| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan M Wilson, Ann Marie L Ogden, Sally Loomis, Gary Gilmour, Anthony J Baucum, Teri L Belecky-Adams, Kalpana M Merchan. Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in dopamine D2 neurons than in D1 neurons in the neostriatum. Neuropharmacology. vol 99. 2016-08-30. PMID:26256420. |
studies described here tested the hypothesis that phosphodiesterase 10a inhibition by a selective antagonist, mp-10, activates the dopamine d2 receptor expressing medium spiny neurons to a greater extent than the d1 receptor expressing neurons. |
2016-08-30 |
2023-08-13 |
mouse |
| Nobuyuki Kai, Kayo Nishizawa, Yuji Tsutsui, Shuichi Ueda, Kazuto Kobayash. Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization. Journal of neurochemistry. vol 135. issue 6. 2016-08-22. PMID:26442961. |
each of these contains two subtypes of medium spiny neurons, which express either dopamine d1 (d1r) or d2 (d2r) receptors. |
2016-08-22 |
2023-08-13 |
mouse |
| Erin S Calipari, Rosemary C Bagot, Immanuel Purushothaman, Thomas J Davidson, Jordan T Yorgason, Catherine J Peña, Deena M Walker, Stephen T Pirpinias, Kevin G Guise, Charu Ramakrishnan, Karl Deisseroth, Eric J Nestle. In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 10. 2016-08-09. PMID:26831103. |
dopamine produces these effects by controlling the activity of two subpopulations of nac medium spiny neurons (msns) that are defined by their predominant expression of either dopamine d1 or d2 receptors. |
2016-08-09 |
2023-08-13 |
Not clear |
| Chiung-Chun Huang, Ying-Ching Liang, Cheng-Che Lee, Kuei-Sen Hs. Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways. Molecular neurobiology. vol 52. issue 3. 2016-08-08. PMID:25319571. |
to determine whether such impairment occurs in the nac in a cell-type-specific manner, we used bacterial artificial chromosome (bac) transgenic mice expressing enhanced green fluorescent protein (egfp) under the control of gene regulatory elements for the dopamine d1 receptor (drd1) or dopamine d2 receptor (drd2) to identify distinct subpopulations of medium spiny neurons (msns). |
2016-08-08 |
2023-08-13 |
mouse |
| Svetlana A Ivanova, Anton J M Loone. Levodopa-Induced Dyskinesia Is Related to Indirect Pathway Medium Spiny Neuron Excitotoxicity: A Hypothesis Based on an Unexpected Finding. Parkinson's disease. vol 2016. 2016-05-04. PMID:27144051. |
particularly the combination of increased oxidative stress due to aberrant dopamine metabolism, increased vulnerability to nmda induced excitotoxicity, and the particular sensitivity of indirect pathway medium spiny neurons for this excitotoxicity may explain the observed increased prevalence of levodopa-induced dyskinesia. |
2016-05-04 |
2023-08-13 |
Not clear |
| Mandy L Roberts-Crowley, Ann R Rittenhous. Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels. PloS one. vol 10. issue 7. 2016-04-13. PMID:26147123. |
in medium spiny neurons (msns) of the striatum, dopamine d2 receptors (d2rs) specifically inhibit the ca(v)1.3 subtype of l-type ca(2+) channels (ltcs). |
2016-04-13 |
2023-08-13 |
Not clear |
| Pedro Barroso-Chinea, Marie-Laure Thiolat, Simone Bido, Audrey Martinez, Evelyne Doudnikoff, Jérôme Baufreton, Mathieu Bourdenx, Bertrand Bloch, Erwan Bezard, Marie-Laure Martin-Negrie. D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly. Neurobiology of disease. vol 78. 2016-03-28. PMID:25766677. |
among the mechanisms underlying the development of l-dopa-induced dyskinesia (lid) in parkinson's disease, complex alterations in dopamine signaling in d1 receptor (d1r)-expressing medium spiny striatal neurons have been unraveled such as, but not limited to, dysregulation of d1r expression, lateral diffusion, intraneuronal trafficking, subcellular localization and desensitization, leading to a pathological anchorage of d1r at the plasma membrane. |
2016-03-28 |
2023-08-13 |
Not clear |
| Manuela Eisenhardt, Sarah Leixner, Rafael Luján, Rainer Spanagel, Ainhoa Bilba. Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 47. 2016-03-14. PMID:26609150. |
in conclusion, dopamine neurons as well as d1r-expressing medium spiny neurons and their glutamatergic inputs via nmdars and ampars act in concert to influence relapse responses. |
2016-03-14 |
2023-08-13 |
mouse |
| Jin Ma, Li-Hong Long, Zhuang-Li Hu, Hai Zhang, Jun Han, Lan Ni, Fang Wang, Jian-Guo Chen, Peng-Fei W. Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain research. vol 1615. 2016-02-29. PMID:25912434. |
dopamine, a key neurotransmitter mediating the rewarding effects, exerts some of its effects by modulating neuronal excitability of striatal medium spiny neurons. |
2016-02-29 |
2023-08-13 |
Not clear |
| Jyotika Bahuguna, Ad Aertsen, Arvind Kuma. Existence and control of Go/No-Go decision transition threshold in the striatum. PLoS computational biology. vol 11. issue 4. 2016-01-11. PMID:25910230. |
medium spiny neurons (msns) in the striatum, receiving input from cortex and projecting to the direct and indirect pathways express d1 and d2 type dopamine receptors, respectively. |
2016-01-11 |
2023-08-13 |
Not clear |
| Jun Wang, Yifeng Cheng, Xuehua Wang, Emily Roltsch Hellard, Tengfei Ma, Hannah Gil, Sami Ben Hamida, Dorit Ro. Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 33. 2015-11-05. PMID:26290240. |
the majority of dms cells are medium spiny neurons (msns) that express dopamine d1 receptors (d1rs) or d2 receptors (d2rs), which drive "go" or "no-go" behaviors, respectively. |
2015-11-05 |
2023-08-13 |
mouse |
| K A Neve, C P Ford, D C Buck, D K Grandy, R L Neve, T J Phillip. Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S. Neuroscience. vol 248. 2015-11-03. PMID:23811070. |
furthermore, work with mice that constitutively express only the d2 receptor short form (d2s), as a result of genetic deletion of the long form (d2l), provides the basis for a current model in which d2l is thought to be the postsynaptic d2 receptor on medium spiny neurons in the basal forebrain, and d2s the autoreceptor that regulates the activity of dopamine neurons and dopamine synthesis and release. |
2015-11-03 |
2023-08-12 |
mouse |
| E Cahill, V Pascoli, P Trifilieff, D Savoldi, V Kappès, C Lüscher, J Caboche, P Vanhoutt. D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses. Molecular psychiatry. vol 19. issue 12. 2015-10-15. PMID:25070539. |
convergent dopamine and glutamate signalling onto the extracellular signal-regulated kinase (erk) pathway in medium spiny neurons (msns) of the striatum controls psychostimulant-initiated adaptive processes underlying long-lasting behavioural changes. |
2015-10-15 |
2023-08-13 |
mouse |
| Sabrine Aidi-Knani, Imed Regaya, Marianne Amalric, Christiane Mourr. Kv4 channel blockade reduces motor and neuropsychiatric symptoms in rodent models of Parkinson's disease. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25356731. |
nigrostriatal dopamine (da) neurodegeneration in parkinson's disease causes a loss of spinal and glutamatergic synapses in the striatal medium spiny neurons (msns). |
2015-09-03 |
2023-08-13 |
rat |
| Xincai Ji, Gilles E Marti. BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons. Brain research. vol 1588. 2015-08-04. PMID:25219484. |
bk channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons. |
2015-08-04 |
2023-08-13 |
Not clear |
| Xincai Ji, Gilles E Marti. BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons. Brain research. vol 1588. 2015-08-04. PMID:25219484. |
dopamine, a key neurotransmitter mediating the rewarding properties of drugs of abuse, is widely believed to exert some of its effects by modulating neuronal activity of nucleus accumbens (nacc) medium spiny neurons (msns). |
2015-08-04 |
2023-08-13 |
Not clear |
| Erik Södersten, Michael Feyder, Mads Lerdrup, Ana-Luisa Gomes, Hanna Kryh, Giada Spigolon, Jocelyne Caboche, Gilberto Fisone, Klaus Hanse. Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS genetics. vol 10. issue 9. 2015-07-23. PMID:25254549. |
the induction of the h3k27me3s28p histone mark specifically occurs in medium spiny neurons expressing dopamine d1 receptors and is dependent on msk1 kinase activity and darpp-32-mediated inhibition of protein phosphatase-1. |
2015-07-23 |
2023-08-13 |
mouse |
| Matthew F Lazenka, Bethany G David, Aron H Lichtman, Eric J Nestler, Dana E Selley, Laura J Sim-Selle. Delta FosB and AP-1-mediated transcription modulate cannabinoid CB₁ receptor signaling and desensitization in striatal and limbic brain regions. Biochemical pharmacology. vol 91. issue 3. 2015-04-28. PMID:25093286. |
overexpression of Δfosb in striatal dopamine type 1 receptor-containing (d1r) medium spiny neurons (msns) attenuated cb₁r desensitization in the substantia nigra, ventral tegmental area (vta) and amygdala. |
2015-04-28 |
2023-08-13 |
mouse |
| Thomas Portmann, Mu Yang, Rong Mao, Georgia Panagiotakos, Jacob Ellegood, Gul Dolen, Patrick L Bader, Brad A Grueter, Carleton Goold, Elaine Fisher, Katherine Clifford, Pavitra Rengarajan, David Kalikhman, Darren Loureiro, Nay L Saw, Zhou Zhengqui, Michael A Miller, Jason P Lerch, Mark Henkelman, Mehrdad Shamloo, Robert C Malenka, Jacqueline N Crawley, Ricardo E Dolmetsc. Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome. Cell reports. vol 7. issue 4. 2015-04-20. PMID:24794428. |
we found elevated numbers of striatal medium spiny neurons (msns) expressing the dopamine d2 receptor (drd2(+)) and fewer dopamine-sensitive (drd1(+)) neurons in deep layers of cortex. |
2015-04-20 |
2023-08-13 |
mouse |
| Gaynor A Smith, Emily M Rocha, Jesse R McLean, Melissa A Hayes, Sarah C Izen, Ole Isacson, Penelope J Hallet. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human molecular genetics. vol 23. issue 17. 2015-03-30. PMID:24728190. |
at 12-16 months of age, q175 ki mice displayed motor and cognitive deficits, which were paralleled at postmortem by striatal atrophy, cortical thinning, degeneration of medium spiny neurons, dense mutant htt inclusion formation, decreased striatal dopamine levels and loss of striatal brain-derived neurotrophic factor (bdnf). |
2015-03-30 |
2023-08-13 |
mouse |