| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luciana Chessa, Maria Piane, Monia Magliozzi, Isabella Torrente, Camilla Savio, Patrizia Lulli, Alessandro De Luca, Bruno Dallapiccol. Founder effects for ATM gene mutations in Italian Ataxia Telangiectasia families. Annals of human genetics. vol 73. issue Pt 5. 2009-12-03. PMID:19691550. |
founder effects for atm gene mutations in italian ataxia telangiectasia families. |
2009-12-03 |
2023-08-12 |
Not clear |
| Penny A Jegg. Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health physics. vol 97. issue 5. 2009-12-01. PMID:19820451. |
the major dsb repair pathways are dna non-homologous end-joining (nhej) and homologous recombination (hr) and ataxia telangiectasia mutated (atm) activates the dsb signaling response. |
2009-12-01 |
2023-08-12 |
Not clear |
| Grace K Mahowald, Jason M Baron, Michael A Mahowald, Shashikant Kulkarni, Andrea L Bredemeyer, Craig H Bassing, Barry P Sleckma. Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 43. 2009-11-24. PMID:19820166. |
however, in ataxia telangiectasia mutated (atm)-deficient lymphocytes, rag breaks are frequently joined aberrantly, forming chromosomal lesions such as translocations that predispose (atm)-deficient mice and humans to the development of lymphoid malignancies. |
2009-11-24 |
2023-08-12 |
mouse |
| Jeffrey R Skaar, Derek J Richard, Anita Saraf, Alfredo Toschi, Emma Bolderson, Laurence Florens, Michael P Washburn, Kum Kum Khanna, Michele Pagan. INTS3 controls the hSSB1-mediated DNA damage response. The Journal of cell biology. vol 187. issue 1. 2009-11-17. PMID:19786574. |
human ssb1 (single-stranded binding protein 1 [hssb1]) was recently identified as a part of the ataxia telangiectasia mutated (atm) signaling pathway. |
2009-11-17 |
2023-08-12 |
human |
| Yingli Sun, Xiaofeng Jiang, Ye Xu, Marina K Ayrapetov, Lisa A Moreau, Johnathan R Whetstine, Brendan D Pric. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nature cell biology. vol 11. issue 11. 2009-11-16. PMID:19783983. |
tip60 is an acetyltransferase that acetylates both histones and atm (ataxia telangiectasia mutated) kinase. |
2009-11-16 |
2023-08-12 |
Not clear |
| Sean V Tavtigian, Peter J Oefner, Davit Babikyan, Anne Hartmann, Sue Healey, Florence Le Calvez-Kelm, Fabienne Lesueur, Graham B Byrnes, Shu-Chun Chuang, Nathalie Forey, Corinna Feuchtinger, Lydie Gioia, Janet Hall, Mia Hashibe, Barbara Herte, Sandrine McKay-Chopin, Alun Thomas, Maxime P Vallée, Catherine Voegele, Penelope M Webb, David C Whiteman, Suleeporn Sangrajrang, John L Hopper, Melissa C Southey, Irene L Andrulis, Esther M John, Georgia Chenevix-Trenc. Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer. American journal of human genetics. vol 85. issue 4. 2009-10-27. PMID:19781682. |
the susceptibility gene for ataxia telangiectasia, atm, is also an intermediate-risk breast-cancer-susceptibility gene. |
2009-10-27 |
2023-08-12 |
Not clear |
| Arun Gupta, Qin Yang, Raj K Pandita, Clayton R Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessei Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C Kaul, Ramon Parsons, Kum Kum Khanna, Tej K Pandit. Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell cycle (Georgetown, Tex.). vol 8. issue 14. 2009-10-20. PMID:19502790. |
we found that pten deficient cells displayed a normal dna damage response (ddr) as evidenced by the ionizing radiation (ir)-induced phosphorylation of ataxia telangiectasia mutated (atm) as well as its effectors. |
2009-10-20 |
2023-08-12 |
Not clear |
| Wenqiang Chen, Salomon Kuizon, Bair L Chiou, David C Bolton, Raju K Pullarkat, Mohammed A Junai. Differential expression of small heat shock protein 27 (Hsp27) in Ataxia telangiectasia brains. Neurochemical research. vol 34. issue 9. 2009-10-19. PMID:19322656. |
ataxia telangiectasia (a-t) is a progressive neurodegenerative disorder caused by disruption of the gene, ataxia telangiectasia mutated (atm). |
2009-10-19 |
2023-08-12 |
Not clear |
| Olivier Sordet, Christophe E Redon, Josée Guirouilh-Barbat, Susan Smith, Stéphanie Solier, Céline Douarre, Chiara Conti, Asako J Nakamura, Benu B Das, Estelle Nicolas, Kurt W Kohn, William M Bonner, Yves Pommie. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. EMBO reports. vol 10. issue 8. 2009-10-15. PMID:19557000. |
ataxia telangiectasia mutated (atm), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the dna damage response (ddr). |
2009-10-15 |
2023-08-12 |
Not clear |
| Y Yang, K S Lee, C Xiang, H Li. Biological mechanisms revealed by a mathematical model for p53-Mdm2 core regulation. IET systems biology. vol 3. issue 4. 2009-10-01. PMID:19640162. |
the dynamics of atm (ataxia telangiectasia mutated) is introduced to the model so as to connect dna damage signal with the core regulation. |
2009-10-01 |
2023-08-12 |
Not clear |
| Janet Hall, Virginie Marcel, Celeste Bolin, Marie Fernet, Laurence Tartier, Laurence Vaslin, Pierre Hainau. The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations. Biochemical Society transactions. vol 37. issue Pt 3. 2009-09-29. PMID:19442246. |
for instance, atm (ataxia telangiectasia mutated) snps have been associated with increased risk of breast, prostate, leukaemia, colon and early-onset lung cancer, and the intron 3 16-bp repeat in tp53 (tumour protein 53) is associated with an increased risk of lung cancer. |
2009-09-29 |
2023-08-12 |
human |
| Tomas Lindahl, Deborah E Barnes, Yun-Gui Yang, Peter Robin. Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. Biochemical Society transactions. vol 37. issue Pt 3. 2009-09-29. PMID:19442247. |
subsequently, we have shown that ags1 cells exhibit chronic atm (ataxia telangiectasia mutated)-dependent checkpoint activation, and these trex1-deficient cells accumulate ssdna fragments of a distinct size generated during dna replication. |
2009-09-29 |
2023-08-12 |
human |
| Aaron A Goodarzi, Angela T Noon, Penny A Jegg. The impact of heterochromatin on DSB repair. Biochemical Society transactions. vol 37. issue Pt 3. 2009-09-29. PMID:19442252. |
although nhej-defective cell lines show marked dsb-repair defects, cells defective in atm (ataxia telangiectasia mutated) repair most dsbs normally. |
2009-09-29 |
2023-08-12 |
Not clear |
| Xiao-Peng Zhang, Feng Liu, Zhang Cheng, Wei Wan. Cell fate decision mediated by p53 pulses. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 30. 2009-09-28. PMID:19617533. |
first, dna repair proteins bind to ir-induced double-strand breaks, forming complexes, which are then detected by ataxia telangiectasia mutated (atm). |
2009-09-28 |
2023-08-12 |
Not clear |
| Ivan Y Iourov, Svetlana G Vorsanova, Thomas Liehr, Alexei D Kolotii, Yuri B Yuro. Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain. Human molecular genetics. vol 18. issue 14. 2009-09-14. PMID:19414482. |
ataxia telangiectasia (at) is a chromosome instability (cin) neurological syndrome arising from dna damage response defects due to atm gene mutations. |
2009-09-14 |
2023-08-12 |
Not clear |
| Yibin Deng, Xiaolan Guo, David O Ferguson, Sandy Chan. Multiple roles for MRE11 at uncapped telomeres. Nature. vol 460. issue 7257. 2009-09-14. PMID:19633651. |
telomere deprotection activates both ataxia telangiectasia mutated (atm) and telangiectasia and rad3-related (atr) kinase-dependent dna damage response pathways, and promotes efficient non-homologous end-joining (nhej) of dysfunctional telomeres. |
2009-09-14 |
2023-08-12 |
mouse |
| Min ZHANG, RuiPeng WANG, YanYi WANG, FeiCi DIAO, Fei LU, Dong GAO, DanYing CHEN, ZhongHe ZHAI, HongBing SH. The CXXC finger 5 protein is required for DNA damage-induced p53 activation. Science in China. Series C, Life sciences. vol 52. issue 6. 2009-09-10. PMID:19557330. |
the ataxia telangiectasia mutated protein kinase (atm) responds to dna-damage stimuli and signals p53 stabilization and activation, thereby facilitating transactivation of p53 inducible genes and maintainence of genome integrity. |
2009-09-10 |
2023-08-12 |
Not clear |
| Lian Xue, Dong Yu, Yoshiya Furusawa, Jianping Cao, Ryuichi Okayasu, Saijun Fa. ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions. International journal of radiation oncology, biology, physics. vol 75. issue 1. 2009-09-10. PMID:19695441. |
the aim of this study was to find out whether equivalent hypersensitivity occurred in high let radiation, and the roles of ataxia telangiectasia mutated (atm) kinase. |
2009-09-10 |
2023-08-12 |
Not clear |
| Wen-Wen Chou, Jinn-Yuh Guh, Jung-Fa Tsai, Chi-Ching Hwang, Shean-Jaw Chiou, Lea-Yea Chuan. Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells. Journal of cellular biochemistry. vol 107. issue 3. 2009-09-01. PMID:19343784. |
the ataxia telangiectasia mutated (atm)/rad3-related (atr)-p53-p21(waf1) and the phosphatidylinositol-3-kinase (pi3k)-mammalian target of rapamycin (mtor) pathways are involved in the dna damage response and the pathogenesis of cancers. |
2009-09-01 |
2023-08-12 |
rat |
| Consuelo Amantini, Patrizia Ballarini, Sara Caprodossi, Massimo Nabissi, Maria Beatrice Morelli, Roberta Lucciarini, Marco Andrea Cardarelli, Gabriele Mammana, Giorgio Santon. Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. vol 30. issue 8. 2009-09-01. PMID:19502594. |
these events were associated with rapid co-ordinated transcription of pro-apoptotic genes including fas/cd95, bcl-2 and caspase families and ataxia telangiectasia mutated (atm)/chk2/p53 dna damage response pathway. |
2009-09-01 |
2023-08-12 |
human |