassim, Xin-Kang Tong, Yiu Chung Tse, Tak-Pan Wong, Sang B Woo, Kenneth E Neet, Fouad Brahimi, Edith Hamel, H Uri Saragov. Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory. Molecular pharmacology. vol 80. issue 3. 2011-10-18. PMID:21616921. |
in the central nervous system, the nerve growth factor (ngf) receptor trka is expressed primarily in cholinergic neurons that are implicated in spatial learning and memory, whereas the ngf receptor p75(ntr) is expressed in many neuronal populations and glia. |
2011-10-18 |
2023-08-12 |
mouse |
| Reinhard Schliebs, Thomas Arend. The cholinergic system in aging and neuronal degeneration. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:21145918. |
in particular imbalances in the expression of ngf, its precursor prongf, the high and low ngf receptors, trka and p75ntr, respectively, changes in acetylcholine release, high-affinity choline uptake, as well as alterations in muscarinic and nicotinic acetylcholine receptor expression may contribute to the cholinergic dysfunction. |
2011-09-09 |
2023-08-12 |
Not clear |
| Reinhard Schliebs, Thomas Arend. The cholinergic system in aging and neuronal degeneration. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:21145918. |
indeed, there is abundant evidence that β-amyloid may trigger cholinergic dysfunction through action on α7 nicotinic acetylcholine receptors, affecting ngf signaling, mediating tau phosphorylation, interacting with acetylcholinesterase, and specifically affecting the proteome in cholinergic neurons. |
2011-09-09 |
2023-08-12 |
Not clear |
| Valerio Ricci, Giovanni Martinotti, Francesca Gelfo, Federico Tonioni, Carlo Caltagirone, Pietro Bria, Francesco Angelucc. Chronic ketamine use increases serum levels of brain-derived neurotrophic factor. Psychopharmacology. vol 215. issue 1. 2011-08-15. PMID:21161184. |
neurotrophins such as brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) serve as survival factors for selected populations of central nervous system neurons, including cholinergic and dopaminergic neurons. |
2011-08-15 |
2023-08-12 |
Not clear |
| Christian Humpe. Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease? Experimental gerontology. vol 46. issue 4. 2011-08-09. PMID:21112383. |
the role of ngf on the cell death of cholinergic neurons is discussed. |
2011-08-09 |
2023-08-12 |
Not clear |
| C E Krewson, W M Saltzma. Nerve growth factor delivery and cell aggregation enhance choline acetyltransferase activity after neural transplantation. Tissue engineering. vol 2. issue 3. 2011-07-14. PMID:19877941. |
in some cases, transplanted cells were supplied with nerve growth factor (ngf), a neurotrophin known to promote the survival and function of septal cholinergic cells; ngf was delivered to the transplant site by controlled-release polymers or genetically engineered fibroblasts. |
2011-07-14 |
2023-08-12 |
rat |
| Oscar M Lazo, Jocelyn C Mauna, Claudia A Pissani, Nibaldo C Inestrosa, Francisca C Bronfma. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:20205865. |
axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of ngf signalling, but not death of septal cholinergic neurons. |
2011-07-14 |
2023-08-12 |
rat |
| Oscar M Lazo, Jocelyn C Mauna, Claudia A Pissani, Nibaldo C Inestrosa, Francisca C Bronfma. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:20205865. |
disruption of the septo-hippocampal pathway by an experimental transection of the fimbria-fornix drastically reduces the target-derived trophic support received by cholinergic septal neurons, mainly nerve growth factor (ngf) from the hippocampus. |
2011-07-14 |
2023-08-12 |
rat |
| Oscar M Lazo, Jocelyn C Mauna, Claudia A Pissani, Nibaldo C Inestrosa, Francisca C Bronfma. Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:20205865. |
understanding the mechanism of cholinergic neurodegeneration after axotomy is relevant, since this paradigm has been extensively explored as an animal model of the cholinergic impairment observed in neuropathologies such as alzheimer's disease.the principal aim of this study was to evaluate, using modern quantitative confocal microscopy, neurodegenerative changes in septal cholinergic neurons after axotomy and to assess their response to delayed infusion of ngf in rats. |
2011-07-14 |
2023-08-12 |
rat |
| E Formaggio, A C Dalfini, F Fazzini, G Fumagalli, C Chiamuler. GABAergic neurons expressing p75 in rat substantia innominata and nucleus basalis. Molecular and cellular neurosciences. vol 46. issue 3. 2011-06-16. PMID:21238591. |
ngf increased p75 expression exclusively in cholinergic neurons, whereas bdnf induced p75 expression only in a subset of gabaergic neurons (p75(+)/gad67(+)/chat(-)) through a p75- and tyrosine-kinase-dependent mechanism. |
2011-06-16 |
2023-08-12 |
rat |