| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tom Macpherson, Makiko Morita, Yanyan Wang, Toshikuni Sasaoka, Akira Sawa, Takatoshi Hikid. Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage. Learning & memory (Cold Spring Harbor, N.Y.). vol 23. issue 7. 2018-01-17. PMID:27317196. |
these processes are guided by the activity of two discrete neuron types, dopamine d1- or d2-receptor expressing medium spiny neurons (d1-/d2-msns). |
2018-01-17 |
2023-08-13 |
mouse |
| Luz M Suarez, Oscar Solis, Carolina Aguado, Rafael Lujan, Rosario Moratall. L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 11. 2018-01-12. PMID:27613437. |
dopamine depletion in parkinson's disease (pd) produces dendritic spine loss in striatal medium spiny neurons (msns) and increases their excitability. |
2018-01-12 |
2023-08-13 |
mouse |
| Matthew Brodsky, Alec W Gibson, Denis Smirnov, Sunila G Nair, John F Neumaie. Striatal 5-HT6 Receptors Regulate Cocaine Reinforcement in a Pathway-Selective Manner. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 9. 2018-01-09. PMID:27032690. |
although d1 and d2 dopamine receptors are differentially expressed in the direct and indirect pathway medium spiny neurons (dmsns and imsns, respectively), 5-ht6 receptors are expressed in both pathways, more strongly than anywhere else in the brain, and are an intriguing target for neuropsychiatric disorders. |
2018-01-09 |
2023-08-13 |
rat |
| Mehrak Javadi-Paydar, Robert F Roscoe, Adam R Denton, Charles F Mactutus, Rosemarie M Booz. HIV-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum. PloS one. vol 12. issue 11. 2017-12-11. PMID:29176843. |
hiv-1 and cocaine disrupt dopamine reuptake and medium spiny neurons in female rat striatum. |
2017-12-11 |
2023-08-13 |
rat |
| Agnieszka Nikiforuk, Agnieszka Potasiewicz, Dominik Rafa, Karla Drescher, Anton Bespalov, Piotr Popi. The effects of PDE10 inhibition on attentional set-shifting do not depend on the activation of dopamine D1 receptors. Behavioural pharmacology. vol 27. issue 4. 2017-11-20. PMID:26580130. |
these principles increase the level of camp and cgmp in the medium spiny neurons of the striatum and resemble the neurochemical consequences of dopamine d2 receptor inhibition and dopamine d1 receptor stimulation. |
2017-11-20 |
2023-08-13 |
rat |
| Aura Carole Meirsman, Anne Robé, Alban de Kerchove d'Exaerde, Brigitte Lina Kieffe. GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors. eNeuro. vol 3. issue 4. 2017-10-25. PMID:27570825. |
gpr88 is an orphan g-protein-coupled receptor highly expressed in striatal dopamine d1 (receptor) r- and d2r-expressing medium spiny neurons. |
2017-10-25 |
2023-08-13 |
mouse |
| Mikael Lindahl, Jeanette Hellgren Kotalesk. Untangling Basal Ganglia Network Dynamics and Function: Role of Dopamine Depletion and Inhibition Investigated in a Spiking Network Model. eNeuro. vol 3. issue 6. 2017-10-24. PMID:28101525. |
the dopamine depletion-induced increase of ampa efficacy in corticostriatal synapses to medium spiny neurons (msns) with dopamine receptor d2 synapses (ctx-msn d2) and the reduction of msn lateral connectivity (msn-msn) were found to contribute significantly to the enhanced synchrony and oscillations seen in pd. |
2017-10-24 |
2023-08-13 |
Not clear |
| Meaghan Creed, Niels R Ntamati, Ramesh Chandra, Mary Kay Lobo, Christian Lüsche. Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum. Neuron. vol 92. issue 1. 2017-10-03. PMID:27667004. |
here, we identify the ventral pallidum (vp) as a site of convergence of medium spiny neurons expressing dopamine (da) receptor type 1 (d1-msns) and type 2 (d2-msns) of the nac. |
2017-10-03 |
2023-08-13 |
Not clear |
| Haitao Wang, Mohd Farhan, Jiangping Xu, Philip Lazarovici, Wenhua Zhen. The involvement of DARPP-32 in the pathophysiology of schizophrenia. Oncotarget. vol 8. issue 32. 2017-09-25. PMID:28881851. |
dopamine and cyclic amp-regulated phosphoprotein of relative molecular mass 32,000 (darpp-32) is a cytosolic protein highly enriched in the medium spiny neurons of the neostriatum, considered as the most important integrator between the cortical input and the basal ganglia, and associated with motor control. |
2017-09-25 |
2023-08-13 |
Not clear |
| Taku Nagai, Junichiro Yoshimoto, Takayuki Kannon, Keisuke Kuroda, Kozo Kaibuch. Phosphorylation Signals in Striatal Medium Spiny Neurons. Trends in pharmacological sciences. vol 37. issue 10. 2017-09-04. PMID:27546785. |
medium spiny neurons (msns) play a major role in dopamine signaling through dopamine d1 receptors (d1rs) or dopamine d2 receptors (d2rs) in the striatum. |
2017-09-04 |
2023-08-13 |
Not clear |
| Shuntaro Kohnomi, Katsuko Ebihara, Masayuki Kobayash. Suppressive regulation of lateral inhibition between medium spiny neurons via dopamine D Neuroscience letters. vol 636. 2017-08-24. PMID:27793700. |
suppressive regulation of lateral inhibition between medium spiny neurons via dopamine d the nucleus accumbens (nac) shell is closely associated with reward, psychiatric disorders (depression or schizophrenia), and drug abuse. |
2017-08-24 |
2023-08-13 |
Not clear |
| Erika C Andrade, Veronica Musante, Atsuko Horiuchi, Hideo Matsuzaki, A Harrison Brody, Terence Wu, Paul Greengard, Jane R Taylor, Angus C Nair. ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 10. 2017-08-21. PMID:28167675. |
arpp-16 (camp-regulated phospho-protein of molecular weight 16 kda) is one of several small acid-soluble proteins highly expressed in medium spiny neurons of striatum that are phosphorylated in response to dopamine acting via d1 receptor/protein kinase a (pka) signaling. |
2017-08-21 |
2023-08-13 |
Not clear |
| Hee-Dae Kim, Jennifer Hesterman, Tanessa Call, Samantha Magazu, Elizabeth Keeley, Kristyna Armenta, Hope Kronman, Rachael L Neve, Eric J Nestler, Deveroux Ferguso. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 32. 2017-07-14. PMID:27511015. |
using a cre-inducible viral vector system to overexpress sirt1 selectively in dopamine d1 or d2 subpopulations of medium spiny neurons (msns) in the nac, we found that sirt1 promotes depressive-like behaviors only when overexpressed in d1 msns, with no effect seen in d2 msns. |
2017-07-14 |
2023-08-13 |
mouse |
| Bing Xue, Elton C Chen, Nan He, Dao-Zhong Jin, Li-Min Mao, John Q Wan. Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine. Neuropharmacology. vol 112. issue Pt A. 2017-07-11. PMID:27060412. |
dopamine (da) and acetylcholine (ach) signals converge onto protein kinase a (pka) in medium spiny neurons of the striatum to control cellular and synaptic activities of these neurons, although underlying molecular mechanisms are less clear. |
2017-07-11 |
2023-08-13 |
rat |
| Tiago Reis Marques, Sridhar Natesan, Flavia Niccolini, Marios Politis, Roger N Gunn, Graham E Searle, Oliver Howes, Eugenii A Rabiner, Shitij Kapu. Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107. The American journal of psychiatry. vol 173. issue 7. 2017-04-28. PMID:26892941. |
phosphodiesterase 10a (pde10a) is an enzyme present in striatal medium spiny neurons that degrades the intracellular second messengers triggered by dopamine signaling. |
2017-04-28 |
2023-08-13 |
Not clear |
| Immani Swapna, Brian Bondy, Hitoshi Morikaw. Differential Dopamine Regulation of Ca(2+) Signaling and Its Timing Dependence in the Nucleus Accumbens. Cell reports. vol 15. issue 3. 2017-01-10. PMID:27068462. |
however, it remains controversial how dopamine achieves these behavioral effects by regulating medium spiny projection neurons (msns) of the nac, especially on a behaviorally relevant timescale. |
2017-01-10 |
2023-08-13 |
Not clear |
| Larisa Tratnjek, Gordana Glavan, Tanja Višnjar, Marko Živi. Upregulation and axonal transport of synaptotagmin-IV in the direct-pathway medium spiny neurons in hemi-parkinsonian rats induced by dopamine D1 receptor stimulation. The European journal of neuroscience. vol 43. issue 7. 2016-12-19. PMID:26750488. |
upregulation and axonal transport of synaptotagmin-iv in the direct-pathway medium spiny neurons in hemi-parkinsonian rats induced by dopamine d1 receptor stimulation. |
2016-12-19 |
2023-08-13 |
rat |
| Ana M Vicente, Pedro Galvão-Ferreira, Fatuel Tecuapetla, Rui M Cost. Direct and indirect dorsolateral striatum pathways reinforce different action strategies. Current biology : CB. vol 26. issue 7. 2016-12-19. PMID:27046807. |
the dorsal striatum, which can be further subdivided into dorsomedial (dms) and dorsolateral (dls) striatum, is mainly composed of two subpopulations of striatal medium spiny projection neurons (msns): dopamine d1 receptor-expressing msns that constitute the striatonigral or direct pathway (dmsns); and dopamine d2 receptor-expressing msns that constitute the striatopallidal or indirect pathway (imsns) [3]. |
2016-12-19 |
2023-08-13 |
mouse |
| Motokazu Uchigashima, Toshihisa Ohtsuka, Kazuto Kobayashi, Masahiko Watanab. Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 15. 2016-12-13. PMID:27035941. |
midbrain dopamine neurons project densely to the striatum and form so-called dopamine synapses on medium spiny neurons (msns), principal neurons in the striatum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yan Li, John Partridge, Carissa Berger, Alberto Sepulveda-Rodriguez, Stefano Vicini, Katherine Conan. Dopamine increases NMDA-stimulated calcium flux in striatopallidal neurons through a matrix metalloproteinase-dependent mechanism. The European journal of neuroscience. vol 43. issue 2. 2016-10-17. PMID:26660285. |
dopamine (da) is a potent neuromodulator known to influence glutamatergic transmission in striatal medium spiny neurons (msns). |
2016-10-17 |
2023-08-13 |
mouse |