| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuichi Yamaguchi, Maki Hasegawa, Shiro Aizawa, Kaoru Tanaka, Kazuko Yoshida, Yuko Noda, Kouichi Tatsumi, Katsuiku Hirokawa, Masanobu Kitagaw. DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70. Leukemia research. vol 29. issue 3. 2005-03-23. PMID:15661267. |
neither of dna-dependent protein kinase (dna-pk)-deficient scid mice nor ataxia telangiectasia mutated (atm) gene knockout mice with the c3h background exhibited a remarkable enhancement of apoptosis or p53 activation on flv + tbi-treatment indicating that dna-pk and atm were both essential. |
2005-03-23 |
2023-08-12 |
mouse |
| Yi Tie, Jian-Ping Mao, Bin Liu, Yi Song, Yan Dong, Zhi-Xian Su. [Effect of papillary thyroid carcinoma related gene PTC1 on subcellular localization and function of ATM cell]. Ai zheng = Aizheng = Chinese journal of cancer. vol 23. issue 5. 2005-03-22. PMID:15142440. |
this study was designed to investigate the interaction between dna double-strand break sensor atm (mutated in ataxia telangiectasia) kinase and ptc1, a rearranged form of proto-oncogene ret, to explore the role of ret rearrangements in carcinogenesis. |
2005-03-22 |
2023-08-12 |
Not clear |
| T Ashley, C Westphal, A Plug-de Maggio, D G de Rooi. The mammalian mid-pachytene checkpoint: meiotic arrest in spermatocytes with a mutation in Atm alone or in combination with a Trp53 (p53) or Cdkn1a (p21/cip1) mutation. Cytogenetic and genome research. vol 107. issue 3-4. 2005-03-21. PMID:15467370. |
atm, the protein product of the gene mutated in the human autosomal recessive disorder ataxia telangiectasia, is involved in detection of double strand breaks (dsbs) and is a key component of the damage surveillance network of cell cycle proteins. |
2005-03-21 |
2023-08-12 |
mouse |
| Mazen W Karaman, Susan Groshen, Chi-Chiang Lee, Brian L Pike, Joseph G Haci. Comparisons of substitution, insertion and deletion probes for resequencing and mutational analysis using oligonucleotide microarrays. Nucleic acids research. vol 33. issue 3. 2005-03-17. PMID:15722479. |
here, we compare and contrast the hybridization properties of oligonucleotide microarrays consisting of 25mer probes complementary to all possible single nucleotide substitutions and insertions, and one and two base deletions in the 9168 bp coding region of the atm (ataxia telangiectasia mutated) gene. |
2005-03-17 |
2023-08-12 |
Not clear |
| J K A Jameel, V S R Rao, L Cawkwell, P J Dre. Radioresistance in carcinoma of the breast. Breast (Edinburgh, Scotland). vol 13. issue 6. 2005-03-03. PMID:15563851. |
ataxia telangiectasia mutant (atm) kinase, which is a member of phosphatidylinositol-3 kinase (pi-3k) family appears to play a central role in dna damage check point pathways. |
2005-03-03 |
2023-08-12 |
human |
| Christopher E Helt, William A Cliby, Peter C Keng, Robert A Bambara, Michael A O'Reill. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. The Journal of biological chemistry. vol 280. issue 2. 2005-02-25. PMID:15533933. |
ataxia telangiectasia mutated (atm) and atm and rad3-related protein exhibit selective target specificities in response to different forms of dna damage. |
2005-02-25 |
2023-08-12 |
Not clear |
| Christopher E Helt, William A Cliby, Peter C Keng, Robert A Bambara, Michael A O'Reill. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. The Journal of biological chemistry. vol 280. issue 2. 2005-02-25. PMID:15533933. |
the ataxia telangiectasia mutated (atm) and atr (atm and rad3-related) protein kinases exert cell cycle delay, in part, by phosphorylating checkpoint kinase (chk) 1, chk2, and p53. |
2005-02-25 |
2023-08-12 |
Not clear |
| Hongyan Wang, Minli Wang, Huichen Wang, Wilfried Böcker, George Iliaki. Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors. Journal of cellular physiology. vol 202. issue 2. 2005-02-18. PMID:15389585. |
it remains open whether atm (ataxia telangiectasia mutated) is the major h2ax kinase, or whether other members of the family, such as dna-pk (dna dependent protein kinase) or atr (atm and rad3 related), contribute in a functionally complementary manner. |
2005-02-18 |
2023-08-12 |
human |
| Peter J McKinno. ATM and ataxia telangiectasia. EMBO reports. vol 5. issue 8. 2005-02-17. PMID:15289825. |
atm and ataxia telangiectasia. |
2005-02-17 |
2023-08-12 |
Not clear |
| Peter J McKinno. ATM and ataxia telangiectasia. EMBO reports. vol 5. issue 8. 2005-02-17. PMID:15289825. |
following the identification of mutations in atm (ataxia telangiectasia, mutated) as the underlying cause of the disease, biochemical analysis of this protein kinase has shown that it is a crucial nexus for the cellular response to dna double-stranded breaks. |
2005-02-17 |
2023-08-12 |
Not clear |
| Xianghong Kuang, Mingshan Yan, Na Liu, Virginia L Scofield, Wenan Qiang, Jodi Cahill, Williams S Lynn, Paul K Y Won. Control of Atm-/- thymic lymphoma cell proliferation in vitro and in vivo by dexamethasone. Cancer chemotherapy and pharmacology. vol 55. issue 3. 2005-02-16. PMID:15570424. |
ataxia telangiectasia (a-t) is an autosomal recessive disease in humans caused by mutations in the atm (a-t mutated) gene. |
2005-02-16 |
2023-08-12 |
mouse |
| Henry T Lynch, Carolyn A Deters, Jane F Lynch, Randall E Bran. Familial pancreatic carcinoma in Jews. Familial cancer. vol 3. issue 3-4. 2005-02-15. PMID:15516847. |
other hereditary disorders predisposing to pc include peutz-jeghers syndrome, due to the stk11 mutation, familial pancreatitis due to the cationic trypsinogen gene, site-specific familial pancreatic cancer which may be due to the 4q32-34 mutation, hereditary breast-ovarian cancer (hboc) syndrome that is due to brca2 and possibly some families with hboc that is due to brca1 , familial adenomatous polyposis due to the atp gene, and ataxia telangiectasia due to the atm germline mutation. |
2005-02-15 |
2023-08-12 |
Not clear |
| Lovorka Stojic, Richard Brun, Josef Jiricn. Mismatch repair and DNA damage signalling. DNA repair. vol 3. issue 8-9. 2005-02-14. PMID:15279797. |
to date, signalling cascades involving the ataxia telangiectasia mutated (atm), atm- and rad3-related (atr), as well as the stress-activated kinases jnk/sapk and p38alpha have been linked with methylating agent and 6-thioguanine (tg) treatments, while cisplatin damage was reported to activate the c-abl and jnk/sapk kinases in mmr-dependent manner. |
2005-02-14 |
2023-08-12 |
human |
| Tao Yan, Anand B Desai, James W Jacobberger, R Michael Sramkoski, Tamalette Loh, Timothy J Kinsell. CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. Molecular cancer therapeutics. vol 3. issue 9. 2005-02-09. PMID:15367709. |
in this study, using 6-thioguanine (6-tg) as a mismatch-inducing drug, we examine the role of ataxia telangiectasia mutated (atm)/chk2 and atm and rad-3 related (atr)/chk1 signaling pathways in mmr-mediated cell cycle responses in mmr-proficient human colorectal cancer rko cells. |
2005-02-09 |
2023-08-12 |
human |
| Jin-Hui Yuan, Yang Feng, Rebecca H Fisher, Sharon Maloid, Dan L Longo, Douglas K Ferri. Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase. Molecular cancer research : MCR. vol 2. issue 7. 2005-01-28. PMID:15280449. |
ataxia telangiectasia mutated kinase (atm) is an important enzyme involved in g2 phase cell cycle arrest following interphase dna damage, and inhibition of plk1 by dna damage during g2 occurs in an atm-/atm-rad3-related kinase (atr)-dependent fashion. |
2005-01-28 |
2023-08-12 |
Not clear |
| Bernardo Reina-San-Martin, Hua Tang Chen, André Nussenzweig, Michel C Nussenzwei. ATM is required for efficient recombination between immunoglobulin switch regions. The Journal of experimental medicine. vol 200. issue 9. 2005-01-18. PMID:15520243. |
ataxia telangiectasia mutated (atm) kinase is critical for initiating the signaling pathways that lead to cell cycle checkpoints and dna double strand break repair. |
2005-01-18 |
2023-08-12 |
mouse |
| Enriqueta Riballo, Martin Kühne, Nicole Rief, Aidan Doherty, Graeme C M Smith, María-José Recio, Caroline Reis, Kirsten Dahm, Andreas Fricke, Andrea Krempler, Antony R Parker, Stephen P Jackson, Andrew Gennery, Penny A Jeggo, Markus Löbric. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Molecular cell. vol 16. issue 5. 2005-01-13. PMID:15574327. |
by epistasis analysis, we show that ataxia telangiectasia mutated protein (atm) and artemis, the protein defective in patients with rs-scid, function in a common double-strand break (dsb) repair pathway that also requires h2ax, 53bp1, nbs1, mre11, and dna-pk. |
2005-01-13 |
2023-08-12 |
Not clear |
| Naoko Shima, Robert J Munroe, John C Schiment. The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Molecular and cellular biology. vol 24. issue 23. 2005-01-04. PMID:15542845. |
to investigate the potential involvement of polq in dna double-strand break repair, we introduced chaos1 into an atm (for ataxia telangiectasia mutated)-deficient background. |
2005-01-04 |
2023-08-12 |
mouse |
| Ashley L Craig, Ted R Hup. The regulation of CHK2 in human cancer. Oncogene. vol 23. issue 52. 2004-12-16. PMID:15361833. |
the p53 tumour suppressor is a central component of a dna-damage-inducible pathway controlled by the ataxia telangiectasia mutated (atm) and chk2 protein kinases that have a central role in cancer suppression. |
2004-12-16 |
2023-08-12 |
human |
| Atsushi Suzuki, Gen-ichi Kusakai, Atsuhiro Kishimoto, Yosuke Shimojo, Tsutomu Ogura, Martin F Lavin, Hiroyasu Esum. IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner. Biochemical and biophysical research communications. vol 324. issue 3. 2004-12-14. PMID:15485651. |
in the human pancreatic cancer cell line panc-1, ampk-alpha subunit phosphorylation promoted by igf-1 was suppressed by antisense ataxia telangiectasia mutated (atm) expression. |
2004-12-14 |
2023-08-12 |
human |