| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adrian L Oblak, Terrell T Gibbs, Gene J Blat. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20557420. |
emerging evidence demonstrates abnormalities in the gabaergic (gamma-aminobutyric acid) system in autism, which likely contributes to these deficits. |
2010-09-13 |
2023-08-12 |
human |
| Adrian L Oblak, Terrell T Gibbs, Gene J Blat. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20557420. |
the density of gaba(b) receptors in subjects with autism and matched controls was quantified in the anterior and posterior cingulate cortex, important for socio-emotional and cognitive processing, and the fusiform gyrus, important for identification of faces and facial expressions. |
2010-09-13 |
2023-08-12 |
human |
| Adrian L Oblak, Terrell T Gibbs, Gene J Blat. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20557420. |
significant reductions in gaba(b) receptor density were demonstrated in all three regions examined suggesting that alterations in this key inhibitory receptor subtype may contribute to the functional deficits in individuals with autism. |
2010-09-13 |
2023-08-12 |
human |
| Adrian L Oblak, Terrell T Gibbs, Gene J Blat. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20557420. |
interestingly, the presence of seizure in a subset of autism cases did not have a significant effect on the density of gaba(b) receptors in any of the three regions. |
2010-09-13 |
2023-08-12 |
human |
| S Hossein Fatemi, Teri J Reutiman, Timothy D Folsom, Robert J Rooney, Diven H Patel, Paul D Thura. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. Journal of autism and developmental disorders. vol 40. issue 6. 2010-08-03. PMID:20066485. |
we have shown altered expression of gamma-aminobutyric acid a (gaba(a)) and gamma-aminobutyric acid b (gaba(b)) receptors in the brains of subjects with autism. |
2010-08-03 |
2023-08-12 |
human |
| S Hossein Fatemi, Teri J Reutiman, Timothy D Folsom, Robert J Rooney, Diven H Patel, Paul D Thura. mRNA and protein levels for GABAAalpha4, alpha5, beta1 and GABABR1 receptors are altered in brains from subjects with autism. Journal of autism and developmental disorders. vol 40. issue 6. 2010-08-03. PMID:20066485. |
in the current study, we sought to verify our western blotting data for gabbr1 via qrt-pcr and to expand our previous work to measure mrna and protein levels of 3 gaba(a) subunits previously associated with autism (gabralpha4; gabralpha5; gabrbeta1). |
2010-08-03 |
2023-08-12 |
human |
| Robert W Thatcher, Duane M North, James Neubrander, Carl J Biver, Stewart Cutler, Phillip Defin. Autism and EEG phase reset: deficient GABA mediated inhibition in thalamo-cortical circuits. Developmental neuropsychology. vol 34. issue 6. 2010-06-08. PMID:20183733. |
autism and eeg phase reset: deficient gaba mediated inhibition in thalamo-cortical circuits. |
2010-06-08 |
2023-08-12 |
human |
| A Oblak, T T Gibbs, G J Blat. Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism. Autism research : official journal of the International Society for Autism Research. vol 2. issue 4. 2009-12-02. PMID:19650112. |
multiple lines of evidence, including genetic and imaging studies, suggest that the acc and gamma-amino-butyric acid (gaba) system may be affected in autism. |
2009-12-02 |
2023-08-12 |
Not clear |
| S Hossein Fatemi, Timothy D Folsom, Teri J Reutiman, Paul D Thura. Expression of GABA(B) receptors is altered in brains of subjects with autism. Cerebellum (London, England). vol 8. issue 1. 2009-05-15. PMID:19002745. |
expression of gaba(b) receptors is altered in brains of subjects with autism. |
2009-05-15 |
2023-08-12 |
human |
| S Hossein Fatemi, Timothy D Folsom, Teri J Reutiman, Paul D Thura. Expression of GABA(B) receptors is altered in brains of subjects with autism. Cerebellum (London, England). vol 8. issue 1. 2009-05-15. PMID:19002745. |
we compared levels of gaba(b) receptor subunits gaba(b) receptor 1 (gabbr1) and gaba(b) receptor 2 (gabbr2) in cerebellum, brodmann's area 9 (ba9), and ba40 of subjects with autism and matched controls. |
2009-05-15 |
2023-08-12 |
human |
| S Hossein Fatemi, Timothy D Folsom, Teri J Reutiman, Paul D Thura. Expression of GABA(B) receptors is altered in brains of subjects with autism. Cerebellum (London, England). vol 8. issue 1. 2009-05-15. PMID:19002745. |
decreases in gaba(b) receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism. |
2009-05-15 |
2023-08-12 |
human |
| S Hossein Fatemi, Teri J Reutiman, Timothy D Folsom, Paul D Thura. GABA(A) receptor downregulation in brains of subjects with autism. Journal of autism and developmental disorders. vol 39. issue 2. 2009-04-02. PMID:18821008. |
gaba(a) receptor downregulation in brains of subjects with autism. |
2009-04-02 |
2023-08-12 |
human |
| S Hossein Fatemi, Teri J Reutiman, Timothy D Folsom, Paul D Thura. GABA(A) receptor downregulation in brains of subjects with autism. Journal of autism and developmental disorders. vol 39. issue 2. 2009-04-02. PMID:18821008. |
preliminary reports have demonstrated altered expression of gaba receptors in the brains of subjects with autism suggesting gaba/glutamate system dysregulation. |
2009-04-02 |
2023-08-12 |
human |
| S Hossein Fatemi, Teri J Reutiman, Timothy D Folsom, Paul D Thura. GABA(A) receptor downregulation in brains of subjects with autism. Journal of autism and developmental disorders. vol 39. issue 2. 2009-04-02. PMID:18821008. |
our results demonstrate that gaba(a) receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread gabaergic dysfunction in the brains of subjects with autism. |
2009-04-02 |
2023-08-12 |
human |
| Soo-Jeong Kim, Camille W Brune, Emily O Kistner, Susan L Christian, Eric H Courchesne, Nancy J Cox, Edwin H Coo. Transmission disequilibrium testing of the chromosome 15q11-q13 region in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 147B. issue 7. 2008-11-17. PMID:18361419. |
tdt revealed nominally significant transmission disequilibrium between autism and five snps, three of which are located within close proximity of the gaba(a) receptor subunit gene clusters. |
2008-11-17 |
2023-08-12 |
Not clear |
| Harvey R Weiss, Xia Liu, Oak Z Ch. Cerebral O(2) consumption in young Eker rats, effects of GABA blockade: implications for autism. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 5. 2008-07-31. PMID:18282678. |
cerebral o(2) consumption in young eker rats, effects of gaba blockade: implications for autism. |
2008-07-31 |
2023-08-12 |
rat |
| Kenneth J Aitke. Intersubjectivity, affective neuroscience, and the neurobiology of autistic spectrum disorders: a systematic review. The Keio journal of medicine. vol 57. issue 1. 2008-06-09. PMID:18382122. |
we focus in particular on social interaction; the role of the intrinsic motive formation and recent work on mirror neurons in autism; genetic and teratogenic factors in the genesis of autism; and the role of a number of biological factors in pathogenesis - tryptophan; vitamin b12; sterol metabolism; glutamate and gaba; and the fragile-x expansion. |
2008-06-09 |
2023-08-12 |
Not clear |
| Jane Yip, Jean-Jacques Soghomonian, Gene J Blat. Increased GAD67 mRNA expression in cerebellar interneurons in autism: implications for Purkinje cell dysfunction. Journal of neuroscience research. vol 86. issue 3. 2008-04-28. PMID:17918742. |
we investigated the capacity for interneuronal synthesis of gamma-amino butyric acid (gaba) in both types of interneurons that innervate the remaining pcs in the posterolateral cerebellar hemisphere in autism. |
2008-04-28 |
2023-08-12 |
Not clear |
| Mamoru Tochigi, Chieko Kato, Shinko Koishi, Yuki Kawakubo, Kenji Yamamoto, Hideo Matsumoto, Ohiko Hashimoto, Soo-Yung Kim, Keiichiro Watanabe, Yukiko Kano, Eiji Nanba, Nobumasa Kato, Tsukasa Sasak. No evidence for significant association between GABA receptor genes in chromosome 15q11-q13 and autism in a Japanese population. Journal of human genetics. vol 52. issue 12. 2008-02-06. PMID:17957331. |
no evidence for significant association between gaba receptor genes in chromosome 15q11-q13 and autism in a japanese population. |
2008-02-06 |
2023-08-12 |
human |
| Mamoru Tochigi, Chieko Kato, Shinko Koishi, Yuki Kawakubo, Kenji Yamamoto, Hideo Matsumoto, Ohiko Hashimoto, Soo-Yung Kim, Keiichiro Watanabe, Yukiko Kano, Eiji Nanba, Nobumasa Kato, Tsukasa Sasak. No evidence for significant association between GABA receptor genes in chromosome 15q11-q13 and autism in a Japanese population. Journal of human genetics. vol 52. issue 12. 2008-02-06. PMID:17957331. |
the gamma-aminobutyric acid (gaba) receptor genes gabrb3, gabra5, and gabrg3 located on chromosome 15q11-q13 have been major candidates for susceptibility genes for autism, a neurodevelopmental disorder with a complex genetic etiology. |
2008-02-06 |
2023-08-12 |
human |