| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Carla Crescitelli, M Belén Rauschemberger, Sabrina Cepeda, Marisa Sandoval, Virginia L Massheime. Role of estrone on the regulation of osteoblastogenesis. Molecular and cellular endocrinology. vol 498. 2020-06-24. PMID:31525430. |
the hormone significantly increased cell proliferation (38% above control), nitric oxide production (108% above control), alkaline phosphatase activity (50% above control), in addition to stimulation of extracellular matrix mineralization. |
2020-06-24 |
2023-08-13 |
Not clear |
| Kurt Farrell, Phillip Simmers, Gautam Mahajan, Ludovic Boytard, Andrew Camardo, Jyotsna Joshi, Anand Ramamurthi, Florence Pinet, Chandrasekhar R Kothapall. Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide. Experimental cell research. vol 384. issue 1. 2020-06-15. PMID:31473210. |
abdominal aortic aneurysms (aaa) are characterized by matrix remodeling, elastin degradation, absence of nitric oxide (no) signaling, and inflammation, influencing smooth muscle cell (smc) phenotype and gene expression. |
2020-06-15 |
2023-08-13 |
human |
| Jun Yao, Huiping Long, Jianping Zhao, Gang Zhong, Jia L. Nifedipine inhibits oxidative stress and ameliorates osteoarthritis by activating the nuclear factor erythroid-2-related factor 2 pathway. Life sciences. vol 253. 2020-06-15. PMID:31927051. |
the result showed that nifedipine inhibited the expression of matrix metalloprotein(mmp)-13, interleukin (il)-1β, il-6, tumor necrosis factor (tnf)-α, cyclooxygenase (cox)-2, inducible nitric oxide (no) synthase (inos), and prostaglandin e2 (pge2), as well as reduced ros production in human oa chondrocytes, which was partially reversed by br. |
2020-06-15 |
2023-08-13 |
human |
| Bozidarka Zaric, Milan Obradovic, Andreja Trpkovic, Maciej Banach, Dimitri P Mikhailidis, Esma R Isenovi. Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications. Current medicinal chemistry. vol 27. issue 7. 2020-04-28. PMID:31480995. |
ecs synthesize and release compounds such as nitric oxide (no), metabolites of arachidonic acid, reactive oxygen species (ros) and enzymes that degrade the extracellular matrix. |
2020-04-28 |
2023-08-13 |
Not clear |
| Gordon Minru Xiong, Shaojun Yuan, Chek Kun Tan, Jun Kit Wang, Yang Liu, Timothy Thatt Yang Tan, Nguan Soon Tan, Cleo Choon. Endothelial cell thrombogenicity is reduced by ATRP-mediated grafting of gelatin onto PCL surfaces. Journal of materials chemistry. B. vol 2. issue 5. 2020-04-08. PMID:32261529. |
we observed that polycaprolactone (pcl) surfaces functionalized with poly(glycidyl methacrylate) [(p(gma)] brushes via atom transfer radical polymerization (atrp) alone resulted in the enhancement of an activated ec profile characterized by low production of nitric oxide (no), platelet activation and elevated expression levels of von willebrand factor (vwf) and matrix metalloproteinase-2 (mmp-2). |
2020-04-08 |
2023-08-13 |
Not clear |
| Shunsuke Shiba, Kohei Yamada, Masanobu Matsuguch. Humidity-Resistive Optical NO Gas Sensor Devices Based on Cobalt Tetraphenylporphyrin Dispersed in Hydrophobic Polymer Matrix. Sensors (Basel, Switzerland). vol 20. issue 5. 2020-03-25. PMID:32120957. |
we report on an optical nitrogen oxide (no) gas sensor device using cobalt tetraphenylporphyrin (cotpp) dispersed in three kinds of hydrophobic polymer film matrix (polystyrene (pst), ethylcellulose (ec), and polycyclohexyl methacrylate (pchma)) to improve humidity resistance. |
2020-03-25 |
2023-08-13 |
Not clear |
| Jochen Steppan, Huilei Wang, Yehudit Bergman, Marcel J Rauer, Siqi Tan, Sandeep Jandu, Kavitha Nandakumar, Sebastian Barreto-Ortiz, Robert N Cole, Tatiana N Boronina, Wanqu Zhu, Marc K Halushka, Steven S An, Dan E Berkowitz, Lakshmi Santhana. Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening. American journal of physiology. Heart and circulatory physiology. vol 317. issue 1. 2020-03-23. PMID:31002285. |
we determined that exogenous and endogenous nitric oxide markedly decreased loxl2 abundance and activity in the extracellular matrix of isolated smcs and loxl2 endothelial cells suppress loxl2 abundance in the aorta. |
2020-03-23 |
2023-08-13 |
Not clear |
| Eben G Estell, Amy M Silverstein, Robert M Stefani, Andy J Lee, Lance A Murphy, Roshan P Shah, Gerard A Ateshian, Clark T Hun. Cartilage Wear Particles Induce an Inflammatory Response Similar to Cytokines in Human Fibroblast-Like Synoviocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 37. issue 9. 2020-02-25. PMID:31062877. |
wear particles significantly increased proliferation and release of nitric oxide, interleukin-6 and -8, and matrix metalloproteinase-9, -10, and -13 in osteoarthritic synoviocytes, mirroring the effects of both cytokines, with similar trends in non-osteoarthritic cells. |
2020-02-25 |
2023-08-13 |
human |
| Xinxin Chen, Chengyong Zhang, Xiao Wang, Shousong Hu. Juglanin inhibits IL-1β-induced inflammation in human chondrocytes. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2020-02-05. PMID:31468982. |
nitric oxide (no) production was determined using the griess method and prostaglandin e2 (pge2), matrix metalloproteinase-3, -9 and -13 (mmp-3, mmp-9 and mmp-13), tnf-α, and il-6 were assessed using elisa. |
2020-02-05 |
2023-08-13 |
human |
| Jae Woo Kim, Jong Been Lee, So Hyung Le. Effect and Mechanism of Phosphodiesterase Inhibitors on Trabecular Outflow. Korean journal of ophthalmology : KJO. vol 33. issue 5. 2019-12-30. PMID:31612651. |
phosphodiesterase (pde) inhibitors increase matrix metalloproteinase (mmp) production by inhibiting re-uptake of adenosine and may potentiate nitric oxide (no) activity. |
2019-12-30 |
2023-08-13 |
human |
| Shishido, de Oliveira M. Polyethylene glycol matrix reduces the rates of photochemical and thermal release of nitric oxide from S-nitroso-N-acetylcysteine Photochemistry and photobiology. vol 71. issue 3. 2019-11-20. PMID:10732444. |
polyethylene glycol matrix reduces the rates of photochemical and thermal release of nitric oxide from s-nitroso-n-acetylcysteine s-nitrosothiols have many biological activities and may act as nitric oxide (no) carriers and donors, prolonging no half-life in vivo. |
2019-11-20 |
2023-08-12 |
Not clear |
| Albino Carrizzo, Giulio Maria Conte, Eduardo Sommella, Antonio Damato, Mariateresa Ambrosio, Marina Sala, Maria Carmina Scala, Rita Patrizia Aquino, Massimiliano De Lucia, Michele Madonna, Francesca Sansone, Carmine Ostacolo, Mario Capunzo, Serena Migliarino, Sebastiano Sciarretta, Giacomo Frati, Pietro Campiglia, Carmine Vecchion. Novel Potent Decameric Peptide of Spirulina platensis Reduces Blood Pressure Levels Through a PI3K/AKT/eNOS-Dependent Mechanism. Hypertension (Dallas, Tex. : 1979). vol 73. issue 2. 2019-11-18. PMID:30595120. |
here, we demonstrate that s platensis matrix processed in vitro by simulated gastrointestinal digestion induces direct endothelial nitric oxide (no)-mediated vasorelaxation of resistance vessels in mice. |
2019-11-18 |
2023-08-13 |
mouse |
| Guanghong Jia, Michael A Hill, James R Sower. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circulation research. vol 122. issue 4. 2019-08-13. PMID:29449364. |
impaired cardiac insulin metabolic signaling, mitochondrial dysfunction, increases in oxidative stress, reduced nitric oxide bioavailability, elevations in advanced glycation end products and collagen-based cardiomyocyte and extracellular matrix stiffness, impaired mitochondrial and cardiomyocyte calcium handling, inflammation, renin-angiotensin-aldosterone system activation, cardiac autonomic neuropathy, endoplasmic reticulum stress, microvascular dysfunction, and a myriad of cardiac metabolic abnormalities have all been implicated in the development and progression of diabetic cardiomyopathy. |
2019-08-13 |
2023-08-13 |
Not clear |
| Xiao Dong, Hai-Jun Liu, Hai-Yi Feng, Si-Cong Yang, Xue-Liang Liu, Xing Lai, Qin Lu, Jonathan F Lovell, Hong-Zhuan Chen, Chao Fan. Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion. Nano letters. vol 19. issue 2. 2019-06-24. PMID:30676760. |
here we present a protein-free collagen depletion strategy for drug delivery into solid tumors, based on activating endogenous matrix metalloproteinases (mmp-1 and -2) using nitric oxide (no). |
2019-06-24 |
2023-08-13 |
Not clear |
| Fatma H Rizk, Naglaa I Sarhan, Nema A Soliman, Marwa A A Ibrahim, Marwa Abd-Elsalam, Sherief Abd-Elsala. Heat shock protein 47 as indispensible participant in liver fibrosis: Possible protective effect of lactoferrin. IUBMB life. vol 70. issue 8. 2019-06-21. PMID:30092114. |
after 6 weeks, both lf and sm improved the grade of cirrhosis, reduced collagen fibers deposition, inactivated hscs, significantly decreased elevated liver enzymes, hsp47, hydroxyproline content, transforming growth factor-beta 1, matrix metalloproteinase-2, 8-hydroxydeoxyguanosine, malondialdehyde, nitric oxide levels and the percentage of alpha smooth muscle actin positive hscs compared with taa group. |
2019-06-21 |
2023-08-13 |
human |
| Shotaro Michinaga, Yutaka Koyam. Dual Roles of Astrocyte-Derived Factors in Regulation of Blood-Brain Barrier Function after Brain Damage. International journal of molecular sciences. vol 20. issue 3. 2019-05-13. PMID:30699952. |
the astrocyte-derived vascular permeability factors include vascular endothelial growth factors, matrix metalloproteinases, nitric oxide, glutamate and endothelin-1, which enhance bbb permeability leading to bbb disruption. |
2019-05-13 |
2023-08-13 |
Not clear |
| Bhavana Mohanraj, Alice H Huang, Meira J Yeger-McKeever, Megan J Schmidt, George R Dodge, Robert L Mauc. Chondrocyte and mesenchymal stem cell derived engineered cartilage exhibits differential sensitivity to pro-inflammatory cytokines. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 36. issue 11. 2019-05-09. PMID:29809295. |
compositional (extracellular matrix) and functional (mechanical) characteristics, as well as the release of catabolic mediators (matrix metalloproteinases [mmps], nitric oxide [no]) were assessed to determine cell- and tissue-level changes following exposure to il-1β or tnf-α. |
2019-05-09 |
2023-08-13 |
Not clear |
| Durgesh Kumar, Kripa Shankar, Saraswati Patel, Abhishek Gupta, Salil Varshney, Sanchita Gupta, Sujith Rajan, Ankita Srivastava, Achchhe Lal Vishwakarma, Anil N Gaikwa. Chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: Implications of nitric oxide. Molecular and cellular endocrinology. vol 477. 2019-05-06. PMID:29753026. |
chronic hyperinsulinemia promotes meta-inflammation and extracellular matrix deposition in adipose tissue: implications of nitric oxide. |
2019-05-06 |
2023-08-13 |
mouse |
| Adchara Janyou, Piyawadee Wicha, Jinatta Jittiwat, Apichart Suksamrarn, Chainarong Tocharus, Jiraporn Tocharu. Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory. Scientific reports. vol 7. issue 1. 2019-05-01. PMID:28874782. |
dhc also activated nuclear-related factor-2 (nrf2) which involves antioxidant enzymes like superoxide dismutase (sod) and glutathione peroxidase (gpx), and significantly decreased oxidative stress and inflammation via down-regulated reactive oxygen species (ros), nadph oxidase (nox2, nox4), nuclear factor kappa-beta (nf-ĸb), and nitric oxide (no), including matrix metalloproteinases-9 (mmp-9) levels. |
2019-05-01 |
2023-08-13 |
rat |
| Nina Westphal, Gabriele Loers, David Lutz, Thomas Theis, Ralf Kleene, Melitta Schachne. Generation and intracellular trafficking of a polysialic acid-carrying fragment of the neural cell adhesion molecule NCAM to the cell nucleus. Scientific reports. vol 7. issue 1. 2019-03-25. PMID:28819302. |
moreover, the ncam antibody triggers calmodulin-dependent activation of nitric oxide synthase, nitric oxide (no) production, no-dependent s-nitrosylation of matrix metalloprotease 9 (mmp9) as well as activation of matrix metalloprotease 2 (mmp2) and mmp9, whereas the ed peptide activates phospholipase d (pld) and mmp2, but not mmp9. |
2019-03-25 |
2023-08-13 |
Not clear |