| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lone Fjord-Larsen, Philip Kusk, Jens Tornøe, Bengt Juliusson, Malene Torp, Carsten R Bjarkam, Mette S Nielsen, Aase Handberg, Jens Christian H Sørensen, Lars U Wahlber. Long-term delivery of nerve growth factor by encapsulated cell biodelivery in the Göttingen minipig basal forebrain. Molecular therapy : the journal of the American Society of Gene Therapy. vol 18. issue 12. 2011-04-18. PMID:20664524. |
nerve growth factor (ngf) prevents cholinergic degeneration in alzheimer's disease (ad) and improves memory in ad animal models. |
2011-04-18 |
2023-08-12 |
human |
| Michael Pirchl, Celine Ullrich, Christian Humpe. Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats. The European journal of neuroscience. vol 32. issue 9. 2011-02-23. PMID:21044172. |
in conclusion, our data demonstrate that chronic short- and long-term hhcy differentially caused memory impairment, cholinergic dysfunction, ngf expression and vascular microbleedings. |
2011-02-23 |
2023-08-12 |
rat |
| Gry Houeland, Armando Romani, Cristina Marchetti, Gianluca Amato, Simona Capsoni, Antonino Cattaneo, Hélène Mari. Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 39. 2010-10-25. PMID:20881126. |
the "neurotrophic unbalance" hypothesis, on the other hand, states that ad-related loss of cholinergic signaling and altered app processing are due to alterations in nerve growth factor (ngf) trophic support. |
2010-10-25 |
2023-08-12 |
mouse |
| Simona Capsoni, Cecilia Tiveron, Gianluca Amato, Domenico Vignone, Antonino Cattane. Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182028. |
we previously showed that anti-nerve growth factor (ngf) antibodies expressed in transgenic mice (ad11) elicit a progressive neurodegeneration, comprising the triad of alzheimer's disease (ad) hallmarks: cholinergic loss, tau hyperphosphorylation, and amyloid-beta peptide formation. |
2010-09-07 |
2023-08-12 |
mouse |
| Simona Capsoni, Cecilia Tiveron, Gianluca Amato, Domenico Vignone, Antonino Cattane. Peripheral neutralization of nerve growth factor induces immunosympathectomy and central neurodegeneration in transgenic mice. Journal of Alzheimer's disease : JAD. vol 20. issue 2. 2010-09-07. PMID:20182028. |
consistently, peripherally-delivered ngf is effective in preventing the onset of the central cholinergic deficit. |
2010-09-07 |
2023-08-12 |
mouse |
| Simona Capsoni, Cecilia Tiveron, Domenico Vignone, Gianluca Amato, Antonino Cattane. Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 27. 2010-08-30. PMID:20566851. |
ngf, the principal neurotrophic factor for basal forebrain cholinergic neurons (bfcns), has been correlated to alzheimer's disease (ad) because of the selective vulnerability of bfcns in ad. |
2010-08-30 |
2023-08-12 |
mouse |
| Simona Capsoni, Cecilia Tiveron, Domenico Vignone, Gianluca Amato, Antonino Cattane. Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 27. 2010-08-30. PMID:20566851. |
a demonstration that neutralizing ngf activity could have consequences beyond a direct interference with the cholinergic system came from studies in the ad11 mouse model, in which the expression of a highly specific anti-ngf antibody determines a neurodegeneration that encompasses several features of human ad. |
2010-08-30 |
2023-08-12 |
mouse |
| Aletta C Schnitzler, Tiffany J Mellott, Ignacio Lopez-Coviella, Yvonne N Tallini, Michael I Kotlikoff, Maximillian T Follettie, Jan Krzysztof Blusztaj. BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 24. 2010-07-02. PMID:20554873. |
bmp9 (bone morphogenetic protein 9) induces ngf as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. |
2010-07-02 |
2023-08-12 |
Not clear |
| Aletta C Schnitzler, Tiffany J Mellott, Ignacio Lopez-Coviella, Yvonne N Tallini, Michael I Kotlikoff, Maximillian T Follettie, Jan Krzysztof Blusztaj. BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 24. 2010-07-02. PMID:20554873. |
cholinergic neurons were isolated by fluorescence-activated cell sorting based on either transgenic expression of green fluorescent protein driven by the chat promoter or ngf receptor (p75) immunostaining. |
2010-07-02 |
2023-08-12 |
Not clear |
| Aletta C Schnitzler, Tiffany J Mellott, Ignacio Lopez-Coviella, Yvonne N Tallini, Michael I Kotlikoff, Maximillian T Follettie, Jan Krzysztof Blusztaj. BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 24. 2010-07-02. PMID:20554873. |
although both noncholinergic and cholinergic neurons in untreated cultures expressed similar low levels of ngf, increased ngf gene expression was restricted to chat-positive neurons in bmp9-treated cultures. |
2010-07-02 |
2023-08-12 |
Not clear |
| Ronald J Mande. CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease. Current opinion in molecular therapeutics. vol 12. issue 2. 2010-06-15. PMID:20373268. |
it is well established that nerve growth factor (ngf) enhances the function and survival of basal forebrain cholinergic neurons that are vulnerable in ad. |
2010-06-15 |
2023-08-12 |
human |
| M I Cocket. CRIB (NGF delivery) Cyto Therapeutics Inc. IDrugs : the investigational drugs journal. vol 1. issue 3. 2010-06-09. PMID:18465562. |
the devices contained baby hamster kidney fibroblasts (genetically modified to secrete human ngf) and were implanted into brain ventricles of elderly rhesus monkeys whose cholinergic neurons had been cut. |
2010-06-09 |
2023-08-12 |
human |
| E Formaggio, F Fazzini, A C Dalfini, M Di Chio, C Cantù, I Decimo, Z Fiorini, G Fumagalli, C Chiamuler. Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. vol 166. issue 2. 2010-05-03. PMID:20056136. |
in this study, we investigated whether the potential positive effects of nicotine in alzheimer's disease (ad) may involve neurotrophic factors, such as nerve growth factor (ngf), closely associated with basal forebrain (bf) cholinergic function and survival. |
2010-05-03 |
2023-08-12 |
rat |
| E Formaggio, F Fazzini, A C Dalfini, M Di Chio, C Cantù, I Decimo, Z Fiorini, G Fumagalli, C Chiamuler. Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. vol 166. issue 2. 2010-05-03. PMID:20056136. |
to this aim, we studied the effects of prolonged nicotine treatment on neurotrophin receptors expression and on ngf protein levels in the rat bf cholinergic circuitry. |
2010-05-03 |
2023-08-12 |
rat |
| E Formaggio, F Fazzini, A C Dalfini, M Di Chio, C Cantù, I Decimo, Z Fiorini, G Fumagalli, C Chiamuler. Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. vol 166. issue 2. 2010-05-03. PMID:20056136. |
neutralization experiments with an anti-ngf antibody showed that ngf presence was not necessary for nicotine-induced increase of trka levels in cultured cholinergic neurons, suggesting that nicotine may act through ngf-independent mechanisms. |
2010-05-03 |
2023-08-12 |
rat |
| E Formaggio, F Fazzini, A C Dalfini, M Di Chio, C Cantù, I Decimo, Z Fiorini, G Fumagalli, C Chiamuler. Nicotine increases the expression of neurotrophin receptor tyrosine kinase receptor A in basal forebrain cholinergic neurons. Neuroscience. vol 166. issue 2. 2010-05-03. PMID:20056136. |
this study shows that nicotine, independently of its action on ngf levels, may contribute to the restoration of the trophic support to bf cholinergic neurons by increasing trka levels. |
2010-05-03 |
2023-08-12 |
rat |
| A Claudio Cuello, Martin A Bruno, Simon Allard, Wanda Leon, M Florencia Iulit. Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19680822. |
basal forebrain cholinergic neurons are highly dependent on nerve growth factor (ngf) supply for the maintenance of their cholinergic phenotype as well as their cholinergic synaptic integrity. |
2010-04-21 |
2023-08-12 |
Not clear |
| A Claudio Cuello, Martin A Bruno, Simon Allard, Wanda Leon, M Florencia Iulit. Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19680822. |
in this short review, we describe this ngf metabolic pathway, its significance for the maintenance of basal cholinergic neurons, and its dysregulation in alzheimer's disease. |
2010-04-21 |
2023-08-12 |
Not clear |
| A Claudio Cuello, Martin A Bruno, Simon Allard, Wanda Leon, M Florencia Iulit. Cholinergic involvement in Alzheimer's disease. A link with NGF maturation and degradation. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19680822. |
these combined effects on ngf metabolism would explain the well-known cholinergic atrophy found in alzheimer's disease and would offer new therapeutic opportunities aimed at correcting the ngf dysmetabolism along with abeta-induced inflammatory responses. |
2010-04-21 |
2023-08-12 |
Not clear |
| Danny Böttger, Celine Ullrich, Christian Humpe. Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. Brain research. vol 1312. 2010-03-25. PMID:20004179. |
nerve growth factor (ngf) is the most potent protein to protect cholinergic neurons against degeneration. |
2010-03-25 |
2023-08-12 |
rat |