| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Seidl, S T Kaehler, H Prast, N Singewald, N Cairns, M Gratzer, G Lube. Serotonin (5-HT) in brains of adult patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666678. |
as the serotonergic system plays a well known role in integrating emotion, cognition and motor function, serotonin (5-ht) and its main metabolite, 5-hydroxyindol-3-acetic acid (5-hiaa) were investigated in post-mortem tissue samples from temporal cortex, thalamus, caudate nucleus, occipital cortex and cerebellum of adult patients with ds, alzheimer's disease (ad) and controls by use of high performance liquid chromatography (hplc). |
2000-04-12 |
2023-08-12 |
Not clear |
| J C Stout, M W Bondi, T L Jernigan, S L Archibald, D C Delis, D P Salmo. Regional cerebral volume loss associated with verbal learning and memory in dementia of the Alzheimer type. Neuropsychology. vol 13. issue 2. 1999-07-15. PMID:10353370. |
these results provide evidence that the verbal memory deficit of alzheimer's disease (ad) is associated not only with the mesial temporal limbic cortex, thought to be the site of earliest and most severe pathology in ad, but also with damage in the thalamus. |
1999-07-15 |
2023-08-12 |
human |
| P Riekkinen, M Riekkine. THA improves word priming and clonidine enhances fluency and working memory in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088136. |
tha improves word priming and clonidine enhances fluency and working memory in alzheimer's disease. |
1999-06-03 |
2023-08-12 |
Not clear |
| P Riekkinen, M Riekkine. THA improves word priming and clonidine enhances fluency and working memory in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088136. |
we investigated the effects of a single administration of a cholinesterase inhibitor, tetrahydroaminoacridine (tha, 25 and 50 mg, orally), and an alpha 2-agonist, clonidine (0.5 and 2 micrograms/kg, orally), on neuropsychologic performance in two groups of patients with alzheimer's disease (ad). |
1999-06-03 |
2023-08-12 |
Not clear |
| S Terzano, J A Court, D Fornasari, M Griffiths, D P Spurden, S Lloyd, R H Perry, E K Perry, F Clement. Expression of the alpha3 nicotinic receptor subunit mRNA in aging and Alzheimer's disease. Brain research. Molecular brain research. vol 63. issue 1. 1999-01-21. PMID:9838051. |
to investigate the status of the alpha3 subunit-containing subtypes in such conditions, we assessed by in situ hybridisation the alpha3 mrna density in the hippocampus, entorhinal cortex and thalamus of alzheimer's patients and age-matched controls. |
1999-01-21 |
2023-08-12 |
human |
| D Lagadic-Gossmann, M Rissel, M A Le Bot, A Guillouz. Toxic effects of tacrine on primary hepatocytes and liver epithelial cells in culture. Cell biology and toxicology. vol 14. issue 5. 1999-01-07. PMID:9808364. |
administration of tacrine (tha) for the treatment of alzheimer's disease results in a reversible hepatotoxicity in 30-50% of patients, as indicated by an increase in transaminase levels. |
1999-01-07 |
2023-08-12 |
human |
| T M Itil, E Eralp, I Ahmed, A Kunitz, K Z Iti. The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine. Psychopharmacology bulletin. vol 34. issue 3. 1998-12-09. PMID:9803773. |
tacrine, also known as tetrahydroaminoacrine (tha), and donepezil are currently the only drugs approved in the united states for the treatment of alzheimer's disease. |
1998-12-09 |
2023-08-12 |
human |
| A V Gore, A C Liang, Y W Chie. Comparative biomembrane permeation of tacrine using Yucatan minipigs and domestic pigs as the animal model. Journal of pharmaceutical sciences. vol 87. issue 4. 1998-06-10. PMID:9548896. |
tacrine (tha), a centrally acting acetylcholine-esterase inhibitor, is presently administered perorally for the treatment of alzheimer's disease (ad). |
1998-06-10 |
2023-08-12 |
human |
| P Riekkinen, A Pääkkönen, J Karhu, J Partanen, H Soininen, M Laakso, P Riekkin. THA disrupts mismatch negativity in Alzheimer disease. Psychopharmacology. vol 133. issue 2. 1997-11-20. PMID:9342788. |
tha disrupts mismatch negativity in alzheimer disease. |
1997-11-20 |
2023-08-12 |
human |
| P Riekkinen, A Pääkkönen, J Karhu, J Partanen, H Soininen, M Laakso, P Riekkin. THA disrupts mismatch negativity in Alzheimer disease. Psychopharmacology. vol 133. issue 2. 1997-11-20. PMID:9342788. |
the present study investigates the effects of 25 or 50 mg tetrahydroaminoacridine (tha), a cholinesterase inhibitor, on auditory mismatch negativity (mmn) event-related response in 19 patients with alzheimer disease (ad). |
1997-11-20 |
2023-08-12 |
human |
| P Riekkinen, H Soininen, J Partanen, A Pääkkönen, S Helisalmi, P Riekkine. The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients. Psychopharmacology. vol 129. issue 3. 1997-11-19. PMID:9084068. |
the ability of tha treatment to increase cortical alpha waves is related to apolipoprotein e genotype of alzheimer disease patients. |
1997-11-19 |
2023-08-12 |
Not clear |
| D P Spurden, J A Court, S Lloyd, A Oakley, R Perry, C Pearson, R G Pullen, E K Perr. Nicotinic receptor distribution in the human thalamus: autoradiographical localization of [3H]nicotine and [125I] alpha-bungarotoxin binding. Journal of chemical neuroanatomy. vol 13. issue 2. 1997-10-23. PMID:9285355. |
changes in high affinity nicotine and alpha btx receptors in the thalamus may contribute to symptoms observed in neuropathological conditions associated with disorders of perception and movement such as dementia with lewy bodies, alzheimer's disease and schizophrenia. |
1997-10-23 |
2023-08-12 |
mouse |
| C Ibebunjo, F Donati, G S Fox, D Eshelby, J I Tchervenko. The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat. Anesthesia and analgesia. vol 85. issue 2. 1997-09-03. PMID:9249126. |
tacrine (tha) is an anticholinesterase drug used to manage alzheimer's dementia, but it is not clear how its chronic use might affect response to nondepolarizing muscle relaxants. |
1997-09-03 |
2023-08-12 |
rat |
| C Ibebunjo, F Donati, G S Fox, D Eshelby, J I Tchervenko. The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat. Anesthesia and analgesia. vol 85. issue 2. 1997-09-03. PMID:9249126. |
the same may apply to alzheimer's patients taking tha chronically. |
1997-09-03 |
2023-08-12 |
rat |
| P Riekkinen, M Riekkinen, H Soininen, J Kuikka, M Laakso, P Riekkine. Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease. Neuroreport. vol 8. issue 8. 1997-08-29. PMID:9223063. |
frontal dysfunction blocks the therapeutic effect of tha on attention in alzheimer's disease. |
1997-08-29 |
2023-08-12 |
Not clear |
| P Riekkinen, M Riekkinen, H Soininen, J Kuikka, M Laakso, P Riekkine. Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease. Neuroreport. vol 8. issue 8. 1997-08-29. PMID:9223063. |
we evaluated the effect of a single dose of a cholinesterase inhibitor, tetrahydroaminoacridine (tha; 25 and 50 mg, orally), on attention in patients with alzheimer's disease (ad). |
1997-08-29 |
2023-08-12 |
Not clear |
| C D Bonan, A M Battastini, M R Schetinger, C M Moreira, S S Frassetto, R D Dias, J J Sarki. Effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) on ATP diphosphohydrolase (EC 3.6.1.5) and 5'-nucleotidase (EC 3.1.3.5) from rat brain synaptosomes. General pharmacology. vol 28. issue 5. 1997-08-15. PMID:9184816. |
tha, proposed as a drug for the treatment of alzheimer's disease, can alter in vitro atp degradation in synaptosomes from the central nervous system. |
1997-08-15 |
2023-08-12 |
rat |
| Y Mimori, S Nakamura, M Yukaw. Abnormalities of acetylcholinesterase in Alzheimer's disease with special reference to effect of acetylcholinesterase inhibitor. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062656. |
ache inhibitors, including physostigmine, e-2020, amiridin, tetrahydroaminoacridine (tha) and nicergoline had a poor effect on ache present in the senile plaque-rich fraction isolated from alzheimer brain than that either in the soluble fraction of alzheimer brain or in the control brain. |
1997-07-09 |
2023-08-12 |
human |
| W E Mangano, T J Montine, C M Hulett. Pathologic assessment of cerebellar atrophy following acute lithium intoxication. Clinical neuropathology. vol 16. issue 1. 1997-05-01. PMID:9020392. |
there was also alzheimer type ii cell change in the thalamus and lentiform nuclei possibly due to terminal uremia. |
1997-05-01 |
2023-08-12 |
Not clear |
| G G Benoit, C F Naud, M A Simard, A L Astie. Noninterference of cytochrome P4501A2 in the cytotoxicity of tacrine using genetically engineered V79 Chinese hamster cells for stable expression of the human or rat isoform and two human hepatocyte cell lines. Biochemical pharmacology. vol 53. issue 3. 1997-04-07. PMID:9065747. |
tacrine (tha) is the only drug currently approved for the treatment of alzheimer's disease. |
1997-04-07 |
2023-08-12 |
human |