| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tom Stiff, Mark O'Driscoll, Nicole Rief, Kuniyoshi Iwabuchi, Markus Löbrich, Penny A Jegg. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer research. vol 64. issue 7. 2004-05-19. PMID:15059890. |
it is widely accepted that atm (ataxia telangiectasia mutated protein) phosphorylates h2ax in response to dna double-strand breaks (dsbs). |
2004-05-19 |
2023-08-12 |
mouse |
| Harry A Rogoff, Mary T Pickering, Fiona M Frame, Michelle E Debatis, Yolanda Sanchez, Stephen Jones, Timothy F Kowali. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Molecular and cellular biology. vol 24. issue 7. 2004-05-10. PMID:15024084. |
e2f1- and e7-mediated apoptosis are compromised in cells from patients with the related disorders ataxia telangiectasia and nijmegen breakage syndrome lacking functional atm and nbs1 gene products, respectively. |
2004-05-10 |
2023-08-12 |
human |
| Thomas A Buchholz, Michael M Weil, Cheryl L Ashorn, Eric A Strom, Alice Sigurdson, Melissa Bondy, Ranajit Chakraborty, James D Cox, Marsha D McNeese, Michael D Stor. A Ser49Cys variant in the ataxia telangiectasia, mutated, gene that is more common in patients with breast carcinoma compared with population controls. Cancer. vol 100. issue 7. 2004-05-06. PMID:15042666. |
to test whether sequence variants in the ataxia telangiectasia, mutated, gene (atm) are associated with breast carcinoma, the authors compared the frequency of atm cdna sequence changes in patients with breast carcinoma with the corresponding frequency in control patients. |
2004-05-06 |
2023-08-12 |
Not clear |
| Agnes Baross, Mike Schertzer, Scott D Zuyderduyn, Steven J M Jones, Marco A Marra, Peter M Lansdor. Effect of TERT and ATM on gene expression profiles in human fibroblasts. Genes, chromosomes & cancer. vol 39. issue 4. 2004-05-04. PMID:14978791. |
ataxia telangiectasia mutated (atm) deficiency in a-t human fibroblasts results in accelerated telomere shortening, abnormal cell-cycle response to dna damage, and early senescence. |
2004-05-04 |
2023-08-12 |
human |
| Gabriela Coutinho, Midori Mitui, Catarina Campbell, Beatriz T Costa Carvalho, Shareef Nahas, Xia Sun, Yong Huo, Chih-Hung Lai, Yvonne Thorstenson, Robert Tanouye, Salmo Raskin, Chong A Kim, Juan Llerena, Richard A Gatt. Five haplotypes account for fifty-five percent of ATM mutations in Brazilian patients with ataxia telangiectasia: seven new mutations. American journal of medical genetics. Part A. vol 126A. issue 1. 2004-04-23. PMID:15039971. |
five haplotypes account for fifty-five percent of atm mutations in brazilian patients with ataxia telangiectasia: seven new mutations. |
2004-04-23 |
2023-08-12 |
Not clear |
| Joo Hyeon Lee, Bo Xu, Chang-Hun Lee, Jun-Young Ahn, Min Sup Song, Ho Lee, Christine E Canman, Jong-Soo Lee, Michael B Kastan, Dae-Sik Li. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Molecular cancer research : MCR. vol 1. issue 9. 2004-04-20. PMID:12861053. |
phosphorylation of nbs1, the product of the gene mutated in nijmegen breakage syndrome (nbs), by ataxia telangiectasia mutated (atm), the product of the gene mutated in ataxia telangiectasia, is required for activation of the s phase checkpoint in response to ionizing radiation (ir). |
2004-04-20 |
2023-08-12 |
Not clear |
| Paola Giuliano, Tiziana De Cristofaro, Adelina Affaitati, Grazia M Pizzulo, Antonio Feliciello, Chiara Criscuolo, Giuseppe De Michele, Alessandro Filla, Enrico V Avvedimento, Stelio Varron. DNA damage induced by polyglutamine-expanded proteins. Human molecular genetics. vol 12. issue 18. 2004-04-15. PMID:12915485. |
however, the expression of 43q expanded protein strongly activated the ataxia telangiectasia mutated kinase/atm and rad3-related kinase (atm/atr)-dependent dna damage response, as shown by selective phosphorylation of atm substrates. |
2004-04-15 |
2023-08-12 |
Not clear |
| Ji-Hoon Lee, Tanya T Paul. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science (New York, N.Y.). vol 304. issue 5667. 2004-04-14. PMID:15064416. |
the complex containing the mre11, rad50, and nbs1 proteins (mrn) is essential for the cellular response to dna double-strand breaks, integrating dna repair with the activation of checkpoint signaling through the protein kinase atm (ataxia telangiectasia mutated). |
2004-04-14 |
2023-08-12 |
Not clear |
| Barkhaa Undarmaa, Seiji Kodama, Keiji Suzuki, Otsura Niwa, Masami Watanab. X-ray-induced telomeric instability in Atm-deficient mouse cells. Biochemical and biophysical research communications. vol 315. issue 1. 2004-04-09. PMID:15013424. |
the gene responsible for ataxia telangiectasia (at) encodes atm protein, which plays a major role in the network of a signal transduction initiated by double strand dna breaks. |
2004-04-09 |
2023-08-12 |
mouse |
| Martin Kühne, Enriqueta Riballo, Nicole Rief, Kai Rothkamm, Penny A Jeggo, Markus Löbric. A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer research. vol 64. issue 2. 2004-04-02. PMID:14744762. |
the atm protein, which is mutated in individuals with ataxia telangiectasia (at), is central to cell cycle checkpoint responses initiated by dna double-strand breaks (dsbs). |
2004-04-02 |
2023-08-12 |
human |
| Ganesh R Panta, Swayamjot Kaur, Lakita G Cavin, Maria L Cortés, Frank Mercurio, Leonard Lothstein, Trevor W Sweatman, Mervyn Israel, Marcello Arsur. ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Molecular and cellular biology. vol 24. issue 5. 2004-04-01. PMID:14966265. |
we have identified a novel pathway of ataxia telangiectasia mutated (atm) and dna-dependent protein kinase (dna-pk) signaling that results in nuclear factor kappab (nf-kappab) activation and chemoresistance in response to dna damage. |
2004-04-01 |
2023-08-12 |
Not clear |
| Inna I Kruman, Robert P Wersto, Fernando Cardozo-Pelaez, Lubomir Smilenov, Sic L Chan, Francis J Chrest, Roland Emokpae, Myriam Gorospe, Mark P Mattso. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron. vol 41. issue 4. 2004-03-30. PMID:14980204. |
suppression of the function of ataxia telangiectasia mutated (atm), a proximal component of dna damage-induced cell cycle checkpoint pathways, attenuated both apoptosis and cell cycle reentry triggered by dna damage but did not change the fate of neurons exposed to staurosporine and colchicine. |
2004-03-30 |
2023-08-12 |
Not clear |
| M Fernet, N Moullan, A Lauge, D Stoppa-Lyonnet, J Hal. Cellular responses to ionising radiation of AT heterozygotes: differences between missense and truncating mutation carriers. British journal of cancer. vol 90. issue 4. 2004-03-26. PMID:14970866. |
it has been estimated that approximately 1% of the general population are ataxia telangiectasia (at) mutated (atm) heterozygotes. |
2004-03-26 |
2023-08-12 |
Not clear |
| Lian Zhang, Guang Jia, Wen-Mei Li, Rui-Fang Guo, Jian-Tao Cui, Lin Yang, You-Yong L. Alteration of the ATM gene occurs in gastric cancer cell lines and primary tumors associated with cellular response to DNA damage. Mutation research. vol 557. issue 1. 2004-03-04. PMID:14706517. |
ataxia telangiectasia mutated (atm) is the gene mutated in the genetic disorder ataxia telangiectasia (at), the symptoms of which include sensitivity to radiation and an increased risk of cancer. |
2004-03-04 |
2023-08-12 |
human |
| b' Marta Salido, Laura Astier, Eul\\xc3\\xa0lia Puigdecanet, Blanca Espinet, Lourdes Florensa, Francesc Sol\\xc3\\xa. Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL). Haematologica. vol 88. issue 11. 2004-02-24. PMID:14607769.' |
we used a locus specific probe (11q22.3) that hybridizes with ataxia telangiectasia mutated gene (atm) and a centromeric probe of chromosome 11 as a control. |
2004-02-24 |
2023-08-12 |
Not clear |
| Hayla K Sluss, Heather Armata, Judy Gallant, Stephen N Jone. Phosphorylation of serine 18 regulates distinct p53 functions in mice. Molecular and cellular biology. vol 24. issue 3. 2004-02-24. PMID:14729946. |
recently, it has been proposed that phosphorylation of serine 15 in human p53 by atm (mutated in ataxia telangiectasia) kinase induces p53 activity by interfering with the mdm2-p53 complex formation and inhibiting mdm2-mediated destabilization of p53. |
2004-02-24 |
2023-08-12 |
mouse |
| Masatoshi Takagi, Rika Tsuchida, Kaoru Oguchi, Teruko Shigeta, Shinichiro Nakada, Kimiko Shimizu, Misao Ohki, Domenico Delia, Luciana Chessa, Yoichi Taya, Makoto Nakanishi, Yukiko Tsunematsu, Fumio Bessho, Keiichi Isoyama, Yoshiki Hayashi, Kazuko Kudo, Jun Okamura, Shuki Mizutan. Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. Blood. vol 103. issue 1. 2004-02-17. PMID:12969974. |
identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (atm) gene in childhood hodgkin disease. |
2004-02-17 |
2023-08-12 |
Not clear |
| Masatoshi Takagi, Rika Tsuchida, Kaoru Oguchi, Teruko Shigeta, Shinichiro Nakada, Kimiko Shimizu, Misao Ohki, Domenico Delia, Luciana Chessa, Yoichi Taya, Makoto Nakanishi, Yukiko Tsunematsu, Fumio Bessho, Keiichi Isoyama, Yoshiki Hayashi, Kazuko Kudo, Jun Okamura, Shuki Mizutan. Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. Blood. vol 103. issue 1. 2004-02-17. PMID:12969974. |
there are conflicting reports about the involvement of single nucleotide polymorphisms (snps) of the ataxia telangiectasia mutated (atm) gene with cancer, and the consequences of these snps for atm function remain unclear. |
2004-02-17 |
2023-08-12 |
Not clear |
| Kazuhito Naka, Akira Tachibana, Kyoji Ikeda, Noboru Motoyam. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. The Journal of biological chemistry. vol 279. issue 3. 2004-02-12. PMID:14570874. |
atm, the product of the gene mutated in individuals with ataxia telangiectasia (at), plays a central role in cell cycle arrest in response to dna damage. |
2004-02-12 |
2023-08-12 |
human |
| Yi Tang, Wen-Li Liu, Jian-Feng Zhou, Qing-Lei Gao, Jian-Hong W. [Relationship between ataxia telangiectasia mutant(ATM) expression of HL-60 and SiHA cell lines and their cell cycle arrest after 60Co radiation]. Ai zheng = Aizheng = Chinese journal of cancer. vol 22. issue 7. 2003-12-18. PMID:12866959. |
[relationship between ataxia telangiectasia mutant(atm) expression of hl-60 and siha cell lines and their cell cycle arrest after 60co radiation]. |
2003-12-18 |
2023-08-12 |
Not clear |