| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Qiong Kang, Gregory Barne. A common susceptibility factor of both autism and epilepsy: functional deficiency of GABA A receptors. Journal of autism and developmental disorders. vol 43. issue 1. 2013-06-28. PMID:22555366. |
mutations in gaba(a) receptor subunit have been frequently associated with epilepsy, autism, and other neuropsychiatric disorders. |
2013-06-28 |
2023-08-12 |
Not clear |
| Kizzy Vasquez, Salomon Kuizon, Mohammed Junaid, Abdeslem El Idriss. The effect of folic acid on GABA(A)-B 1 receptor subunit. Advances in experimental medicine and biology. vol 775. 2013-06-12. PMID:23392927. |
gamma-aminobutyric acid (type a) beta 1 receptor (gabrb1) disruption has been implicated in autism. |
2013-06-12 |
2023-08-12 |
Not clear |
| E Lemonnier, C Degrez, M Phelep, R Tyzio, F Josse, M Grandgeorge, N Hadjikhani, Y Ben-Ar. A randomised controlled trial of bumetanide in the treatment of autism in children. Translational psychiatry. vol 2. 2013-05-17. PMID:23233021. |
gamma aminobutyric acid (gaba)-mediated synapses and the oscillations they orchestrate are altered in autism. |
2013-05-17 |
2023-08-12 |
Not clear |
| E Lemonnier, C Degrez, M Phelep, R Tyzio, F Josse, M Grandgeorge, N Hadjikhani, Y Ben-Ar. A randomised controlled trial of bumetanide in the treatment of autism in children. Translational psychiatry. vol 2. 2013-05-17. PMID:23233021. |
gaba-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, gaba excites neurons because of elevated intracellular concentrations of chloride. |
2013-05-17 |
2023-08-12 |
Not clear |
| Caley J Burru. A biochemical rationale for the interaction between gastrointestinal yeast and autism. Medical hypotheses. vol 79. issue 6. 2013-04-18. PMID:23021572. |
an excess of gaba has been proposed as a possible contributor to autism. |
2013-04-18 |
2023-08-12 |
human |
| Dale J Hedges, Kara L Hamilton-Nelson, Stephanie J Sacharow, Laura Nations, Gary W Beecham, Zhanna M Kozhekbaeva, Brittany L Butler, Holly N Cukier, Patrice L Whitehead, Deqiong Ma, James M Jaworski, Lubov Nathanson, Joycelyn M Lee, Stephen L Hauser, Jorge R Oksenberg, Michael L Cuccaro, Jonathan L Haines, John R Gilbert, Margaret A Pericak-Vanc. Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci. Molecular autism. vol 3. 2012-10-02. PMID:22472195. |
multiple lines of evidence, including altered gaba and gaba receptor expression in autistic patients, indicate that the gabaergic system may be involved in the etiology of autism. |
2012-10-02 |
2023-08-12 |
Not clear |
| Bidisha Chattopadhyaya, Graziella Di Crist. GABAergic circuit dysfunctions in neurodevelopmental disorders. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22666213. |
here, we highlight recent studies suggesting a role for alterations of gaba transmission in the pathophysiology of two neurodevelopmental diseases, schizophrenia, and autism. |
2012-10-02 |
2023-08-12 |
Not clear |
| Cynthia Addae, Xiaoping Yi, Ramkishore Gernapudi, Henrique Cheng, Alberto Musto, Eduardo Martinez-Ceballo. All-trans-retinoid acid induces the differentiation of encapsulated mouse embryonic stem cells into GABAergic neurons. Differentiation; research in biological diversity. vol 83. issue 5. 2012-09-25. PMID:22466603. |
because the main output of inhibitory gabaergic interneurons is the gamma-aminobutyric-acid (gaba), a neurotransmitter whose controlled homeostasis is required for normal brain function, the efficient generation in culture of functional interneurons may have future implications on the treatment of neurological disorders such as epilepsy, autism, and schizophrenia. |
2012-09-25 |
2023-08-12 |
mouse |
| Dominique Nouel, Melissa Burt, Ying Zhang, Louise Harvey, Patricia Boks. Prenatal exposure to bacterial endotoxin reduces the number of GAD67- and reelin-immunoreactive neurons in the hippocampus of rat offspring. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 4. 2012-07-16. PMID:21889316. |
subjects with schizophrenia and autism are reported to exhibit reduced levels of glutamic acid decarboxylase 67 (gad67), a marker for gaba neurons, in various brain regions. |
2012-07-16 |
2023-08-12 |
human |
| Adrian L Oblak, Terrell T Gibbs, Gene J Blat. Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain research. vol 1380. 2012-01-18. PMID:20858465. |
on-the-slide ligand binding autoradiography was used to determine if there were alterations in gaba(a) and/or benzodiazepine binding sites in the brain in autism. |
2012-01-18 |
2023-08-12 |
Not clear |
| Adrian L Oblak, Terrell T Gibbs, Gene J Blat. Reduced GABAA receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain research. vol 1380. 2012-01-18. PMID:20858465. |
in addition, the autism group had a higher binding affinity in the superficial layers of the gaba(a) study. |
2012-01-18 |
2023-08-12 |
Not clear |
| S Hossein Fatemi, Timothy D Folsom, Rachel E Kneeland, Stephanie B Liesc. Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:21901840. |
there was also a significant decrease in level of gaba(a) receptor beta 3 (gabrβ3) protein in vermis of adult subjects with autism. |
2012-01-17 |
2023-08-12 |
human |
| S Hossein Fatemi, Timothy D Folsom, Paul D Thura. Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study. Schizophrenia research. vol 128. issue 1-3. 2011-08-24. PMID:21303731. |
postmortem and genetic studies have clearly demonstrated changes in gaba(b) receptors in neuropsychiatric disorders such as autism, bipolar disorder, major depression, and schizophrenia. |
2011-08-24 |
2023-08-12 |
human |
| Masafumi Harada, Masako M Taki, Ayumi Nose, Hitoshi Kubo, Kenji Mori, Hiromu Nishitani, Tsuyoshi Matsud. Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument. Journal of autism and developmental disorders. vol 41. issue 4. 2011-08-05. PMID:20652388. |
the gaba level and [gaba]/[naa] ratio were significantly lower (p < 0.01) in the fl, but not the ln, in patients with autism compared to normal controls. |
2011-08-05 |
2023-08-12 |
Not clear |
| Ryan M Smith, Wolfgang Sade. Synaptic signaling and aberrant RNA splicing in autism spectrum disorders. Frontiers in synaptic neuroscience. vol 3. 2011-07-14. PMID:21423409. |
failure to generate the appropriate synaptic adhesion proteins is associated with disrupted glutamatergic and gamma-aminobutyric acid signaling, resulting in loss of activity-dependent neuronal plasticity, and risk for developmental disorders, including autism. |
2011-07-14 |
2023-08-12 |
Not clear |
| David R Hampson, Daniel C Adusei, Laura K K Pace. The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome. Biochemical pharmacology. vol 81. issue 9. 2011-06-06. PMID:21333634. |
aberrations in gaba(a) receptor ion channels and the g-protein coupled metabotropic glutamate and gaba(b) transmitter systems are also linked to both disorders and these receptors are currently at the forefront of preclinical and clinical research into treatments for both autism and fragile x syndrome. |
2011-06-06 |
2023-08-12 |
human |
| R J Delahanty, J Q Kang, C W Brune, E O Kistner, E Courchesne, N J Cox, E H Cook, R L Macdonald, J S Sutcliff. Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism. Molecular psychiatry. vol 16. issue 1. 2011-04-19. PMID:19935738. |
one 15q11-q13 locus encodes the gaba(a) receptor β3 subunit gene (gabrb3), which has been implicated by several studies in both autism and absence epilepsy, and the co-morbidity of epilepsy in autism is well established. |
2011-04-19 |
2023-08-12 |
human |
| R J Delahanty, J Q Kang, C W Brune, E O Kistner, E Courchesne, N J Cox, E H Cook, R L Macdonald, J S Sutcliff. Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism. Molecular psychiatry. vol 16. issue 1. 2011-04-19. PMID:19935738. |
we thus provide the first evidence of an association between a specific gaba(a) receptor defect and autism, direct evidence that this defect causes synaptic dysfunction that is autism relevant and the first maternal risk effect in the 15q11-q13 autism duplication region that is linked to a coding variant. |
2011-04-19 |
2023-08-12 |
human |
| Lee E Wachtel, Dirk M Dhossch. Self-injury in autism as an alternate sign of catatonia: implications for electroconvulsive therapy. Medical hypotheses. vol 75. issue 1. 2010-09-13. PMID:20202760. |
central gamma-aminobutyric acid (gaba) dysfunction may provide an important explanatory link between autism, catatonia and self-injury. |
2010-09-13 |
2023-08-12 |
Not clear |
| Adrian L Oblak, Terrell T Gibbs, Gene J Blat. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. Journal of neurochemistry. vol 114. issue 5. 2010-09-13. PMID:20557420. |
decreased gaba(b) receptors in the cingulate cortex and fusiform gyrus in autism. |
2010-09-13 |
2023-08-12 |
human |