| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Di Matteo, G Di Giovanni, M Di Mascio, E Esposit. Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors. Brain research. vol 865. issue 1. 2000-07-21. PMID:10814735. |
on the contrary, both (+/-)-doi, a mixed 5-ht(2a/2c) receptor agonist, and the selective 5-ht(2b) agonist bw 723c86, did not affect either da release in the nucleus accumbens or the firing rate of vta da cells. |
2000-07-21 |
2023-08-12 |
Not clear |
| M D Doherty, V M Picke. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain research. vol 864. issue 2. 2000-07-03. PMID:10802024. |
ultrastructural localization of the serotonin 2a receptor in dopaminergic neurons in the ventral tegmental area. |
2000-07-03 |
2023-08-12 |
rat |
| M D Doherty, V M Picke. Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain research. vol 864. issue 2. 2000-07-03. PMID:10802024. |
serotonin (5-hydroxytryptamine, 5-ht) 2a receptor antagonists are clinically effective antipsychotics that may differentially target mesocortical and mesolimbic dopaminergic neurons having partially segregated distribution in the parabrachial (pb) and paranigral (pn) ventral tegmental area (vta). |
2000-07-03 |
2023-08-12 |
rat |
| K Ikemoto, A Nishimura, N Okado, M Mikuni, K Nishi, I Nagats. Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration. Brain research. vol 853. issue 2. 2000-06-21. PMID:10640637. |
we demonstrated intense serotonin (5-ht) 2a receptor immunoreactivity in the human ventral tegmental area (vta) using by a recently raised antibody against 5-ht2a receptor. |
2000-06-21 |
2023-08-12 |
human |
| E B Bunney, S B Appel, M S Brodi. Cocaine potentiates ethanol-induced excitation of dopaminergic reward neurons in the ventral tegmental area. The Journal of pharmacology and experimental therapeutics. vol 293. issue 2. 2000-06-21. PMID:10773006. |
we have previously shown that ethanol increases the firing rate of da neurons in the vta, and that this excitation is enhanced by 5-ht. |
2000-06-21 |
2023-08-12 |
rat |
| J J Rodríguez, M D Doherty, V M Picke. N-methyl-D-aspartate (NMDA) receptors in the ventral tegmental area: subcellular distribution and colocalization with 5-hydroxytryptamine(2A) receptors. Journal of neuroscience research. vol 60. issue 2. 2000-05-17. PMID:10740225. |
n-methyl-d-aspartate (nmda) receptors in the ventral tegmental area: subcellular distribution and colocalization with 5-hydroxytryptamine(2a) receptors. |
2000-05-17 |
2023-08-12 |
rat |
| J J Rodríguez, M D Doherty, V M Picke. N-methyl-D-aspartate (NMDA) receptors in the ventral tegmental area: subcellular distribution and colocalization with 5-hydroxytryptamine(2A) receptors. Journal of neuroscience research. vol 60. issue 2. 2000-05-17. PMID:10740225. |
we examined the electron microscopic immunocytochemical localization of antisera against the nmda r1 subunit (nmdar1) and 5-ht(2a) receptors to determine potential sites for their dual activation in the rat paranigral and parabrachial vta subdivisions that are distinguished, in part, by their respective striatolimbic and cortical projections. |
2000-05-17 |
2023-08-12 |
rat |
| J J Rodríguez, M D Doherty, V M Picke. N-methyl-D-aspartate (NMDA) receptors in the ventral tegmental area: subcellular distribution and colocalization with 5-hydroxytryptamine(2A) receptors. Journal of neuroscience research. vol 60. issue 2. 2000-05-17. PMID:10740225. |
our results indicate that nmda and 5-ht(2a) receptors in the vta are transiently expressed on synaptic plasma membranes of single neurons showing widespread cytoplasmic distributions of each of the receptors. |
2000-05-17 |
2023-08-12 |
rat |
| J Gervais, C Rouillar. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657038. |
depletion of endogenous 5-ht by the neurotoxin, 5,7-dihydroxytryptamine (5,7-dht), and the 5-ht synthesis inhibitor para-chlorophenylalanine (pcpa), almost completely eliminated the inhibition-excitation response in both snpc and vta da cells, without changing the percentage of da cells initially excited. |
2000-03-13 |
2023-08-12 |
rat |
| J Gervais, C Rouillar. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657038. |
consequently, the proportion of da neurons that were not affected by dr stimulation increased after 5-ht depletion (from 13% to 60% in snpc and from 6% to 31% in vta). |
2000-03-13 |
2023-08-12 |
rat |
| J Gervais, C Rouillar. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657038. |
it also suggests that 5-ht afferences modulate snpc and vta da neurons in an opposite manner. |
2000-03-13 |
2023-08-12 |
rat |
| J Gervais, C Rouillar. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657038. |
a differential modulation of vta and snpc da neurons by 5-ht afferences from the drn could have important implications for the development of drugs to treat schizophrenia or other neurologic and psychiatric diseases in which da neurons are involved. |
2000-03-13 |
2023-08-12 |
rat |
| G Di Giovanni, V Di Matteo, M Di Mascio, E Esposit. Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse (New York, N.Y.). vol 35. issue 1. 2000-01-05. PMID:10579808. |
thus, extracellular single unit recordings of neurochemically-identified da neurons in the snc and the vta, as well as simultaneous monitoring of striatal and accumbal da release were performed following the administration of the unselective 5-ht(2c/2b) agonists, mcpp (m-chlorophenylpiperazine) and mk 212 [6-chloro-2-(1-piperazinyl)piperazine]. |
2000-01-05 |
2023-08-12 |
Not clear |
| G Di Giovanni, V Di Matteo, M Di Mascio, E Esposit. Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse (New York, N.Y.). vol 35. issue 1. 2000-01-05. PMID:10579808. |
the inhibitory effect of both mcpp and mk 212 on vta da cell activity was blocked completely by pretreatment with the selective 5-ht(2c) antagonist sb 242084 ¿6-chloro-5-methyl-1-[2-(2-methylpyridyl-3-oxy)-pyrid-5-yl carbamoyl] indoline¿ (200 microg/kg), given intravenously 10 min before the first injection of the 5-ht(2c/2b) agonists. |
2000-01-05 |
2023-08-12 |
Not clear |
| S Jones, J A Kaue. Amphetamine depresses excitatory synaptic transmission via serotonin receptors in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 22. 1999-12-02. PMID:10559387. |
amphetamine depresses excitatory synaptic transmission via serotonin receptors in the ventral tegmental area. |
1999-12-02 |
2023-08-12 |
Not clear |
| S Jones, J A Kaue. Amphetamine depresses excitatory synaptic transmission via serotonin receptors in the ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 22. 1999-12-02. PMID:10559387. |
our findings suggest that an acute effect of amphetamine exposure is the release of serotonin in the vta, which in turn modulates excitation of vta neurons. |
1999-12-02 |
2023-08-12 |
Not clear |
| M Revuelta, J L Venero, A Machado, J Can. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366014. |
this axotomy-induced increase was accompanied by an increased density of the serotonin nerve terminal network in the ipsilateral substantia nigra and ventral tegmental area. |
1999-08-02 |
2023-08-12 |
rat |
| M Revuelta, J L Venero, A Machado, J Can. Serotonin hyperinnervation in the adult rat ventral mesencephalon following unilateral transection of the medial forebrain bundle. Correlation with reactive microglial and astroglial populations. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366014. |
in addition, the distribution pattern of glial fibrillary acidic protein-immunoreactive astrocytes and ox42-immunoreactive microglia correlated highly with the location of increased serotonin fibre density in the ventral mesencephalon, especially in ventral tegmental area and in the most medial part of substantia nigra. |
1999-08-02 |
2023-08-12 |
rat |
| A Bortolozzi, R O Duffard, M Rubio, N Sturtz, A M Evangelista de Duffar. Regionally specific changes in central brain monoamine levels by 2,4-dichlorophenoxyacetic acid in acute treated rats. Neurotoxicology. vol 19. issue 6. 1999-03-16. PMID:9863773. |
we are demonstrating a correlation between rat behavior altered by the herbicide's treatment and the contents of 5-ht and da in brain areas, such as pfc, vta, sn, striatum, na, midbrain and cerebellum. |
1999-03-16 |
2023-08-12 |
rat |
| Z Wang, Y L Li. [Regulation of dopamine neurons in ventral tegmental area on sleep-wakefulness]. Sheng li xue bao : [Acta physiologica Sinica]. vol 49. issue 2. 1999-01-05. PMID:9812847. |
the effects of microinjection of gamma-aminobutyric acid (gaba) and serotonin (5-ht) into the ventral tegmental area (vta) on the activity of dopamine neurons in vta and sleep-wakefulness were studied in rats. |
1999-01-05 |
2023-08-12 |
rat |