| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katsutoshi Sato, Masaharu Nishikino, Yasuaki Okano, Shinsuke Ohshima, Noboru Hasegawa, Masahiko Ishino, Tetsuya Kawachi, Hodaka Numasaki, Teruki Teshima, Hiroaki Nishimur. γ-H2AX and phosphorylated ATM focus formation in cancer cells after laser plasma X irradiation. Radiation research. vol 174. issue 4. 2010-10-14. PMID:20718602. |
moreover, the numbers of γ-h2ax and phosphorylated ataxia telangiectasia mutated (atm) foci induced by 8 kev laser plasma x rays were comparable to those induced by 4 mv x rays. |
2010-10-14 |
2023-08-12 |
Not clear |
| T Shimura, S Kakuda, Y Ochiai, H Nakagawa, Y Kuwahara, Y Takai, J Kobayashi, K Komatsu, M Fukumot. Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta-mediated cyclin D1 overexpression. Oncogene. vol 29. issue 34. 2010-10-07. PMID:20562919. |
cyclin d1 overexpression led to the activation of dna damage response (ddr) consisted of ataxia telangiectasia mutated (atm)- and chk1-dependent dna damage checkpoint and homologous recombination repair (hrr). |
2010-10-07 |
2023-08-12 |
human |
| Hong Zhan, Toru Suzuki, Kenichi Aizawa, Kiyoshi Miyagawa, Ryozo Naga. Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence. The Journal of biological chemistry. vol 285. issue 38. 2010-09-28. PMID:20639198. |
ataxia telangiectasia mutated (atm)-mediated dna damage response in oxidative stress-induced vascular endothelial cell senescence. |
2010-09-28 |
2023-08-12 |
mouse |
| Hong Zhan, Toru Suzuki, Kenichi Aizawa, Kiyoshi Miyagawa, Ryozo Naga. Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence. The Journal of biological chemistry. vol 285. issue 38. 2010-09-28. PMID:20639198. |
the dna damage response and its main signaling pathway involving ataxia telangiectasia mutated (atm) have been implicated in playing a central role in mediating the actions of oxidative stress; however, the role of the atm signaling pathway in vascular pathogenesis has largely remained unclear. |
2010-09-28 |
2023-08-12 |
mouse |
| Jia-Rong Fan, Ting-Hsiang Huang, Chen-Yu Wen, Tang-Long Shen, Tsai-Kun L. Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses. European journal of pharmacology. vol 638. issue 1-3. 2010-09-27. PMID:20406630. |
(5) the activation of ataxia telangiectasia mutated (atm) kinase and dna-dependent protein kinase (dna-pk), two key signal transducers upstream of rpa and p53, was found to be significantly reduced with sodium salicylate treatment. |
2010-09-27 |
2023-08-12 |
Not clear |
| Raja S Vasireddy, Michelle M Tang, Li-Jeen Mah, George T Georgiadis, Assam El-Osta, Tom C Karagianni. Evaluation of the spatial distribution of gammaH2AX following ionizing radiation. Journal of visualized experiments : JoVE. issue 42. 2010-09-21. PMID:20736911. |
this phosphorylation of h2ax is mediated by the phosphatidyl-inosito 3-kinase (pi3k) family of proteins, ataxia telangiectasia mutated (atm), dna-protein kinase catalytic subunit and atm and rad3-related (atr). |
2010-09-21 |
2023-08-12 |
Not clear |
| Masahiro Hitomi, Dennis W Stace. The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 77. issue 6. 2010-09-15. PMID:20506465. |
quantitative cytometric studies show that cyclin d1 levels must decline during s phase for proper cell cycle progression, and that cyclin d1 decline follows phosphorylation induced by the checkpoint kinases ataxia telangiectasia mutated (atm) and atm and rad3-related (atr). |
2010-09-15 |
2023-08-12 |
Not clear |
| Masahiro Hitomi, Dennis W Stace. The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons. Cytometry. Part A : the journal of the International Society for Analytical Cytology. vol 77. issue 6. 2010-09-15. PMID:20506465. |
atm is mutated in ataxia telangiectasia (at), a disease characterized by progressive neurodegeneration. |
2010-09-15 |
2023-08-12 |
Not clear |
| Jason S White, Serah Choi, Christopher J Bakkenis. Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange. Science signaling. vol 3. issue 124. 2010-09-07. PMID:20516478. |
cells derived from ataxia telangiectasia (a-t) patients exhibit defective cell cycle checkpoints because of mutations in the gene encoding atm (ataxia telangiectasia mutated). |
2010-09-07 |
2023-08-12 |
Not clear |
| Martin V Bennetzen, Dorthe Helena Larsen, Jakob Bunkenborg, Jiri Bartek, Jiri Lukas, Jens S Anderse. Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response. Molecular & cellular proteomics : MCP. vol 9. issue 6. 2010-09-02. PMID:20164059. |
sites regulated shortly after radiation were enriched in the ataxia telangiectasia mutated (atm) kinase sq consensus sequence motif and a novel sxxq motif. |
2010-09-02 |
2023-08-12 |
Not clear |
| Simona Giunta, Rimma Belotserkovskaya, Stephen P Jackso. DNA damage signaling in response to double-strand breaks during mitosis. The Journal of cell biology. vol 190. issue 2. 2010-08-27. PMID:20660628. |
here, we show that mitotic cells treated with dsb-inducing agents activate a "primary" dna damage response (ddr) comprised of early signaling events, including activation of the protein kinases ataxia telangiectasia mutated (atm) and dna-dependent protein kinase (dna-pk), histone h2ax phosphorylation together with recruitment of mediator of dna damage checkpoint 1 (mdc1), and the mre11-rad50-nbs1 (mrn) complex to damage sites. |
2010-08-27 |
2023-08-12 |
Not clear |
| Hsu-Feng Lu, Tung-Yuan Lai, Te-Chung Hsia, Yih-Jing Tang, Jai-Sing Yang, Jo-Hua Chiang, Chi-Cheng Lu, Chi-Ming Liu, Hai-Lung Wang, Jing-Gung Chun. Danthron induces DNA damage and inhibits DNA repair gene expressions in GBM 8401 human brain glioblastoma multiforms cells. Neurochemical research. vol 35. issue 7. 2010-08-20. PMID:20369292. |
the results from real-time pcr assay demonstrated that 100 microm of danthron for 24 h treatment in gbm 8401 cells led to decrease all examined ataxia telangiectasia mutated (atm), ataxia-telangiectasia and rad3-related (atr), breast cancer 1, early onset (brca-1), 14-3-3 proteins sigma (14-3-3sigma), dna-dependent serine/threonine protein kinase (dna-pk) and o ( 6 )-methylguanine-dna methyltransferase (mgmt) mrna expressions. |
2010-08-20 |
2023-08-12 |
human |
| Kung-Wen Lu, Jung-Chou Chen, Tung-Yuan Lai, Jai-Sing Yang, Shu-Wen Weng, Yi-Shih Ma, Nou-Ying Tang, Pei-Jung Lu, Jing-Ru Weng, Jing-Gung Chun. Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells. In vivo (Athens, Greece). vol 24. issue 3. 2010-08-16. PMID:20555000. |
the results from real-time pcr analysis indicated that treatment of sas cells with 180 mug/ml of gyp for 24 h led to a decrease in 14-3-3sigma, dna-dependent serine/threonine protein kinase (dnapk), p53, ataxia telangiectasia mutated (atm), ataxia-telangiectasia and rad3-related (atr) and breast cancer gene 1 (brca1) mrna expression. |
2010-08-16 |
2023-08-12 |
human |
| Li Zhang, Ming Yang, Nan Bi, Mingjing Fang, Tong Sun, Wei Ji, Wen Tan, Lujun Zhao, Dianke Yu, Dongxin Lin, Luhua Wan. ATM polymorphisms are associated with risk of radiation-induced pneumonitis. International journal of radiation oncology, biology, physics. vol 77. issue 5. 2010-08-12. PMID:20171797. |
since the ataxia telangiectasia mutated (atm) protein plays crucial roles in repair of double-stranded dna breaks, control of cell cycle checkpoints, and radiosensitivity, we hypothesized that variations in this gene might be associated with radiation-induced pneumonitis (rp). |
2010-08-12 |
2023-08-12 |
Not clear |
| S V Costes, I Chiolo, J M Pluth, M H Barcellos-Hoff, B Jako. Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutation research. vol 704. issue 1-3. 2010-08-11. PMID:20060491. |
discussion is limited to rif formed by three interrelated proteins atm (ataxia telangiectasia mutated), 53bp1 (p53 binding protein 1) and gammah2ax (phosphorylated variant histone h2ax), with an emphasis on the later. |
2010-08-11 |
2023-08-12 |
Not clear |
| I Jeong, A Y Patel, Z Zhang, P B Patil, S T Nadella, S Nair, L Ralston, J K Hoormann, J S Fishe. Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus. Acta physiologica (Oxford, England). vol 198. issue 4. 2010-08-10. PMID:20003097. |
ataxia telangiectasia mutated (atm) reportedly plays a role in insulin-stimulated activation of akt in some cell types but not in others. |
2010-08-10 |
2023-08-12 |
mouse |
| Michelle M Tang, Li-Jeen Mah, Raja S Vasireddy, George T Georgiadis, Assam El-Osta, Simon G Royce, Tom C Karagianni. Quantitation of gammaH2AX foci in tissue samples. Journal of visualized experiments : JoVE. issue 40. 2010-08-09. PMID:20613712. |
this phosphorylation event is mediated by the phosphatidyl-inosito 3-kinase (pi3k) family of proteins, ataxia telangiectasia mutated (atm), dna-protein kinase catalytic subunit and atm and rad3-related (atr). |
2010-08-09 |
2023-08-12 |
mouse |
| Shan Zha, Craig H Bassing, Takaomi Sanda, James W Brush, Harin Patel, Peter H Goff, Michael M Murphy, Suprawee Tepsuporn, Richard A Gatti, A Thomas Look, Frederick W Al. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. The Journal of experimental medicine. vol 207. issue 7. 2010-07-30. PMID:20566716. |
ataxia telangiectasia mutated (atm) deficiency predisposes humans and mice to t lineage lymphomas with recurrent chromosome 14 translocations involving the t cell receptor alpha/delta (tcra/d) locus. |
2010-07-30 |
2023-08-12 |
mouse |
| Cheng-Yen Chuang, Hsiang-Chun Liu, Li-Chen Wu, Chiu-Yuan Chen, Jinghua Tsai Chang, Shih-Lan Hs. Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. Journal of agricultural and food chemistry. vol 58. issue 5. 2010-07-19. PMID:20151649. |
mechanistic studies showed that gallic acid induces early phosphorylation of p53(ser18) and histone 2ax(ser139) (h2ax) via ataxia telangiectasia mutated (atm) activation in response to ros-provoked dna damage. |
2010-07-19 |
2023-08-12 |
mouse |
| Javier G Pizarro, Jaume Folch, Aurelio Vazquez de la Torre, Felix Junyent, Ester Verdaguer, Joaquin Jordan, Merce Pallas, Antoni Camin. ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation. Journal of cellular biochemistry. vol 110. issue 1. 2010-07-19. PMID:20213763. |
ataxia telangiectasia mutated protein (atm) is a member of the phosphatidylinositol-3 kinase (pi3k) family, which has a role in the cellular response to dna double-strand breaks (dsbs). |
2010-07-19 |
2023-08-12 |
rat |