| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian G Cannell, Yi W Kong, Samantha J Johnston, Melissa L Chen, Hilary M Collins, Helen C Dobbyn, Androulla Elia, Theresia R Kress, Martin Dickens, Michael J Clemens, David M Heery, Matthias Gaestel, Martin Eilers, Anne E Willis, Martin Bushel. p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 12. 2010-04-16. PMID:20212154. |
these consist of the well-characterized atr (ataxia telangiectasia and rad-3 related)/chk1 and atm (ataxia telangiectasia mutated)/chk2 pathways in addition to a newly identified atm/atr/p38mapk/mk2 checkpoint. |
2010-04-16 |
2023-08-12 |
Not clear |
| Aya M Westbrook, Robert H Schiest. Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Cancer research. vol 70. issue 5. 2010-04-08. PMID:20179206. |
the role of ataxia telangiectasia mutated (atm), a dna double-strand break recognition and response protein, in inflammation and inflammatory diseases is unclear. |
2010-04-08 |
2023-08-12 |
mouse |
| Carolyn J McNees, Agueda M Tejera, Paula Martínez, Matilde Murga, Francisca Mulero, Oscar Fernandez-Capetillo, Maria A Blasc. ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase. The Journal of cell biology. vol 188. issue 5. 2010-04-01. PMID:20212315. |
in budding yeast, the important ddr kinase tel1 (homologue of atm [ataxia telangiectasia mutated]) is vital for telomerase recruitment to short telomeres, but mammalian atm is dispensable for this function. |
2010-04-01 |
2023-08-12 |
mouse |
| Garth Hamilton, Karen S Yee, Simon Scrace, Eric O'Neil. ATM regulates a RASSF1A-dependent DNA damage response. Current biology : CB. vol 19. issue 23. 2010-03-30. PMID:19962312. |
here we provide evidence for a new pathway linking dna damage signaling to rassf1a via the main sensor of double-strand breaks in cells, ataxia telangiectasia mutated (atm). |
2010-03-30 |
2023-08-12 |
human |
| Emeline de Viron, Laurent Knoops, Thierry Connerotte, Caroline Smal, Lucienne Michaux, Pascale Saussoy, Pascal Vannuffel, Eline Beert, Marie-Christiane Vekemans, Cédric Hermans, Françoise Bontemps, Eric Van Den Nest. Impaired up-regulation of polo-like kinase 2 in B-cell chronic lymphocytic leukaemia lymphocytes resistant to fludarabine and 2-chlorodeoxyadenosine: a potential marker of defective damage response. British journal of haematology. vol 147. issue 5. 2010-03-26. PMID:19764992. |
the functional evaluation of ataxia telangiectasia mutated (atm) and p53 was recently developed in b-cell chronic lymphocytic leukaemia (b-cll), a disease in which the response to dna damage is frequently altered. |
2010-03-26 |
2023-08-12 |
Not clear |
| Narci Teoh, Pawan Pyakurel, Yock Young Dan, Karen Swisshelm, Jing Hou, Claudia Mitchell, Nelson Fausto, Yansong Gu, Geoffrey Farrel. Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. Gastroenterology. vol 138. issue 3. 2010-03-25. PMID:19919837. |
ataxia telangiectasia mutated (atm) kinase senses dna strand breaks and induces p53. |
2010-03-25 |
2023-08-12 |
mouse |
| M E Dujka, N Puebla-Osorio, O Tavana, M Sang, C Zh. ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo. Oncogene. vol 29. issue 7. 2010-03-12. PMID:19915617. |
the ataxia telangiectasia mutated (atm) gene is known to have a central role in sensing general dna damage and mediating cell-cycle checkpoint. |
2010-03-12 |
2023-08-12 |
Not clear |
| Sridevi Yadavilli, Zhenping Chen, Thomas Albrecht, Perpetua M Mugand. Mechanism of diepoxybutane-induced p53 regulation in human cells. Journal of biochemical and molecular toxicology. vol 23. issue 6. 2010-03-10. PMID:20024960. |
a dramatic increase in phosphorylation of p53 at serine 15 in correlation to total p53 levels was observed in deb-exposed ataxia telangiectasia mutated (atm) proficient human lymphoblasts as compared to deb-exposed atm-deficient human lymphoblasts; this implicates the atm kinase in the elevation of p53 levels in deb-exposed cells. |
2010-03-10 |
2023-08-12 |
human |
| Ulrich Bork, Wing-Kee Lee, Anna Kuchler, Thomas Dittmar, Frank Théveno. Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells. American journal of physiology. Renal physiology. vol 298. issue 2. 2010-03-09. PMID:19923412. |
the data indicate that in p53-inactivated pt cells cd(2+)-induced ros formation and dna damage trigger signaling of checkpoint activating kinases ataxia telangiectasia-mutated kinase (atm) and ataxia telangiectasia and rad3-related kinase (atr) to cause g(2)/m arrest. |
2010-03-09 |
2023-08-12 |
Not clear |
| Mang Xiao, Mark H Whitnal. Pharmacological countermeasures for the acute radiation syndrome. Current molecular pharmacology. vol 2. issue 1. 2010-03-02. PMID:20021452. |
among these, the activation of dna non-homologous end-joining (nhej) and homologous recombination (hr), and signaling pathways containing ataxia telangiectasia mutated (atm), play important roles. |
2010-03-02 |
2023-08-12 |
Not clear |
| Angela T Noon, Atsushi Shibata, Nicole Rief, Markus Löbrich, Grant S Stewart, Penelope A Jeggo, Aaron A Goodarz. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nature cell biology. vol 12. issue 2. 2010-02-22. PMID:20081839. |
dna double-strand breaks (dsbs) trigger atm (ataxia telangiectasia mutated) signalling and elicit genomic rearrangements and chromosomal fragmentation if misrepaired or unrepaired. |
2010-02-22 |
2023-08-12 |
human |
| Jan-Bart M Koorstra, Seung-Mo Hong, Chanjuan Shi, Alan K Meeker, Ji Kon Ryu, George Johan A Offerhaus, Michael G Goggins, Ralph H Hruban, Anirban Maitr. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 22. issue 11. 2010-02-19. PMID:19668150. |
in conjunction, activation of the ataxia telangiectasia mutated (atm)-chk2 checkpoint pathway was observed in all histological grades of panin lesions. |
2010-02-19 |
2023-08-12 |
human |
| Sairei So, Anthony J Davis, David J Che. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. The Journal of cell biology. vol 187. issue 7. 2010-02-10. PMID:20026654. |
ataxia telangiectasia mutated (atm) plays a critical role in the cellular response to dna damage. |
2010-02-10 |
2023-08-12 |
Not clear |
| Tibor Pastor, Gabriele Talotti, Marzena Anna Lewandowska, Franco Pagan. An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM. Nucleic acids research. vol 37. issue 21. 2010-01-26. PMID:19773425. |
we have previously reported a natural gtaa deletion within an intronic splicing processing element (ispe) of the ataxia telangiectasia mutated (atm) gene that disrupts a non-canonical u1 snrnp interaction and activates the excision of the upstream portion of the intron. |
2010-01-26 |
2023-08-12 |
Not clear |
| Olga Momcilović, Serah Choi, Sandra Varum, Christopher Bakkenist, Gerald Schatten, Christopher Navar. Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells. Stem cells (Dayton, Ohio). vol 27. issue 8. 2010-01-13. PMID:19544417. |
to understand the response of human es cells to dna damage, we investigated the function of the ataxia telangiectasia mutated (atm) dna damage signaling pathway in response to gamma-irradiation. |
2010-01-13 |
2023-08-12 |
human |
| Sarah E Golding, Elizabeth Rosenberg, Nicholas Valerie, Isa Hussaini, Mark Frigerio, Xiaoling F Cockcroft, Wei Yee Chong, Marc Hummersone, Laurent Rigoreau, Keith A Menear, Mark J O'Connor, Lawrence F Povirk, Timothy van Meter, Kristoffer Valeri. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Molecular cancer therapeutics. vol 8. issue 10. 2010-01-12. PMID:19808981. |
ataxia telangiectasia (a-t) mutated (atm) is critical for cell cycle checkpoints and dna repair. |
2010-01-12 |
2023-08-12 |
human |
| John P Alao, Per Sunnerhage. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiation oncology (London, England). vol 4. 2010-01-08. PMID:19903334. |
the ataxia telangiectasia mutated (atm) and the atm- related (atr) kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens. |
2010-01-08 |
2023-08-12 |
mouse |
| Aliya Ul-Hassan, Karen Sisley, David Hughes, David W Hammond, Martin H Robinson, Malcolm W R Ree. Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement. International journal of experimental pathology. vol 90. issue 5. 2009-12-14. PMID:19765109. |
more importantly, we have shown for the first time a deletion in the ataxia telangiectasia mutated (atm) gene locus with decreased/absent expression of atm protein, and amplification in the region 13q21-q32 in both tumour types, suggesting both regions may play a role in leiomyosarcoma and gist biology. |
2009-12-14 |
2023-08-12 |
Not clear |
| N Ashley, J Poulto. Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling. Oncogene. vol 28. issue 44. 2009-12-08. PMID:19684617. |
in contrast, remodelling was significantly increased by p53 or ataxia telangiectasia mutated inhibition (atm), indicating a link between nucleoid dynamics and the genomic dna damage response. |
2009-12-08 |
2023-08-12 |
Not clear |
| B Gruhne, R Sompallae, M G Masucc. Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints. Oncogene. vol 28. issue 45. 2009-12-04. PMID:19718051. |
ebna-1 promotes the generation of dna damage by inducing reactive oxygen species (ros), whereas dna repair is inhibited in lmp-1-expressing cells through downregulation of the dna damage-sensing kinase, ataxia telangiectasia mutated (atm), reduction of phosphorylation of its downstream targets chk2 and inactivation of the g(2) checkpoint. |
2009-12-04 |
2023-08-12 |
human |