| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryan F Yoshimura, Minhtam B Tran, Derk J Hogenkamp, Narielle L Ayala, Timothy Johnstone, Andrew J Dunnigan, Timothy K Gee, Kelvin W Ge. Allosteric modulation of nicotinic and GABA Neuropharmacology. vol 126. 2018-06-12. PMID:28842344. |
allosteric modulation of nicotinic and gaba autism spectrum disorder (asd) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. |
2018-06-12 |
2023-08-13 |
Not clear |
| Yixin Li, Yang Zhou, Li Peng, Yong Zha. Reduced protein expressions of cytomembrane GABA Brain research. vol 1671. 2018-05-17. PMID:28641949. |
reduced protein expressions of cytomembrane gaba decreased inhibition plays an extremely important role in pathogenesis of autism spectrum disorder (asd). |
2018-05-17 |
2023-08-13 |
Not clear |
| Nicolaas A J Puts, Ericka L Wodka, Ashley D Harris, Deana Crocetti, Mark Tommerdahl, Stewart H Mostofsky, Richard A E Edde. Reduced GABA and altered somatosensory function in children with autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. vol 10. issue 4. 2018-04-24. PMID:27611990. |
reduced gaba and altered somatosensory function in children with autism spectrum disorder. |
2018-04-24 |
2023-08-13 |
Not clear |
| Remmelt R Schür, Luc W R Draisma, Jannie P Wijnen, Marco P Boks, Martijn G J C Koevoets, Marian Joëls, Dennis W Klomp, René S Kahn, Christiaan H Vinker. Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of (1) H-MRS studies. Human brain mapping. vol 37. issue 9. 2018-02-09. PMID:27145016. |
the inhibitory gamma-aminobutyric acid (gaba) system is involved in the etiology of most psychiatric disorders, including schizophrenia, autism spectrum disorder (asd) and major depressive disorder (mdd). |
2018-02-09 |
2023-08-13 |
Not clear |
| S V Ranneva, K S Pavlov, A V Gromova, T G Amstislavskaya, T V Lipin. Features of emotional and social behavioral phenotypes of calsyntenin2 knockout mice. Behavioural brain research. vol 332. 2017-12-12. PMID:28647593. |
given, that impaired functioning of gaba receptors is linked to several psychopathologies, including anxiety and autism, we sought to further characterize clstn2-ko mice with respect to emotional and social behavior. |
2017-12-12 |
2023-08-13 |
mouse |
| J Naaijen, J Bralten, G Poelmans, J C Glennon, B Franke, J K Buitelaa. Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28072412. |
in this study we investigated the role of glutamate and gaba genetics in adhd severity, autism symptom severity and inhibitory performance, based on gene set analysis, an approach to investigate multiple genetic variants simultaneously. |
2017-11-16 |
2023-08-13 |
Not clear |
| b' Lucia Olexov\\xc3\\xa1, Peter \\xc5\\xa0tef\\xc3\\xa1nik, Lucia Kr\\xc5\\xa1kov\\xc3\\xa. Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism. Neuroscience letters. vol 629. 2017-06-29. PMID:27353514.' |
the aim of our study, performed using an animal model of autism in the form of rats prenatally treated with valproic acid (vpa rats), was to investigate changes in anxiety-like behaviour and the gene expression of molecules that control levels of the inhibitory neurotransmitter γ-aminobutyric acid (gaba) in the brain. |
2017-06-29 |
2023-08-13 |
rat |
| Caroline E Robertson, Eva-Maria Ratai, Nancy Kanwishe. Reduced GABAergic Action in the Autistic Brain. Current biology : CB. vol 26. issue 1. 2016-11-04. PMID:26711497. |
evidence supporting this hypothesis has specifically implicated the signaling pathway of the inhibitory neurotransmitter, γ-aminobutyric acid (gaba), in this putative imbalance: gaba receptor genes have been associated with autism in linkage and copy number variation studies [3-7], fewer gaba receptor subunits have been observed in the post-mortem tissue of autistic individuals [8, 9], and gabaergic signaling is disrupted across heterogeneous mouse models of autism [10]. |
2016-11-04 |
2023-08-13 |
mouse |
| Caroline E Robertson, Eva-Maria Ratai, Nancy Kanwishe. Reduced GABAergic Action in the Autistic Brain. Current biology : CB. vol 26. issue 1. 2016-11-04. PMID:26711497. |
finally, we show that the link between gaba and binocular rivalry dynamics is completely and specifically absent in autism. |
2016-11-04 |
2023-08-13 |
mouse |
| Federica Filice, Karl Jakob Vörckel, Ayse Özge Sungur, Markus Wöhr, Beat Schwalle. Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism. Molecular brain. vol 9. 2016-10-10. PMID:26819149. |
reduction in parvalbumin expression not loss of the parvalbumin-expressing gaba interneuron subpopulation in genetic parvalbumin and shank mouse models of autism. |
2016-10-10 |
2023-08-13 |
mouse |
| Johanna Balz, Julian Keil, Yadira Roa Romero, Ralf Mekle, Florian Schubert, Semiha Aydin, Bernd Ittermann, Jürgen Gallinat, Daniel Senkowsk. GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion. NeuroImage. vol 125. 2016-10-05. PMID:26546865. |
gaba neurotransmission could be a promising target for treatment interventions of multisensory processing deficits in clinical populations, such as schizophrenia or autism. |
2016-10-05 |
2023-08-13 |
human |
| Natascia Brondino, Laura Fusar-Poli, Cristina Panisi, Stefano Damiani, Francesco Barale, Pierluigi Polit. Pharmacological Modulation of GABA Function in Autism Spectrum Disorders: A Systematic Review of Human Studies. Journal of autism and developmental disorders. vol 46. issue 3. 2016-09-30. PMID:26443675. |
the present systematic review aimed at evaluating the state-of-the-art of clinical trials of gaba modulators in autism. |
2016-09-30 |
2023-08-13 |
human |
| Xia-Jing Tong, Zhitao Hu, Yu Liu, Dorian Anderson, Joshua M Kapla. A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors. eLife. vol 4. 2016-08-22. PMID:26575289. |
a network of autism linked genes stabilizes two pools of synaptic gaba(a) receptors. |
2016-08-22 |
2023-08-13 |
caenorhabditis_elegans |
| S Hossein Fatemi, Timothy D Folso. GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism. Schizophrenia research. vol 167. issue 1-3. 2016-06-27. PMID:25432637. |
gaba receptor subunit distribution and fmrp-mglur5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism. |
2016-06-27 |
2023-08-13 |
mouse |
| Carla V Sesarini, Lucas Costa, Nora Grañana, Miguel Garcia Coto, Roberto C Pallia, Pablo F Argiba. Association between GABA(A) receptor subunit polymorphisms and autism spectrum disorder (ASD). Psychiatry research. vol 229. issue 1-2. 2016-04-08. PMID:26239769. |
association between gaba(a) receptor subunit polymorphisms and autism spectrum disorder (asd). |
2016-04-08 |
2023-08-13 |
Not clear |
| Alice M S Durieux, Cathy Fernandes, Declan Murphy, Marie Anais Labouesse, Sandra Giovanoli, Urs Meyer, Qi Li, Po-Wah So, Grainne McAlona. Targeting Glia with N-Acetylcysteine Modulates Brain Glutamate and Behaviors Relevant to Neurodevelopmental Disorders in C57BL/6J Mice. Frontiers in behavioral neuroscience. vol 9. 2015-12-23. PMID:26696857. |
an imbalance between excitatory (e) glutamate and inhibitory (i) gaba transmission may underlie neurodevelopmental conditions such as autism spectrum disorder (asd) and schizophrenia. |
2015-12-23 |
2023-08-13 |
mouse |
| Maria D Donovan, Fionn E O'Brien, Geraldine B Boylan, John F Cryan, Brendan T Griffi. The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat. The Journal of pharmacy and pharmacology. vol 67. issue 4. 2015-11-27. PMID:25490899. |
recent data highlight the potential of bumetanide as a treatment for neonatal seizures and autism, as it facilitates the excitatory to inhibitory switch in gamma-aminobutyric acid signalling. |
2015-11-27 |
2023-08-13 |
rat |
| Anthony J Russ. Decreased Phosphorylated Protein Kinase B (Akt) in Individuals with Autism Associated with High Epidermal Growth Factor Receptor (EGFR) and Low Gamma-Aminobutyric Acid (GABA). Biomarker insights. vol 10. 2015-10-28. PMID:26508828. |
decreased phosphorylated protein kinase b (akt) in individuals with autism associated with high epidermal growth factor receptor (egfr) and low gamma-aminobutyric acid (gaba). |
2015-10-28 |
2023-08-13 |
Not clear |
| Nouchine Hadjikhani, Nicole R Zürcher, Ophelie Rogier, Torsten Ruest, Loyse Hippolyte, Yehezkel Ben-Ari, Eric Lemonnie. Improving emotional face perception in autism with diuretic bumetanide: a proof-of-concept behavioral and functional brain imaging pilot study. Autism : the international journal of research and practice. vol 19. issue 2. 2015-10-19. PMID:24343334. |
clinical observations have shown that gaba-acting benzodiazepines exert paradoxical excitatory effects in autism, suggesting elevated intracellular chloride (cl-)i and excitatory action of gaba. |
2015-10-19 |
2023-08-12 |
Not clear |
| Yehezkel Ben-Ar. Is birth a critical period in the pathogenesis of autism spectrum disorders? Nature reviews. Neuroscience. vol 16. issue 8. 2015-10-06. PMID:26152864. |
birth is associated with a neuroprotective, oxytocin-mediated abrupt excitatory-to-inhibitory gaba shift that is abolished in autism, and its restoration attenuates the disorder in offspring. |
2015-10-06 |
2023-08-13 |
Not clear |