| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Tang, Wen-Li Liu, Jian-Feng Zhou, Qing-Lei Gao, Jian-Hong W. [Relationship between ataxia telangiectasia mutant(ATM) expression of HL-60 and SiHA cell lines and their cell cycle arrest after 60Co radiation]. Ai zheng = Aizheng = Chinese journal of cancer. vol 22. issue 7. 2003-12-18. PMID:12866959. |
ataxia telangiectasia is caused by ataxia telangiectasia mutant(atm) gene and it is characterized by hypersensitivity to the radiation. |
2003-12-18 |
2023-08-12 |
Not clear |
| Kai Chen, Adam Albano, Alan Ho, John F Keane. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. The Journal of biological chemistry. vol 278. issue 41. 2003-12-02. PMID:12890678. |
activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (atm) kinase activation. |
2003-12-02 |
2023-08-12 |
Not clear |
| Kai Chen, Adam Albano, Alan Ho, John F Keane. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. The Journal of biological chemistry. vol 278. issue 41. 2003-12-02. PMID:12890678. |
in this study, we characterized the signaling pathway linking oxidative stress to p53 through the platelet-derived growth factor beta (pdgf beta) receptor and the ataxia telangiectasia mutated (atm) kinase. |
2003-12-02 |
2023-08-12 |
Not clear |
| Jun Yang, Yingnian Yu, Hope E Hamrick, Penelope J Duerksen-Hughe. ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Carcinogenesis. vol 24. issue 10. 2003-11-28. PMID:12919958. |
however, the initial activation of the protein kinase cascade is not fully understood, although several protein kinases, such as ataxia telangiectasia, mutated (atm), atm- and rad3-related (atr), and dna-dependent protein kinase (dna-pk) in humans, are increasingly recognized for their potential roles in the sensing of dna damage and initiating the subsequent protein kinase cascade. |
2003-11-28 |
2023-08-12 |
human |
| Mitsumasa Hashimoto, Satish Rao, Osamu Tokuno, Ken-Ichi Yamamoto, Minoru Takata, Shunichi Takeda, Hiroshi Utsum. DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway. Journal of radiation research. vol 44. issue 2. 2003-11-12. PMID:13678345. |
the effect of wortmannin posttreatment was studied in cells derived from different species (hamster, mouse, chicken, and human) with normal and defective dna-dependent protein kinase (dna-pk) activity, cells with and without the ataxia telangiectasia (atm) gene, and cells lacking other regulatory proteins involved in the dna double-strand break (dsb) repair pathways. |
2003-11-12 |
2023-08-12 |
mouse |
| Xiang Wang, Jay Khadpe, Baocheng Hu, George Iliakis, Ya Wan. An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. The Journal of biological chemistry. vol 278. issue 33. 2003-11-10. PMID:12791699. |
ataxia telangiectasia mutated (atm) plays a key role in initiating this response in all three phases of the cell cycle. |
2003-11-10 |
2023-08-12 |
human |
| Mitsuko Yamaguchi, Koh Yamamoto, Tohru Miki, Shuki Mizutani, Osamu Miur. T-cell prolymphocytic leukemia with der(11)t(1;11)(q21;q23) and ATM deficiency. Cancer genetics and cytogenetics. vol 146. issue 1. 2003-11-05. PMID:14499692. |
t-cell prolymphocytic leukemia (t-pll) is a rare mature t-cell malignancy and is similar to a mature t-cell leukemia seen in some patients with ataxia telangiectasia, which is a recessive hereditary chromosomal instability syndrome caused by mutations of the ataxia telangiectasia mutated (atm) gene located on 11q23. |
2003-11-05 |
2023-08-12 |
Not clear |
| Alexandra N Heinloth, Rodney E Shackelford, Cynthia L Innes, Lee Bennett, Leping Li, Rupesh P Amin, Stella O Sieber, Kristina G Flores, Pierre R Bushel, Richard S Paule. ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation. Radiation research. vol 160. issue 3. 2003-10-23. PMID:12926986. |
the ataxia telangiectasia mutated (atm) gene encodes a protein (atm) with serine/threonine kinase activity. |
2003-10-23 |
2023-08-12 |
human |
| Steve S Sommer, Zefei Jiang, Jinong Feng, Carolyn H Buzin, Jian Zheng, Jeffrey Longmate, Mira Jung, Jefferson Moulds, Anatoly Dritschil. ATM missense mutations are frequent in patients with breast cancer. Cancer genetics and cytogenetics. vol 145. issue 2. 2003-10-01. PMID:12935922. |
ataxia telangiectasia (a-t), an autosomal recessive neuro-immunologic disease with cancer susceptibility, results from atm gene mutations. |
2003-10-01 |
2023-08-12 |
Not clear |
| Steve S Sommer, Zefei Jiang, Jinong Feng, Carolyn H Buzin, Jian Zheng, Jeffrey Longmate, Mira Jung, Jefferson Moulds, Anatoly Dritschil. ATM missense mutations are frequent in patients with breast cancer. Cancer genetics and cytogenetics. vol 145. issue 2. 2003-10-01. PMID:12935922. |
epidemiologic evidence suggests that atm gene mutation carriers may be at increased risk for breast cancer, but the protein-truncating mutations that compose the majority of mutations in patients with ataxia telangiectasia are not elevated in women with breast cancer. |
2003-10-01 |
2023-08-12 |
Not clear |
| Kristoffer Valerie, Lawrence F Povir. Regulation and mechanisms of mammalian double-strand break repair. Oncogene. vol 22. issue 37. 2003-10-01. PMID:12947387. |
this review focuses on the mechanisms and regulation of dsb repair in mammalian cells, the signaling pathways that regulate these processes and the potential crosstalk between nhej and hrr, and between repair and other stress-induced pathways with emphasis on the regulatory circuitry associated with the ataxia telangiectasia mutated (atm) protein. |
2003-10-01 |
2023-08-12 |
Not clear |
| Dianne J Watter. Oxidative stress in ataxia telangiectasia. Redox report : communications in free radical research. vol 8. issue 1. 2003-09-11. PMID:12631440. |
the affected gene, atm (ataxia telangiectasia mutated), has been cloned and codes for a protein kinase (atm), which orchestrates the cellular response to dna double-strand breaks after ionising radiation. |
2003-09-11 |
2023-08-12 |
Not clear |
| Jane Starczynski, William Simmons, Joanne R Flavell, Phillip J Byrd, Grant S Stewart, Harjit S Kullar, Alix Groom, John Crocker, Paul A H Moss, Gary M Reynolds, Meri Glavina-Durdov, A Malcolm R Taylor, Christopher Fegan, Tatjana Stankovic, Paul G Murra. Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias. The American journal of pathology. vol 163. issue 2. 2003-09-10. PMID:12875964. |
the ataxia telangiectasia mutated (atm) protein plays a central role in the cellular response to dna double-strand breaks (dsbs). |
2003-09-10 |
2023-08-12 |
Not clear |
| Brad Clifford, Milos Beljin, George R Stark, William R Taylo. G2 arrest in response to topoisomerase II inhibitors: the role of p53. Cancer research. vol 63. issue 14. 2003-08-13. PMID:12874009. |
in ht1080 cells expressing a dominant-negative form of p53, treatment with etoposide still caused g(2) arrest, but the arrest could be overcome by additional treatment with caffeine, which inhibits the damage-responsive kinases ataxia telangiectasia mutated (atm) and atm and rad3-related (atr). |
2003-08-13 |
2023-08-12 |
Not clear |
| Keisuke Ito, Tomonori Nakazato, Yoshitaka Miyakawa, Kenji Yamato, Yasuo Ikeda, Masahiro Kizak. Caffeine induces G2/M arrest and apoptosis via a novel p53-dependent pathway in NB4 promyelocytic leukemia cells. Journal of cellular physiology. vol 196. issue 2. 2003-08-11. PMID:12811820. |
methylxantine derivative, caffeine, is known to prevent the p53-dependent apoptosis pathway via inhibition of atm (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the ser-15 residue. |
2003-08-11 |
2023-08-12 |
Not clear |
| Martine Mauget-Faÿsse, Michèle Vuillaume, Maddalena Quaranta, Norman Moullan, Sandra Angèle, Marlin D Friesen, Janet Hal. Idiopathic and radiation-induced ocular telangiectasia: the involvement of the ATM gene. Investigative ophthalmology & visual science. vol 44. issue 8. 2003-08-11. PMID:12882767. |
to investigate whether individuals, with no family history of ataxia telangiectasia (at), in whom idiopathic or radiation-induced ocular telangiectasia developed are carriers of atm gene mutations. |
2003-08-11 |
2023-08-12 |
Not clear |
| Yvonne R Thorstenson, Adriane Roxas, Regina Kroiss, Mark A Jenkins, Kristine M Yu, Thomas Bachrich, Daniela Muhr, Tierney L Wayne, Gilbert Chu, Ronald W Davis, Teresa M U Wagner, Peter J Oefne. Contributions of ATM mutations to familial breast and ovarian cancer. Cancer research. vol 63. issue 12. 2003-07-28. PMID:12810666. |
seven of these were mutations presumed to cause ataxia telangiectasia based on their effect on the atm protein, including five that caused a protein truncation and two missense mutations in the catalytic kinase domain of the highly conserved cooh terminus of the protein. |
2003-07-28 |
2023-08-12 |
human |
| O Llorca, A Rivera-Calzada, J Grantham, K R Williso. Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA. Oncogene. vol 22. issue 25. 2003-07-24. PMID:12813460. |
the human tumor suppressor gene ataxia telangiectasia mutated (atm) encodes a 3056 amino-acid protein kinase that regulates cell cycle checkpoints. |
2003-07-24 |
2023-08-12 |
human |
| Peilin Zhang, Kunjan S Bhakta, Pier Lorenzo Puri, Robert O Newbury, James R Feramisco, Jean Y Wan. Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma. Cancer biology & therapy. vol 2. issue 1. 2003-07-23. PMID:12673126. |
association of ataxia telangiectasia mutated (atm) gene mutation/deletion with rhabdomyosarcoma. |
2003-07-23 |
2023-08-12 |
Not clear |
| Peilin Zhang, Kunjan S Bhakta, Pier Lorenzo Puri, Robert O Newbury, James R Feramisco, Jean Y Wan. Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma. Cancer biology & therapy. vol 2. issue 1. 2003-07-23. PMID:12673126. |
we report here that there is a high frequency of association of rhabdomyosarcoma with ataxia telangiectasia mutated (atm) gene mutation/deletion. |
2003-07-23 |
2023-08-12 |
Not clear |