| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W P McNally, W F Pool, M W Sinz, P Dehart, D F Ortwine, C C Huang, T Chang, T F Wool. Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue. Drug metabolism and disposition: the biological fate of chemicals. vol 24. issue 6. 1997-03-18. PMID:8781777. |
tacrine [1,2,3,4-tetrahydro-9-acridinamine monohydrochloride monohydrate (tha), cognex] is a potent acetylcholinesterase inhibitor recently approved for treatment of mild-to-moderate alzheimer's disease. |
1997-03-18 |
2023-08-12 |
rat |
| W P McNally, W F Pool, M W Sinz, P Dehart, D F Ortwine, C C Huang, T Chang, T F Wool. Distribution of tacrine and metabolites in rat brain and plasma after single- and multiple-dose regimens. Evidence for accumulation of tacrine in brain tissue. Drug metabolism and disposition: the biological fate of chemicals. vol 24. issue 6. 1997-03-18. PMID:8781777. |
the relevance of tha accumulation in brain tissue to delays observed in tha clinical management of alzheimer's disease remains to be established. |
1997-03-18 |
2023-08-12 |
rat |
| N Katsube, K Sunaga, D M Chuang, R Ishitan. ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons. Neuroscience letters. vol 214. issue 2-3. 1997-01-31. PMID:8878106. |
the common actions of ono-1603 and tha suggest that these properties could be related to their putative antidementia activities and that this model system may be used to screen for drugs effective in the treatment for alzheimer's disease. |
1997-01-31 |
2023-08-12 |
rat |
| A A al-Jafari, M A Kama. Investigation of the effect of tetrahydroaminoacridine on turnover kinetics of camel (Camelus dromedarius) retina acetylcholinesterase. Biochemistry and molecular biology international. vol 39. issue 5. 1997-01-27. PMID:8866008. |
therefore, tha's effect on turnover number must be considered at the time of therapy to the alzheimer's disease patients. |
1997-01-27 |
2023-08-12 |
Not clear |
| Y P Pang, P Quiram, T Jelacic, F Hong, S Brimijoi. Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease. The Journal of biological chemistry. vol 271. issue 39. 1996-11-18. PMID:8798583. |
applying this strategy to 9-amino-1,2,3,4-tetrahydroacridine (tha), a drug for alzheimer's disease, we obtained alkylene linked bis-tha analogs. |
1996-11-18 |
2023-08-12 |
rat |
| P Zatta, P Zambenedetti, M B Marturano, M Palumbo, M Nicolin. Effects of tacrine upon murine neuroblastoma cells. Journal of neural transmission. General section. vol 102. issue 2. 1996-10-24. PMID:8748676. |
tacrine [9-amino-1,2,3,4-tetrahydroacridine] (tha), a potent acetylcholinesterasic inhibitor, is utilized in the pharmacological treatment of alzheimer's disease (birne and arie, 1994). |
1996-10-24 |
2023-08-12 |
Not clear |
| A Ahlin, T Junthé, M Hassan, H Nybäc. One year on tacrine (THA): clinical and biochemical effects in patients with dementia of the Alzheimer type. International psychogeriatrics. vol 7. issue 1. 1995-12-01. PMID:7579023. |
one year on tacrine (tha): clinical and biochemical effects in patients with dementia of the alzheimer type. |
1995-12-01 |
2023-08-12 |
Not clear |
| A Ahlin, T Junthé, M Hassan, H Nybäc. One year on tacrine (THA): clinical and biochemical effects in patients with dementia of the Alzheimer type. International psychogeriatrics. vol 7. issue 1. 1995-12-01. PMID:7579023. |
fourteen patients suffering from dementia of the alzheimer type were treated with tacrine (tetrahydroaminoacridine, tha) for 1 year in an open trial. |
1995-12-01 |
2023-08-12 |
Not clear |
| J C Soares, S Gersho. THA--historical aspects, review of pharmacological properties and therapeutic effects. Dementia (Basel, Switzerland). vol 6. issue 4. 1995-11-06. PMID:7550603. |
a medline search was conducted to identify the trials conducted with tha in alzheimer's disease (ad) patients. |
1995-11-06 |
2023-08-12 |
Not clear |
| J G Shaddock, R J Feuers, M W Chou, D H Swenson, D A Cascian. Genotoxicity of tacrine in primary hepatocytes isolated from B6C3F1 mice and aged ad libitum and calorie restricted Fischer 344 rats. Mutation research. vol 344. issue 1-2. 1995-10-25. PMID:7565897. |
tacrine (1,2,3,4-tetrahydro-9-aminoacridine; tha), a reversible centrally acting anticholinesterase, has been shown to be potentially useful for treatment of patients with alzheimer's disease. |
1995-10-25 |
2023-08-12 |
mouse |
| P Riekkinen, H Soininen, E L Helkala, K Partanen, M Laakso, M Vanhanen, P Riekkine. Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease. Neuroreport. vol 6. issue 9. 1995-10-19. PMID:7669991. |
hippocampal atrophy, acute tha treatment and memory in alzheimer's disease. |
1995-10-19 |
2023-08-12 |
Not clear |
| P Dell'Antone, M Bragadin, P Zatt. Anticholinesterasic drugs: tacrine but not physostigmine, accumulates in acidic compartments of the cells. Biochimica et biophysica acta. vol 1270. issue 2-3. 1995-05-31. PMID:7727536. |
tacrine (tha) and physostigmine (phs) have been used in alzheimer's disease therapy for their anticholinesterasic activity. |
1995-05-31 |
2023-08-12 |
rat |
| P Dell'Antone, M Bragadin, P Zatt. Anticholinesterasic drugs: tacrine but not physostigmine, accumulates in acidic compartments of the cells. Biochimica et biophysica acta. vol 1270. issue 2-3. 1995-05-31. PMID:7727536. |
the accumulation of tha in acidic organelles of the cell may be relevant for the pharmacological action of tha in alzheimer's treatment. |
1995-05-31 |
2023-08-12 |
rat |
| J F Paskavitz, C F Lippa, J E Hamos, D Pulaski-Salo, D A Drachma. Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease. Journal of geriatric psychiatry and neurology. vol 8. issue 1. 1995-05-18. PMID:7710644. |
role of the dorsomedial nucleus of the thalamus in alzheimer's disease. |
1995-05-18 |
2023-08-12 |
Not clear |
| J F Paskavitz, C F Lippa, J E Hamos, D Pulaski-Salo, D A Drachma. Role of the dorsomedial nucleus of the thalamus in Alzheimer's disease. Journal of geriatric psychiatry and neurology. vol 8. issue 1. 1995-05-18. PMID:7710644. |
it is not known whether changes in the thalamus play a role in the memory loss or dementia of alzheimer's disease (ad), although trauma, infarction, and hemorrhage to the thalamus, particularly the dorsomedial nucleus (dmn), can cause these cognitive changes. |
1995-05-18 |
2023-08-12 |
Not clear |
| A Adem, A H Mohammed, B Winblad, B E Henriksso. A novel anticholinesterase THB013: biochemical and behavioural studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 8. issue 1-2. 1995-04-26. PMID:7893376. |
clinical trials with tacrine (tha) have resulted in elevations of liver enzymes in alzheimer patients that showed improvement. |
1995-04-26 |
2023-08-12 |
rat |
| A Adem, A H Mohammed, B Winblad, B E Henriksso. A novel anticholinesterase THB013: biochemical and behavioural studies. Journal of neural transmission. Parkinson's disease and dementia section. vol 8. issue 1-2. 1995-04-26. PMID:7893376. |
it is possible that thb 013 with more potent cholinergic effects than tha might be useful in the treatment of alzheimer's disease. |
1995-04-26 |
2023-08-12 |
rat |
| A Ahlin, M Hassan, T Junthé, H Nybäc. Tacrine in Alzheimer's disease: pharmacokinetic and clinical comparison of oral and rectal administration. International clinical psychopharmacology. vol 9. issue 4. 1995-03-29. PMID:7868848. |
in a previous pharmacokinetic study in alzheimer patients great inter-individual variation and low oral bioavailability of the cholinesterase inhibitor tacrine (tetrahydroaminoacridine, tha) were found. |
1995-03-29 |
2023-08-12 |
Not clear |
| B J Sahakian, A M Owen, N J Morant, S A Eagger, S Boddington, L Crayton, H A Crockford, M Crooks, K Hill, R Lev. Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology. vol 110. issue 4. 1995-03-29. PMID:7870908. |
further analysis of the cognitive effects of tetrahydroaminoacridine (tha) in alzheimer's disease: assessment of attentional and mnemonic function using cantab. |
1995-03-29 |
2023-08-12 |
Not clear |
| B J Sahakian, A M Owen, N J Morant, S A Eagger, S Boddington, L Crayton, H A Crockford, M Crooks, K Hill, R Lev. Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology. vol 110. issue 4. 1995-03-29. PMID:7870908. |
results of a placebo controlled cross-over trial (n = 89) of the anticholinesterase drug tha as a treatment for dementia of the alzheimer's type (dat) are reported, with reference to previous trials of the drug and the cholinergic hypothesis of aging and dementia. |
1995-03-29 |
2023-08-12 |
Not clear |