| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danny Böttger, Celine Ullrich, Christian Humpe. Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. Brain research. vol 1312. 2010-03-25. PMID:20004179. |
the aim of the present study was to test, if primary rat monocytes can be loaded with recombinant ngf and pass an in vitro monolayer of brain capillary endothelial cells (bcec), release ngf, and support the cholinergic neurons in an organotypic brain slice model. |
2010-03-25 |
2023-08-12 |
rat |
| Danny Böttger, Celine Ullrich, Christian Humpe. Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. Brain research. vol 1312. 2010-03-25. PMID:20004179. |
ngf released at the basolateral side counteracted degeneration of cholinergic basal nucleus of meynert neurons. |
2010-03-25 |
2023-08-12 |
rat |
| Eunjung Moon, Youngjin Her, Jung Bok Lee, Ji-Ho Park, Eunjoo H Lee, Sung-Hoon Kim, Myung Sook Oh, Choon-Gon Jang, Sun Yeou Ki. The multi-herbal medicine Gongjin-dan enhances memory and learning tasks via NGF regulation. Neuroscience letters. vol 466. issue 3. 2010-01-14. PMID:19788912. |
nerve growth factor (ngf) decreases degeneration of cholinergic neurons, improves memory loss, and increases long-term potentiation and learning tasks. |
2010-01-14 |
2023-08-12 |
mouse |
| Martin A Bruno, Elliott J Mufson, Joanne Wuu, A Claudio Cuell. Increased matrix metalloproteinase 9 activity in mild cognitive impairment. Journal of neuropathology and experimental neurology. vol 68. issue 12. 2009-12-22. PMID:19915485. |
nerve growth factor (ngf)-dependent cholinergic basal forebrain neurons degenerate during the progression of alzheimer disease (ad). |
2009-12-22 |
2023-08-12 |
human |
| Valeria Colafrancesco, Francesca Cirulli, Simona Rossi, Alessandra Berry, Luigi Alo. Anti-NGF-antibody administration as collyrium reduces the presence of NGF and enhances the expression of VEGF in the retina, lacrimal gland and hippocampus. Neuroscience letters. vol 463. issue 3. 2009-12-11. PMID:19651190. |
moreover, ana treatment reduced the number of basal forebrain neurons expressing choline acetyltransferase, chat, a cholinergic enzyme regulated by ngf. |
2009-12-11 |
2023-08-12 |
mouse |
| Raheleh Masoudi, Maria S Ioannou, Michael D Coughlin, Promila Pagadala, Kenneth E Neet, Oliver Clewes, Shelley J Allen, David Dawbarn, Margaret Fahnestoc. Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. The Journal of biological chemistry. vol 284. issue 27. 2009-10-27. PMID:19389705. |
in alzheimer disease brain, cholinergic neurons degenerate and can no longer transport ngf as efficiently, leading to an increase in untransported ngf in the target tissue. |
2009-10-27 |
2023-08-12 |
Not clear |
| Kamila B Kurakhmaeva, Irma A Djindjikhashvili, Valery E Petrov, Vadim U Balabanyan, Tatiana A Voronina, Sergey S Trofimov, Jörg Kreuter, Svetlana Gelperina, David Begley, Renad N Alyautdi. Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles. Journal of drug targeting. vol 17. issue 8. 2009-10-26. PMID:19694610. |
the nerve growth factor (ngf) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons in the basal forebrain. |
2009-10-26 |
2023-08-12 |
rat |
| Kamila B Kurakhmaeva, Irma A Djindjikhashvili, Valery E Petrov, Vadim U Balabanyan, Tatiana A Voronina, Sergey S Trofimov, Jörg Kreuter, Svetlana Gelperina, David Begley, Renad N Alyautdi. Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles. Journal of drug targeting. vol 17. issue 8. 2009-10-26. PMID:19694610. |
the accelerated loss of central cholinergic neurons during alzheimer's disease may be a determinant cause of dementia, and this observation may suggest a possible therapeutic benefit from treatment with ngf. |
2009-10-26 |
2023-08-12 |
rat |
| James M Conner, Kevin M Franks, Andrea K Titterness, Kyle Russell, David A Merrill, Brian R Christie, Terrence J Sejnowski, Mark H Tuszynsk. NGF is essential for hippocampal plasticity and learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 35. 2009-09-21. PMID:19726646. |
nerve growth factor (ngf) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. |
2009-09-21 |
2023-08-12 |
rat |
| James M Conner, Kevin M Franks, Andrea K Titterness, Kyle Russell, David A Merrill, Brian R Christie, Terrence J Sejnowski, Mark H Tuszynsk. NGF is essential for hippocampal plasticity and learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 35. 2009-09-21. PMID:19726646. |
to explore ngf modulation of hippocampal plasticity and function, ngf levels were augmented or blocked in intact adult rats, and subsequent in vivo effects on cholinergic neurons, hippocampal long-term potentiation (ltp), and learning were examined. |
2009-09-21 |
2023-08-12 |
rat |
| James M Conner, Kevin M Franks, Andrea K Titterness, Kyle Russell, David A Merrill, Brian R Christie, Terrence J Sejnowski, Mark H Tuszynsk. NGF is essential for hippocampal plasticity and learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 35. 2009-09-21. PMID:19726646. |
ngf augmentation significantly enhanced cholinergic neuronal markers and facilitated induction of hippocampal ltp. |
2009-09-21 |
2023-08-12 |
rat |
| Martin A Bruno, Wanda C Leon, Gabriela Fragoso, Walter E Mushynski, Guillermina Almazan, A Claudio Cuell. Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 68. issue 8. 2009-09-01. PMID:19606067. |
the effects of amyloid-beta amyloid cns burden on ngf metabolism may explain the paradoxical upregulation of pro-ngf in ad accompanied by atrophy of forebrain cholinergic neurons. |
2009-09-01 |
2023-08-12 |
mouse |
| Sonia Covaceuszach, Simona Capsoni, Gatsuella Ugolini, F Spirito, D Vignone, Antonio Cattane. Development of a non invasive NGF-based therapy for Alzheimer's disease. Current Alzheimer research. vol 6. issue 2. 2009-06-22. PMID:19355851. |
nerve growth factor (ngf) deficits are linked to alzheimer's disease (ad), due to the role of ngf on basal forebrain cholinergic neurons (bfcn). |
2009-06-22 |
2023-08-12 |
mouse |
| Sonia Covaceuszach, Simona Capsoni, Gatsuella Ugolini, F Spirito, D Vignone, Antonio Cattane. Development of a non invasive NGF-based therapy for Alzheimer's disease. Current Alzheimer research. vol 6. issue 2. 2009-06-22. PMID:19355851. |
the therapeutic potential of using human ngf to provide a long-lasting cholinergic trophic support, thereby preventing or slowing cognitive decline in ad patients, has therefore a strong rationale. |
2009-06-22 |
2023-08-12 |
mouse |
| Alan H Nagahara, Tim Bernot, Rod Moseanko, Laurie Brignolo, Armin Blesch, James M Conner, Anthony Ramirez, Mehdi Gasmi, Mark H Tuszynsk. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Experimental neurology. vol 215. issue 1. 2009-04-08. PMID:19013154. |
long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral ngf gene delivery. |
2009-04-08 |
2023-08-12 |
human |
| Alan H Nagahara, Tim Bernot, Rod Moseanko, Laurie Brignolo, Armin Blesch, James M Conner, Anthony Ramirez, Mehdi Gasmi, Mark H Tuszynsk. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Experimental neurology. vol 215. issue 1. 2009-04-08. PMID:19013154. |
we tested the hypothesis that long-term lentiviral ngf intraparenchymal gene delivery would reverse age-related cholinergic decline, without induction of adverse effects previously observed following sustained intracerebroventricular growth factor protein exposure. |
2009-04-08 |
2023-08-12 |
human |
| Alan H Nagahara, Tim Bernot, Rod Moseanko, Laurie Brignolo, Armin Blesch, James M Conner, Anthony Ramirez, Mehdi Gasmi, Mark H Tuszynsk. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Experimental neurology. vol 215. issue 1. 2009-04-08. PMID:19013154. |
three aged rhesus monkeys underwent intraparenchymal lentiviral ngf gene delivery to the cholinergic basal forebrain. |
2009-04-08 |
2023-08-12 |
human |
| Alan H Nagahara, Tim Bernot, Rod Moseanko, Laurie Brignolo, Armin Blesch, James M Conner, Anthony Ramirez, Mehdi Gasmi, Mark H Tuszynsk. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Experimental neurology. vol 215. issue 1. 2009-04-08. PMID:19013154. |
we now report that lentiviral gene delivery of ngf to the aged primate basal forebrain sustains gene expression for at least 1 year, and significantly restores cholinergic neuronal markers to levels of young monkeys. |
2009-04-08 |
2023-08-12 |
human |
| Alan H Nagahara, Tim Bernot, Rod Moseanko, Laurie Brignolo, Armin Blesch, James M Conner, Anthony Ramirez, Mehdi Gasmi, Mark H Tuszynsk. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Experimental neurology. vol 215. issue 1. 2009-04-08. PMID:19013154. |
similarly, the size of cholinergic neurons in aged monkeys was significantly reduced by 16% compared to young subjects (p<0.05), and lentiviral ngf delivery to aged subjects induced complete recovery of neuronal size. |
2009-04-08 |
2023-08-12 |
human |
| Alan H Nagahara, Tim Bernot, Rod Moseanko, Laurie Brignolo, Armin Blesch, James M Conner, Anthony Ramirez, Mehdi Gasmi, Mark H Tuszynsk. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Experimental neurology. vol 215. issue 1. 2009-04-08. PMID:19013154. |
these findings also support the safety and feasibility of lentiviral ngf gene transfer for potential testing in human clinical trials to protect degenerating cholinergic neurons in alzheimer's disease. |
2009-04-08 |
2023-08-12 |
human |