| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong J Lee, In J Lim, Seung W Park, Yun B Kim, Yong Ko, Seung U Ki. Human neural stem cells genetically modified to express human nerve growth factor (NGF) gene restore cognition in the mouse with ibotenic acid-induced cognitive dysfunction. Cell transplantation. vol 21. issue 11. 2013-11-01. PMID:22526467. |
nerve growth factor (ngf) therapy has been proposed as a potential treatment of preventing degeneration of basal forebrain cholinergic neurons in ad. |
2013-11-01 |
2023-08-12 |
mouse |
| Hong J Lee, In J Lim, Seung W Park, Yun B Kim, Yong Ko, Seung U Ki. Human neural stem cells genetically modified to express human nerve growth factor (NGF) gene restore cognition in the mouse with ibotenic acid-induced cognitive dysfunction. Cell transplantation. vol 21. issue 11. 2013-11-01. PMID:22526467. |
in a previous study, ad patient's own fibroblasts genetically modified to produce ngf were transplanted directly into the brain and protected cholinergic neurons from degeneration and improved cognitive function in ad patients. |
2013-11-01 |
2023-08-12 |
mouse |
| Antonino Cattaneo, Pietro Calissan. Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis. Molecular neurobiology. vol 46. issue 3. 2013-07-30. PMID:22940884. |
initially connected to ad on a purely correlative basis, because of its neurotrophic actions on basal forebrain cholinergic neurons, two independent lines of research, reviewed in this article, place alterations of ngf processing and signaling at the center stage of a new mechanism, leading to the activation of amyloidogenesis and tau processing. |
2013-07-30 |
2023-08-12 |
mouse |
| Antonino Cattaneo, Pietro Calissan. Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis. Molecular neurobiology. vol 46. issue 3. 2013-07-30. PMID:22940884. |
according to the new ngf hypothesis for ad, therapies aimed at reestablishing a correct homeostatic balance between ligands (and receptors) of the ngf pathway appear to have a clear and strong rationale, not just as long-term cholinergic neuroprotection, but also as a truly disease-modifying approach. |
2013-07-30 |
2023-08-12 |
mouse |
| Vinay Parikh, William M Howe, Ryan M Welchko, Sean X Naughton, Drew E D'Amore, Daniel H Han, Monika Deo, David L Turner, Martin Sarte. Diminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23228124. |
furthermore, age-related increases in cortical prongf and p75 receptor levels interacted with the vector-induced loss of trka receptors to shift ngf signaling toward p75-mediated suppression of the cholinergic phenotype, thereby attenuating cholinergic function and impairing attentional performance. |
2013-06-27 |
2023-08-12 |
rat |
| Maria Luisa Rocco, Andrea Pristerà, Luana Pistillo, Luigi Aloe, Nadia Canu, Luigi Mann. Brain cholinergic markers and Tau phosphorylation are altered in experimental type 1 diabetes: normalization by electroacupuncture. Journal of Alzheimer's disease : JAD. vol 33. issue 3. 2013-06-25. PMID:23001708. |
both are associated with brain cholinergic dysfunction that could benefit from nerve growth factor (ngf)-based therapies. |
2013-06-25 |
2023-08-12 |
rat |
| Maria Luisa Rocco, Andrea Pristerà, Luana Pistillo, Luigi Aloe, Nadia Canu, Luigi Mann. Brain cholinergic markers and Tau phosphorylation are altered in experimental type 1 diabetes: normalization by electroacupuncture. Journal of Alzheimer's disease : JAD. vol 33. issue 3. 2013-06-25. PMID:23001708. |
we found that ea counteracts diabetes-associated tau hyperphosphorylation and decreases in ngf and choline acetyltransferase, suggesting a possible beneficial effect of ea on brain cholinergic system in diabetes. |
2013-06-25 |
2023-08-12 |
rat |
| Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi, Luigi Mann. Nerve growth factor: from the early discoveries to the potential clinical use. Journal of translational medicine. vol 10. 2013-06-25. PMID:23190582. |
from a translational standpoint, the action of ngf on cholinergic neurons of the basal forebrain and on sensory neurons in dorsal root ganglia first gained researcher's attention, in view of possible clinical use in alzheimer's disease patients and in peripheral neuropathies respectively. |
2013-06-25 |
2023-08-12 |
Not clear |
| Lindsay A Hohsfield, Stephan Geley, Markus Reindl, Christian Humpe. The generation of NGF-secreting primary rat monocytes: a comparison of different transfer methods. Journal of immunological methods. vol 391. issue 1-2. 2013-06-06. PMID:23474426. |
nerve growth factor (ngf), a member of the neurotrophin family, is responsible for the maintenance and survival of cholinergic neurons in the basal forebrain. |
2013-06-06 |
2023-08-12 |
rat |
| Lindsay A Hohsfield, Stephan Geley, Markus Reindl, Christian Humpe. The generation of NGF-secreting primary rat monocytes: a comparison of different transfer methods. Journal of immunological methods. vol 391. issue 1-2. 2013-06-06. PMID:23474426. |
thus far, ngf has proven the most potent neuroprotective molecule against cholinergic neurodegeneration. |
2013-06-06 |
2023-08-12 |
rat |
| Stefano Pieretti, Marica Mastriota, Paolo Tucci, Giuseppe Battaglia, Luigia Trabace, Ferdinando Nicoletti, Sergio Scaccianoc. Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rats. Medicine and science in sports and exercise. vol 45. issue 1. 2013-05-17. PMID:22895368. |
hence, we decided to study the effect of chronic aas exposure on brain ngf profile, ngf-dependent cholinergic function, and related behavioral performance. |
2013-05-17 |
2023-08-12 |
rat |
| Erik Keimpema, Giuseppe Tortoriello, Alán Alpár, Simona Capsoni, Ivan Arisi, Daniela Calvigioni, Sherry Shu-Jung Hu, Antonino Cattaneo, Patrick Doherty, Kenneth Mackie, Tibor Harkan. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 5. 2013-05-03. PMID:23319656. |
we show that nerve growth factor (ngf), implicated in the morphogenesis and survival of cholinergic projection neurons, dose-dependently and coordinately regulates the molecular machinery for 2-ag signaling via tropomyosine kinase a receptors in vitro. |
2013-05-03 |
2023-08-12 |
Not clear |
| Erik Keimpema, Giuseppe Tortoriello, Alán Alpár, Simona Capsoni, Ivan Arisi, Daniela Calvigioni, Sherry Shu-Jung Hu, Antonino Cattaneo, Patrick Doherty, Kenneth Mackie, Tibor Harkan. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 5. 2013-05-03. PMID:23319656. |
these data indicate that ngf can orchestrate endocannabinoid signaling to promote cholinergic differentiation and implicate brca1 in determining neuronal morphology. |
2013-05-03 |
2023-08-12 |
Not clear |
| Carmela Matrone, Siro Luvisetto, Luca R La Rosa, Robert Tamayev, Annabella Pignataro, Nadia Canu, Li Yang, Alessia P M Barbagallo, Fabrizio Biundo, Franco Lombino, Hui Zheng, Martine Ammassari-Teule, Luciano D'Adami. Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging cell. vol 11. issue 6. 2013-04-18. PMID:23020178. |
these data are consistent with our previous findings linking ngf and app signaling and suggest a causal relationship between altered synaptic connectivity, cholinergic tone depression and trka signaling deficit, and cognitive and neuromuscular decline in app(yg/yg) mice. |
2013-04-18 |
2023-08-12 |
mouse |
| Bingbing Song, Jinsuk Song, Shanshan Zhang, Mark A Anderson, Yan Ao, Chu-Ya Yang, Timothy J Deming, Michael V Sofronie. Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots. Biomaterials. vol 33. issue 35. 2013-03-22. PMID:22985994. |
to evaluate bioactive protein delivery in vivo, we used nerve growth factor (ngf) and measured the size of mouse forebrain cholinergic neurons, which respond to ngf with cellular hypertrophy. |
2013-03-22 |
2023-08-12 |
mouse |
| Bingbing Song, Jinsuk Song, Shanshan Zhang, Mark A Anderson, Yan Ao, Chu-Ya Yang, Timothy J Deming, Michael V Sofronie. Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots. Biomaterials. vol 33. issue 35. 2013-03-22. PMID:22985994. |
in comparison with ngf injected in buffer, depots of ngf dissolved in either k(180)l(20) or e(180)l(20) provided significantly longer delivery of ngf bioactivity, maintaining hypertrophy of local forebrain cholinergic neurons for at least 4 weeks and inducing hypertrophy a further distance away (up to 5 mm) from injection sites. |
2013-03-22 |
2023-08-12 |
mouse |
| b' Lucia Lichv\\xc3\\xa1rov\\xc3\\xa1, Katar\\xc3\\xadna Ja\\xc5\\xa1kov\\xc3\\xa1, L\'ubica Lacinov\\xc3\\xa. NGF-induced neurite outgrowth in PC12 cells is independent of calcium entry through L-type calcium channels. General physiology and biophysics. vol 31. issue 4. 2013-03-07. PMID:23255675.' |
neuronal growth factor (ngf) induces neurodifferentiation of pc12 cells into cholinergic neurons-like cells. |
2013-03-07 |
2023-08-12 |
Not clear |
| L Fjord-Larsen, P Kusk, D F Emerich, C Thanos, M Torp, B Bintz, J Tornøe, A H Johnsen, L U Wahlber. Increased encapsulated cell biodelivery of nerve growth factor in the brain by transposon-mediated gene transfer. Gene therapy. vol 19. issue 10. 2013-03-06. PMID:22113314. |
nerve growth factor (ngf) is a potential therapeutic agent for alzheimer's disease (ad) as it has positive effects on the basal forebrain cholinergic neurons whose degeneration correlates with the cognitive decline in ad. |
2013-03-06 |
2023-08-12 |
human |
| Martin A Bruno, A Claudio Cuell. Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:22035590. |
basal forebrain cholinergic neurons (bfcn), a system involved in learning and memory processes, are highly dependent on a continuous supply of biologically active nerve growth factor (ngf). |
2012-11-29 |
2023-08-12 |
human |
| Martin A Bruno, A Claudio Cuell. Cortical peroxynitration of nerve growth factor in aged and cognitively impaired rats. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:22035590. |
age-related cholinergic atrophy and cell loss in normal brains is apparently not complemented by reductions in the levels of ngf as could be expected. |
2012-11-29 |
2023-08-12 |
human |