| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adayabalam S Balajee, Charles R Gear. Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks. Experimental cell research. vol 300. issue 2. 2004-11-24. PMID:15474997. |
additionally, radiosensitive ataxia telangiectasia (at) cells harboring mutations in atm gene product were found to be deficient in rpa and gamma-h2ax colocalization after ir. |
2004-11-24 |
2023-08-12 |
human |
| Constantinos Demonacos, Marija Krstic-Demonacos, Linda Smith, Danmei Xu, Darran P O'Connor, Martin Jansson, Nicholas B La Thangu. A new effector pathway links ATM kinase with the DNA damage response. Nature cell biology. vol 6. issue 10. 2004-11-09. PMID:15448695. |
strap remains localized in the cytoplasm in cells derived from ataxia telangiectasia individuals with defective atm, as well as in cells expressing a strap mutant that cannot be phosphorylated by atm. |
2004-11-09 |
2023-08-12 |
Not clear |
| Rulla M Tamimi, Susan E Hankinson, Donna Spiegelman, Peter Kraft, Graham A Colditz, David J Hunte. Common ataxia telangiectasia mutated haplotypes and risk of breast cancer: a nested case-control study. Breast cancer research : BCR. vol 6. issue 4. 2004-11-04. PMID:15217510. |
the ataxia telangiectasia mutated (atm) gene is a tumor suppressor gene with functions in cell cycle arrest, apoptosis, and repair of dna double-strand breaks. |
2004-11-04 |
2023-08-12 |
Not clear |
| Geert Hamer, Henk B Kal, Christoph H Westphal, Terry Ashley, Dirk G de Rooi. Ataxia telangiectasia mutated expression and activation in the testis. Biology of reproduction. vol 70. issue 4. 2004-11-02. PMID:14681204. |
ionizing radiation (ir) and consequent induction of dna double-strand breaks (dsbs) causes activation of the protein ataxia telangiectasia mutated (atm). |
2004-11-02 |
2023-08-12 |
mouse |
| Joshua Silverman, Hiroyuki Takai, Sara B C Buonomo, Frank Eisenhaber, Titia de Lang. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes & development. vol 18. issue 17. 2004-11-02. PMID:15342490. |
this response was strictly dependent on atm (ataxia telangiectasia mutated) and 53bp1, but not affected by diminished function of atr (atm- and rad3-related kinase), brca1, chk2, nbs1, and mre11. |
2004-11-02 |
2023-08-12 |
human |
| Timothy P Wakeman, Wan-Ju Kim, Shannon Callens, Arthur Chiu, Kevin D Brown, Bo X. The ATM-SMC1 pathway is essential for activation of the chromium[VI]-induced S-phase checkpoint. Mutation research. vol 554. issue 1-2. 2004-11-02. PMID:15450422. |
we also demonstrated that ataxia telangiectasia mutated (atm) is activated in response to cr[vi] and exposure to cr[vi] triggers a dose and atm-dependent s-phase arrest. |
2004-11-02 |
2023-08-12 |
human |
| Hong-Mei Wang, Yun-Fei Xia, Xin-Yao W. [ATM and telomere instability]. Yi chuan xue bao = Acta genetica Sinica. vol 31. issue 2. 2004-10-28. PMID:15473314. |
the gene responsible for ataxia telangiectasia (a-t) is atm (ataxia-telangiectasia mutant), a master controller of cellular pathways and networks, orchestrating the response to a specific type of dna damage, i.e., the double strand break. |
2004-10-28 |
2023-08-12 |
Not clear |
| Y H Shen, B Utama, J Wang, M Raveendran, D Senthil, W J Waldman, J D Belcher, G Vercellotti, D Martin, B M Mitchelle, X L Wan. Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways. Circulation research. vol 94. issue 10. 2004-10-15. PMID:15105295. |
further exploration of the upstream pathway demonstrated upregulation of the tumor suppressor p53 gene and activation of the ataxia telangiectasia mutant (atm) pathway in the infected cells. |
2004-10-15 |
2023-08-12 |
human |
| Sarah R Oikemus, Nadine McGinnis, Joana Queiroz-Machado, Hanna Tukachinsky, Saeko Takada, Claudio E Sunkel, Michael H Brodsk. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Genes & development. vol 18. issue 15. 2004-08-24. PMID:15256487. |
in mammals, ataxia telangiectasia mutated (atm) is activated by dna damage and acts through an unknown, telomerase-independent mechanism to regulate telomere length and protection. |
2004-08-24 |
2023-08-12 |
drosophila_melanogaster |
| Aatur D Singhi, Roman V Kondratov, Nickolay Neznanov, Mikhail V Chernov, Andrei V Gudko. Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 25. 2004-08-23. PMID:15187233. |
applications of ssa for gene discovery, target discovery, and generation of mutant proteins have been demonstrated, by using p53 and ataxia telangiectasia mutated (atm) as models to isolate growth inhibitory proteins, peptides and antisense rnas, and temperature-sensitive mutant proteins. |
2004-08-23 |
2023-08-12 |
Not clear |
| Carlos E Irarrazabal, Jennifer C Liu, Maurice B Burg, Joan D Ferrari. ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 23. 2004-08-17. PMID:15173573. |
high nacl damages dna, and dna damage activates ataxia telangiectasia mutated (atm) kinase through autophosphorylation on ser-1981. |
2004-08-17 |
2023-08-12 |
Not clear |
| Yuko Otsuka, Tomoaki Tanaka, Daigaku Uchida, Yoshihiko Noguchi, Naokatsu Saeki, Yasushi Saito, Ichiro Tatsun. Roles of cyclin-dependent kinase 4 and p53 in neuronal cell death induced by doxorubicin on cerebellar granule neurons in mouse. Neuroscience letters. vol 365. issue 3. 2004-08-09. PMID:15246544. |
wortmannin, an inhibitor of atm (ataxia telangiectasia, mutated) that has high homology with the phosphatidyl-inositol-3-kinase (pi3k) family and has protein kinase activity for the induction of p53 with specificity for serine and threonine residues, inhibited the activation of cdk4 without the induction of p53 in d-ncd. |
2004-08-09 |
2023-08-12 |
mouse |
| Virginie Eclache, Sylvie Caulet-Maugendre, Hélène A Poirel, Mohand Djemai, Jacqueline Robert, Françoise Lejeune, Martine Raphaë. Cryptic deletion involving the ATM locus at 11q22.3 approximately q23.1 in B-cell chronic lymphocytic leukemia and related disorders. Cancer genetics and cytogenetics. vol 152. issue 1. 2004-07-27. PMID:15193446. |
this region, which contains the ataxia telangiectasia mutated (atm) locus, may be implicated in the pathogenesis of lymphoid malignancies. |
2004-07-27 |
2023-08-12 |
Not clear |
| Ian J Sutton, James I K Last, Susan J Ritchie, Hugh J Harrington, Philip J Byrd, A Malcolm R Taylo. Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity. Annals of neurology. vol 55. issue 6. 2004-07-12. PMID:15174027. |
adult-onset ataxia telangiectasia due to atm 5762ins137 mutation homozygosity. |
2004-07-12 |
2023-08-12 |
Not clear |
| Ian J Sutton, James I K Last, Susan J Ritchie, Hugh J Harrington, Philip J Byrd, A Malcolm R Taylo. Adult-onset ataxia telangiectasia due to ATM 5762ins137 mutation homozygosity. Annals of neurology. vol 55. issue 6. 2004-07-12. PMID:15174027. |
ataxia telangiectasia (a-t) is an autosomal recessive neurodegenerative disorder that arises because of mutations in the atm gene. |
2004-07-12 |
2023-08-12 |
Not clear |
| Lovorka Stojic, Nina Mojas, Petr Cejka, Massimiliano Di Pietro, Stefano Ferrari, Giancarlo Marra, Josef Jiricn. Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes & development. vol 18. issue 11. 2004-07-09. PMID:15175264. |
downstream targets of both atm (ataxia telangiectasia mutated) and atr (atm and rad3-related) kinases were modified, but only the ablation of atr, or the inhibition of chk1, attenuated the arrest. |
2004-07-09 |
2023-08-12 |
human |
| Kai Treuner, Rob Helton, Carrolee Barlo. Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice. Oncogene. vol 23. issue 27. 2004-06-29. PMID:15122331. |
ataxia telangiectasia (a-t) is an autosomal recessive disease caused by loss of function of the protein kinase atm. |
2004-06-29 |
2023-08-12 |
mouse |
| Charles K Brown, Nikolai N Khodarev, Jianqing Yu, Tricia Moo-Young, Edwardine Labay, Thomas E Darga, Mitchell C Posner, Ralph R Weichselbaum, Helena J Maucer. Glioblastoma cells block radiation-induced programmed cell death of endothelial cells. FEBS letters. vol 565. issue 1-3. 2004-06-23. PMID:15135073. |
an increase in protein expression of integrin alphav, integrin beta1, mapk(p42), rad51, dna-pk(cs), and ataxia telangiectasia gene (atm) was detected in huvec grown in cc with gfp-u87 cells compared with huvec grown in mono-culture. |
2004-06-23 |
2023-08-12 |
human |
| Kevin C E Little, Pierre Chartran. Genomic DNA is captured and amplified during double-strand break (DSB) repair in human cells. Oncogene. vol 23. issue 23. 2004-06-15. PMID:15048077. |
the availability of the human genome sequence enabled us to characterize these inserts in cells from a normal individual and from a patient with ataxia telangiectasia (at), deficient for the damage response kinase atm and prone to genomic instability. |
2004-06-15 |
2023-08-12 |
human |
| Shujuan Chen, Gang Wang, G Mike Makrigiorgos, Brendan D Pric. Stable siRNA-mediated silencing of ATM alters the transcriptional profile of HeLa cells. Biochemical and biophysical research communications. vol 317. issue 4. 2004-06-01. PMID:15094373. |
the atm protein, which is mutated in the inherited disease ataxia telangiectasia (at), is a key regulator of the cells' dna damage response. |
2004-06-01 |
2023-08-12 |
Not clear |