| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathrin M Kniewallner, Natalia Grimm, Christian Humpe. Platelet-derived nerve growth factor supports the survival of cholinergic neurons in organotypic rat brain slices. Neuroscience letters. vol 574. 2014-12-18. PMID:24861506. |
since ngf is the most potent growth factor to support survival of cholinergic neurons, we aimed to study the effects of platelet-derived ngf on cholinergic neurons in organotypic brain slices. |
2014-12-18 |
2023-08-13 |
rat |
| Kathrin M Kniewallner, Natalia Grimm, Christian Humpe. Platelet-derived nerve growth factor supports the survival of cholinergic neurons in organotypic rat brain slices. Neuroscience letters. vol 574. 2014-12-18. PMID:24861506. |
our data show that recombinant ngf markedly supports survival of cholinergic neurons. |
2014-12-18 |
2023-08-13 |
rat |
| Kazuyo Tujioka, Panicha Thanapreedawat, Takashi Yamada, Hidehiko Yokogoshi, Kenji Horie, Mujo Kim, Kazumi Tsutsui, Kazutoshi Hayas. Effect of dietary γ-aminobutyric acid on the nerve growth factor and the choline acetyltransferase in the cerebral cortex and hippocampus of ovariectomized female rats. Journal of nutritional science and vitaminology. vol 60. issue 1. 2014-12-11. PMID:24759261. |
the brain protein synthesis and the plasma concentration of growth hormone (gh) is sensitive to the dietary γ-aminobutyric acid (gaba) in ovariectomized female rats; however, the role of dietary gaba on biomarkers including nerve growth factor (ngf) and choline acetyltransferase for the function of cholinergic neurons remains unknown in ovariectomized female rats. |
2014-12-11 |
2023-08-13 |
rat |
| B Yegla, V Parik. Effects of sustained proNGF blockade on attentional capacities in aged rats with compromised cholinergic system. Neuroscience. vol 261. 2014-09-19. PMID:24374328. |
disruption in nerve growth factor (ngf) signaling via tropomyosin-related kinase a (trka) receptors compromises the integrity of the basal forebrain (bf) cholinergic system, yielding cognitive, specifically attentional, impairments in alzheimer's disease (ad). |
2014-09-19 |
2023-08-12 |
rat |
| Hongyu Zhang, Géraldine H Petit, Philip M Gaughwin, Christian Hansen, Srikanth Ranganathan, Xiaoyi Zuo, Ruben Smith, Laurent Roybon, Patrik Brundin, William C Mobley, Jia-Yi L. NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease. Journal of Huntington's disease. vol 2. issue 1. 2014-09-08. PMID:25063430. |
ngf rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of huntington's disease. |
2014-09-08 |
2023-08-13 |
mouse |
| Hongyu Zhang, Géraldine H Petit, Philip M Gaughwin, Christian Hansen, Srikanth Ranganathan, Xiaoyi Zuo, Ruben Smith, Laurent Roybon, Patrik Brundin, William C Mobley, Jia-Yi L. NGF rescues hippocampal cholinergic neuronal markers, restores neurogenesis, and improves the spatial working memory in a mouse model of Huntington's Disease. Journal of Huntington's disease. vol 2. issue 1. 2014-09-08. PMID:25063430. |
nerve growth factor (ngf) is an essential regulator of cholinergic neuronal survival and neurotransmission. |
2014-09-08 |
2023-08-13 |
mouse |
| Jeremy Biane, James M Conner, Mark H Tuszynsk. Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Frontiers in cellular neuroscience. vol 8. 2014-08-22. PMID:25147503. |
within the cortex, nerve growth factor (ngf) mediates the innervation of cholinergic neurons during development, maintains cholinergic corticopetal projections during adulthood and modulates cholinergic function through phenotypic control of the cholinergic gene locus. |
2014-08-22 |
2023-08-13 |
rat |
| Jeremy Biane, James M Conner, Mark H Tuszynsk. Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Frontiers in cellular neuroscience. vol 8. 2014-08-22. PMID:25147503. |
classification of cells producing ngf in the cortex is lacking, however, and cholinergic corticopetal projections have been shown to innervate both pyramidal and gabaergic neurons in the cortex. |
2014-08-22 |
2023-08-13 |
rat |
| Jeremy Biane, James M Conner, Mark H Tuszynsk. Nerve growth factor is primarily produced by GABAergic neurons of the adult rat cortex. Frontiers in cellular neuroscience. vol 8. 2014-08-22. PMID:25147503. |
these findings demonstrate that gabaergic cells are the primary source of ngf production in the cortex, and likely support the maintenance and function of basal forebrain cholinergic projections in adulthood. |
2014-08-22 |
2023-08-13 |
rat |
| Amy R Nelson, Krystyna Kolasa, Lori L McMaho. Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AβPP. Journal of Alzheimer's disease : JAD. vol 38. issue 4. 2014-08-17. PMID:24081376. |
hippocampal cholinergic denervation disrupts retrograde nerve growth factor (ngf) transport, leading to its accumulation, which subsequently triggers sprouting of noradrenergic sympathetic fibers from the superior cervical ganglia into hippocampus. |
2014-08-17 |
2023-08-12 |
human |
| Amy R Nelson, Krystyna Kolasa, Lori L McMaho. Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AβPP. Journal of Alzheimer's disease : JAD. vol 38. issue 4. 2014-08-17. PMID:24081376. |
we found that ngf stimulates sprouting, that sprouting maintains non-amyloidogenic aβpp processing, and that aβ42 is not only toxic to central cholinergic fibers innervating hippocampus but it prevents and reverses noradrenergic sympathetic sprouting and the accompanying cholinergic reinnervation. |
2014-08-17 |
2023-08-12 |
human |
| Gloria Roberti, Flavio Mantelli, Ilaria Macchi, Mina Massaro-Giordano, Marco Centofant. Nerve growth factor modulation of retinal ganglion cell physiology. Journal of cellular physiology. vol 229. issue 9. 2014-07-19. PMID:24501088. |
additionally, ngf is known to have trophic and differentiating activity on several populations of cholinergic neurons of the central nervous system (cns), and to act as a differentiation factor in the development of the visual cortex. |
2014-07-19 |
2023-08-12 |
Not clear |
| Puei-Lene Lai, Murali Naidu, Vikineswary Sabaratnam, Kah-Hui Wong, Rosie Pamela David, Umah Rani Kuppusamy, Noorlidah Abdullah, Sri Nurestri A Male. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International journal of medicinal mushrooms. vol 15. issue 6. 2014-06-26. PMID:24266378. |
nerve growth factor (ngf) is essential for the maintenance of the basal forebrain cholinergic system. |
2014-06-26 |
2023-08-12 |
human |
| Claudia Fantacci, Domenico Capozzi, Pietro Ferrara, Antonio Chiarett. Neuroprotective role of nerve growth factor in hypoxic-ischemic brain injury. Brain sciences. vol 3. issue 3. 2014-06-25. PMID:24961518. |
the improvement in motor and cognitive functions of these children could be related to the neuroprotective role exerted by ngf in residual viable cholinergic neurons, leading to the restoration of neuronal networks in the damaged brain. |
2014-06-25 |
2023-08-13 |
Not clear |
| Mostofa Jamal, Kiyoshi Ameno, Mostofa Ruby, Takanori Miki, Naoko Tanaka, Yu Nakamura, Hiroshi Kinoshit. Ethanol- and acetaldehyde-induced cholinergic imbalance in the hippocampus of Aldh2-knockout mice does not affect nerve growth factor or brain-derived neurotrophic factor. Brain research. vol 1539. 2014-06-20. PMID:24096209. |
our observations suggest that administration of etoh and elevated ach can alter cholinergic markers in the hippocampus of mice, and this effect did not change the levels of ngf or bdnf. |
2014-06-20 |
2023-08-12 |
mouse |
| M Florencia Iulita, Sonia Do Carmo, Alison K Ower, Ashley M Fortress, Lisi Flores Aguilar, Michael Hanna, Thomas Wisniewski, Ann-Charlotte Granholm, Mona Buhusi, Jorge Busciglio, A Claudio Cuell. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain : a journal of neurology. vol 137. issue Pt 3. 2014-05-26. PMID:24519975. |
our results indicate a failure in ngf precursor maturation in down's syndrome brains and a likely enhanced proteolytic degradation of ngf, changes which can compromise the trophic support of basal forebrain cholinergic neurons. |
2014-05-26 |
2023-08-12 |
mouse |
| Carmela Matron. A new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor protein. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 35. issue 10. 2014-04-21. PMID:23943322. |
mutation of tyr682 induces an early and progressive age-dependent cognitive and locomotor decline that is associated with a loss of synaptic connections, a decrease in cholinergic tone, and defects in ngf signaling. |
2014-04-21 |
2023-08-12 |
Not clear |
| Takeyasu Tomioka, Takuya Shimazaki, Toshihiko Yamauchi, Toru Oki, Makoto Ohgoh, Hideyuki Okan. LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop. The Journal of biological chemistry. vol 289. issue 2. 2014-04-08. PMID:24265310. |
together, our findings suggest that positive feedback regulation between lhx8, trka, and ngf is an important regulatory mechanism for cholinergic functions of the septum. |
2014-04-08 |
2023-08-12 |
rat |
| Dongsun Park, Yun-Hui Yang, Dae Kwon Bae, Sun Hee Lee, Goeun Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Seong Won Lee, Gon Hyung Kim, Jin Tae Hong, Kyung-Chul Choi, Hong Jun Lee, Seung U Kim, Yun-Bae Ki. Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23731954. |
transplantation of the stem cells increased brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf), enhanced expression of trk b, and restored host microtubule-associated protein 2 and cholinergic nervous system. |
2014-03-05 |
2023-08-12 |
mouse |
| Dongsun Park, Yun-Hui Yang, Dae Kwon Bae, Sun Hee Lee, Goeun Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Seong Won Lee, Gon Hyung Kim, Jin Tae Hong, Kyung-Chul Choi, Hong Jun Lee, Seung U Kim, Yun-Bae Ki. Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23731954. |
the results demonstrate that human nscs over-expressing chat improve cognitive function and physical activity of aging mice, not only by producing ach directly but also by restoring cholinergic neuronal integrity, which might be mediated by neurotrophins bdnf and ngf. |
2014-03-05 |
2023-08-12 |
mouse |