| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kirsten E Rakkestad, Ida Skaar, Vibeke E Ansteinsson, Anita Solhaug, Jørn A Holme, James J Pestka, Jan T Samuelsen, Hans J Dahlman, Jan K Hongslo, Rune Beche. DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. Toxicological sciences : an official journal of the Society of Toxicology. vol 115. issue 1. 2010-07-06. PMID:20150440. |
increased ataxia telangiectasia mutated (atm) phosphorylation, indicating dna damage, was observed after all exposures. |
2010-07-06 |
2023-08-12 |
Not clear |
| J-L Perfettini, R Nardacci, C Séror, S Q Raza, S Sepe, H Saïdi, F Brottes, A Amendola, F Subra, F Del Nonno, L Chessa, A D'Incecco, M-L Gougeon, M Piacentini, G Kroeme. 53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope. Cell death and differentiation. vol 17. issue 5. 2010-06-28. PMID:19876065. |
it colocalizes partially with the promyelomonocytic leukemia protein (pml), and the ataxia telangiectasia mutated kinase (atm), the two components of the ddr that mediate apoptosis induced by the hiv-1 envelope. |
2010-06-28 |
2023-08-12 |
human |
| Stergios J Moschos, Nicole R Dodd, Drazen M Jukic, Shelley L Fayewicz, Xiaolei Wang, Dorothea Becke. Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation. Cancer biology & therapy. vol 8. issue 19. 2010-06-21. PMID:19684476. |
in line with efforts to identify genes that are key regulators of the disease and as such, may prove valuable targets for adjuvant and neo-adjuvant therapy of melanomas, we previously reported the presence of serial analysis of gene expression (sage) tags, corresponding to the ataxia telangiectasia mutated (atm) gene, in sage libraries generated from tissues representing primary and metastatic melanomas. |
2010-06-21 |
2023-08-12 |
Not clear |
| Ryo Sakasai, Hirobumi Teraoka, Masatoshi Takagi, Randal S Tibbett. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. The Journal of biological chemistry. vol 285. issue 20. 2010-06-14. PMID:20304914. |
cpt-induced dna double-strand breaks (dsbs) are considered a major cause of its tumoricidal activity, and it has been shown that cpt induces dna damage signaling through the phosphatidylinositol 3-kinase-related kinases, including atm (ataxia telangiectasia mutated), atr (atm and rad3-related), and dna-pk (dna-dependent protein kinase). |
2010-06-14 |
2023-08-12 |
Not clear |
| Neus Abella, Sonia Brun, Maria Calvo, Olga Tapia, Jason D Weber, Maria T Berciano, Miguel Lafarga, Oriol Bachs, Neus Agel. Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage. Traffic (Copenhagen, Denmark). vol 11. issue 6. 2010-06-14. PMID:20331843. |
we show here that the nuclear accumulation of p21(cip1) is not only a consequence of its increased levels but to a dna damage cellular response, which is ataxia telangiectasia and rad3 related (atr)/ataxia telangiectasia mutated (atm) and p53 independent. |
2010-06-14 |
2023-08-12 |
Not clear |
| Pamela J Sykes, Tanya K Day, Sarah J Swinburne, Joanne M Lane, Alexander A Morley, Antony M Hooker, Madhava Bha. In vivo mutagenic effect of very low dose radiation. Dose-response : a publication of International Hormesis Society. vol 4. issue 4. 2010-06-09. PMID:18648587. |
we have observed 1) a non-linear dose response of induced inversions in pkz1 mice exposed to a wide dose range of low let radiation, 2) the ability of low priming doses to cause an adaptive response to subsequent higher test doses and 3) the effect of genetic susceptibility where animals that are heterozygous for the ataxia telangiectasia gene (atm) exhibit different responses to low dose radiation compared to their normal litter-mates. |
2010-06-09 |
2023-08-12 |
mouse |
| Nicola J Maclaine, Ted R Hup. The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. Aging. vol 1. issue 5. 2010-06-02. PMID:20157532. |
we demonstrate that distinct stress-activated kinases, including ataxia telangiectasia mutated (atm), casein kinase 1 (ck1) and amp-activated protein kinase (ampk), mediate phosphorylation of a key phospho-acceptor site in the p53 transactivation domain in response to diverse stresses including ionizing radiation, dna virus infection, and elevation in the intracellular amp/atp ratio. |
2010-06-02 |
2023-08-12 |
mouse |
| Benjamin Orsburn, Beatriz Escudero, Mansi Prakash, Silvia Gesheva, Guosheng Liu, David L Huso, Sonia Franc. Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1. Molecular and cellular biology. vol 30. issue 10. 2010-06-02. PMID:20231360. |
combined deficiencies of poly(adp)ribosyl polymerase 1 (parp1) and ataxia telangiectasia mutated (atm) result in synthetic lethality and, in the mouse, early embryonic death. |
2010-06-02 |
2023-08-12 |
mouse |
| Akihisa Takahashi, Eiichiro Mori, Takeo Ohnish. The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment. Journal of radiation research. vol 51. issue 1. 2010-05-25. PMID:20173316. |
recently, there have been many reports concerning proteins which can recognize dna double strand break (dsbs), and such proteins include histone h2ax phosphorylated at serine 139 (gammah2ax), ataxia telangiectasia mutated (atm) phospho-serine 1981, dna-dependent protein kinase catalytic subunit (dna-pkcs) phospho-threonine 2609, nijmegen breakage syndrome 1 (nbs1) phospho-serine 343, checkpoint kinase 2 (chk2), phospho-threonine 68, and structural maintenance of chromosomes 1 (smc1) phospho-serine 966. |
2010-05-25 |
2023-08-12 |
human |
| Stefano J Mandriota, Raphaële Buser, Laurence Lesne, Christelle Stouder, Vincent Favaudon, Pierre Maechler, Frédérique Béna, Virginie Clément, Curzio Rüegg, Roberto Montesano, André-Pascal Sappin. Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20177072. |
ataxia telangiectasia mutated (atm) inhibition transforms human mammary gland epithelial cells. |
2010-05-20 |
2023-08-12 |
mouse |
| Stefano J Mandriota, Raphaële Buser, Laurence Lesne, Christelle Stouder, Vincent Favaudon, Pierre Maechler, Frédérique Béna, Virginie Clément, Curzio Rüegg, Roberto Montesano, André-Pascal Sappin. Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20177072. |
carriers of mutations in the cell cycle checkpoint protein kinase ataxia telangiectasia mutated (atm), which represent 1-2% of the general population, have an increased risk of breast cancer. |
2010-05-20 |
2023-08-12 |
mouse |
| Ya-Yin Chen, Su-Yin Chiang, Jaung-Geng Lin, Jai-Sing Yang, Yi-Shih Ma, Ching-Lung Liao, Tung-Yuan Lai, Nou-Ying Tang, Jing-Gung Chun. Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells. Anticancer research. vol 30. issue 3. 2010-05-18. PMID:20393018. |
the results from real-time pcr assay demonstrated that 30 microm of emodin or aloe-emodin used for 24 and 48 h treatment in scc-4 cells significantly inhibited expression of genes associated with dna damage and repair [ataxia telangiectasia mutated (atm); ataxia-telangiectasia and rad3-related (atr); 14-3-3sigma (14-3-3sigma); breast cancer 1, early onset (brca1); and dna-dependent serine/threonine protein kinase (dna-pk)]; only rhein suppressed the expression of o(6)-methylguanine-dna methyltransferase (mgmt) mrna with 48 h treatment, but had no effect on atm expression. |
2010-05-18 |
2023-08-12 |
human |
| Min Wu, Mandy M Kang, Norberta W Schoene, Wen-Hsing Chen. Selenium compounds activate early barriers of tumorigenesis. The Journal of biological chemistry. vol 285. issue 16. 2010-05-06. PMID:20157118. |
in response to clastogens, the ataxia telangiectasia mutated (atm) protein is rapidly activated, which in turn initiates a cascade of dna damage response. |
2010-05-06 |
2023-08-12 |
Not clear |
| Nathalie Vonlaufen, Arunasalam Naguleswaran, Isabelle Coppens, William J Sulliva. MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii. The Journal of biological chemistry. vol 285. issue 15. 2010-05-04. PMID:20159970. |
myst family lysine acetyltransferase facilitates ataxia telangiectasia mutated (atm) kinase-mediated dna damage response in toxoplasma gondii. |
2010-05-04 |
2023-08-12 |
Not clear |
| Nathalie Vonlaufen, Arunasalam Naguleswaran, Isabelle Coppens, William J Sulliva. MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii. The Journal of biological chemistry. vol 285. issue 15. 2010-05-04. PMID:20159970. |
we demonstrate that cells overexpressing tgmyst-b have increased levels of ataxia telangiectasia mutated (atm) kinase and phosphorylated h2ax and that tgmyst-b localizes to the atm kinase gene. |
2010-05-04 |
2023-08-12 |
Not clear |
| Anastas Gospodinov, Boyka Anachkov. Lack of effect of RuvB-like proteins on DNA damage signaling activation. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 65. issue 1-2. 2010-04-30. PMID:20355335. |
ataxia telangiectasia mutated (atm) kinase is a central player in cellular response to dna damage. |
2010-04-30 |
2023-08-12 |
Not clear |
| Li-Jeen Mah, Raja S Vasireddy, Michelle M Tang, George T Georgiadis, Assam El-Osta, Tom C Karagianni. Quantification of gammaH2AX foci in response to ionising radiation. Journal of visualized experiments : JoVE. issue 38. 2010-04-30. PMID:20372103. |
following induction of dsbs, h2ax is rapidly phosphorylated by the phosphatidyl-inosito 3-kinase (pikk) family of proteins, ataxia telangiectasia mutated (atm), dna-protein kinase catalytic subunit and atm and rad3-related (atr)(2). |
2010-04-30 |
2023-08-12 |
human |
| b' Lilian Ricaud, Caroline Proux, Jean-Pierre Renou, Olivier Pichon, Sylvain Fochesato, Philippe Ortet, Marie-H\\xc3\\xa9l\\xc3\\xa8ne Montan\\xc3\\xa. ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis. PloS one. vol 2. issue 5. 2010-04-29. PMID:17487278.' |
atm (ataxia telangiectasia mutated) is an essential checkpoint kinase that signals dna double-strand breaks in eukaryotes. |
2010-04-29 |
2023-08-12 |
human |
| Simona Negrini, Vassilis G Gorgoulis, Thanos D Halazoneti. Genomic instability--an evolving hallmark of cancer. Nature reviews. Molecular cell biology. vol 11. issue 3. 2010-04-23. PMID:20177397. |
instead, the mutation patterns of the tumour suppressor tp53 (which encodes p53), ataxia telangiectasia mutated (atm) and cyclin-dependent kinase inhibitor 2a (cdkn2a; which encodes p16ink4a and p14arf) support the oncogene-induced dna replication stress model, which attributes genomic instability and tp53 and atm mutations to oncogene-induced dna damage. |
2010-04-23 |
2023-08-12 |
Not clear |
| Sricharan Bandhakavi, Young-Mi Kim, Seung-Hyun Ro, Hongwei Xie, Getiria Onsongo, Chang-Bong Jun, Do-Hyung Kim, Timothy J Griffi. Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response. Molecular & cellular proteomics : MCP. vol 9. issue 2. 2010-04-22. PMID:19955088. |
consistent with these proteomic changes and ddr activation, mtor inhibition enhanced interaction between 53bp1 and p53 and increased phosphorylation of ataxia telangiectasia mutated (atm) kinase substrates. |
2010-04-22 |
2023-08-12 |
human |